Cheap Flights from Myrtle Beach, SC to Chicago, IL from $48

On Cheapflightsplus.com you will find 7 direct and 369 connecting flights from Myrtle Beach to Chicago. You can compare airfare deals from 4 airlines and multiple travel sites from $48, book and save on cheap plane tickets and last minute offers. Also check out MYR-CHI flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Myrtle Beach to Chicago Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $48 (one-way), $82 (round-trip).
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Full flight schedule will help you in detecting at what time planes fly from Myrtle Beach to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
11:35 — 13:05
11:35 — 13:05 UA752 United Airlines
Myrtle Beach — Chicago
2h 30m
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from$168
13:53 — 15:17
13:53 — 15:17 NK3033 Spirit Airlines
Myrtle Beach — Chicago
2h 24m
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from$78
15:16 — 16:41
15:16 — 16:41 NK1815 Spirit Airlines
Myrtle Beach — Chicago
2h 25m
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from$48
16:45 — 18:22
16:45 — 18:22 UA5335 United Airlines
Myrtle Beach — Chicago
2h 37m
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from$105
16:45 — 18:14
16:45 — 18:14 UA444 United Airlines
Myrtle Beach — Chicago
2h 29m
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from$153
16:50 — 18:20
16:50 — 18:20 UA1580 United Airlines
Myrtle Beach — Chicago
2h 30m
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from$105
17:54 — 19:19
17:54 — 19:19 NK3190 Spirit Airlines
Myrtle Beach — Chicago
2h 25m
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from$48
05:00 — 09:55
05:00 — 06:52 NK3646 Spirit Airlines
Myrtle Beach — Miami
48m stop
07:40 — 09:55 NK2 Spirit Airlines
Miami — Chicago
5h 55m
including layover
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from$72
05:00 — 14:34
05:00 — 06:52 NK3646 Spirit Airlines
Myrtle Beach — Miami
5h 25m stop
12:17 — 14:34 NK866 Spirit Airlines
Miami — Chicago
10h 34m
including layover
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from$72
06:10 — 15:31
06:10 — 07:32 NK1289 Spirit Airlines
Myrtle Beach — Orlando
5h 51m stop
13:23 — 15:31 NK1369 Spirit Airlines
Orlando — Chicago
10h 21m
including layover
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from$80
06:10 — 17:17
06:10 — 07:32 NK1289 Spirit Airlines
Myrtle Beach — Orlando
7h 36m stop
15:08 — 17:17 NK1114 Spirit Airlines
Orlando — Chicago
12h 7m
including layover
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from$80
08:34 — 14:41
08:34 — 10:30 NK1003 Spirit Airlines
Myrtle Beach — Newark
2h 27m stop
12:57 — 14:41 NK1183 Spirit Airlines
Newark — Chicago
7h 7m
including layover
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from$72
08:34 — 20:00
08:34 — 10:30 NK1003 Spirit Airlines
Myrtle Beach — New York
8h stop
18:30 — 20:00 NK1179 Spirit Airlines
New York — Chicago
12h 26m
including layover
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from$108
10:33 — 23:10
10:33 — 12:23 NK3020 Spirit Airlines
Myrtle Beach — Newark
9h 10m stop
21:33 — 23:10 NK329 Spirit Airlines
Newark — Chicago
13h 37m
including layover
Find flight
from$113
11:28 — 20:23
06:00 — 07:28 NK2644 Spirit Airlines
Myrtle Beach — Orlando
5h 22m stop
17:55 — 20:03 NK2541 Spirit Airlines
Orlando — Chicago
9h 55m
including layover
Find flight
from$132
11:28 — 18:44
06:00 — 07:28 NK2644 Spirit Airlines
Myrtle Beach — Orlando
3h 45m stop
21:25 — 23:29 NK2190 Spirit Airlines
Orlando — Chicago
8h 16m
including layover
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from$139
14:52 — 19:17
14:52 — 16:40 NK2965 Spirit Airlines
Myrtle Beach — New York
55m stop
17:35 — 19:17 NK918 Spirit Airlines
New York — Chicago
5h 25m
including layover
Find flight
from$76
19:13 — 20:00
+1 day
19:13 — 21:10 NK1809 Spirit Airlines
Myrtle Beach — New York
21h 20m stop
18:30 — 20:00 NK1179 Spirit Airlines
New York — Chicago
25h 47m
including layover
Find flight
from$102
19:13 — 14:41
+1 day
19:13 — 21:10 NK1809 Spirit Airlines
Myrtle Beach — Newark
15h 47m stop
12:57 — 14:41 NK1183 Spirit Airlines
Newark — Chicago
20h 28m
including layover
Find flight
from$142
20:30 — 20:00
+1 day
20:30 — 22:12 NK1696 Spirit Airlines
Myrtle Beach — New York
20h 18m stop
18:30 — 20:00 NK1179 Spirit Airlines
New York — Chicago
24h 30m
including layover
Find flight
from$117
10:33 — 18:43
+1 day
10:33 — 12:23 NK3020 Spirit Airlines
Myrtle Beach — Newark
4h 22m stop
16:45 — 19:35 NK1900 Spirit Airlines
Newark — Orlando
20h 58m stop
16:33 — 18:43 NK506 Spirit Airlines
Orlando — Chicago
33h 10m
including layover
Find flight
from$115
12:11 — 08:22
+1 day
12:09 — 13:34 G4982 Allegiant Air
Myrtle Beach — Lexington
9h 5m stop
22:44 — 23:26 G41481 Allegiant Air
Lexington — Fort Walton Beach
6h 35m stop
06:00 — 08:22 G41455 Allegiant Air
Fort Walton Beach — Chicago
21h 11m
including layover
Find flight
from$115
12:37 — 08:55
+1 day
12:37 — 13:52 G42598 Allegiant Air
Myrtle Beach — Huntington
6h 4m stop
19:56 — 22:18 G43471 Allegiant Air
Huntington — Miami
8h 22m stop
06:40 — 08:55 NK1986 Spirit Airlines
Miami — Chicago
21h 18m
including layover
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from$123
14:31 — 08:22
+1 day
14:31 — 15:27 G43112 Allegiant Air
Myrtle Beach — Belleville
5h 35m stop
21:02 — 22:45 G43102 Allegiant Air
Belleville — Fort Walton Beach
7h 15m stop
06:00 — 08:22 G41455 Allegiant Air
Fort Walton Beach — Chicago
18h 51m
including layover
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from$113
17:07 — 20:00
+1 day
17:07 — 17:40 NK1492 Spirit Airlines
Myrtle Beach — Nashville
3h 10m stop
20:50 — 23:59 NK1419 Spirit Airlines
Nashville — New York
18h 31m stop
18:30 — 20:00 NK1179 Spirit Airlines
New York — Chicago
27h 53m
including layover
Find flight
from$126
18:04 — 09:55
+1 day
18:04 — 19:33 NK137 Spirit Airlines
Myrtle Beach — Orlando
9h 57m stop
05:30 — 06:35 NK195 Spirit Airlines
Orlando — Miami
1h 5m stop
07:40 — 09:55 NK2 Spirit Airlines
Miami — Chicago
16h 51m
including layover
Find flight
from$128
18:04 — 13:51
+1 day
18:04 — 19:33 NK137 Spirit Airlines
Myrtle Beach — Orlando
10h 42m stop
06:15 — 07:02 NK423 Spirit Airlines
Orlando — New Orleans
4h 15m stop
11:17 — 13:51 NK1834 Spirit Airlines
New Orleans — Chicago
20h 47m
including layover
Find flight
from$128
20:34 — 15:33
+1 day
20:34 — 22:16 NK2473 Spirit Airlines
Myrtle Beach — Newark
8h 37m stop
06:53 — 08:16 NK2214 Spirit Airlines
Newark — Nashville
5h 14m stop
13:30 — 15:33 NK2028 Spirit Airlines
Nashville — Chicago
19h 59m
including layover
Find flight
from$119
21:20 — 17:15
+1 day
21:20 — 23:25 NK2475 Spirit Airlines
Myrtle Beach — Detroit
6h 50m stop
06:15 — 07:02 NK2567 Spirit Airlines
Detroit — Minneapolis
8h 34m stop
17:36 — 19:17 SY261 Sun Country Airlines
Minneapolis — Chicago
20h 55m
including layover
Find flight
from$138
*Departure and arrival times - local. Updated on June 7, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Myrtle Beach to Chicago depends on and how to choose the most interesting flight option for you.

Distance between Myrtle Beach and Chicago is 1189 miles. Time difference between the cities is 1h. Airplanes depart 05:00 to 21:55 from 2 Myrtle Beach airports and arrive 05:00 to 21:55 to 7 Chicago airports. Average flight time is 2h 29m.

  • The fastest flight 2h 24m
  • Average flight time 2h 29m
  • The earliest flight 05:00
  • The latest flight 21:55
  • Distance 739 ml

The cheapest months to travel to Chicago are july (from 64 $), august (from 64 $), october (from 102 $).

The most expensive months are may (from 190 $), june (from 108 $), september (from 106 $).

What is the lowest airfare Myrtle Beach to Chicago?

The cheapest plane ticket found by our users is $48. This airfare is for economy class on one-way NK1815 flight by Spirit Airlines for July 24, 2025 which leaves AFB in Myrtle Beach at 15:16 am and arrives at Chicago O'Hare International at 16:41.

Economy class
$48
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Business class
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First class
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Popular Airlines on the Route

The flight Myrtle Beach — Chicago is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Mexicana - 7 departures per week at the price of from $ 187 . And the most expensive tickets are offered by United Airlines airline - from $ 1026.

Direct flights

There are 7 nonstop flights on the route. The fastest direct flight is NK3033 by Spirit Airlines takes 2h 24m and the cheapest is NK1815 by Spirit Airlines for $48.

  • UA - United Airlines
    from $105
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  • NK - Spirit Airlines
    from $48
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See more direct flights

Connecting Flights

There are 369 flights with layovers on the route. The fastest connecting flight is UA4334 by United Airlines takes 4h 50m and the cheapest is NK1815 by Spirit Airlines for $72.

  • MX - Mexicana
    from $187
    Find
  • UA - United Airlines
    from $159
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  • NK - Spirit Airlines
    from $72
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  • G4 - Allegiant Air
    from $113
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See more connecting flights

Airports

You can fly from Myrtle Beach to Chicago from 2 airports (AFB, Grand Strand Airport).

Myrtle Beach airports

  • AFB-MYR
    from $48
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  • Grand Strand Airport-CRE
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Chicago airports

  • O'Hare International-ORD
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  • Midway-MDW
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  • Dupage County-DPA
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  • Chicago FSS-CHI
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  • Merrill C Meigs (closed)-CGX
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  • Pal-Waukee-PWK
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  • Chicago NAS-NOH
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How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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