Cheap Flights from Chicago, IL to Knoxville, TN from $64

One way Round trip

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On Cheapflightsplus.com you will find 12 direct and 203 connecting flights from Chicago to Knoxville. You can compare airfare deals from 6 airlines and multiple travel sites from $64, book and save on cheap plane tickets and last minute offers. Also check out CHI-TYS flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Chicago to Knoxville Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $64 (one-way), $110 (round-trip).

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Best Flights from Chicago to Knoxville Today

Take a look at the list of non stop flights and flights with layovers from Chicago to Knoxville with the lowest price of $64. The fastest direct flight takes 1h 25m and the fastest connecting – 4h 45m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $68 Find flight	15:08 Chicago Midway	17:33 Knoxville Mc Ghee Tyson	1h 25m	Allegiant Air	G41399
from $142 Find flight	10:35 Chicago O'Hare International	13:17 Knoxville Mc Ghee Tyson	1h 42m	United Airlines	UA5836
from $142 Find flight	14:10 Chicago O'Hare International	16:54 Knoxville Mc Ghee Tyson	1h 44m	United Airlines	UA5379
from $142 Find flight	19:58 Chicago O'Hare International	22:43 Knoxville Mc Ghee Tyson	1h 45m	United Airlines	UA1156
from $196 Find flight	20:15 Chicago O'Hare International	23:00 Knoxville Mc Ghee Tyson	1h 45m	United Airlines	UA1871
from $311 Find flight	17:50 Chicago O'Hare International	20:35 Knoxville Mc Ghee Tyson	1h 45m	United Airlines	UA1238
from $361 Find flight	19:40 Chicago O'Hare International	22:24 Knoxville Mc Ghee Tyson	1h 44m	United Airlines	UA454
from $443 Find flight	10:35 Chicago O'Hare International	13:15 Knoxville Mc Ghee Tyson	1h 40m	United Airlines	UA4505
from $64 Find flight	07:15 Chicago Midway	15:16 Knoxville Mc Ghee Tyson	7h 1m layover 1h 31m - Denver	Frontier Airlines	F92209 F92374
from $71 Find flight	07:25 Chicago O'Hare International	15:16 Knoxville Mc Ghee Tyson	6h 51m layover 1h 10m - Denver	Frontier Airlines	F93173 F92374
from $91 Find flight	16:44 Chicago O'Hare International	18:29+1 день Knoxville Mc Ghee Tyson	24h 45m layover 19h 10m - Denver	Frontier Airlines	F92003 F92374
from $144 Find flight	05:00 Chicago O'Hare International	16:14 Knoxville Mc Ghee Tyson	10h 14m layover 4h 58m - Miami	Spirit Airlines	NK2 G41428
from $154 Find flight	08:50 Chicago O'Hare International	14:43 Knoxville Mc Ghee Tyson	4h 53m layover 1h 7m - Washington D.C.	United Airlines	UA2490 UA4251
from $154 Find flight	13:15 Chicago O'Hare International	19:36 Knoxville Mc Ghee Tyson	5h 21m layover 1h 31m - Washington D.C.	United Airlines	UA2431 UA4914
from $161 Find flight	06:00 Chicago O'Hare International	15:25 Knoxville Mc Ghee Tyson	8h 25m layover 4h 5m - Clearwater	Spirit Airlines	NK138 G41061
from $167 Find flight	05:10 Chicago O'Hare International	15:23 Knoxville Mc Ghee Tyson	9h 13m layover 4h 20m - Houston	Spirit Airlines	NK963 G43025

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on May 09, 2025

Flight Schedule Chicago (Illinois) to Knoxville (Tennessee)

Full flight schedule will help you in detecting at what time planes fly from Chicago to Knoxville. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
07:20 — 10:08	07:20 — 10:08 UA5666 United Airlines Chicago — Knoxville	1h 48m	Find flight from$311
10:35 — 13:17	10:35 — 13:17 UA5836 United Airlines Chicago — Knoxville	1h 42m	Find flight from$142
10:35 — 13:25	10:35 — 13:25 UA3686 United Airlines Chicago — Knoxville	1h 50m	Find flight from$361
10:35 — 13:15	10:35 — 13:15 UA4505 United Airlines Chicago — Knoxville	1h 40m	Find flight from$443
14:05 — 16:55	14:05 — 16:55 UA5272 United Airlines Chicago — Knoxville	1h 50m	Find flight from$361
14:10 — 16:54	14:10 — 16:54 UA5379 United Airlines Chicago — Knoxville	1h 44m	Find flight from$142
15:08 — 17:33	15:08 — 17:33 G41399 Allegiant Air Chicago — Knoxville	1h 25m	Find flight from$68
17:50 — 20:35	17:50 — 20:35 UA1238 United Airlines Chicago — Knoxville	1h 45m	Find flight from$311
18:00 — 20:48	18:00 — 20:48 UA5370 United Airlines Chicago — Knoxville	1h 48m	Find flight from$314
19:40 — 22:24	19:40 — 22:24 UA454 United Airlines Chicago — Knoxville	1h 44m	Find flight from$361
19:58 — 22:43	19:58 — 22:43 UA1156 United Airlines Chicago — Knoxville	1h 45m	Find flight from$142
20:15 — 23:00	20:15 — 23:00 UA1871 United Airlines Chicago — Knoxville	1h 45m	Find flight from$196
05:00 — 16:14	05:00 — 09:09 NK2 Spirit Airlines Chicago — Miami 4h 58m stop 14:07 — 16:14 G41428 Allegiant Air Miami — Knoxville	10h 14m including layover	Find flight from$144
05:10 — 15:23	05:10 — 08:01 NK963 Spirit Airlines Chicago — Houston 4h 20m stop 12:21 — 15:23 G43025 Allegiant Air Houston — Knoxville	9h 13m including layover	Find flight from$167
06:00 — 15:25	06:00 — 09:41 NK138 Spirit Airlines Chicago — Clearwater 4h 5m stop 13:46 — 15:25 G41061 Allegiant Air Clearwater — Knoxville	8h 25m including layover	Find flight from$161
07:15 — 15:16	09:45 — 11:33 F92209 Frontier Airlines Chicago — Denver 1h 31m stop 13:45 — 18:29 F92374 Frontier Airlines Denver — Knoxville	7h 1m including layover	Find flight from$64
07:25 — 15:16	10:57 — 12:46 F93173 Frontier Airlines Chicago — Denver 1h 10m stop 16:52 — 21:35 F92374 Frontier Airlines Denver — Knoxville	6h 51m including layover	Find flight from$71
08:13 — 16:25	08:13 — 12:03 NK222 Spirit Airlines Chicago — Orlando 2h 32m stop 14:35 — 16:25 G43476 Allegiant Air Orlando — Knoxville	7h 12m including layover	Find flight from$267
08:50 — 14:43	08:50 — 11:48 UA2490 United Airlines Chicago — Washington D.C. 1h 7m stop 12:55 — 14:43 UA4251 United Airlines Washington D.C. — Knoxville	4h 53m including layover	Find flight from$154
11:25 — 21:04	11:25 — 15:15 NK138 Spirit Airlines Chicago — Clearwater 4h 11m stop 19:26 — 21:04 G43063 Allegiant Air Clearwater — Knoxville	8h 39m including layover	Find flight from$197
11:25 — 22:22	11:25 — 15:15 NK138 Spirit Airlines Chicago — Clearwater 5h 29m stop 20:44 — 22:22 G43023 Allegiant Air Clearwater — Knoxville	9h 57m including layover	Find flight from$236
12:00 — 21:09	12:00 — 15:47 NK1686 Spirit Airlines Chicago — Sanford 3h 43m stop 19:30 — 21:09 G41422 Allegiant Air Sanford — Knoxville	8h 9m including layover	Find flight from$241
12:45 — 22:30	12:45 — 14:34 UA2311 United Airlines Chicago — Denver 2h 59m stop 17:33 — 22:30 UA4798 United Airlines Denver — Knoxville	8h 45m including layover	Find flight from$297
13:15 — 19:36	13:15 — 16:13 UA2431 United Airlines Chicago — Washington D.C. 1h 31m stop 17:44 — 19:36 UA4914 United Airlines Washington D.C. — Knoxville	5h 21m including layover	Find flight from$154
14:30 — 22:30	14:30 — 16:20 UA2402 United Airlines Chicago — Denver 1h 13m stop 17:33 — 22:30 UA4798 United Airlines Denver — Knoxville	7h including layover	Find flight from$297
16:44 — 18:29 +1 day	16:44 — 18:35 F92003 Frontier Airlines Chicago — Denver 19h 10m stop 13:45 — 18:29 F92374 Frontier Airlines Denver — Knoxville	24h 45m including layover	Find flight from$91
17:50 — 15:01 +1 day	17:50 — 19:40 UA2370 United Airlines Chicago — Denver 14h 30m stop 10:10 — 15:01 UA2420 United Airlines Denver — Knoxville	20h 11m including layover	Find flight from$327
18:48 — 16:50 +1 day	18:48 — 20:32 F91483 Frontier Airlines Chicago — Denver 15h 26m stop 11:58 — 16:50 F92374 Frontier Airlines Denver — Knoxville	21h 2m including layover	Find flight from$322
21:36 — 22:30 +1 day	19:40 — 21:29 UA2485 United Airlines Chicago — Denver 18h 14m stop 17:33 — 22:30 UA4798 United Airlines Denver — Knoxville	23h 54m including layover	Find flight from$287
10:55 — 12:38 +1 day	10:55 — 12:51 NK183 Spirit Airlines Chicago — Las Vegas 9h 20m stop 22:11 — 05:56 NK954 Spirit Airlines Las Vegas — Miami 4h 33m stop 10:29 — 12:38 G41428 Allegiant Air Miami — Knoxville	24h 43m including layover	Find flight from$297
13:14 — 12:38 +1 day	13:14 — 15:10 NK188 Spirit Airlines Chicago — Las Vegas 7h 1m stop 22:11 — 05:56 NK954 Spirit Airlines Las Vegas — Miami 4h 33m stop 10:29 — 12:38 G41428 Allegiant Air Miami — Knoxville	22h 24m including layover	Find flight from$297
16:19 — 07:47 +1 day	16:19 — 19:29 NK3385 Spirit Airlines Chicago — New York 1h 5m stop 20:34 — 23:39 NK475 Spirit Airlines New York — Sanford 6h 31m stop 06:10 — 07:47 G43061 Allegiant Air Sanford — Knoxville	14h 28m including layover	Find flight from$286
19:46 — 14:42 +1 day	19:46 — 23:54 NK158 Spirit Airlines Chicago — Miami 6h 21m stop 06:15 — 09:24 NK1987 Spirit Airlines Miami — Boston 2h 42m stop 12:06 — 14:42 G43034 Allegiant Air Boston — Knoxville	17h 56m including layover	Find flight from$235
20:52 — 14:00 +1 day	20:52 — 00:44 NK1686 Spirit Airlines Chicago — Orlando 6h 16m stop 07:00 — 09:45 NK1475 Spirit Airlines Orlando — Newark 2h 10m stop 11:55 — 14:00 G41397 Allegiant Air Newark — Knoxville	16h 8m including layover	Find flight from$224
21:11 — 15:02 +1 day	21:11 — 00:05 NK1150 Spirit Airlines Chicago — Houston 5h 10m stop 05:15 — 08:34 NK1571 Spirit Airlines Houston — Sanford 4h 52m stop 13:26 — 15:02 G41422 Allegiant Air Sanford — Knoxville	16h 51m including layover	Find flight from$300
22:13 — 18:58 +1 day	22:13 — 00:21 NK330 Spirit Airlines Chicago — Las Vegas 5h 9m stop 05:30 — 13:02 NK867 Spirit Airlines Las Vegas — Miami 3h 52m stop 18:26 — 20:30 G41435 Allegiant Air Miami — Knoxville	19h 45m including layover	Find flight from$222
22:47 — 21:18 +1 day	22:47 — 00:54 NK713 Spirit Airlines Chicago — Las Vegas 9h 16m stop 10:10 — 12:28 NK2007 Spirit Airlines Las Vegas — Phoenix 3h 26m stop 15:54 — 21:18 G41408 Allegiant Air Phoenix — Knoxville	21h 31m including layover	Find flight from$212

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on May 9, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Chicago to Knoxville depends on and how to choose the most interesting flight option for you.

Distance between Chicago and Knoxville is 745 miles. Time difference between the cities is 1h. Airplanes depart 03:45 to 22:47 from 7 Chicago airports and arrive 03:45 to 22:47 to 1 Knoxville airport. Average flight time is 1h 45m.

The fastest flight 1h 25m
Average flight time 1h 45m
The earliest flight 03:45
The latest flight 22:47
Distance 463 ml

The cheapest months to travel to Knoxville are november (from 64 $), december (from 71 $), january (from 142 $).

The most expensive months are february (from 142 $), january (from 142 $), december (from 71 $).

What is the lowest airfare Chicago to Knoxville?

The cheapest plane ticket found by our users is $64. This airfare is for economy class on one-way F92209 flight by Frontier Airlines for December 12, 2024 which leaves Midway in Chicago at 07:15 am and arrives at Knoxville Mc Ghee Tyson at 15:16.

Economy class

$64

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Business class

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First class

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Popular Airlines on the Route

The flight Chicago — Knoxville is served by 6 regular airlines and 5 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 4 departures per week at the price of from $ 64 . And the most expensive tickets are offered by Volaris airline - from $ 922.

Direct flights

There are 12 nonstop flights on the route. The fastest direct flight is G41399 by Allegiant Air takes 1h 25m and the cheapest is F92209 by Frontier Airlines for $68.

UA - United Airlines

from $142

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G4 - Allegiant Air

from $68

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Connecting Flights

There are 203 flights with layovers on the route. The fastest connecting flight is UA210 by United Airlines takes 4h 45m and the cheapest is F92209 by Frontier Airlines for $64.

F9 - Frontier Airlines

from $64

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SY - Sun Country Airlines

from $384

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Y4 - Volaris

from $922

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UA - United Airlines

from $154

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NK - Spirit Airlines

from $144

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See more connecting flights

Airports

You can fly from Chicago to Knoxville from 7 airports (O'Hare International, Midway, Dupage County, Chicago FSS, Merrill C Meigs (closed), Pal-Waukee, Chicago NAS).

Chicago airports

O'Hare International-ORD

from $71
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Midway-MDW

from $64
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Dupage County-DPA

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Chicago FSS-CHI

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Merrill C Meigs (closed)-CGX

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Pal-Waukee-PWK

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Chicago NAS-NOH

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Knoxville airports

Mc Ghee Tyson-TYS

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Airplanes

There are flights to Knoxville from Chicago by 6 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Chicago

You may also consider searching for discounted plane tickets to some other popular places from Chicago within United States.

Chicago — Las Vegas

from $508

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Chicago — New York

from $74

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Chicago — Atlanta

from $76

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Chicago — Orlando

from $62

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Chicago — Miami

from $66

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Chicago — Dallas

from $70

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Chicago — Houston

from $66

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Chicago — Boston

from $61

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Chicago — Phoenix

from $65

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Chicago — Denver

from $61

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Top International Destinations from Chicago

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Chicago — London

from $60

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Chicago — Cancun

from $72

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Chicago — Toronto

from $73

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Chicago — Paris

from $61

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Chicago — Rome

from $79

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Chicago — Hyderabad

from $73

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Chicago — Mexico City

from $76

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Chicago — Tokyo

from $60

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Chicago — Dublin

from $59

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Chicago — Mumbai

from $74

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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