Cheap Flights from Des Moines, IA to San Diego, CA from $48
On Cheapflightsplus.com you will find 2 direct and 192 connecting flights from Des Moines to San Diego. You can compare airfare deals from 4 airlines and multiple travel sites from $48, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAN flight schedule to find best flight time, convenient departure and arrival airports.
Find One-Way and Round-Trip Des Moines to San Diego Flight Deals
To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights».
To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight.
Cheapest flights in November: $48 (one-way), $82 (round-trip).
Direct flights
Check prices for return flight
Best Flights from Des Moines to San Diego Today
Take a look at the list of non stop flights and flights with layovers from Des Moines to San Diego with the lowest price of $48. The fastest direct flight takes 3h 31m and the fastest connecting – 5h 9m.
| Price | Departure | Arrival | Flight Duration | Airline | Flight |
|---|---|---|---|---|---|
| from $48 | 14:39 Des Moines Des Moines International Airport | 16:10 San Diego San Diego | 3h 31m | Allegiant Air | G42074 |
| from $56 | 14:54 Des Moines Des Moines International Airport | 16:30 San Diego San Diego | 3h 36m | Allegiant Air | G4474 |
| from $77 | 22:31 Des Moines Des Moines International Airport | 07:13+1 день San Diego San Diego | 10h 42m layover 6h 23m - Las Vegas | Allegiant Air | G415 NK2502 |
| from $80 | 15:44 Des Moines Des Moines International Airport | 20:30 San Diego San Diego | 6h 46m layover 2h 24m - Las Vegas | Allegiant Air | G42100 NK1150 |
| from $80 | 15:44 Des Moines Des Moines International Airport | 23:00 San Diego San Diego | 9h 16m layover 4h 56m - Las Vegas | Allegiant Air | G42100 NK1152 |
| from $81 | 13:15 Des Moines Des Moines International Airport | 23:29 San Diego San Diego | 12h 14m layover 7h 54m - Las Vegas | Allegiant Air | G448 NK2390 |
| from $81 | 15:44 Des Moines Des Moines International Airport | 09:55+1 день San Diego San Diego | 20h 11m layover 15h 50m - Las Vegas | Allegiant Air | G42100 NK1154 |
| from $81 | 13:15 Des Moines Des Moines International Airport | 13:17+1 день San Diego San Diego | 26h 2m layover 21h 39m - Las Vegas | Allegiant Air | G448 NK2295 |
| from $87 | 13:25 Des Moines Des Moines International Airport | 09:55+1 день San Diego San Diego | 22h 30m layover 18h 9m - Las Vegas | Allegiant Air | G448 NK1154 |
| from $90 | 13:15 Des Moines Des Moines International Airport | 17:55 San Diego San Diego | 6h 40m layover 2h 17m - Las Vegas | Allegiant Air | G449 NK1150 |
| from $92 | 20:38 Des Moines Des Moines International Airport | 23:55 San Diego San Diego | 5h 17m layover 0h 41m - Denver | Frontier Airlines | F91677 F92711 |
| from $97 | 13:25 Des Moines Des Moines International Airport | 17:55 San Diego San Diego | 6h 30m layover 2h 7m - Las Vegas | Allegiant Air | G448 NK1150 |
| from $97 | 13:25 Des Moines Des Moines International Airport | 23:00 San Diego San Diego | 11h 35m layover 7h 15m - Las Vegas | Allegiant Air | G448 NK1152 |
| from $119 | 15:44 Des Moines Des Moines International Airport | 13:07+1 день San Diego San Diego | 23h 23m layover 16h 19m - Las Vegas 0h 55m - San Jose | Allegiant Air | G42100 NK1140 NK1826 |
| from $119 | 15:44 Des Moines Des Moines International Airport | 16:02+1 день San Diego San Diego | 26h 18m layover 14h 10m - Las Vegas 5h 54m - Oakland | Allegiant Air | G42100 NK1405 NK1156 |
| from $126 | 14:00 Des Moines Des Moines International Airport | 17:55+1 день San Diego San Diego | 29h 55m layover 6h 8m - Nashville 16h 44m - Las Vegas | Allegiant Air | G4451 NK1772 NK1150 |
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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on June 25, 2025
Flight Schedule Des Moines (Iowa) to San Diego (California)
Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Diego. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
| Departure | Arrival | Flight Details | Flight Duration | Price |
|---|---|---|---|---|
|
14:39 — 16:10
|
14:39 — 16:10
G42074
Allegiant Air
Des Moines — San Diego
|
3h 31m |
Find flight
from$48 |
|
|
14:54 — 16:30
|
14:54 — 16:30
G4474
Allegiant Air
Des Moines — San Diego
|
3h 36m |
Find flight
from$56 |
|
|
06:24 — 11:33
|
06:24 — 08:05
UA4677
United Airlines
Des Moines — Chicago
1h stop
09:05 — 11:33
UA660
United Airlines
Chicago — San Diego
|
7h 9m including layover |
Find flight
from$149 |
|
|
09:15 — 12:52
|
09:15 — 10:17
UA581
United Airlines
Des Moines — Denver
1h 11m stop
11:28 — 12:52
UA2412
United Airlines
Denver — San Diego
|
5h 37m including layover |
Find flight
from$149 |
|
|
09:15 — 15:08
|
09:15 — 10:17
UA581
United Airlines
Des Moines — Denver
3h 27m stop
13:44 — 15:08
UA1302
United Airlines
Denver — San Diego
|
7h 53m including layover |
Find flight
from$149 |
|
|
13:15 — 23:29
|
13:15 — 14:21
G448
Allegiant Air
Des Moines — Las Vegas
7h 54m stop
22:15 — 23:29
NK2390
Spirit Airlines
Las Vegas — San Diego
|
12h 14m including layover |
Find flight
from$81 |
|
|
13:15 — 09:55
+1 day
|
13:15 — 14:21
G449
Allegiant Air
Des Moines — Las Vegas
18h 19m stop
08:40 — 09:55
NK1154
Spirit Airlines
Las Vegas — San Diego
|
22h 40m including layover |
Find flight
from$81 |
|
|
15:44 — 20:30
|
15:44 — 16:50
G42100
Allegiant Air
Des Moines — Las Vegas
2h 24m stop
19:14 — 20:30
NK1150
Spirit Airlines
Las Vegas — San Diego
|
6h 46m including layover |
Find flight
from$80 |
|
|
15:44 — 23:00
|
15:44 — 16:50
G42100
Allegiant Air
Des Moines — Las Vegas
4h 56m stop
21:46 — 23:00
NK1152
Spirit Airlines
Las Vegas — San Diego
|
9h 16m including layover |
Find flight
from$80 |
|
|
20:38 — 23:55
|
19:33 — 20:33
F91677
Frontier Airlines
Des Moines — Denver
41m stop
22:29 — 23:52
F92711
Frontier Airlines
Denver — San Diego
|
5h 17m including layover |
Find flight
from$92 |
|
|
20:38 — 11:10
+1 day
|
19:33 — 20:33
F91677
Frontier Airlines
Des Moines — Denver
11h 56m stop
09:44 — 11:10
F92817
Frontier Airlines
Denver — San Diego
|
16h 32m including layover |
Find flight
from$96 |
|
|
21:10 — 09:14
+1 day
|
21:10 — 22:26
G415
Allegiant Air
Des Moines — Las Vegas
9h 34m stop
08:00 — 09:14
NK1496
Spirit Airlines
Las Vegas — San Diego
|
14h 4m including layover |
Find flight
from$87 |
|
|
21:10 — 10:45
+1 day
|
21:10 — 22:26
G415
Allegiant Air
Des Moines — Las Vegas
11h 4m stop
09:30 — 10:45
NK1475
Spirit Airlines
Las Vegas — San Diego
|
15h 35m including layover |
Find flight
from$87 |
|
|
22:31 — 07:13
+1 day
|
22:31 — 23:37
G415
Allegiant Air
Des Moines — Las Vegas
6h 23m stop
06:00 — 07:13
NK2502
Spirit Airlines
Las Vegas — San Diego
|
10h 42m including layover |
Find flight
from$77 |
|
|
22:31 — 18:26
+1 day
|
22:31 — 23:37
G415
Allegiant Air
Des Moines — Las Vegas
17h 32m stop
17:09 — 18:26
NK2295
Spirit Airlines
Las Vegas — San Diego
|
21h 55m including layover |
Find flight
from$77 |
|
|
06:00 — 13:57
|
06:00 — 07:03
UA4790
United Airlines
Des Moines — Denver
58m stop
08:01 — 09:34
UA1638
United Airlines
Denver — Los Angeles
3h 18m stop
12:52 — 13:57
UA4712
United Airlines
Los Angeles — San Diego
|
9h 57m including layover |
Find flight
from$153 |
|
|
07:00 — 07:13
+1 day
|
07:00 — 08:31
G4464
Allegiant Air
Des Moines — Santa Ana
8h 51m stop
17:22 — 18:44
NK3171
Spirit Airlines
Santa Ana — Las Vegas
11h 16m stop
06:00 — 07:13
NK2502
Spirit Airlines
Las Vegas — San Diego
|
26h 13m including layover |
Find flight
from$132 |
|
|
07:00 — 07:13
+1 day
|
07:00 — 08:31
G4464
Allegiant Air
Des Moines — Santa Ana
11h 9m stop
19:40 — 20:56
NK2337
Spirit Airlines
Santa Ana — Las Vegas
9h 4m stop
06:00 — 07:13
NK2502
Spirit Airlines
Las Vegas — San Diego
|
26h 13m including layover |
Find flight
from$132 |
|
|
08:35 — 09:55
+1 day
|
08:35 — 12:05
G4431
Allegiant Air
Des Moines — Newark
9h 55m stop
22:00 — 00:37
NK1386
Spirit Airlines
Newark — Las Vegas
8h 3m stop
08:40 — 09:55
NK1154
Spirit Airlines
Las Vegas — San Diego
|
27h 20m including layover |
Find flight
from$144 |
|
|
08:35 — 17:55
+1 day
|
08:35 — 12:05
G4431
Allegiant Air
Des Moines — Newark
19h 15m stop
07:20 — 09:50
NK1585
Spirit Airlines
Newark — Las Vegas
6h 48m stop
16:38 — 17:55
NK1150
Spirit Airlines
Las Vegas — San Diego
|
35h 20m including layover |
Find flight
from$144 |
|
|
11:25 — 20:38
|
11:25 — 12:57
UA2306
United Airlines
Des Moines — Chicago
1h 38m stop
14:35 — 16:27
UA503
United Airlines
Chicago — Denver
2h 47m stop
19:14 — 20:38
UA540
United Airlines
Denver — San Diego
|
11h 13m including layover |
Find flight
from$153 |
|
|
17:12 — 23:44
|
17:12 — 18:15
UA2681
United Airlines
Des Moines — Denver
1h 10m stop
19:25 — 20:58
UA1368
United Airlines
Denver — Los Angeles
1h 45m stop
22:43 — 23:44
UA5612
United Airlines
Los Angeles — San Diego
|
8h 32m including layover |
Find flight
from$153 |
|
*Departure and arrival times - local. Updated on June 25, 2025
Flight Information
Below we will explain in detail what the flights cost on the destination from Des Moines to San Diego depends on and how to choose the most interesting flight option for you.
Distance between Des Moines and San Diego is 2295 miles. Time difference between the cities is 2h. Airplanes depart 05:00 to 22:31 from 1 Des Moines airport and arrive 05:00 to 22:31 to 11 San Diego airports. Average flight time is 3h 34m.
- The fastest flight 3h 31m
- Average flight time 3h 34m
- The earliest flight 05:00
- The latest flight 22:31
- Distance 1427 ml
The cheapest months to travel to San Diego are july (from 65 $), august (from 65 $), september (from 221 $).
The most expensive months are february (from 394 $), november (from 386 $), september (from 221 $).
What is the lowest airfare Des Moines to San Diego?
The cheapest plane ticket found by our users is $48. This airfare is for economy class on one-way G42074 flight by Allegiant Air for July 4, 2025 which leaves Des Moines International Airport in Des Moines at 14:39 am and arrives at San Diego San Diego at 16:10.
Economy class
$48
Business class
?
First class
?
Popular Airlines on the Route
The flight Des Moines — San Diego is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Alaska Airlines - 11 departures per week at the price of from $ 150 . And the most expensive tickets are offered by United Airlines airline - from $ 720.
Direct flights
There are 2 nonstop flights on the route. The fastest direct flight is G42074 by Allegiant Air takes 3h 31m and the cheapest is G42074 by Allegiant Air for $48.
- G4 - Allegiant Airfrom $48Find
See more direct flights
Connecting Flights
There are 192 flights with layovers on the route. The fastest connecting flight is UA4790 by United Airlines takes 5h 9m and the cheapest is G42074 by Allegiant Air for $77.
- AS - Alaska Airlinesfrom $150Find
- F9 - Frontier Airlinesfrom $92Find
- UA - United Airlinesfrom $149Find
- G4 - Allegiant Airfrom $77Find
See more connecting flights
Airports
You can fly from Des Moines to San Diego from 1 airports (Des Moines International Airport).
Des Moines airports
- Des Moines International Airport-DSMfrom $48Find
San Diego airports
- San Diego-SANFind
- San Diego Regional-USAFind
- Gillespie Field-SEEFind
- Golden Triangle Reg.-GTRFind
- El Cajon-CJNFind
- Lowndes County-UBSFind
- Miramar NAS-NKXFind
- Montgomery Field-MYFFind
- North Island NAS-NZYFind
- Brown Field Municipal-SDMFind
- AFB-CBMFind
Airplanes
There are flights to San Diego from Des Moines by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.
Top Domestic Destinations from Des Moines
You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.
- from $55Find
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Top International Destinations from Des Moines
Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.
- from $77Find
- from $70Find
How to book a plane ticket yourself?
- Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
- Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
- Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
- Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
- That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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