Cheap Flights from Knoxville, TN to Chicago, IL from $51
Return flight: Chicago – Knoxville
On Cheapflightsplus.com you will find 13 direct and 554 connecting flights from Knoxville to Chicago. You can compare airfare deals from 3 airlines and multiple travel sites from $51, book and save on cheap plane tickets and last minute offers. Also check out TYS-CHI flight schedule to find best flight time, convenient departure and arrival airports.
Find One-Way and Round-Trip Knoxville to Chicago Flight Deals
To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights».
To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight.
Cheapest flights in November: $51 (one-way), $87 (round-trip).
Direct flights
Check prices for return flight
Best Flights from Knoxville to Chicago Today
Take a look at the list of non stop flights and flights with layovers from Knoxville to Chicago with the lowest price of $51. The fastest direct flight takes 1h 33m and the fastest connecting – 4h 50m.
| Price | Departure | Arrival | Flight Duration | Airline | Flight |
|---|---|---|---|---|---|
| from $51 | 13:29 Knoxville Mc Ghee Tyson | 14:03 Chicago Midway | 1h 34m | Allegiant Air | G43062 |
| from $61 | 13:31 Knoxville Mc Ghee Tyson | 14:04 Chicago Midway | 1h 33m | Allegiant Air | G43026 |
| from $67 | 13:31 Knoxville Mc Ghee Tyson | 14:04 Chicago Midway | 1h 33m | Allegiant Air | G43027 |
| from $265 | 07:00 Knoxville Mc Ghee Tyson | 07:55 Chicago O'Hare International | 1h 55m | United Airlines | UA1562 |
| from $399 | 17:33 Knoxville Mc Ghee Tyson | 18:35 Chicago O'Hare International | 2h 2m | United Airlines | UA4606 |
| from $104 | 17:25 Knoxville Mc Ghee Tyson | 23:43 Chicago O'Hare International | 7h 18m layover 1h 17m - Denver | Frontier Airlines | F94369 F93174 |
| from $105 | 08:00 Knoxville Mc Ghee Tyson | 08:22+1 день Chicago Midway | 25h 22m layover 21h 39m - Fort Walton Beach | Allegiant Air | G41398 G41455 |
| from $111 | 11:01 Knoxville Mc Ghee Tyson | 17:15 Chicago O'Hare International | 7h 14m layover 3h 17m - Minneapolis | Allegiant Air | G41414 SY259 |
| from $111 | 11:01 Knoxville Mc Ghee Tyson | 12:28+1 день Chicago O'Hare International | 26h 27m layover 22h 31m - Minneapolis | Allegiant Air | G41414 SY1629 |
| from $113 | 07:15 Knoxville Mc Ghee Tyson | 06:32+1 день Chicago O'Hare International | 24h 17m layover 19h 55m - Newark | Allegiant Air | G41396 NK2543 |
| from $115 | 10:59 Knoxville Mc Ghee Tyson | 17:21 Chicago O'Hare International | 7h 22m layover 3h 24m - Minneapolis | Allegiant Air | G43024 SY259 |
| from $115 | 11:01 Knoxville Mc Ghee Tyson | 19:11 Chicago O'Hare International | 9h 10m layover 5h 11m - Minneapolis | Allegiant Air | G43064 SY261 |
| from $116 | 10:54 Knoxville Mc Ghee Tyson | 20:40 Chicago O'Hare International | 10h 46m layover 5h 22m - Miami | Allegiant Air | G4494 NK3 |
| from $116 | 15:34 Knoxville Mc Ghee Tyson | 09:55+1 день Chicago O'Hare International | 19h 21m layover 14h 2m - Miami | Allegiant Air | G4488 NK2 |
| from $107 | 12:45 Knoxville Mc Ghee Tyson | 23:29+1 день Chicago O'Hare International | 35h 44m layover 22h 28m - Baltimore 6h 11m - Orlando | Allegiant Air | G41397 NK1961 NK2190 |
| from $123 | 07:15 Knoxville Mc Ghee Tyson | 00:05+1 день Chicago O'Hare International | 17h 50m layover 8h 34m - Newark 1h 9m - Miami | Allegiant Air | G41396 NK2692 NK1 |
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on August 08, 2025
Flight Schedule Knoxville (Tennessee) to Chicago (Illinois)
Full flight schedule will help you in detecting at what time planes fly from Knoxville to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
| Departure | Arrival | Flight Details | Flight Duration | Price |
|---|---|---|---|---|
|
07:00 — 07:55
|
07:00 — 07:55
UA1562
United Airlines
Knoxville — Chicago
|
1h 55m |
Find flight
from$265 |
|
|
07:00 — 07:57
|
07:00 — 07:57
UA1594
United Airlines
Knoxville — Chicago
|
1h 57m |
Find flight
from$267 |
|
|
10:55 — 11:58
|
10:55 — 11:58
UA5921
United Airlines
Knoxville — Chicago
|
2h 3m |
Find flight
from$268 |
|
|
13:29 — 14:03
|
13:29 — 14:03
G43062
Allegiant Air
Knoxville — Chicago
|
1h 34m |
Find flight
from$51 |
|
|
13:31 — 14:04
|
13:31 — 14:04
G43026
Allegiant Air
Knoxville — Chicago
|
1h 33m |
Find flight
from$61 |
|
|
13:31 — 14:04
|
13:31 — 14:04
G43027
Allegiant Air
Knoxville — Chicago
|
1h 33m |
Find flight
from$67 |
|
|
13:56 — 14:55
|
13:56 — 14:55
UA5844
United Airlines
Knoxville — Chicago
|
1h 59m |
Find flight
from$268 |
|
|
13:58 — 14:59
|
13:58 — 14:59
UA4388
United Airlines
Knoxville — Chicago
|
2h 1m |
Find flight
from$265 |
|
|
14:00 — 15:02
|
14:00 — 15:02
UA4513
United Airlines
Knoxville — Chicago
|
2h 2m |
Find flight
from$265 |
|
|
14:04 — 15:08
|
14:04 — 15:08
UA3649
United Airlines
Knoxville — Chicago
|
2h 4m |
Find flight
from$400 |
|
|
17:33 — 18:35
|
17:33 — 18:35
UA4606
United Airlines
Knoxville — Chicago
|
2h 2m |
Find flight
from$399 |
|
|
17:35 — 18:37
|
17:35 — 18:37
UA5767
United Airlines
Knoxville — Chicago
|
2h 2m |
Find flight
from$265 |
|
|
17:38 — 18:42
|
17:38 — 18:42
UA5237
United Airlines
Knoxville — Chicago
|
2h 4m |
Find flight
from$266 |
|
|
06:00 — 20:03
|
06:00 — 07:34
G41439
Allegiant Air
Knoxville — Orlando
10h 21m stop
17:55 — 20:03
NK2541
Spirit Airlines
Orlando — Chicago
|
15h 3m including layover |
Find flight
from$135 |
|
|
06:00 — 23:29
|
06:00 — 07:34
G41439
Allegiant Air
Knoxville — Orlando
13h 51m stop
21:25 — 23:29
NK2190
Spirit Airlines
Orlando — Chicago
|
18h 29m including layover |
Find flight
from$135 |
|
|
07:15 — 06:32
+1 day
|
07:15 — 09:05
G41396
Allegiant Air
Knoxville — Newark
19h 55m stop
05:55 — 07:27
NK2543
Spirit Airlines
Newark — Chicago
|
24h 17m including layover |
Find flight
from$113 |
|
|
08:00 — 08:22
+1 day
|
08:00 — 08:21
G41398
Allegiant Air
Knoxville — Fort Walton Beach
21h 39m stop
06:00 — 08:22
G41455
Allegiant Air
Fort Walton Beach — Chicago
|
25h 22m including layover |
Find flight
from$105 |
|
|
10:54 — 20:40
|
10:54 — 12:58
G4494
Allegiant Air
Knoxville — Miami
5h 22m stop
18:20 — 20:40
NK3
Spirit Airlines
Miami — Chicago
|
10h 46m including layover |
Find flight
from$116 |
|
|
10:59 — 17:21
|
10:59 — 12:18
G43024
Allegiant Air
Knoxville — Minneapolis
3h 24m stop
15:42 — 17:21
SY259
Sun Country Airlines
Minneapolis — Chicago
|
7h 22m including layover |
Find flight
from$115 |
|
|
11:01 — 17:15
|
11:01 — 12:19
G41414
Allegiant Air
Knoxville — Minneapolis
3h 17m stop
15:36 — 17:15
SY259
Sun Country Airlines
Minneapolis — Chicago
|
7h 14m including layover |
Find flight
from$111 |
|
|
11:01 — 12:28
+1 day
|
11:01 — 12:19
G41414
Allegiant Air
Knoxville — Minneapolis
22h 31m stop
10:50 — 12:28
SY1629
Sun Country Airlines
Minneapolis — Chicago
|
26h 27m including layover |
Find flight
from$111 |
|
|
14:28 — 06:03
+1 day
|
14:28 — 15:35
G444
Allegiant Air
Knoxville — Las Vegas
8h 59m stop
00:34 — 06:03
NK1053
Spirit Airlines
Las Vegas — Chicago
|
16h 35m including layover |
Find flight
from$150 |
|
|
14:47 — 00:05
+1 day
|
14:47 — 16:51
G4487
Allegiant Air
Knoxville — Miami
5h 1m stop
21:52 — 00:05
NK1
Spirit Airlines
Miami — Chicago
|
10h 18m including layover |
Find flight
from$145 |
|
|
15:34 — 09:55
+1 day
|
15:34 — 17:38
G4488
Allegiant Air
Knoxville — Miami
14h 2m stop
07:40 — 09:55
NK2
Spirit Airlines
Miami — Chicago
|
19h 21m including layover |
Find flight
from$116 |
|
|
15:34 — 14:34
+1 day
|
15:34 — 17:38
G4488
Allegiant Air
Knoxville — Miami
18h 39m stop
12:17 — 14:34
NK866
Spirit Airlines
Miami — Chicago
|
24h including layover |
Find flight
from$137 |
|
|
17:25 — 23:43
|
17:30 — 19:01
F94369
Frontier Airlines
Knoxville — Denver
1h 17m stop
20:22 — 23:52
F93174
Frontier Airlines
Denver — Chicago
|
7h 18m including layover |
Find flight
from$104 |
|
|
17:25 — 11:40
+1 day
|
17:25 — 18:48
F94369
Frontier Airlines
Knoxville — Denver
13h 27m stop
08:15 — 11:40
F92210
Frontier Airlines
Denver — Chicago
|
19h 15m including layover |
Find flight
from$125 |
|
|
20:54 — 08:55
+1 day
|
20:54 — 22:55
G42154
Allegiant Air
Knoxville — Miami
7h 45m stop
06:40 — 08:55
NK1986
Spirit Airlines
Miami — Chicago
|
13h 1m including layover |
Find flight
from$126 |
|
|
20:54 — 08:55
+1 day
|
20:54 — 22:55
G4533
Allegiant Air
Knoxville — Miami
7h 45m stop
06:40 — 08:55
NK1986
Spirit Airlines
Miami — Chicago
|
13h 1m including layover |
Find flight
from$137 |
|
|
07:15 — 00:05
+1 day
|
07:15 — 09:05
G41396
Allegiant Air
Knoxville — Newark
8h 34m stop
17:39 — 20:43
NK2692
Spirit Airlines
Newark — Miami
1h 9m stop
21:52 — 00:05
NK1
Spirit Airlines
Miami — Chicago
|
17h 50m including layover |
Find flight
from$123 |
|
|
08:00 — 20:40
|
08:00 — 10:11
G41396
Allegiant Air
Knoxville — Boston
1h 45m stop
11:56 — 15:17
NK2887
Spirit Airlines
Boston — Miami
3h 3m stop
18:20 — 20:40
NK3
Spirit Airlines
Miami — Chicago
|
13h 40m including layover |
Find flight
from$128 |
|
|
12:45 — 23:29
+1 day
|
12:45 — 14:23
G41397
Allegiant Air
Knoxville — Baltimore
22h 28m stop
12:51 — 15:14
NK1961
Spirit Airlines
Baltimore — Orlando
6h 11m stop
21:25 — 23:29
NK2190
Spirit Airlines
Orlando — Chicago
|
35h 44m including layover |
Find flight
from$107 |
|
|
12:45 — 08:50
+1 day
|
12:45 — 14:23
G41397
Allegiant Air
Knoxville — Baltimore
5h 34m stop
19:57 — 22:38
NK2563
Spirit Airlines
Baltimore — Miami
7h 52m stop
06:30 — 08:50
NK2188
Spirit Airlines
Miami — Chicago
|
21h 5m including layover |
Find flight
from$130 |
|
|
18:34 — 08:22
+1 day
|
18:34 — 18:51
G43024
Allegiant Air
Knoxville — Belleville
2h 11m stop
21:02 — 22:45
G43102
Allegiant Air
Belleville — Fort Walton Beach
7h 15m stop
06:00 — 08:22
G41455
Allegiant Air
Fort Walton Beach — Chicago
|
14h 48m including layover |
Find flight
from$149 |
|
|
19:43 — 16:25
+1 day
|
19:43 — 21:14
G43027
Allegiant Air
Knoxville — Sanford
13h 23m stop
10:37 — 11:28
G4360
Allegiant Air
Sanford — Nashville
3h stop
14:28 — 16:25
NK2028
Spirit Airlines
Nashville — Chicago
|
21h 42m including layover |
Find flight
from$146 |
|
*Departure and arrival times - local. Updated on August 8, 2025
Flight Information
Below we will explain in detail what the flights cost on the destination from Knoxville to Chicago depends on and how to choose the most interesting flight option for you.
Distance between Knoxville and Chicago is 745 miles. Time difference between the cities is 1h. Airplanes depart 05:45 to 21:34 from 1 Knoxville airport and arrive 05:45 to 21:34 to 7 Chicago airports. Average flight time is 2h 1m.
- The fastest flight 1h 33m
- Average flight time 2h 1m
- The earliest flight 05:45
- The latest flight 21:34
- Distance 463 ml
The cheapest months to travel to Chicago are july (from 50 $), june (from 51 $), may (from 55 $).
The most expensive months are november (from 590 $), december (from 450 $), february (from 159 $).
What is the lowest airfare Knoxville to Chicago?
The cheapest plane ticket found by our users is $51. This airfare is for economy class on one-way G43062 flight by Allegiant Air for June 6, 2025 which leaves Mc Ghee Tyson in Knoxville at 13:29 am and arrives at Chicago Midway at 14:03.
Economy class
$51
Business class
?
First class
?
Popular Airlines on the Route
The flight Knoxville — Chicago is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 3 departures per week at the price of from $ 104 . And the most expensive tickets are offered by United Airlines airline - from $ 843.
Direct flights
There are 13 nonstop flights on the route. The fastest direct flight is G43026 by Allegiant Air takes 1h 33m and the cheapest is G43062 by Allegiant Air for $51.
- UA - United Airlinesfrom $265Find
- G4 - Allegiant Airfrom $51Find
See more direct flights
Connecting Flights
There are 554 flights with layovers on the route. The fastest connecting flight is UA4324 by United Airlines takes 4h 50m and the cheapest is G43062 by Allegiant Air for $104.
- F9 - Frontier Airlinesfrom $104Find
- UA - United Airlinesfrom $159Find
- G4 - Allegiant Airfrom $105Find
See more connecting flights
Airports
You can fly from Knoxville to Chicago from 1 airports (Mc Ghee Tyson).
Knoxville airports
- Mc Ghee Tyson-TYSfrom $51Find
Chicago airports
- O'Hare International-ORDFind
- Midway-MDWFind
- Dupage County-DPAFind
- Chicago FSS-CHIFind
- Merrill C Meigs (closed)-CGXFind
- Pal-Waukee-PWKFind
- Chicago NAS-NOHFind
Airplanes
There are flights to Chicago from Knoxville by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.
Top Domestic Destinations from Knoxville
You may also consider searching for discounted plane tickets to some other popular places from Knoxville within United States.
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Top International Destinations from Knoxville
Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.
- from $69Find
- from $61Find
How to book a plane ticket yourself?
- Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
- Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
- Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
- Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
- That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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