Cheap Flights from Chicago, IL to Knoxville, TN from $161

Return flight: Knoxville – Chicago
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On Cheapflightsplus.com you will find 3 direct and 19 connecting flights from Chicago to Knoxville. You can compare airfare deals from 3 airlines and multiple travel sites from $161, book and save on cheap plane tickets and last minute offers. Also check out CHI-TYS flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Chicago to Knoxville Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $161 (one-way), $276 (round-trip).
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Best Flights from Chicago to Knoxville Today

Take a look at the list of non stop flights and flights with layovers from Chicago to Knoxville with the lowest price of $161. The fastest direct flight takes 1h 40m and the fastest connecting – 4h 54m.
Price Departure Arrival Flight Duration Airline Flight
from $161
Find flight
20:15
Chicago
O'Hare International
 23:00
Knoxville
Mc Ghee Tyson
 1h 45m United Airlines
UA1871
from $262
Find flight
14:10
Chicago
O'Hare International
 16:54
Knoxville
Mc Ghee Tyson
 1h 44m United Airlines
UA5379
from $364
Find flight
10:35
Chicago
O'Hare International
 13:15
Knoxville
Mc Ghee Tyson
 1h 40m United Airlines
UA4505
from $230
Find flight
05:05
Chicago
O'Hare International
 16:14
Knoxville
Mc Ghee Tyson
 10h 9m
layover
4h 55m - Miami
 Spirit Airlines
NK19
G41402
from $234
Find flight
08:30
Chicago
O'Hare International
 16:14
Knoxville
Mc Ghee Tyson
 6h 44m
layover
1h 28m - Miami
 Spirit Airlines
NK1986
G41402
from $264
Find flight
18:48
Chicago
O'Hare International
 16:50+1 день
Knoxville
Mc Ghee Tyson
 21h 2m
layover
15h 26m - Denver
 Frontier Airlines
F91483
F92374
from $294
Find flight
21:30
Chicago
O'Hare International
 18:07+1 день
Knoxville
Mc Ghee Tyson
 19h 37m
layover
14h 20m - Houston
 United Airlines
UA2665
UA4890
from $374
Find flight
13:20
Chicago
O'Hare International
 19:39
Knoxville
Mc Ghee Tyson
 5h 19m
layover
1h 39m - Washington D.C.
 United Airlines
UA2649
UA4914
from $460
Find flight
08:45
Chicago
O'Hare International
 14:39
Knoxville
Mc Ghee Tyson
 4h 54m
layover
1h 14m - Washington D.C.
 United Airlines
UA545
UA4227
from $471
Find flight
09:20
Chicago
O'Hare International
 20:02
Knoxville
Mc Ghee Tyson
 9h 42m
layover
4h 22m - Houston
 United Airlines
UA1851
UA4900
from $481
Find flight
07:35
Chicago
O'Hare International
 18:07
Knoxville
Mc Ghee Tyson
 9h 32m
layover
4h 12m - Houston
 United Airlines
UA1913
UA4890
from $567
Find flight
14:35
Chicago
O'Hare International
 22:30
Knoxville
Mc Ghee Tyson
 6h 55m
layover
1h 5m - Denver
 United Airlines
UA1588
UA4798
from $244
Find flight
13:14
Chicago
O'Hare International
 12:38+1 день
Knoxville
Mc Ghee Tyson
 22h 24m
layover
7h 1m - Las Vegas
4h 33m - Miami
 Spirit Airlines
NK188
NK954
G41428
from $244
Find flight
10:55
Chicago
O'Hare International
 12:38+1 день
Knoxville
Mc Ghee Tyson
 24h 43m
layover
9h 20m - Las Vegas
4h 33m - Miami
 Spirit Airlines
NK183
NK954
G41428
from $248
Find flight
20:42
Chicago
O'Hare International
 12:38+1 день
Knoxville
Mc Ghee Tyson
 14h 56m
layover
6h 1m - Houston
1h 23m - Miami
 Spirit Airlines
NK1150
NK221
G41428
from $374
Find flight
17:42
Chicago
O'Hare International
 14:16+1 день
Knoxville
Mc Ghee Tyson
 19h 34m
layover
7h 59m - Orlando
3h 4m - Boston
 Spirit Airlines
NK507
NK1848
G43039
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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on February 05, 2025
Full flight schedule will help you in detecting at what time planes fly from Chicago to Knoxville. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
10:35 — 13:15
10:35 — 13:15 UA4505 United Airlines
Chicago — Knoxville
1h 40m
Find flight
from$364
14:10 — 16:54
14:10 — 16:54 UA5379 United Airlines
Chicago — Knoxville
1h 44m
Find flight
from$262
20:15 — 23:00
20:15 — 23:00 UA1871 United Airlines
Chicago — Knoxville
1h 45m
Find flight
from$161
05:05 — 16:14
05:05 — 09:10 NK19 Spirit Airlines
Chicago — Miami
4h 55m stop
14:05 — 16:14 G41402 Allegiant Air
Miami — Knoxville
10h 9m
including layover
Find flight
from$230
05:45 — 14:02
05:45 — 08:44 UA2606 United Airlines
Chicago — Houston
2h 1m stop
10:45 — 14:02 UA4887 United Airlines
Houston — Knoxville
7h 17m
including layover
Find flight
from$630
07:35 — 18:07
07:35 — 10:38 UA1913 United Airlines
Chicago — Houston
4h 12m stop
14:50 — 18:07 UA4890 United Airlines
Houston — Knoxville
9h 32m
including layover
Find flight
from$481
08:30 — 16:14
08:30 — 12:37 NK1986 Spirit Airlines
Chicago — Miami
1h 28m stop
14:05 — 16:14 G41402 Allegiant Air
Miami — Knoxville
6h 44m
including layover
Find flight
from$234
08:45 — 14:39
08:45 — 11:41 UA545 United Airlines
Chicago — Washington D.C.
1h 14m stop
12:55 — 14:39 UA4227 United Airlines
Washington D.C. — Knoxville
4h 54m
including layover
Find flight
from$460
09:20 — 20:02
09:20 — 12:23 UA1851 United Airlines
Chicago — Houston
4h 22m stop
16:45 — 20:02 UA4900 United Airlines
Houston — Knoxville
9h 42m
including layover
Find flight
from$471
09:20 — 18:07
09:20 — 12:23 UA1851 United Airlines
Chicago — Houston
2h 27m stop
14:50 — 18:07 UA4890 United Airlines
Houston — Knoxville
7h 47m
including layover
Find flight
from$598
10:35 — 20:02
10:35 — 13:38 UA237 United Airlines
Chicago — Houston
3h 7m stop
16:45 — 20:02 UA4900 United Airlines
Houston — Knoxville
8h 27m
including layover
Find flight
from$592
10:35 — 18:07
10:35 — 13:38 UA237 United Airlines
Chicago — Houston
1h 12m stop
14:50 — 18:07 UA4890 United Airlines
Houston — Knoxville
6h 32m
including layover
Find flight
from$598
12:45 — 20:02
12:45 — 15:47 UA2417 United Airlines
Chicago — Houston
1h stop
16:45 — 20:03 UA4900 United Airlines
Houston — Knoxville
6h 17m
including layover
Find flight
from$592
13:20 — 19:39
13:20 — 16:16 UA2649 United Airlines
Chicago — Washington D.C.
1h 39m stop
17:55 — 19:39 UA4914 United Airlines
Washington D.C. — Knoxville
5h 19m
including layover
Find flight
from$374
14:35 — 22:30
14:35 — 16:28 UA1588 United Airlines
Chicago — Denver
1h 5m stop
17:33 — 22:30 UA4798 United Airlines
Denver — Knoxville
6h 55m
including layover
Find flight
from$567
15:59 — 23:30
15:59 — 19:02 UA725 United Airlines
Chicago — Houston
1h 11m stop
20:13 — 23:30 UA4810 United Airlines
Houston — Knoxville
6h 31m
including layover
Find flight
from$592
18:48 — 16:50
+1 day
18:48 — 20:32 F91483 Frontier Airlines
Chicago — Denver
15h 26m stop
11:58 — 16:50 F92374 Frontier Airlines
Denver — Knoxville
21h 2m
including layover
Find flight
from$264
21:30 — 18:07
+1 day
21:30 — 00:30 UA2665 United Airlines
Chicago — Houston
14h 20m stop
14:50 — 18:07 UA4890 United Airlines
Houston — Knoxville
19h 37m
including layover
Find flight
from$294
10:55 — 12:38
+1 day
10:55 — 12:51 NK183 Spirit Airlines
Chicago — Las Vegas
9h 20m stop
22:11 — 05:56 NK954 Spirit Airlines
Las Vegas — Miami
4h 33m stop
10:29 — 12:38 G41428 Allegiant Air
Miami — Knoxville
24h 43m
including layover
Find flight
from$244
13:14 — 12:38
+1 day
13:14 — 15:10 NK188 Spirit Airlines
Chicago — Las Vegas
7h 1m stop
22:11 — 05:56 NK954 Spirit Airlines
Las Vegas — Miami
4h 33m stop
10:29 — 12:38 G41428 Allegiant Air
Miami — Knoxville
22h 24m
including layover
Find flight
from$244
17:42 — 14:16
+1 day
17:42 — 21:31 NK507 Spirit Airlines
Chicago — Orlando
7h 59m stop
05:30 — 08:31 NK1848 Spirit Airlines
Orlando — Boston
3h 4m stop
11:35 — 14:16 G43039 Allegiant Air
Boston — Knoxville
19h 34m
including layover
Find flight
from$374
20:42 — 12:38
+1 day
20:42 — 23:29 NK1150 Spirit Airlines
Chicago — Houston
6h 1m stop
05:30 — 09:06 NK221 Spirit Airlines
Houston — Miami
1h 23m stop
10:29 — 12:38 G41428 Allegiant Air
Miami — Knoxville
14h 56m
including layover
Find flight
from$248
*Departure and arrival times - local. Updated on February 5, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Chicago to Knoxville depends on and how to choose the most interesting flight option for you.

Distance between Chicago and Knoxville is 745 miles. Time difference between the cities is 1h. Airplanes depart 05:05 to 21:30 from 7 Chicago airports and arrive 05:05 to 21:30 to 1 Knoxville airport. Average flight time is 1h 44m.

  • The fastest flight 1h 40m
  • Average flight time 1h 44m
  • The earliest flight 05:05
  • The latest flight 21:30
  • Distance 463 ml

The cheapest months to travel to Knoxville are january (from 117 $), february (from 117 $), december (from 256 $).

What is the lowest airfare Chicago to Knoxville?

The cheapest plane ticket found by our users is $161. This airfare is for economy class on one-way UA1871 flight by United Airlines for February 21, 2025 which leaves O'Hare International in Chicago at 20:15 am and arrives at Knoxville Mc Ghee Tyson at 23:00.

Economy class
$161
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Business class
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First class
?
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Popular Airlines on the Route

The flight Chicago — Knoxville is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 1 departures per week at the price of from $ 264 . And the most expensive tickets are offered by United Airlines airline - from $ 630.

Direct flights

There are 3 nonstop flights on the route. The fastest direct flight is UA4505 by United Airlines takes 1h 40m and the cheapest is UA1871 by United Airlines for $161.

See more direct flights

Connecting Flights

There are 19 flights with layovers on the route. The fastest connecting flight is UA545 by United Airlines takes 4h 54m and the cheapest is UA1871 by United Airlines for $230.

See more connecting flights

Airports

You can fly from Chicago to Knoxville from 7 airports (O'Hare International, Midway, Dupage County, Chicago FSS, Merrill C Meigs (closed), Pal-Waukee, Chicago NAS).

Chicago airports

  • O'Hare International-ORD
    from $161
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  • Midway-MDW
    Find
  • Dupage County-DPA
    Find
  • Chicago FSS-CHI
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  • Merrill C Meigs (closed)-CGX
    Find
  • Pal-Waukee-PWK
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  • Chicago NAS-NOH
    Find

Knoxville airports

  • Mc Ghee Tyson-TYS
    Find

Airplanes

There are flights to Knoxville from Chicago by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Chicago

You may also consider searching for discounted plane tickets to some other popular places from Chicago within United States.

Top International Destinations from Chicago

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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