Cheap Flights from Des Moines, IA to San Francisco, CA from $73

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On Cheapflightsplus.com you will find 39 connecting flights from Des Moines to San Francisco. You can compare airfare deals from 3 airlines and multiple travel sites from $73, book and save on cheap plane tickets and last minute offers. Also check out DSM-SFO flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to San Francisco Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $73 (one-way), $125 (round-trip).

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Best Flights from Des Moines to San Francisco Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to San Francisco with the lowest price of $73. Take a look at the list of flights with layovers from Des Moines to San Francisco from $73. There’re no direct flights. The fastest connecting flight – 5h 51m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $73 Find flight	21:21 Des Moines Des Moines International Airport	08:13+1 день San Francisco San Francisco	12h 52m layover 8h 11m - Denver	Frontier Airlines	F91677 F91093
from $263 Find flight	05:45 Des Moines Des Moines International Airport	09:36 San Francisco San Francisco	5h 51m layover 0h 43m - Denver	United Airlines	UA4700 UA2391
from $263 Find flight	17:15 Des Moines Des Moines International Airport	21:09 San Francisco San Francisco	5h 54m layover 1h 0m - Denver	United Airlines	UA1781 UA281
from $263 Find flight	13:49 Des Moines Des Moines International Airport	19:11 San Francisco San Francisco	7h 22m layover 2h 21m - Denver	United Airlines	UA5835 UA1076
from $263 Find flight	17:15 Des Moines Des Moines International Airport	22:56 San Francisco San Francisco	7h 41m layover 2h 45m - Denver	United Airlines	UA1781 UA2190
from $263 Find flight	15:27 Des Moines Des Moines International Airport	21:21 San Francisco San Francisco	7h 54m layover 1h 17m - Chicago	United Airlines	UA3457 UA1761
from $263 Find flight	11:35 Des Moines Des Moines International Airport	17:30 San Francisco San Francisco	7h 55m layover 1h 25m - Chicago	United Airlines	UA2306 UA1577
from $263 Find flight	15:05 Des Moines Des Moines International Airport	21:05 San Francisco San Francisco	8h 0m layover 0h 47m - Houston	United Airlines	UA6033 UA2636
from $263 Find flight	09:00 Des Moines Des Moines International Airport	15:25 San Francisco San Francisco	8h 25m layover 3h 24m - Denver	United Airlines	UA581 UA304
from $263 Find flight	08:00 Des Moines Des Moines International Airport	14:50 San Francisco San Francisco	8h 50m layover 1h 40m - Houston	United Airlines	UA735 UA1057
from $263 Find flight	11:35 Des Moines Des Moines International Airport	18:57 San Francisco San Francisco	9h 22m layover 2h 52m - Chicago	United Airlines	UA2306 UA2409
from $263 Find flight	15:27 Des Moines Des Moines International Airport	23:13 San Francisco San Francisco	9h 46m layover 3h 20m - Chicago	United Airlines	UA3457 UA210
from $263 Find flight	15:05 Des Moines Des Moines International Airport	23:00 San Francisco San Francisco	9h 55m layover 2h 47m - Houston	United Airlines	UA6033 UA2313
from $267 Find flight	16:00 Des Moines Des Moines International Airport	22:10 San Francisco San Francisco	8h 10m layover 1h 27m - Chicago	Alaska Airlines	AS4136 AS597
from $273 Find flight	13:49 Des Moines Des Moines International Airport	22:56 San Francisco San Francisco	11h 7m layover 6h 6m - Denver	United Airlines	UA5835 UA2190
from $255 Find flight	18:50 Des Moines Des Moines International Airport	07:53+1 день San Francisco San Francisco	15h 3m layover 1h 16m - Chicago 6h 30m - Denver	United Airlines	UA3433 UA1748 UA573

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on January 15, 2025

Flight Schedule Des Moines (Iowa) to San Francisco (California)

Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Francisco. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
05:45 — 09:36	05:45 — 07:02 UA4700 United Airlines Des Moines — Denver 43m stop 07:45 — 09:36 UA2391 United Airlines Denver — San Francisco	5h 51m including layover	Find flight from$263
05:45 — 10:56	05:45 — 07:02 UA4700 United Airlines Des Moines — Denver 2h 3m stop 09:05 — 10:56 UA538 United Airlines Denver — San Francisco	7h 11m including layover	Find flight from$263
08:00 — 14:50	08:00 — 10:37 UA735 United Airlines Des Moines — Houston 1h 40m stop 12:17 — 14:50 UA1057 United Airlines Houston — San Francisco	8h 50m including layover	Find flight from$263
08:00 — 17:27	08:00 — 09:35 UA1363 United Airlines Des Moines — Chicago 4h 57m stop 14:35 — 17:30 UA1577 United Airlines Chicago — San Francisco	11h 27m including layover	Find flight from$309
09:00 — 15:25	09:00 — 10:10 UA581 United Airlines Des Moines — Denver 3h 24m stop 13:34 — 15:25 UA304 United Airlines Denver — San Francisco	8h 25m including layover	Find flight from$263
09:00 — 19:11	09:00 — 10:10 UA581 United Airlines Des Moines — Denver 7h 10m stop 17:20 — 19:11 UA1076 United Airlines Denver — San Francisco	12h 11m including layover	Find flight from$294
11:35 — 17:30	11:35 — 13:10 UA2306 United Airlines Des Moines — Chicago 1h 25m stop 14:35 — 17:30 UA1577 United Airlines Chicago — San Francisco	7h 55m including layover	Find flight from$263
11:35 — 18:57	11:35 — 13:10 UA2306 United Airlines Des Moines — Chicago 2h 52m stop 16:02 — 18:57 UA2409 United Airlines Chicago — San Francisco	9h 22m including layover	Find flight from$263
13:49 — 19:11	13:49 — 14:59 UA5835 United Airlines Des Moines — Denver 2h 21m stop 17:20 — 19:11 UA1076 United Airlines Denver — San Francisco	7h 22m including layover	Find flight from$263
13:49 — 22:56	13:45 — 14:51 UA5835 United Airlines Des Moines — Denver 6h 6m stop 21:06 — 22:55 UA2190 United Airlines Denver — San Francisco	11h 7m including layover	Find flight from$273
15:05 — 21:05	15:05 — 17:48 UA6033 United Airlines Des Moines — Houston 47m stop 18:35 — 21:05 UA2636 United Airlines Houston — San Francisco	8h including layover	Find flight from$263
15:05 — 23:00	15:00 — 17:35 UA6033 United Airlines Des Moines — Houston 2h 47m stop 20:35 — 22:57 UA2313 United Airlines Houston — San Francisco	9h 55m including layover	Find flight from$263
16:00 — 22:10	16:00 — 17:33 AS4136 Alaska Airlines Des Moines — Chicago 1h 27m stop 19:00 — 22:10 AS597 Alaska Airlines Chicago — San Francisco	8h 10m including layover	Find flight from$267
17:15 — 21:09	17:10 — 18:19 UA1781 United Airlines Des Moines — Denver 1h stop 06:01 — 07:50 UA281 United Airlines Denver — San Francisco	5h 54m including layover	Find flight from$263
17:15 — 22:56	17:10 — 18:19 UA1781 United Airlines Des Moines — Denver 2h 45m stop 21:05 — 22:55 UA2190 United Airlines Denver — San Francisco	7h 41m including layover	Find flight from$263
21:21 — 08:13 +1 day	18:51 — 19:57 F91677 Frontier Airlines Des Moines — Denver 8h 11m stop 13:35 — 15:23 F91093 Frontier Airlines Denver — San Francisco	12h 52m including layover	Find flight from$73
18:50 — 07:53 +1 day	18:50 — 20:22 UA3433 United Airlines Des Moines — Chicago 1h 16m stop 21:38 — 23:30 UA1748 United Airlines Chicago — Denver 6h 30m stop 06:00 — 07:53 UA573 United Airlines Denver — San Francisco	15h 3m including layover	Find flight from$255
18:50 — 07:45 +1 day	18:50 — 20:22 UA3433 United Airlines Des Moines — Chicago 49m stop 21:11 — 00:15 UA2000 United Airlines Chicago — Phoenix 6h 15m stop 06:30 — 07:45 UA1954 United Airlines Phoenix — San Francisco	14h 55m including layover	Find flight from$375

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on January 15, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to San Francisco depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and San Francisco is 2488 miles. Time difference between the cities is 2h. Airplanes depart 05:45 to 21:21 from 1 Des Moines airport and arrive 05:45 to 21:21 to 3 San Francisco airports. Average flight time is 11h 7m.

The fastest flight 5h 51m
Average flight time 11h 7m
The earliest flight 05:45
The latest flight 21:21
Distance 1546 ml

The cheapest months to travel to San Francisco are november (from 53 $), february (from 73 $), december (from 192 $).

The most expensive months are january (from 263 $), december (from 192 $), february (from 73 $).

What is the lowest airfare Des Moines to San Francisco?

The cheapest plane ticket found by our users is $73. This airfare is for economy class on one-way F91677 flight by Frontier Airlines for February 21, 2025 which leaves Des Moines International Airport in Des Moines at 21:21 am and arrives at San Francisco San Francisco at 08:13.

Economy class

$73

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Business class

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First class

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Popular Airlines on the Route

The flight Des Moines — San Francisco is served by 3 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by Frontier Airlines - 1 departures per week at the price of from $ 73 . And the most expensive tickets are offered by United Airlines airline - from $ 535.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 39 flights with layovers on the route. The fastest connecting flight is UA4700 by United Airlines takes 5h 51m and the cheapest is F91677 by Frontier Airlines for $73.

F9 - Frontier Airlines

from $73

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UA - United Airlines

from $255

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AS - Alaska Airlines

from $267

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Airports

You can fly from Des Moines to San Francisco from 1 airports (Des Moines International Airport).

Des Moines airports

Des Moines International Airport-DSM

from $73
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San Francisco airports

San Francisco-SFO

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Embarkadero-EMB

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China Basin Heliport-JCC

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Airplanes

There are flights to San Francisco from Des Moines by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Des Moines — Denver

from $54

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Des Moines — Philadelphia

from $71

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Des Moines — Colorado Springs

from $73

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Des Moines — San Antonio

from $61

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Des Moines — Orlando

from $74

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Des Moines — Chicago

from $72

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Des Moines — Indianapolis

from $62

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Des Moines — Boston

from $65

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Des Moines — San Diego

from $58

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Des Moines — El Paso

from $73

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Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Des Moines — Guadalajara

from $71

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Des Moines — Cancun

from $77

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Des Moines — London

from $70

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How to book a plane ticket yourself?

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That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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