Cheap Flights from Knoxville, TN to Panama City from $199
On Cheapflightsplus.com you will find 342 connecting flights from Knoxville to Panama City. You can compare airfare deals from 3 airlines and multiple travel sites from $199, book and save on cheap plane tickets and last minute offers. Also check out TYS-PTY flight schedule to find best flight time, convenient departure and arrival airports.
Flight Information
Below we will explain in detail what the flights cost on the destination from Knoxville to Panama City depends on and how to choose the most interesting flight option for you.
Distance between Knoxville and Panama City is 3010 miles. Time difference between the cities is 0h. Airplanes depart 05:45 to 22:05 from 1 Knoxville airport and arrive 05:45 to 22:05 to 2 Panama City airports. Average flight time is 25h 4m.
- The fastest flight 7h 37m
- Average flight time 25h 4m
- The earliest flight 05:45
- The latest flight 22:05
- Distance 1871 ml
Best Flights from Knoxville to Panama City Today
| Price | Departure | Arrival | Flight Duration | Airline | Flight |
|---|---|---|---|---|---|
| from $199 | 09:35 Knoxville Mc Ghee Tyson | 16:12 Panama City Tocumen | 7h 37m layover 0h 58m - Houston | United Airlines | UA4841 UA1250 |
| from $240 | 17:20 Knoxville Mc Ghee Tyson | 14:14+1 день Panama City Tocumen | 21h 54m layover 15h 9m - Houston | United Airlines | UA4854 UA1916 |
| from $220 | 21:37 Knoxville Mc Ghee Tyson | 12:35+2 дня Panama City Tocumen | 39h 58m layover 12h 13m - Orlando 21h 35m - San Jose | Allegiant Air | G41217 NK1309 AV643 |
| from $253 | 06:00 Knoxville Mc Ghee Tyson | 12:35+1 день Panama City Tocumen | 31h 35m layover 3h 45m - Orlando 21h 35m - San Jose | Allegiant Air | G43030 NK1309 AV643 |
The cheapest months to travel to Panama City are july (from 199 $), august (from 203 $), september (from 231 $).
The most expensive months are december (from 798 $), november (from 467 $), october (from 243 $).
What is the lowest airfare Knoxville to Panama City?
The cheapest plane ticket found by our users is $199. This airfare is for economy class on one-way UA4913 flight by United Airlines for September 27, 2025 which leaves Mc Ghee Tyson in Knoxville at 07:00 am and arrives at Panama City Tocumen at 14:14.
Flight Schedule Knoxville (Tennessee) to Panama City
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Popular Airlines on the Route
The flight Knoxville — Panama City is served by 3 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by Compania Panamena de Aviacion - 4 departures per week at the price of from $ 1014 . And the most expensive tickets are offered by United Airlines airline - from $ 3613.
Direct flights
There’re no direct flights on this route. Try flights with stops.
Connecting Flights
There are 342 flights with layovers on the route. The fastest connecting flight is UA4841 by United Airlines takes 7h 37m and the cheapest is UA4913 by United Airlines for $199.
- CM - Compania Panamena de Aviacionfrom $1014Find
- UA - United Airlinesfrom $199Find
- G4 - Allegiant Airfrom $220Find
Airports
You can fly from Knoxville to Panama City from 1 airports (Mc Ghee Tyson).
Knoxville airports
- Mc Ghee Tyson-TYSfrom $199Find
Panama City airports
- Tocumen-PTYFind
- Paitilla-PACFind
Airplanes
There are flights to Panama City from Knoxville by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.
Top Domestic Destinations from Knoxville
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Top International Destinations from Knoxville
Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.
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How to book a plane ticket yourself?
- Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
- Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
- Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
- Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
- That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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