Cheap Flights from Knoxville, TN to Panama City from $156

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On Cheapflightsplus.com you will find 342 connecting flights from Knoxville to Panama City. You can compare airfare deals from 3 airlines and multiple travel sites from $156, book and save on cheap plane tickets and last minute offers. Also check out TYS-PTY flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Knoxville to Panama City Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $156 (one-way), $268 (round-trip).

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Best Flights from Knoxville to Panama City Today

Take a look at the list of non stop flights and flights with layovers from Knoxville to Panama City with the lowest price of $156. Take a look at the list of flights with layovers from Knoxville to Panama City from $156. There’re no direct flights. The fastest connecting flight – 7h 37m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $156 Find flight	09:35 Knoxville Mc Ghee Tyson	16:12 Panama City Tocumen	7h 37m layover 0h 58m - Houston	United Airlines	UA4841 UA1250
from $156 Find flight	12:00 Knoxville Mc Ghee Tyson	18:37 Panama City Tocumen	7h 37m layover 0h 58m - Houston	United Airlines	UA4302 UA1034
from $156 Find flight	07:00 Knoxville Mc Ghee Tyson	14:14 Panama City Tocumen	8h 14m layover 1h 33m - Houston	United Airlines	UA4913 UA1916
from $156 Find flight	07:00 Knoxville Mc Ghee Tyson	16:12 Panama City Tocumen	10h 12m layover 3h 33m - Houston	United Airlines	UA4913 UA1250
from $156 Find flight	07:00 Knoxville Mc Ghee Tyson	18:37 Panama City Tocumen	12h 37m layover 6h 1m - Houston	United Airlines	UA4913 UA1034
from $175 Find flight	12:00 Knoxville Mc Ghee Tyson	14:14+1 день Panama City Tocumen	27h 14m layover 20h 32m - Houston	United Airlines	UA4302 UA1916
from $175 Find flight	12:00 Knoxville Mc Ghee Tyson	16:12+1 день Panama City Tocumen	29h 12m layover 22h 30m - Houston	United Airlines	UA4302 UA1250
from $189 Find flight	17:20 Knoxville Mc Ghee Tyson	14:14+1 день Panama City Tocumen	21h 54m layover 15h 9m - Houston	United Airlines	UA4854 UA1916
from $219 Find flight	17:15 Knoxville Mc Ghee Tyson	18:37+1 день Panama City Tocumen	26h 22m layover 19h 46m - Houston	United Airlines	UA6068 UA1034
from $174 Find flight	21:37 Knoxville Mc Ghee Tyson	12:35+2 дня Panama City Tocumen	39h 58m layover 12h 13m - Orlando 21h 35m - San Jose	Allegiant Air	G41217 NK1309 AV643
from $180 Find flight	06:00 Knoxville Mc Ghee Tyson	12:35+1 день Panama City Tocumen	31h 35m layover 1h 33m - Orlando 23h 46m - San Jose	Allegiant Air	G43063 NK1309 AV643
from $182 Find flight	20:55 Knoxville Mc Ghee Tyson	21:10+1 день Panama City Tocumen	25h 15m layover 15h 39m - Tampa 2h 15m - Bogota	Allegiant Air	G4974 AV195 AV56
from $186 Find flight	06:00 Knoxville Mc Ghee Tyson	12:35+1 день Panama City Tocumen	31h 35m layover 1h 45m - Orlando 23h 39m - San Jose	Allegiant Air	G43039 NK1309 AV643
from $189 Find flight	15:34 Knoxville Mc Ghee Tyson	07:50+2 дня Panama City Tocumen	41h 16m layover 17h 2m - Miami 16h 56m - Guatemala City	Allegiant Air	G4488 NK293 CM407
from $190 Find flight	08:52 Knoxville Mc Ghee Tyson	14:40+1 день Panama City Tocumen	30h 48m layover 5h 37m - Miami 18h 35m - Medellin	Allegiant Air	G42120 AV191 AV322
from $204 Find flight	07:10 Knoxville Mc Ghee Tyson	10:10+1 день Panama City Tocumen	28h 0m layover 15h 25m - New York 2h 50m - Bogota	Allegiant Air	G43038 AV245 AV58

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on June 25, 2025

Flight Schedule Knoxville (Tennessee) to Panama City

Full flight schedule will help you in detecting at what time planes fly from Knoxville to Panama City. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
05:45 — 20:34	05:45 — 07:26 UA4311 United Airlines Knoxville — Washington D.C. 8h 59m stop 16:25 — 20:34 CM444 Compania Panamena de Aviacion Washington D.C. — Panama City	15h 49m including layover	Find flight from$771
05:45 — 13:31	05:45 — 07:26 CM1502 Compania Panamena de Aviacion Knoxville — Washington D.C. 2h 6m stop 09:32 — 13:31 CM357 Compania Panamena de Aviacion Washington D.C. — Panama City	8h 46m including layover	Find flight from$800
07:00 — 14:14	07:00 — 08:24 UA4913 United Airlines Knoxville — Houston 1h 33m stop 09:59 — 14:14 UA1916 United Airlines Houston — Panama City	8h 14m including layover	Find flight from$156
07:00 — 16:12	07:00 — 08:24 UA4913 United Airlines Knoxville — Houston 3h 33m stop 11:57 — 16:12 UA1250 United Airlines Houston — Panama City	10h 12m including layover	Find flight from$156
09:35 — 16:12	09:25 — 11:06 UA4841 United Airlines Knoxville — Houston 58m stop 11:56 — 17:07 UA1250 United Airlines Houston — Panama City	7h 37m including layover	Find flight from$156
09:35 — 18:37	09:25 — 11:06 UA4841 United Airlines Knoxville — Houston 3h 26m stop 14:27 — 19:38 UA1034 United Airlines Houston — Panama City	10h 2m including layover	Find flight from$156
10:55 — 20:35	10:55 — 11:58 UA5921 United Airlines Knoxville — Chicago 3h 9m stop 15:07 — 20:35 CM229 Compania Panamena de Aviacion Chicago — Panama City	10h 40m including layover	Find flight from$771
10:55 — 20:35	10:55 — 11:58 UA5921 United Airlines Knoxville — Chicago 3h 9m stop 15:07 — 20:35 UA7173 United Airlines Chicago — Panama City	10h 40m including layover	Find flight from$2625
12:00 — 18:37	11:50 — 13:26 UA4302 United Airlines Knoxville — Houston 58m stop 14:27 — 19:38 UA1034 United Airlines Houston — Panama City	7h 37m including layover	Find flight from$156
12:00 — 14:14 +1 day	12:00 — 13:27 UA4302 United Airlines Knoxville — Houston 20h 32m stop 09:59 — 14:14 UA1916 United Airlines Houston — Panama City	27h 14m including layover	Find flight from$175
13:31 — 13:22 +1 day	13:31 — 14:04 G43026 Allegiant Air Knoxville — Chicago 17h 50m stop 07:54 — 13:22 CM236 Compania Panamena de Aviacion Chicago — Panama City	24h 51m including layover	Find flight from$473
14:30 — 06:13 +1 day	14:30 — 16:06 UA4848 United Airlines Knoxville — Washington D.C. 10h 16m stop 02:22 — 06:13 CM403 Compania Panamena de Aviacion Washington D.C. — Panama City	16h 43m including layover	Find flight from$771
14:30 — 06:13 +1 day	14:30 — 16:06 UA4848 United Airlines Knoxville — Washington D.C. 10h 16m stop 02:22 — 06:13 UA7065 United Airlines Washington D.C. — Panama City	16h 43m including layover	Find flight from$2416
16:35 — 05:33 +1 day	16:35 — 17:50 UA1787 United Airlines Knoxville — Denver 4h 52m stop 22:42 — 05:33 CM477 Compania Panamena de Aviacion Denver — Panama City	13h 58m including layover	Find flight from$1872
17:15 — 14:14 +1 day	17:15 — 18:39 UA6068 United Airlines Knoxville — Houston 15h 20m stop 09:59 — 14:14 UA1916 United Airlines Houston — Panama City	21h 59m including layover	Find flight from$177
17:15 — 16:12 +1 day	17:15 — 18:39 UA6068 United Airlines Knoxville — Houston 17h 18m stop 11:57 — 16:12 UA1250 United Airlines Houston — Panama City	23h 57m including layover	Find flight from$177
18:10 — 17:40 +1 day	18:10 — 19:51 G43030 Allegiant Air Knoxville — Tampa 19h 23m stop 15:14 — 17:40 CM394 Compania Panamena de Aviacion Tampa — Panama City	24h 30m including layover	Find flight from$477
18:58 — 06:13 +1 day	18:58 — 20:33 CM2242 Compania Panamena de Aviacion Knoxville — Washington D.C. 5h 49m stop 02:22 — 06:13 CM403 Compania Panamena de Aviacion Washington D.C. — Panama City	12h 15m including layover	Find flight from$807
22:05 — 19:28 +1 day	22:05 — 23:38 G41258 Allegiant Air Knoxville — Orlando 17h 21m stop 16:59 — 19:28 CM459 Compania Panamena de Aviacion Orlando — Panama City	22h 23m including layover	Find flight from$384
06:00 — 12:35 +1 day	06:00 — 07:37 G43063 Allegiant Air Knoxville — Orlando 1h 33m stop 09:10 — 10:29 NK1309 Spirit Airlines Orlando — San Jose 23h 46m stop 10:15 — 12:35 AV643 Avianca San Jose — Panama City	31h 35m including layover	Find flight from$180
06:00 — 12:35 +1 day	06:00 — 07:37 G43039 Allegiant Air Knoxville — Orlando 1h 45m stop 09:10 — 10:29 NK1309 Spirit Airlines Orlando — San Jose 23h 39m stop 10:15 — 12:35 AV643 Avianca San Jose — Panama City	31h 35m including layover	Find flight from$186
08:52 — 14:40 +1 day	08:52 — 10:53 G42120 Allegiant Air Knoxville — Miami 5h 37m stop 16:30 — 18:50 AV191 Avianca Miami — Medellin 18h 35m stop 13:25 — 14:40 AV322 Avianca Medellin — Panama City	30h 48m including layover	Find flight from$190
08:52 — 19:15 +1 day	08:52 — 10:53 G42120 Allegiant Air Knoxville — Miami 5h 37m stop 16:30 — 18:50 AV191 Avianca Miami — Medellin 23h 5m stop 17:55 — 19:15 AV316 Avianca Medellin — Panama City	35h 23m including layover	Find flight from$190
11:23 — 14:40 +1 day	11:08 — 13:12 G4502 Allegiant Air Knoxville — Miami 3h 7m stop 16:30 — 18:50 AV191 Avianca Miami — Medellin 18h 35m stop 13:25 — 14:40 AV322 Avianca Medellin — Panama City	28h 17m including layover	Find flight from$192
11:23 — 21:10	11:23 — 13:23 G4502 Allegiant Air Knoxville — Miami 1h 57m stop 15:20 — 17:59 AV37 Avianca Miami — Bogota 1h 26m stop 19:25 — 21:10 AV56 Avianca Bogota — Panama City	10h 47m including layover	Find flight from$198
15:34 — 07:50 +2 days	15:34 — 17:38 G4488 Allegiant Air Knoxville — Miami 17h 2m stop 10:40 — 11:27 NK293 Spirit Airlines Miami — Guatemala City 16h 56m stop 04:23 — 07:50 CM407 Compania Panamena de Aviacion Guatemala City — Panama City	41h 16m including layover	Find flight from$189
19:44 — 12:35 +2 days	19:44 — 21:15 G43056 Allegiant Air Knoxville — Orlando 11h 55m stop 09:10 — 10:29 NK1309 Spirit Airlines Orlando — San Jose 23h 46m stop 10:15 — 12:35 AV643 Avianca San Jose — Panama City	41h 51m including layover	Find flight from$193
20:55 — 21:10 +1 day	20:55 — 22:36 G4974 Allegiant Air Knoxville — Tampa 15h 39m stop 14:15 — 17:10 AV195 Avianca Tampa — Bogota 2h 15m stop 19:25 — 21:10 AV56 Avianca Bogota — Panama City	25h 15m including layover	Find flight from$182
21:30 — 14:40 +2 days	21:30 — 23:29 G42152 Allegiant Air Knoxville — Miami 17h 1m stop 16:30 — 18:50 AV191 Avianca Miami — Medellin 18h 35m stop 13:25 — 14:40 AV322 Avianca Medellin — Panama City	42h 10m including layover	Find flight from$197
21:37 — 12:35 +2 days	21:37 — 23:12 G41217 Allegiant Air Knoxville — Orlando 12h 13m stop 11:25 — 12:40 NK1309 Spirit Airlines Orlando — San Jose 21h 35m stop 10:15 — 12:35 AV643 Avianca San Jose — Panama City	39h 58m including layover	Find flight from$174
22:05 — 12:35 +2 days	22:05 — 23:38 G41258 Allegiant Air Knoxville — Orlando 9h 32m stop 09:10 — 10:29 NK1309 Spirit Airlines Orlando — San Jose 23h 46m stop 10:15 — 12:35 AV643 Avianca San Jose — Panama City	39h 30m including layover	Find flight from$192

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on June 25, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Knoxville to Panama City depends on and how to choose the most interesting flight option for you.

Distance between Knoxville and Panama City is 3010 miles. Time difference between the cities is 0h. Airplanes depart 05:45 to 22:05 from 1 Knoxville airport and arrive 05:45 to 22:05 to 2 Panama City airports. Average flight time is 25h 4m.

The fastest flight 7h 37m
Average flight time 25h 4m
The earliest flight 05:45
The latest flight 22:05
Distance 1871 ml

The cheapest months to travel to Panama City are july (from 209 $), august (from 214 $), september (from 243 $).

The most expensive months are december (from 839 $), november (from 492 $), october (from 256 $).

What is the lowest airfare Knoxville to Panama City?

The cheapest plane ticket found by our users is $156. This airfare is for economy class on one-way UA4913 flight by United Airlines for July 24, 2025 which leaves Mc Ghee Tyson in Knoxville at 07:00 am and arrives at Panama City Tocumen at 14:14.

Economy class

$156

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Business class

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First class

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Popular Airlines on the Route

The flight Knoxville — Panama City is served by 3 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by Compania Panamena de Aviacion - 4 departures per week at the price of from $ 800 . And the most expensive tickets are offered by United Airlines airline - from $ 2850.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 342 flights with layovers on the route. The fastest connecting flight is UA4841 by United Airlines takes 7h 37m and the cheapest is UA4913 by United Airlines for $156.

CM - Compania Panamena de Aviacion

from $800

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UA - United Airlines

from $156

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G4 - Allegiant Air

from $174

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Airports

You can fly from Knoxville to Panama City from 1 airports (Mc Ghee Tyson).

Knoxville airports

Mc Ghee Tyson-TYS

from $156
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Panama City airports

Tocumen-PTY

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Paitilla-PAC

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Airplanes

There are flights to Panama City from Knoxville by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Knoxville

You may also consider searching for discounted plane tickets to some other popular places from Knoxville within United States.

Knoxville — Orlando

from $73

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Knoxville — Las Vegas

from $74

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Knoxville — Chicago

from $76

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Knoxville — Denver

from $74

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Knoxville — Miami

from $66

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Knoxville — Boston

from $69

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Knoxville — Houston

from $54

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Knoxville — New Orleans

from $56

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Knoxville — Tampa

from $80

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Knoxville — Austin

from $54

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Top International Destinations from Knoxville

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Knoxville — Cancun

from $69

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Knoxville — Panama City

from $61

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How to book a plane ticket yourself?

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