Cheap Flights from Myrtle Beach, SC to Chicago, IL from $53
Return flight: Chicago – Myrtle Beach
On Cheapflightsplus.com you will find 10 direct and 498 connecting flights from Myrtle Beach to Chicago. You can compare airfare deals from 6 airlines and multiple travel sites from $53, book and save on cheap plane tickets and last minute offers. Also check out MYR-CHI flight schedule to find best flight time, convenient departure and arrival airports.
Find One-Way and Round-Trip Myrtle Beach to Chicago Flight Deals
To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights».
To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight.
Cheapest flights in November: $53 (one-way), $91 (round-trip).
Direct flights
Check prices for return flight
Best Flights from Myrtle Beach to Chicago Today
Take a look at the list of non stop flights and flights with layovers from Myrtle Beach to Chicago with the lowest price of $53. The fastest direct flight takes 2h 10m and the fastest connecting – 4h 50m.
| Price | Departure | Arrival | Flight Duration | Airline | Flight |
|---|---|---|---|---|---|
| from $53 | 11:36 Myrtle Beach AFB | 12:46 Chicago O'Hare International | 2h 10m | Spirit Airlines | NK2520 |
| from $63 | 15:16 Myrtle Beach AFB | 16:41 Chicago O'Hare International | 2h 25m | Spirit Airlines | NK1815 |
| from $64 | 17:54 Myrtle Beach AFB | 19:19 Chicago O'Hare International | 2h 25m | Spirit Airlines | NK3190 |
| from $103 | 13:53 Myrtle Beach AFB | 15:17 Chicago O'Hare International | 2h 24m | Spirit Airlines | NK3033 |
| from $138 | 16:45 Myrtle Beach AFB | 18:22 Chicago O'Hare International | 2h 37m | United Airlines | UA5335 |
| from $201 | 16:45 Myrtle Beach AFB | 18:14 Chicago O'Hare International | 2h 29m | United Airlines | UA444 |
| from $86 | 17:32 Myrtle Beach AFB | 00:05+1 день Chicago O'Hare International | 7h 33m layover 2h 34m - Miami | Spirit Airlines | NK2656 NK1 |
| from $96 | 05:00 Myrtle Beach AFB | 09:55 Chicago O'Hare International | 5h 55m layover 0h 48m - Miami | Spirit Airlines | NK3646 NK2 |
| from $96 | 08:34 Myrtle Beach AFB | 14:41 Chicago O'Hare International | 7h 7m layover 2h 27m - Newark | Spirit Airlines | NK1003 NK1183 |
| from $101 | 14:52 Myrtle Beach AFB | 19:17 Chicago O'Hare International | 5h 25m layover 0h 55m - New York | Spirit Airlines | NK2965 NK918 |
| from $101 | 05:00 Myrtle Beach AFB | 14:34 Chicago O'Hare International | 10h 34m layover 5h 25m - Miami | Spirit Airlines | NK3646 NK866 |
| from $106 | 06:10 Myrtle Beach AFB | 15:31 Chicago O'Hare International | 10h 21m layover 5h 51m - Orlando | Spirit Airlines | NK1289 NK1369 |
| from $106 | 06:10 Myrtle Beach AFB | 17:17 Chicago O'Hare International | 12h 7m layover 7h 36m - Orlando | Spirit Airlines | NK1289 NK1114 |
| from $107 | 11:28 Myrtle Beach AFB | 18:44 Chicago O'Hare International | 8h 16m layover 3h 45m - Orlando | Spirit Airlines | NK2644 NK2190 |
| from $107 | 11:28 Myrtle Beach AFB | 20:23 Chicago O'Hare International | 9h 55m layover 5h 22m - Orlando | Spirit Airlines | NK2644 NK2541 |
| from $113 | 10:07 Myrtle Beach AFB | 17:01 Chicago O'Hare International | 7h 54m layover 3h 53m - Philadelphia | Frontier Airlines | F93272 F92111 |
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 04, 2025
Flight Schedule Myrtle Beach (South Carolina) to Chicago (Illinois)
Full flight schedule will help you in detecting at what time planes fly from Myrtle Beach to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
| Departure | Arrival | Flight Details | Flight Duration | Price |
|---|---|---|---|---|
|
11:18 — 12:55
|
11:18 — 12:55
UA3631
United Airlines
Myrtle Beach — Chicago
|
2h 37m |
Find flight
from$216 |
|
|
11:35 — 13:05
|
11:35 — 13:05
UA752
United Airlines
Myrtle Beach — Chicago
|
2h 30m |
Find flight
from$222 |
|
|
11:36 — 12:46
|
11:36 — 12:46
NK2520
Spirit Airlines
Myrtle Beach — Chicago
|
2h 10m |
Find flight
from$53 |
|
|
13:53 — 15:17
|
13:53 — 15:17
NK3033
Spirit Airlines
Myrtle Beach — Chicago
|
2h 24m |
Find flight
from$103 |
|
|
15:16 — 16:41
|
15:16 — 16:41
NK1815
Spirit Airlines
Myrtle Beach — Chicago
|
2h 25m |
Find flight
from$63 |
|
|
16:45 — 18:22
|
16:45 — 18:22
UA5335
United Airlines
Myrtle Beach — Chicago
|
2h 37m |
Find flight
from$138 |
|
|
16:45 — 18:14
|
16:45 — 18:14
UA444
United Airlines
Myrtle Beach — Chicago
|
2h 29m |
Find flight
from$201 |
|
|
16:50 — 18:20
|
16:50 — 18:20
UA1580
United Airlines
Myrtle Beach — Chicago
|
2h 30m |
Find flight
from$139 |
|
|
16:55 — 18:25
|
16:55 — 18:25
UA1923
United Airlines
Myrtle Beach — Chicago
|
2h 30m |
Find flight
from$154 |
|
|
17:54 — 19:19
|
17:54 — 19:19
NK3190
Spirit Airlines
Myrtle Beach — Chicago
|
2h 25m |
Find flight
from$64 |
|
|
05:00 — 09:55
|
05:00 — 06:52
NK3646
Spirit Airlines
Myrtle Beach — Miami
48m stop
07:40 — 09:55
NK2
Spirit Airlines
Miami — Chicago
|
5h 55m including layover |
Find flight
from$96 |
|
|
05:00 — 14:34
|
05:00 — 06:52
NK3646
Spirit Airlines
Myrtle Beach — Miami
5h 25m stop
12:17 — 14:34
NK866
Spirit Airlines
Miami — Chicago
|
10h 34m including layover |
Find flight
from$101 |
|
|
06:10 — 15:31
|
06:10 — 07:32
NK1289
Spirit Airlines
Myrtle Beach — Orlando
5h 51m stop
13:23 — 15:31
NK1369
Spirit Airlines
Orlando — Chicago
|
10h 21m including layover |
Find flight
from$106 |
|
|
06:10 — 17:17
|
06:10 — 07:32
NK1289
Spirit Airlines
Myrtle Beach — Orlando
7h 36m stop
15:08 — 17:17
NK1114
Spirit Airlines
Orlando — Chicago
|
12h 7m including layover |
Find flight
from$106 |
|
|
08:34 — 14:41
|
08:34 — 10:30
NK1003
Spirit Airlines
Myrtle Beach — Newark
2h 27m stop
12:57 — 14:41
NK1183
Spirit Airlines
Newark — Chicago
|
7h 7m including layover |
Find flight
from$96 |
|
|
08:34 — 20:00
|
08:34 — 10:30
NK1003
Spirit Airlines
Myrtle Beach — New York
8h stop
18:30 — 20:00
NK1179
Spirit Airlines
New York — Chicago
|
12h 26m including layover |
Find flight
from$144 |
|
|
10:07 — 17:01
|
10:07 — 11:46
F93272
Frontier Airlines
Myrtle Beach — Philadelphia
3h 53m stop
15:39 — 17:01
F92111
Frontier Airlines
Philadelphia — Chicago
|
7h 54m including layover |
Find flight
from$113 |
|
|
10:33 — 23:10
|
10:33 — 12:23
NK3020
Spirit Airlines
Myrtle Beach — Newark
9h 10m stop
21:33 — 23:10
NK329
Spirit Airlines
Newark — Chicago
|
13h 37m including layover |
Find flight
from$149 |
|
|
11:28 — 18:44
|
06:00 — 07:28
NK2644
Spirit Airlines
Myrtle Beach — Orlando
3h 45m stop
21:25 — 23:29
NK2190
Spirit Airlines
Orlando — Chicago
|
8h 16m including layover |
Find flight
from$107 |
|
|
14:52 — 19:17
|
14:52 — 16:40
NK2965
Spirit Airlines
Myrtle Beach — New York
55m stop
17:35 — 19:17
NK918
Spirit Airlines
New York — Chicago
|
5h 25m including layover |
Find flight
from$101 |
|
|
17:32 — 00:05
+1 day
|
17:32 — 19:18
NK2656
Spirit Airlines
Myrtle Beach — Miami
2h 34m stop
21:52 — 00:05
NK1
Spirit Airlines
Miami — Chicago
|
7h 33m including layover |
Find flight
from$86 |
|
|
19:06 — 06:32
+1 day
|
19:06 — 21:00
NK2115
Spirit Airlines
Myrtle Beach — Newark
8h stop
05:55 — 07:27
NK2543
Spirit Airlines
Newark — Chicago
|
12h 26m including layover |
Find flight
from$139 |
|
|
19:13 — 20:00
+1 day
|
19:13 — 21:10
NK1809
Spirit Airlines
Myrtle Beach — New York
21h 20m stop
18:30 — 20:00
NK1179
Spirit Airlines
New York — Chicago
|
25h 47m including layover |
Find flight
from$135 |
|
|
20:24 — 20:23
+1 day
|
19:25 — 21:00
NK2089
Spirit Airlines
Myrtle Beach — Orlando
20h 25m stop
17:55 — 20:03
NK2541
Spirit Airlines
Orlando — Chicago
|
24h 59m including layover |
Find flight
from$109 |
|
|
20:40 — 06:32
+1 day
|
20:40 — 22:23
NK2473
Spirit Airlines
Myrtle Beach — Newark
6h 37m stop
05:55 — 07:27
NK2543
Spirit Airlines
Newark — Chicago
|
10h 52m including layover |
Find flight
from$147 |
|
|
12:11 — 08:22
+1 day
|
12:09 — 13:34
G4982
Allegiant Air
Myrtle Beach — Lexington
9h 5m stop
22:44 — 23:26
G41481
Allegiant Air
Lexington — Fort Walton Beach
6h 35m stop
06:00 — 08:22
G41455
Allegiant Air
Fort Walton Beach — Chicago
|
21h 11m including layover |
Find flight
from$152 |
|
|
12:11 — 08:22
+1 day
|
12:11 — 13:38
G4982
Allegiant Air
Myrtle Beach — Lexington
2h stop
22:46 — 23:28
G43111
Allegiant Air
Lexington — Fort Walton Beach
13h 40m stop
06:00 — 08:22
G41455
Allegiant Air
Fort Walton Beach — Chicago
|
21h 11m including layover |
Find flight
from$154 |
|
|
13:46 — 18:10
+1 day
|
13:46 — 14:43
G43099
Allegiant Air
Myrtle Beach — Belleville
6h 38m stop
21:21 — 23:33
G41417
Allegiant Air
Belleville — Knoxville
18h 4m stop
17:37 — 18:10
G43026
Allegiant Air
Knoxville — Chicago
|
29h 24m including layover |
Find flight
from$137 |
|
|
14:29 — 14:03
+1 day
|
14:29 — 15:26
G43097
Allegiant Air
Myrtle Beach — Belleville
3h 34m stop
19:00 — 21:07
G41417
Allegiant Air
Belleville — Knoxville
16h 22m stop
13:29 — 14:03
G43062
Allegiant Air
Knoxville — Chicago
|
24h 34m including layover |
Find flight
from$141 |
|
|
18:12 — 20:03
+1 day
|
18:12 — 18:44
NK2248
Spirit Airlines
Myrtle Beach — Nashville
19h 16m stop
14:00 — 16:54
NK2040
Spirit Airlines
Nashville — Orlando
1h 1m stop
17:55 — 20:03
NK2541
Spirit Airlines
Orlando — Chicago
|
26h 51m including layover |
Find flight
from$134 |
|
|
18:12 — 20:03
+1 day
|
18:12 — 18:44
NK2248
Spirit Airlines
Myrtle Beach — Nashville
12h 46m stop
07:30 — 10:24
NK2241
Spirit Airlines
Nashville — Orlando
7h 31m stop
17:55 — 20:03
NK2541
Spirit Airlines
Orlando — Chicago
|
26h 51m including layover |
Find flight
from$134 |
|
*Departure and arrival times - local. Updated on September 4, 2025
Flight Information
Below we will explain in detail what the flights cost on the destination from Myrtle Beach to Chicago depends on and how to choose the most interesting flight option for you.
Distance between Myrtle Beach and Chicago is 1189 miles. Time difference between the cities is 1h. Airplanes depart 05:00 to 21:55 from 2 Myrtle Beach airports and arrive 05:00 to 21:55 to 7 Chicago airports. Average flight time is 2h 30m.
- The fastest flight 2h 10m
- Average flight time 2h 30m
- The earliest flight 05:00
- The latest flight 21:55
- Distance 739 ml
The cheapest months to travel to Chicago are may (from 53 $), july (from 63 $), june (from 63 $).
The most expensive months are september (from 105 $), october (from 101 $), august (from 63 $).
What is the lowest airfare Myrtle Beach to Chicago?
The cheapest plane ticket found by our users is $53. This airfare is for economy class on one-way NK2520 flight by Spirit Airlines for June 6, 2025 which leaves AFB in Myrtle Beach at 11:36 am and arrives at Chicago O'Hare International at 12:46.
Economy class
$53
Business class
?
First class
?
Popular Airlines on the Route
The flight Myrtle Beach — Chicago is served by 6 regular airlines and 4 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 1 departures per week at the price of from $ 113 . And the most expensive tickets are offered by United Airlines airline - from $ 1351.
Direct flights
There are 10 nonstop flights on the route. The fastest direct flight is NK2520 by Spirit Airlines takes 2h 10m and the cheapest is NK2520 by Spirit Airlines for $53.
- UA - United Airlinesfrom $138Find
- NK - Spirit Airlinesfrom $53Find
See more direct flights
Connecting Flights
There are 498 flights with layovers on the route. The fastest connecting flight is UA4334 by United Airlines takes 4h 50m and the cheapest is NK2520 by Spirit Airlines for $86.
- F9 - Frontier Airlinesfrom $113Find
- SY - Sun Country Airlinesfrom $311Find
- MX - Mexicanafrom $236Find
- UA - United Airlinesfrom $210Find
- NK - Spirit Airlinesfrom $86Find
- G4 - Allegiant Airfrom $137Find
See more connecting flights
Airports
You can fly from Myrtle Beach to Chicago from 2 airports (AFB, Grand Strand Airport).
Myrtle Beach airports
- AFB-MYRfrom $53Find
- Grand Strand Airport-CREFind
Chicago airports
- O'Hare International-ORDFind
- Midway-MDWFind
- Dupage County-DPAFind
- Chicago FSS-CHIFind
- Merrill C Meigs (closed)-CGXFind
- Pal-Waukee-PWKFind
- Chicago NAS-NOHFind
Airplanes
There are flights to Chicago from Myrtle Beach by 6 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.
Top Domestic Destinations from Myrtle Beach
You may also consider searching for discounted plane tickets to some other popular places from Myrtle Beach within United States.
- from $66Find
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Top International Destinations from Myrtle Beach
Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.
- from $57Find
How to book a plane ticket yourself?
- Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
- Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
- Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
- Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
- That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
To find a plane ticket, please select dates.