Cheap Flights from Chicago, IL to Knoxville, TN from $51
Return flight: Knoxville – Chicago
On Cheapflightsplus.com you will find 16 direct and 612 connecting flights from Chicago to Knoxville. You can compare airfare deals from 6 airlines and multiple travel sites from $51, book and save on cheap plane tickets and last minute offers. Also check out CHI-TYS flight schedule to find best flight time, convenient departure and arrival airports.
Find One-Way and Round-Trip Chicago to Knoxville Flight Deals
To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights».
To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight.
Cheapest flights in November: $51 (one-way), $87 (round-trip).
Direct flights
Check prices for return flight
Best Flights from Chicago to Knoxville Today
Take a look at the list of non stop flights and flights with layovers from Chicago to Knoxville with the lowest price of $51. The fastest direct flight takes 1h 25m and the fastest connecting – 4h 41m.
| Price | Departure | Arrival | Flight Duration | Airline | Flight |
|---|---|---|---|---|---|
| from $51 | 14:46 Chicago Midway | 17:12 Knoxville Mc Ghee Tyson | 1h 26m | Allegiant Air | G41430 |
| from $51 | 19:00 Chicago Midway | 21:28 Knoxville Mc Ghee Tyson | 1h 28m | Allegiant Air | G41433 |
| from $53 | 14:53 Chicago Midway | 17:18 Knoxville Mc Ghee Tyson | 1h 25m | Allegiant Air | G43025 |
| from $55 | 14:54 Chicago Midway | 17:22 Knoxville Mc Ghee Tyson | 1h 28m | Allegiant Air | G43036 |
| from $61 | 14:54 Chicago Midway | 17:20 Knoxville Mc Ghee Tyson | 1h 26m | Allegiant Air | G43046 |
| from $258 | 10:35 Chicago O'Hare International | 13:25 Knoxville Mc Ghee Tyson | 1h 50m | United Airlines | UA4194 |
| from $392 | 10:35 Chicago O'Hare International | 13:23 Knoxville Mc Ghee Tyson | 1h 48m | United Airlines | UA3641 |
| from $106 | 07:15 Chicago O'Hare International | 20:41 Knoxville Mc Ghee Tyson | 12h 26m layover 8h 3m - Sanford | Spirit Airlines | NK3200 G42839 |
| from $111 | 14:44 Chicago Midway | 16:29+1 день Knoxville Mc Ghee Tyson | 24h 45m layover 19h 8m - Denver | Frontier Airlines | F92209 F92374 |
| from $113 | 21:08 Chicago O'Hare International | 12:50+1 день Knoxville Mc Ghee Tyson | 14h 42m layover 10h 26m - Newark | Spirit Airlines | NK2542 G43024 |
| from $114 | 06:00 Chicago O'Hare International | 16:29 Knoxville Mc Ghee Tyson | 9h 29m layover 3h 50m - Denver | Frontier Airlines | F91483 F92374 |
| from $117 | 18:17 Chicago O'Hare International | 16:11+1 день Knoxville Mc Ghee Tyson | 20h 54m layover 17h 11m - Minneapolis | Sun Country Airlines | SY262 G41416 |
| from $118 | 19:39 Chicago O'Hare International | 13:27+1 день Knoxville Mc Ghee Tyson | 16h 48m layover 12h 18m - Sanford | Spirit Airlines | NK507 G41400 |
| from $119 | 09:05 Chicago O'Hare International | 16:29 Knoxville Mc Ghee Tyson | 6h 24m layover 0h 43m - Denver | Frontier Airlines | F93173 F92374 |
| from $119 | 21:28 Chicago O'Hare International | 11:50+1 день Knoxville Mc Ghee Tyson | 13h 22m layover 9h 9m - Newark | Spirit Airlines | NK2542 G41405 |
| from $122 | 11:45 Chicago Midway | 08:09+1 день Knoxville Mc Ghee Tyson | 19h 24m layover 14h 49m - Punta Gorda | Allegiant Air | G4877 G4892 |
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on August 08, 2025
Flight Schedule Chicago (Illinois) to Knoxville (Tennessee)
Full flight schedule will help you in detecting at what time planes fly from Chicago to Knoxville. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
| Departure | Arrival | Flight Details | Flight Duration | Price |
|---|---|---|---|---|
|
07:25 — 10:17
|
07:25 — 10:17
UA5726
United Airlines
Chicago — Knoxville
|
1h 52m |
Find flight
from$260 |
|
|
10:35 — 13:25
|
10:35 — 13:25
UA4194
United Airlines
Chicago — Knoxville
|
1h 50m |
Find flight
from$258 |
|
|
10:35 — 13:23
|
10:35 — 13:23
UA4182
United Airlines
Chicago — Knoxville
|
1h 48m |
Find flight
from$259 |
|
|
10:35 — 13:21
|
10:35 — 13:21
UA5836
United Airlines
Chicago — Knoxville
|
1h 46m |
Find flight
from$260 |
|
|
10:35 — 13:23
|
10:35 — 13:23
UA3641
United Airlines
Chicago — Knoxville
|
1h 48m |
Find flight
from$392 |
|
|
14:00 — 16:57
|
14:00 — 16:57
UA5523
United Airlines
Chicago — Knoxville
|
1h 57m |
Find flight
from$259 |
|
|
14:00 — 16:56
|
14:00 — 16:56
UA4498
United Airlines
Chicago — Knoxville
|
1h 56m |
Find flight
from$392 |
|
|
14:08 — 17:05
|
14:08 — 17:05
UA5429
United Airlines
Chicago — Knoxville
|
1h 57m |
Find flight
from$261 |
|
|
14:10 — 17:00
|
14:10 — 17:00
UA5399
United Airlines
Chicago — Knoxville
|
1h 50m |
Find flight
from$258 |
|
|
14:46 — 17:12
|
14:46 — 17:12
G41430
Allegiant Air
Chicago — Knoxville
|
1h 26m |
Find flight
from$51 |
|
|
14:53 — 17:18
|
14:53 — 17:18
G43025
Allegiant Air
Chicago — Knoxville
|
1h 25m |
Find flight
from$53 |
|
|
14:54 — 17:22
|
14:54 — 17:22
G43036
Allegiant Air
Chicago — Knoxville
|
1h 28m |
Find flight
from$55 |
|
|
14:54 — 17:20
|
14:54 — 17:20
G43046
Allegiant Air
Chicago — Knoxville
|
1h 26m |
Find flight
from$61 |
|
|
15:46 — 18:38
|
15:46 — 18:38
UA454
United Airlines
Chicago — Knoxville
|
1h 52m |
Find flight
from$259 |
|
|
19:00 — 21:28
|
19:00 — 21:28
G41433
Allegiant Air
Chicago — Knoxville
|
1h 28m |
Find flight
from$51 |
|
|
19:50 — 22:35
|
19:50 — 22:35
UA2005
United Airlines
Chicago — Knoxville
|
1h 45m |
Find flight
from$260 |
|
|
05:05 — 10:04
+1 day
|
05:05 — 09:10
NK19
Spirit Airlines
Chicago — Miami
22h 50m stop
08:00 — 10:04
G4527
Allegiant Air
Miami — Knoxville
|
27h 59m including layover |
Find flight
from$134 |
|
|
06:00 — 16:29
|
06:00 — 08:02
F91483
Frontier Airlines
Chicago — Denver
3h 50m stop
11:41 — 16:35
F92374
Frontier Airlines
Denver — Knoxville
|
9h 29m including layover |
Find flight
from$114 |
|
|
07:15 — 20:41
|
07:15 — 11:03
NK3200
Spirit Airlines
Chicago — Sanford
8h 3m stop
19:06 — 20:41
G42839
Allegiant Air
Sanford — Knoxville
|
12h 26m including layover |
Find flight
from$106 |
|
|
08:00 — 10:04
+1 day
|
08:00 — 12:07
NK1986
Spirit Airlines
Chicago — Miami
19h 53m stop
08:00 — 10:04
G4527
Allegiant Air
Miami — Knoxville
|
25h 4m including layover |
Find flight
from$146 |
|
|
09:05 — 16:29
|
09:05 — 10:58
F93173
Frontier Airlines
Chicago — Denver
43m stop
11:41 — 16:29
F92374
Frontier Airlines
Denver — Knoxville
|
6h 24m including layover |
Find flight
from$119 |
|
|
09:55 — 08:19
+1 day
|
09:55 — 14:02
NK2187
Spirit Airlines
Chicago — Miami
16h 13m stop
06:15 — 08:19
G4499
Allegiant Air
Miami — Knoxville
|
21h 24m including layover |
Find flight
from$145 |
|
|
10:46 — 22:11
|
05:15 — 08:58
NK2189
Spirit Airlines
Chicago — Orlando
6h 7m stop
08:24 — 10:09
G43060
Allegiant Air
Orlando — Knoxville
|
10h 25m including layover |
Find flight
from$148 |
|
|
11:37 — 08:12
+1 day
|
11:37 — 15:26
G42467
Allegiant Air
Chicago — Punta Gorda
14h 59m stop
06:25 — 08:12
G4892
Allegiant Air
Punta Gorda — Knoxville
|
19h 35m including layover |
Find flight
from$122 |
|
|
11:45 — 08:09
+1 day
|
11:45 — 15:31
G4877
Allegiant Air
Chicago — Punta Gorda
14h 49m stop
06:20 — 08:09
G4892
Allegiant Air
Punta Gorda — Knoxville
|
19h 24m including layover |
Find flight
from$122 |
|
|
13:03 — 13:27
+1 day
|
13:03 — 16:51
NK1108
Spirit Airlines
Chicago — Sanford
18h 59m stop
11:50 — 13:27
G41400
Allegiant Air
Sanford — Knoxville
|
23h 24m including layover |
Find flight
from$152 |
|
|
15:29 — 10:04
+1 day
|
15:29 — 19:39
NK867
Spirit Airlines
Chicago — Miami
12h 21m stop
08:00 — 10:04
G4527
Allegiant Air
Miami — Knoxville
|
17h 35m including layover |
Find flight
from$134 |
|
|
15:29 — 15:36
+1 day
|
15:29 — 19:39
NK867
Spirit Airlines
Chicago — Miami
17h 54m stop
13:33 — 15:36
G42112
Allegiant Air
Miami — Knoxville
|
23h 7m including layover |
Find flight
from$143 |
|
|
16:36 — 10:11
+1 day
|
16:36 — 20:23
NK1370
Spirit Airlines
Chicago — Orlando
12h 4m stop
08:27 — 10:11
G43064
Allegiant Air
Orlando — Knoxville
|
16h 35m including layover |
Find flight
from$142 |
|
|
16:36 — 21:20
+1 day
|
16:36 — 20:23
NK1370
Spirit Airlines
Chicago — Sanford
23h 22m stop
19:45 — 21:20
G42885
Allegiant Air
Sanford — Knoxville
|
27h 44m including layover |
Find flight
from$147 |
|
|
17:38 — 08:02
+1 day
|
17:38 — 21:48
NK1106
Spirit Airlines
Chicago — Miami
8h 12m stop
06:00 — 08:02
G4520
Allegiant Air
Miami — Knoxville
|
13h 24m including layover |
Find flight
from$146 |
|
|
18:17 — 16:11
+1 day
|
18:17 — 19:57
SY262
Sun Country Airlines
Chicago — Minneapolis
17h 11m stop
13:08 — 16:11
G41416
Allegiant Air
Minneapolis — Knoxville
|
20h 54m including layover |
Find flight
from$117 |
|
|
18:34 — 10:04
+1 day
|
18:34 — 22:32
NK1027
Spirit Airlines
Chicago — Miami
9h 28m stop
08:00 — 10:04
G4527
Allegiant Air
Miami — Knoxville
|
14h 30m including layover |
Find flight
from$134 |
|
|
19:39 — 13:27
+1 day
|
19:39 — 23:32
NK507
Spirit Airlines
Chicago — Sanford
12h 18m stop
11:50 — 13:27
G41400
Allegiant Air
Sanford — Knoxville
|
16h 48m including layover |
Find flight
from$118 |
|
|
20:05 — 11:42
+1 day
|
18:18 — 20:02
SY262
Sun Country Airlines
Chicago — Minneapolis
10h 45m stop
08:34 — 11:42
G41428
Allegiant Air
Minneapolis — Knoxville
|
14h 37m including layover |
Find flight
from$128 |
|
|
21:08 — 12:50
+1 day
|
21:08 — 00:29
NK2542
Spirit Airlines
Chicago — Newark
10h 26m stop
10:55 — 12:50
G43024
Allegiant Air
Newark — Knoxville
|
14h 42m including layover |
Find flight
from$113 |
|
|
21:28 — 11:50
+1 day
|
21:08 — 00:29
NK2542
Spirit Airlines
Chicago — Newark
9h 9m stop
09:55 — 11:55
G41405
Allegiant Air
Newark — Knoxville
|
13h 22m including layover |
Find flight
from$119 |
|
|
05:05 — 12:50
+1 day
|
05:05 — 09:06
NK2
Spirit Airlines
Chicago — Miami
4h 28m stop
13:34 — 16:34
NK2691
Spirit Airlines
Miami — Newark
18h 21m stop
10:55 — 12:50
G43024
Allegiant Air
Newark — Knoxville
|
30h 45m including layover |
Find flight
from$130 |
|
|
10:00 — 12:41
+1 day
|
10:00 — 13:06
NK2708
Spirit Airlines
Chicago — Atlanta
1h 39m stop
14:45 — 16:08
NK2468
Spirit Airlines
Atlanta — Clearwater
18h 52m stop
11:00 — 12:41
G43028
Allegiant Air
Clearwater — Knoxville
|
25h 41m including layover |
Find flight
from$152 |
|
|
12:41 — 12:50
+1 day
|
12:41 — 16:44
NK2187
Spirit Airlines
Chicago — Miami
3h 47m stop
20:31 — 23:24
NK2014
Spirit Airlines
Miami — Newark
11h 31m stop
10:55 — 12:50
G43024
Allegiant Air
Newark — Knoxville
|
23h 9m including layover |
Find flight
from$136 |
|
|
13:11 — 18:14
+1 day
|
13:11 — 15:49
G41846
Allegiant Air
Chicago — Fletcher
6h 13m stop
22:02 — 23:31
G41208
Allegiant Air
Fletcher — Sanford
17h 8m stop
16:39 — 18:14
G43040
Allegiant Air
Sanford — Knoxville
|
28h 3m including layover |
Find flight
from$153 |
|
|
20:04 — 21:47
+1 day
|
20:04 — 22:39
G4253
Allegiant Air
Chicago — Fletcher
14h 32m stop
13:11 — 13:40
G41852
Allegiant Air
Fletcher — Fort Walton Beach
5h 46m stop
19:26 — 21:47
G43025
Allegiant Air
Fort Walton Beach — Knoxville
|
24h 43m including layover |
Find flight
from$155 |
|
*Departure and arrival times - local. Updated on August 8, 2025
Flight Information
Below we will explain in detail what the flights cost on the destination from Chicago to Knoxville depends on and how to choose the most interesting flight option for you.
Distance between Chicago and Knoxville is 745 miles. Time difference between the cities is 1h. Airplanes depart 05:00 to 22:15 from 7 Chicago airports and arrive 05:00 to 22:15 to 1 Knoxville airport. Average flight time is 1h 48m.
- The fastest flight 1h 25m
- Average flight time 1h 48m
- The earliest flight 05:00
- The latest flight 22:15
- Distance 463 ml
The cheapest months to travel to Knoxville are may (from 51 $), august (from 51 $), june (from 53 $).
The most expensive months are december (from 335 $), september (from 276 $), october (from 106 $).
What is the lowest airfare Chicago to Knoxville?
The cheapest plane ticket found by our users is $51. This airfare is for economy class on one-way G41430 flight by Allegiant Air for August 8, 2025 which leaves Midway in Chicago at 14:46 am and arrives at Knoxville Mc Ghee Tyson at 17:12.
Economy class
$51
Business class
?
First class
?
Popular Airlines on the Route
The flight Chicago — Knoxville is served by 6 regular airlines and 4 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 3 departures per week at the price of from $ 111 . And the most expensive tickets are offered by United Airlines airline - from $ 742.
Direct flights
There are 16 nonstop flights on the route. The fastest direct flight is G43025 by Allegiant Air takes 1h 25m and the cheapest is G41430 by Allegiant Air for $51.
- UA - United Airlinesfrom $258Find
- G4 - Allegiant Airfrom $51Find
See more direct flights
Connecting Flights
There are 612 flights with layovers on the route. The fastest connecting flight is UA2029 by United Airlines takes 4h 41m and the cheapest is G41430 by Allegiant Air for $106.
- F9 - Frontier Airlinesfrom $111Find
- SY - Sun Country Airlinesfrom $117Find
- UA - United Airlinesfrom $253Find
- KG - Aerogaviotafrom $320Find
- NK - Spirit Airlinesfrom $106Find
- G4 - Allegiant Airfrom $122Find
See more connecting flights
Airports
You can fly from Chicago to Knoxville from 7 airports (O'Hare International, Midway, Dupage County, Chicago FSS, Merrill C Meigs (closed), Pal-Waukee, Chicago NAS).
Chicago airports
- O'Hare International-ORDfrom $106Find
- Midway-MDWfrom $51Find
- Dupage County-DPAFind
- Chicago FSS-CHIFind
- Merrill C Meigs (closed)-CGXFind
- Pal-Waukee-PWKFind
- Chicago NAS-NOHFind
Knoxville airports
- Mc Ghee Tyson-TYSFind
Airplanes
There are flights to Knoxville from Chicago by 6 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.
Top Domestic Destinations from Chicago
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Top International Destinations from Chicago
Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.
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How to book a plane ticket yourself?
- Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
- Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
- Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
- Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
- That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
To find a plane ticket, please select dates.