Cheap Flights from Knoxville, TN to Panama City from $194

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On Cheapflightsplus.com you will find 342 connecting flights from Knoxville to Panama City. You can compare airfare deals from 3 airlines and multiple travel sites from $194, book and save on cheap plane tickets and last minute offers. Also check out TYS-PTY flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Knoxville to Panama City Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $194 (one-way), $333 (round-trip).
Direct flights
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Best Flights from Knoxville to Panama City Today

Take a look at the list of non stop flights and flights with layovers from Knoxville to Panama City with the lowest price of $194. Take a look at the list of flights with layovers from Knoxville to Panama City from $194. There’re no direct flights. The fastest connecting flight – 7h 37m.
Price Departure Arrival Flight Duration Airline Flight
from $194
Find flight
09:35
Knoxville
Mc Ghee Tyson
 16:12
Panama City
Tocumen
 7h 37m
layover
0h 58m - Houston
 United Airlines
UA4841
UA1250
from $235
Find flight
17:00
Knoxville
Mc Ghee Tyson
 16:12+1 день
Panama City
Tocumen
 24h 12m
layover
17h 30m - Houston
 United Airlines
UA4854
UA1250
from $215
Find flight
21:37
Knoxville
Mc Ghee Tyson
 12:35+2 дня
Panama City
Tocumen
 39h 58m
layover
12h 13m - Orlando
21h 35m - San Jose
 Allegiant Air
G41217
NK1309
AV643
from $248
Find flight
12:45
Knoxville
Mc Ghee Tyson
 10:25+1 день
Panama City
Tocumen
 22h 40m
layover
11h 59m - Washington D.C.
2h 48m - San Salvador
 Allegiant Air
G41397
N34313
AV323
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 15, 2025
Full flight schedule will help you in detecting at what time planes fly from Knoxville to Panama City. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
06:00 — 12:35
+1 day
06:00 — 07:37 G43063 Allegiant Air
Knoxville — Orlando
1h 33m stop
09:10 — 10:29 NK1309 Spirit Airlines
Orlando — San Jose
23h 46m stop
10:15 — 12:35 AV643 Avianca
San Jose — Panama City
31h 35m
including layover
Find flight
from$223
06:00 — 12:35
+1 day
06:00 — 07:37 G43039 Allegiant Air
Knoxville — Orlando
1h 45m stop
09:10 — 10:29 NK1309 Spirit Airlines
Orlando — San Jose
23h 39m stop
10:15 — 12:35 AV643 Avianca
San Jose — Panama City
31h 35m
including layover
Find flight
from$232
07:00 — 16:12
07:00 — 08:24 UA4913 United Airlines
Knoxville — Houston
3h 33m stop
11:57 — 16:12 UA1250 United Airlines
Houston — Panama City
10h 12m
including layover
Find flight
from$194
07:00 — 18:37
07:00 — 08:24 UA4913 United Airlines
Knoxville — Houston
6h 1m stop
14:25 — 18:37 UA1034 United Airlines
Houston — Panama City
12h 37m
including layover
Find flight
from$194
09:35 — 16:12
09:25 — 11:06 UA4841 United Airlines
Knoxville — Houston
58m stop
11:56 — 17:07 UA1250 United Airlines
Houston — Panama City
7h 37m
including layover
Find flight
from$194
09:35 — 18:37
09:25 — 11:06 UA4841 United Airlines
Knoxville — Houston
3h 26m stop
14:27 — 19:38 UA1034 United Airlines
Houston — Panama City
10h 2m
including layover
Find flight
from$194
09:35 — 14:14
+1 day
09:35 — 10:59 UA4841 United Airlines
Knoxville — Houston
23h stop
09:59 — 14:14 UA1916 United Airlines
Houston — Panama City
29h 39m
including layover
Find flight
from$212
12:00 — 18:37
11:50 — 13:26 UA4302 United Airlines
Knoxville — Houston
58m stop
14:27 — 19:38 UA1034 United Airlines
Houston — Panama City
7h 37m
including layover
Find flight
from$194
12:00 — 14:14
+1 day
12:00 — 13:27 UA4302 United Airlines
Knoxville — Houston
20h 32m stop
09:59 — 14:14 UA1916 United Airlines
Houston — Panama City
27h 14m
including layover
Find flight
from$218
12:00 — 16:12
+1 day
12:00 — 13:27 UA4302 United Airlines
Knoxville — Houston
22h 30m stop
11:57 — 16:12 UA1250 United Airlines
Houston — Panama City
29h 12m
including layover
Find flight
from$218
15:34 — 07:50
+2 days
15:34 — 17:38 G4488 Allegiant Air
Knoxville — Miami
17h 2m stop
10:40 — 11:27 NK293 Spirit Airlines
Miami — Guatemala City
16h 56m stop
04:23 — 07:50 CM407 Compania Panamena de Aviacion
Guatemala City — Panama City
41h 16m
including layover
Find flight
from$235
17:15 — 14:14
+1 day
17:15 — 18:39 UA6068 United Airlines
Knoxville — Houston
15h 20m stop
09:59 — 14:14 UA1916 United Airlines
Houston — Panama City
21h 59m
including layover
Find flight
from$221
17:15 — 16:12
+1 day
17:15 — 18:39 UA6068 United Airlines
Knoxville — Houston
17h 18m stop
11:57 — 16:12 UA1250 United Airlines
Houston — Panama City
23h 57m
including layover
Find flight
from$221
20:55 — 21:10
+1 day
20:55 — 22:36 G4974 Allegiant Air
Knoxville — Tampa
15h 39m stop
14:15 — 17:10 AV195 Avianca
Tampa — Bogota
2h 15m stop
19:25 — 21:10 AV56 Avianca
Bogota — Panama City
25h 15m
including layover
Find flight
from$226
21:37 — 12:35
+2 days
21:37 — 23:12 G41217 Allegiant Air
Knoxville — Orlando
12h 13m stop
11:25 — 12:40 NK1309 Spirit Airlines
Orlando — San Jose
21h 35m stop
10:15 — 12:35 AV643 Avianca
San Jose — Panama City
39h 58m
including layover
Find flight
from$215
*Departure and arrival times - local. Updated on September 15, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Knoxville to Panama City depends on and how to choose the most interesting flight option for you.

Distance between Knoxville and Panama City is 3010 miles. Time difference between the cities is 0h. Airplanes depart 05:45 to 22:05 from 1 Knoxville airport and arrive 05:45 to 22:05 to 2 Panama City airports. Average flight time is 25h 4m.

  • The fastest flight 7h 37m
  • Average flight time 25h 4m
  • The earliest flight 05:45
  • The latest flight 22:05
  • Distance 1871 ml

The cheapest months to travel to Panama City are july (from 194 $), august (from 199 $), september (from 226 $).

The most expensive months are december (from 781 $), november (from 457 $), october (from 238 $).

What is the lowest airfare Knoxville to Panama City?

The cheapest plane ticket found by our users is $194. This airfare is for economy class on one-way UA4913 flight by United Airlines for July 4, 2025 which leaves Mc Ghee Tyson in Knoxville at 07:00 am and arrives at Panama City Tocumen at 16:12.

Economy class
$194
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Business class
?
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First class
?
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Popular Airlines on the Route

The flight Knoxville — Panama City is served by 3 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by Compania Panamena de Aviacion - 4 departures per week at the price of from $ 993 . And the most expensive tickets are offered by United Airlines airline - from $ 3537.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 342 flights with layovers on the route. The fastest connecting flight is UA4841 by United Airlines takes 7h 37m and the cheapest is UA4913 by United Airlines for $194.

  • CM - Compania Panamena de Aviacion
    from $993
    Find
  • UA - United Airlines
    from $194
    Find
  • G4 - Allegiant Air
    from $215
    Find
See more connecting flights

Airports

You can fly from Knoxville to Panama City from 1 airports (Mc Ghee Tyson).

Knoxville airports

  • Mc Ghee Tyson-TYS
    from $194
    Find

Panama City airports

  • Tocumen-PTY
    Find
  • Paitilla-PAC
    Find

Airplanes

There are flights to Panama City from Knoxville by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Knoxville

You may also consider searching for discounted plane tickets to some other popular places from Knoxville within United States.

Top International Destinations from Knoxville

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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