Cheap Flights from Knoxville, TN to Chicago, IL from $140

One way Round trip

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On Cheapflightsplus.com you will find 3 direct and 36 connecting flights from Knoxville to Chicago. You can compare airfare deals from 2 airlines and multiple travel sites from $140, book and save on cheap plane tickets and last minute offers. Also check out TYS-CHI flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Knoxville to Chicago Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $140 (one-way), $240 (round-trip).

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Best Flights from Knoxville to Chicago Today

Take a look at the list of non stop flights and flights with layovers from Knoxville to Chicago with the lowest price of $140. The fastest direct flight takes 1h 55m and the fastest connecting – 5h 8m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $162 Find flight	07:00 Knoxville Mc Ghee Tyson	08:03 Chicago O'Hare International	2h 3m	United Airlines	UA2046
from $263 Find flight	14:00 Knoxville Mc Ghee Tyson	14:55 Chicago O'Hare International	1h 55m	United Airlines	UA4408
from $263 Find flight	17:35 Knoxville Mc Ghee Tyson	18:37 Chicago O'Hare International	2h 2m	United Airlines	UA5305
from $140 Find flight	12:25 Knoxville Mc Ghee Tyson	22:29 Chicago O'Hare International	11h 4m layover 6h 24m - Tampa	Allegiant Air	G43049 NK1171
from $222 Find flight	07:30 Knoxville Mc Ghee Tyson	16:52 Chicago O'Hare International	10h 22m layover 5h 38m - Orlando	Allegiant Air	G43052 NK506
from $245 Find flight	11:06 Knoxville Mc Ghee Tyson	20:40 Chicago O'Hare International	10h 34m layover 5h 5m - Miami	Allegiant Air	G41438 NK3
from $275 Find flight	09:55 Knoxville Mc Ghee Tyson	14:03 Chicago O'Hare International	5h 8m layover 1h 8m - Washington D.C.	United Airlines	UA4325 UA1709
from $345 Find flight	16:20 Knoxville Mc Ghee Tyson	22:38 Chicago O'Hare International	7h 18m layover 1h 10m - Denver	United Airlines	UA2132 UA2258
from $345 Find flight	16:20 Knoxville Mc Ghee Tyson	23:58 Chicago O'Hare International	8h 38m layover 2h 30m - Denver	United Airlines	UA2132 UA377
from $257 Find flight	11:06 Knoxville Mc Ghee Tyson	22:29 Chicago O'Hare International	12h 23m layover 1h 50m - Miami 4h 22m - Tampa	Allegiant Air	G41438 NK322 NK1171
from $265 Find flight	13:50 Knoxville Mc Ghee Tyson	01:13+1 день Chicago O'Hare International	12h 23m layover 4h 51m - Orlando 0h 40m - Dallas	Allegiant Air	G43053 NK503 NK828
from $265 Find flight	13:50 Knoxville Mc Ghee Tyson	01:13+1 день Chicago O'Hare International	12h 23m layover 3h 24m - Orlando 2h 1m - Dallas	Allegiant Air	G43053 NK1096 NK828
from $274 Find flight	08:15 Knoxville Mc Ghee Tyson	01:13+1 день Chicago O'Hare International	17h 58m layover 3h 47m - Newark 6h 24m - Dallas	Allegiant Air	G41396 NK3718 NK828
from $281 Find flight	11:06 Knoxville Mc Ghee Tyson	01:13+1 день Chicago O'Hare International	15h 7m layover 6h 15m - Miami 1h 25m - Dallas	Allegiant Air	G41438 NK214 NK828
from $283 Find flight	09:00 Knoxville Mc Ghee Tyson	09:55+1 день Chicago O'Hare International	25h 55m layover 6h 7m - Las Vegas 6h 57m - Miami	Allegiant Air	G41400 NK2330 NK2
from $485 Find flight	14:40 Knoxville Mc Ghee Tyson	22:03 Chicago O'Hare International	8h 23m layover 1h 26m - Washington D.C. 1h 1m - Newark	United Airlines	UA4848 UA2398 UA546

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on February 05, 2025

Flight Schedule Knoxville (Tennessee) to Chicago (Illinois)

Full flight schedule will help you in detecting at what time planes fly from Knoxville to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
07:00 — 08:03	07:00 — 08:03 UA2046 United Airlines Knoxville — Chicago	2h 3m	Find flight from$162
14:00 — 14:55	14:00 — 14:55 UA4408 United Airlines Knoxville — Chicago	1h 55m	Find flight from$263
17:35 — 18:37	17:35 — 18:37 UA5305 United Airlines Knoxville — Chicago	2h 2m	Find flight from$263
07:30 — 16:52	07:30 — 09:07 G43052 Allegiant Air Knoxville — Orlando 5h 38m stop 14:45 — 16:52 NK506 Spirit Airlines Orlando — Chicago	10h 22m including layover	Find flight from$222
08:30 — 14:54	08:30 — 10:20 UA5382 United Airlines Knoxville — Denver 1h stop 11:20 — 14:54 UA598 United Airlines Denver — Chicago	7h 24m including layover	Find flight from$591
09:55 — 14:03	09:55 — 11:37 UA4325 United Airlines Knoxville — Washington D.C. 1h 8m stop 12:45 — 14:03 UA1709 United Airlines Washington D.C. — Chicago	5h 8m including layover	Find flight from$275
10:35 — 17:06	10:35 — 12:20 UA4302 United Airlines Knoxville — Houston 2h stop 14:20 — 17:06 UA2097 United Airlines Houston — Chicago	7h 31m including layover	Find flight from$599
10:35 — 19:05	10:35 — 12:20 UA4302 United Airlines Knoxville — Houston 4h stop 16:20 — 19:05 UA2659 United Airlines Houston — Chicago	9h 30m including layover	Find flight from$599
11:06 — 20:40	11:06 — 13:15 G41438 Allegiant Air Knoxville — Miami 5h 5m stop 18:20 — 20:40 NK3 Spirit Airlines Miami — Chicago	10h 34m including layover	Find flight from$245
12:25 — 22:29	12:25 — 14:08 G43049 Allegiant Air Knoxville — Tampa 6h 24m stop 20:32 — 22:29 NK1171 Spirit Airlines Tampa — Chicago	11h 4m including layover	Find flight from$140
16:20 — 22:38	16:20 — 18:00 UA2132 United Airlines Knoxville — Denver 1h 10m stop 19:10 — 22:38 UA2258 United Airlines Denver — Chicago	7h 18m including layover	Find flight from$345
16:20 — 23:58	16:20 — 18:00 UA2132 United Airlines Knoxville — Denver 2h 30m stop 20:30 — 23:58 UA377 United Airlines Denver — Chicago	8h 38m including layover	Find flight from$345
06:00 — 18:40	06:00 — 07:43 G41434 Allegiant Air Knoxville — Tampa 4h 24m stop 12:07 — 12:45 NK1441 Spirit Airlines Tampa — New Orleans 3h 22m stop 16:07 — 18:40 NK1109 Spirit Airlines New Orleans — Chicago	13h 40m including layover	Find flight from$608
08:15 — 01:13 +1 day	08:15 — 10:05 G41396 Allegiant Air Knoxville — Newark 3h 47m stop 13:52 — 16:35 NK3718 Spirit Airlines Newark — Dallas 6h 24m stop 22:59 — 01:13 NK828 Spirit Airlines Dallas — Chicago	17h 58m including layover	Find flight from$274
09:00 — 09:55 +1 day	09:00 — 10:48 G41400 Allegiant Air Knoxville — Las Vegas 6h 7m stop 16:55 — 00:43 NK2330 Spirit Airlines Las Vegas — Miami 6h 57m stop 07:40 — 09:55 NK2 Spirit Airlines Miami — Chicago	25h 55m including layover	Find flight from$283
11:06 — 22:29	11:06 — 13:15 G41438 Allegiant Air Knoxville — Miami 1h 50m stop 15:05 — 16:10 NK322 Spirit Airlines Miami — Tampa 4h 22m stop 20:32 — 22:29 NK1171 Spirit Airlines Tampa — Chicago	12h 23m including layover	Find flight from$257
13:50 — 01:13 +1 day	13:50 — 15:39 G43053 Allegiant Air Knoxville — Orlando 4h 51m stop 20:30 — 22:19 NK503 Spirit Airlines Orlando — Dallas 40m stop 22:59 — 01:13 NK828 Spirit Airlines Dallas — Chicago	12h 23m including layover	Find flight from$265
13:50 — 01:13 +1 day	13:50 — 15:39 G43053 Allegiant Air Knoxville — Orlando 3h 24m stop 19:03 — 20:58 NK1096 Spirit Airlines Orlando — Dallas 2h 1m stop 22:59 — 01:13 NK828 Spirit Airlines Dallas — Chicago	12h 23m including layover	Find flight from$265
14:40 — 22:03	14:40 — 16:21 UA4848 United Airlines Knoxville — Washington D.C. 1h 26m stop 17:47 — 19:19 UA2398 United Airlines Washington D.C. — Newark 1h 1m stop 20:20 — 22:03 UA546 United Airlines Newark — Chicago	8h 23m including layover	Find flight from$485

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on February 5, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Knoxville to Chicago depends on and how to choose the most interesting flight option for you.

Distance between Knoxville and Chicago is 745 miles. Time difference between the cities is 1h. Airplanes depart 06:00 to 17:35 from 1 Knoxville airport and arrive 06:00 to 17:35 to 7 Chicago airports. Average flight time is 2h 2m.

The fastest flight 1h 55m
Average flight time 2h 2m
The earliest flight 06:00
The latest flight 17:35
Distance 463 ml

The cheapest months to travel to Chicago are january (from 118 $), february (from 118 $), december (from 260 $).

What is the lowest airfare Knoxville to Chicago?

The cheapest plane ticket found by our users is $140. This airfare is for economy class on one-way G43049 flight by Allegiant Air for February 21, 2025 which leaves Mc Ghee Tyson in Knoxville at 12:25 am and arrives at Chicago O'Hare International at 22:29.

Economy class

$140

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Business class

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First class

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Popular Airlines on the Route

The flight Knoxville — Chicago is served by 2 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by United Airlines - 26 departures per week at the price of from $ 162 . And the most expensive tickets are offered by United Airlines airline - from $ 749.

Direct flights

There are 3 nonstop flights on the route. The fastest direct flight is UA4408 by United Airlines takes 1h 55m and the cheapest is G43049 by Allegiant Air for $162.

UA - United Airlines

from $162

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Connecting Flights

There are 36 flights with layovers on the route. The fastest connecting flight is UA4325 by United Airlines takes 5h 8m and the cheapest is G43049 by Allegiant Air for $140.

UA - United Airlines

from $275

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G4 - Allegiant Air

from $140

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Airports

You can fly from Knoxville to Chicago from 1 airports (Mc Ghee Tyson).

Knoxville airports

Mc Ghee Tyson-TYS

from $140
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Chicago airports

O'Hare International-ORD

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Midway-MDW

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Dupage County-DPA

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Chicago FSS-CHI

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Merrill C Meigs (closed)-CGX

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Pal-Waukee-PWK

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Chicago NAS-NOH

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Airplanes

There are flights to Chicago from Knoxville by 2 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Knoxville

You may also consider searching for discounted plane tickets to some other popular places from Knoxville within United States.

Knoxville — Tampa

from $80

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Knoxville — Houston

from $54

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Knoxville — New Orleans

from $56

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Knoxville — Orlando

from $73

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Knoxville — Chicago

from $76

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Knoxville — Boston

from $69

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Knoxville — San Francisco

from $78

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Knoxville — Las Vegas

from $74

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Knoxville — Key West

from $64

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Knoxville — Seattle

from $73

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Top International Destinations from Knoxville

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Knoxville — Cancun

from $69

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Knoxville — Panama City

from $61

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Knoxville — Manchester

from $64

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
To find a plane ticket, please select dates.