Cheap Flights from Knoxville, TN to Chicago, IL from $67

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On Cheapflightsplus.com you will find 15 direct and 268 connecting flights from Knoxville to Chicago. You can compare airfare deals from 4 airlines and multiple travel sites from $67, book and save on cheap plane tickets and last minute offers. Also check out TYS-CHI flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Knoxville to Chicago Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $67 (one-way), $115 (round-trip).

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Best Flights from Knoxville to Chicago Today

Take a look at the list of non stop flights and flights with layovers from Knoxville to Chicago with the lowest price of $67. The fastest direct flight takes 1h 33m and the fastest connecting – 4h 44m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $68 Find flight	13:50 Knoxville Mc Ghee Tyson	14:24 Chicago Midway	1h 34m	Allegiant Air	G41399
from $83 Find flight	13:45 Knoxville Mc Ghee Tyson	14:18 Chicago Midway	1h 33m	Allegiant Air	G41416
from $97 Find flight	18:50 Knoxville Mc Ghee Tyson	19:23 Chicago Midway	1h 33m	Allegiant Air	G43046
from $142 Find flight	13:55 Knoxville Mc Ghee Tyson	14:51 Chicago O'Hare International	1h 56m	United Airlines	UA5844
from $142 Find flight	07:00 Knoxville Mc Ghee Tyson	08:02 Chicago O'Hare International	2h 2m	United Airlines	UA1677
from $142 Find flight	17:35 Knoxville Mc Ghee Tyson	18:37 Chicago O'Hare International	2h 2m	United Airlines	UA5305
from $195 Find flight	07:00 Knoxville Mc Ghee Tyson	08:03 Chicago O'Hare International	2h 3m	United Airlines	UA2046
from $313 Find flight	07:00 Knoxville Mc Ghee Tyson	08:01 Chicago O'Hare International	2h 1m	United Airlines	UA776
from $360 Find flight	07:00 Knoxville Mc Ghee Tyson	08:01 Chicago O'Hare International	2h 1m	United Airlines	UA1469
from $67 Find flight	16:19 Knoxville Mc Ghee Tyson	00:13+1 день Chicago Midway	8h 54m layover 3h 4m - Denver	Frontier Airlines	F94369 F92210
from $154 Find flight	05:45 Knoxville Mc Ghee Tyson	09:44 Chicago O'Hare International	4h 59m layover 0h 54m - Washington D.C.	United Airlines	UA4311 UA2440
from $154 Find flight	14:35 Knoxville Mc Ghee Tyson	18:55 Chicago O'Hare International	5h 20m layover 1h 16m - Washington D.C.	United Airlines	UA4848 UA1117
from $154 Find flight	09:35 Knoxville Mc Ghee Tyson	14:34 Chicago O'Hare International	5h 59m layover 1h 54m - Washington D.C.	United Airlines	UA4325 UA1193
from $169 Find flight	12:25 Knoxville Mc Ghee Tyson	22:29 Chicago O'Hare International	11h 4m layover 6h 24m - Tampa	Allegiant Air	G43049 NK1171
from $169 Find flight	08:30 Knoxville Mc Ghee Tyson	18:57 Chicago O'Hare International	11h 27m layover 6h 29m - Tampa	Allegiant Air	G43051 NK572
from $179 Find flight	14:00 Knoxville Mc Ghee Tyson	20:48 Chicago O'Hare International	7h 48m layover 2h 21m - Miami	Allegiant Air	G43040 NK7

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on May 09, 2025

Flight Schedule Knoxville (Tennessee) to Chicago (Illinois)

Full flight schedule will help you in detecting at what time planes fly from Knoxville to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
06:55 — 08:00	06:55 — 08:00 UA5281 United Airlines Knoxville — Chicago	2h 5m	Find flight from$313
07:00 — 08:02	07:00 — 08:02 UA1677 United Airlines Knoxville — Chicago	2h 2m	Find flight from$142
07:00 — 08:03	07:00 — 08:03 UA2046 United Airlines Knoxville — Chicago	2h 3m	Find flight from$195
07:00 — 08:01	07:00 — 08:01 UA776 United Airlines Knoxville — Chicago	2h 1m	Find flight from$313
07:00 — 08:01	07:00 — 08:01 UA1469 United Airlines Knoxville — Chicago	2h 1m	Find flight from$360
10:45 — 11:52	10:45 — 11:52 UA5843 United Airlines Knoxville — Chicago	2h 7m	Find flight from$364
10:50 — 11:54	10:50 — 11:54 UA5300 United Airlines Knoxville — Chicago	2h 4m	Find flight from$313
13:45 — 14:18	13:45 — 14:18 G41416 Allegiant Air Knoxville — Chicago	1h 33m	Find flight from$83
13:50 — 14:24	13:50 — 14:24 G41399 Allegiant Air Knoxville — Chicago	1h 34m	Find flight from$68
13:55 — 14:51	13:55 — 14:51 UA5844 United Airlines Knoxville — Chicago	1h 56m	Find flight from$142
14:00 — 14:55	14:00 — 14:55 UA4408 United Airlines Knoxville — Chicago	1h 55m	Find flight from$317
14:06 — 15:12	14:06 — 15:12 UA3716 United Airlines Knoxville — Chicago	2h 6m	Find flight from$360
17:35 — 18:37	17:35 — 18:37 UA5305 United Airlines Knoxville — Chicago	2h 2m	Find flight from$142
17:43 — 18:52	17:43 — 18:52 UA5330 United Airlines Knoxville — Chicago	2h 9m	Find flight from$360
18:50 — 19:23	18:50 — 19:23 G43046 Allegiant Air Knoxville — Chicago	1h 33m	Find flight from$97
05:45 — 09:44	05:45 — 07:31 UA4311 United Airlines Knoxville — Washington D.C. 54m stop 08:25 — 09:44 UA2440 United Airlines Washington D.C. — Chicago	4h 59m including layover	Find flight from$154
08:15 — 13:44	08:15 — 10:05 G41396 Allegiant Air Knoxville — Newark 2h 3m stop 12:08 — 13:44 NK329 Spirit Airlines Newark — Chicago	6h 29m including layover	Find flight from$219
08:30 — 18:57	08:30 — 10:21 G43051 Allegiant Air Knoxville — Tampa 6h 29m stop 16:50 — 18:57 NK572 Spirit Airlines Tampa — Chicago	11h 27m including layover	Find flight from$169
09:00 — 16:08	09:00 — 10:44 G43032 Allegiant Air Knoxville — Orlando 3h 13m stop 13:57 — 16:08 NK223 Spirit Airlines Orlando — Chicago	8h 8m including layover	Find flight from$267
09:35 — 14:34	09:35 — 11:21 UA4325 United Airlines Knoxville — Washington D.C. 1h 54m stop 13:15 — 14:34 UA1193 United Airlines Washington D.C. — Chicago	5h 59m including layover	Find flight from$154
11:00 — 20:13	11:00 — 13:17 G41415 Allegiant Air Knoxville — Miami 4h 33m stop 17:50 — 20:13 NK19 Spirit Airlines Miami — Chicago	10h 13m including layover	Find flight from$181
12:25 — 22:29	12:25 — 14:08 G43049 Allegiant Air Knoxville — Tampa 6h 24m stop 20:32 — 22:29 NK1171 Spirit Airlines Tampa — Chicago	11h 4m including layover	Find flight from$169
12:25 — 18:50	12:25 — 14:03 G41420 Allegiant Air Knoxville — Orlando 2h 43m stop 16:46 — 18:50 NK1147 Spirit Airlines Orlando — Chicago	7h 25m including layover	Find flight from$184
14:00 — 20:48	14:00 — 16:04 G43040 Allegiant Air Knoxville — Miami 2h 21m stop 18:25 — 20:48 NK7 Spirit Airlines Miami — Chicago	7h 48m including layover	Find flight from$179
14:35 — 18:55	14:35 — 16:20 UA4848 United Airlines Knoxville — Washington D.C. 1h 16m stop 17:36 — 18:55 UA1117 United Airlines Washington D.C. — Chicago	5h 20m including layover	Find flight from$154
16:19 — 00:13 +1 day	19:30 — 20:46 F94369 Frontier Airlines Knoxville — Denver 3h 4m stop 08:50 — 12:13 F92210 Frontier Airlines Denver — Chicago	8h 54m including layover	Find flight from$67
16:19 — 00:48 +1 day	22:35 — 23:54 F94369 Frontier Airlines Knoxville — Denver 3h 24m stop 19:42 — 23:16 F93174 Frontier Airlines Denver — Chicago	9h 29m including layover	Find flight from$70
19:30 — 09:47 +1 day	19:30 — 20:46 F94369 Frontier Airlines Knoxville — Denver 9h 24m stop 06:10 — 09:47 F91484 Frontier Airlines Denver — Chicago	15h 17m including layover	Find flight from$67
19:31 — 00:58 +1 day	19:31 — 20:44 F94369 Frontier Airlines Knoxville — Denver 40m stop 21:24 — 00:58 F93172 Frontier Airlines Denver — Chicago	6h 27m including layover	Find flight from$196
21:59 — 07:18 +1 day	21:59 — 23:43 G41417 Allegiant Air Knoxville — Orlando 5h 27m stop 05:10 — 07:18 NK1683 Spirit Airlines Orlando — Chicago	10h 19m including layover	Find flight from$215
22:35 — 15:50 +1 day	22:35 — 23:54 F94369 Frontier Airlines Knoxville — Denver 12h 34m stop 12:28 — 15:50 F91228 Frontier Airlines Denver — Chicago	18h 15m including layover	Find flight from$71
06:00 — 20:26	06:00 — 07:48 G43046 Allegiant Air Knoxville — Orlando 5h 41m stop 13:29 — 15:32 NK1096 Spirit Airlines Orlando — Dallas 2h 26m stop 17:58 — 20:26 NK241 Spirit Airlines Dallas — Chicago	15h 26m including layover	Find flight from$303
10:00 — 23:07	10:00 — 11:31 G43020 Allegiant Air Knoxville — Houston 4h 26m stop 15:57 — 20:24 NK3929 Spirit Airlines Houston — New York 1h 5m stop 21:29 — 23:07 NK3386 Spirit Airlines New York — Chicago	14h 7m including layover	Find flight from$213
10:00 — 10:55 +1 day	10:00 — 12:22 G43045 Allegiant Air Knoxville — Phoenix 5h 58m stop 18:20 — 22:15 SY600 Sun Country Airlines Phoenix — Minneapolis 10h 52m stop 09:07 — 10:55 SY259 Sun Country Airlines Minneapolis — Chicago	25h 55m including layover	Find flight from$276
11:00 — 22:55	11:00 — 13:17 G41415 Allegiant Air Knoxville — Miami 2h 50m stop 16:07 — 19:00 NK220 Spirit Airlines Miami — New York 2h 15m stop 21:15 — 22:55 NK225 Spirit Airlines New York — Chicago	12h 55m including layover	Find flight from$210
15:07 — 12:05 +1 day	15:07 — 16:43 G467 Allegiant Air Knoxville — Las Vegas 2h 28m stop 19:11 — 20:30 NK1495 Spirit Airlines Las Vegas — Los Angeles 9h 30m stop 06:00 — 12:05 NK466 Spirit Airlines Los Angeles — Chicago	21h 58m including layover	Find flight from$270
21:59 — 11:47 +1 day	21:59 — 23:43 G41417 Allegiant Air Knoxville — Orlando 6h 17m stop 06:00 — 08:08 NK538 Spirit Airlines Orlando — Dallas 1h 5m stop 09:13 — 11:47 NK539 Spirit Airlines Dallas — Chicago	14h 48m including layover	Find flight from$258

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on May 9, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Knoxville to Chicago depends on and how to choose the most interesting flight option for you.

Distance between Knoxville and Chicago is 745 miles. Time difference between the cities is 1h. Airplanes depart 05:40 to 22:35 from 1 Knoxville airport and arrive 05:40 to 22:35 to 7 Chicago airports. Average flight time is 2h 2m.

The fastest flight 1h 33m
Average flight time 2h 2m
The earliest flight 05:40
The latest flight 22:35
Distance 463 ml

The cheapest months to travel to Chicago are november (from 67 $), december (from 88 $), january (from 98 $).

The most expensive months are february (from 142 $), january (from 98 $), december (from 88 $).

What is the lowest airfare Knoxville to Chicago?

The cheapest plane ticket found by our users is $67. This airfare is for economy class on one-way F94369 flight by Frontier Airlines for December 12, 2024 which leaves Mc Ghee Tyson in Knoxville at 16:19 am and arrives at Chicago Midway at 00:13.

Economy class

$67

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Business class

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First class

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Popular Airlines on the Route

The flight Knoxville — Chicago is served by 4 regular airlines and 3 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 5 departures per week at the price of from $ 67 . And the most expensive tickets are offered by United Airlines airline - from $ 1280.

Direct flights

There are 15 nonstop flights on the route. The fastest direct flight is G41416 by Allegiant Air takes 1h 33m and the cheapest is F94369 by Frontier Airlines for $68.

UA - United Airlines

from $142

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G4 - Allegiant Air

from $68

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Connecting Flights

There are 268 flights with layovers on the route. The fastest connecting flight is UA4311 by United Airlines takes 4h 44m and the cheapest is F94369 by Frontier Airlines for $67.

F9 - Frontier Airlines

from $67

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UA - United Airlines

from $154

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WS - WestJet

from $394

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G4 - Allegiant Air

from $169

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See more connecting flights

Airports

You can fly from Knoxville to Chicago from 1 airports (Mc Ghee Tyson).

Knoxville airports

Mc Ghee Tyson-TYS

from $67
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Chicago airports

O'Hare International-ORD

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Midway-MDW

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Dupage County-DPA

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Chicago FSS-CHI

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Merrill C Meigs (closed)-CGX

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Pal-Waukee-PWK

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Chicago NAS-NOH

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Airplanes

There are flights to Chicago from Knoxville by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Knoxville

You may also consider searching for discounted plane tickets to some other popular places from Knoxville within United States.

Knoxville — Orlando

from $73

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Knoxville — Las Vegas

from $74

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Knoxville — Chicago

from $76

Find
Knoxville — Denver

from $74

Find
Knoxville — Miami

from $66

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Knoxville — Boston

from $69

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Knoxville — Houston

from $54

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Knoxville — New Orleans

from $56

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Knoxville — Tampa

from $80

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Knoxville — Austin

from $54

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Top International Destinations from Knoxville

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Knoxville — Cancun

from $69

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Knoxville — Panama City

from $61

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
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Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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