Cheap Flights from Des Moines, IA to San Diego, CA from $61

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On Cheapflightsplus.com you will find 2 direct and 192 connecting flights from Des Moines to San Diego. You can compare airfare deals from 4 airlines and multiple travel sites from $61, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAN flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to San Diego Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $61 (one-way), $105 (round-trip).

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Best Flights from Des Moines to San Diego Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to San Diego with the lowest price of $61. The fastest direct flight takes 3h 31m and the fastest connecting – 5h 9m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $61 Find flight	14:39 Des Moines Des Moines International Airport	16:10 San Diego San Diego	3h 31m	Allegiant Air	G42074
from $71 Find flight	14:54 Des Moines Des Moines International Airport	16:30 San Diego San Diego	3h 36m	Allegiant Air	G4474
from $97 Find flight	22:31 Des Moines Des Moines International Airport	07:13+1 день San Diego San Diego	10h 42m layover 6h 23m - Las Vegas	Allegiant Air	G415 NK2502
from $114 Find flight	13:15 Des Moines Des Moines International Airport	17:55 San Diego San Diego	6h 40m layover 2h 17m - Las Vegas	Allegiant Air	G449 NK1150

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 17, 2025

Flight Schedule Des Moines (Iowa) to San Diego (California)

Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Diego. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
13:15 — 23:29	13:15 — 14:21 G448 Allegiant Air Des Moines — Las Vegas 7h 54m stop 22:15 — 23:29 NK2390 Spirit Airlines Las Vegas — San Diego	12h 14m including layover	Find flight from$102
13:15 — 09:55 +1 day	13:15 — 14:21 G449 Allegiant Air Des Moines — Las Vegas 18h 19m stop 08:40 — 09:55 NK1154 Spirit Airlines Las Vegas — San Diego	22h 40m including layover	Find flight from$102
13:15 — 13:17 +1 day	13:15 — 14:21 G448 Allegiant Air Des Moines — Las Vegas 21h 39m stop 12:00 — 13:17 NK2295 Spirit Airlines Las Vegas — San Diego	26h 2m including layover	Find flight from$102
13:25 — 09:55 +1 day	13:15 — 14:21 G448 Allegiant Air Des Moines — Las Vegas 18h 9m stop 08:40 — 09:55 NK1154 Spirit Airlines Las Vegas — San Diego	22h 30m including layover	Find flight from$111
14:39 — 16:10	14:39 — 16:10 G42074 Allegiant Air Des Moines — San Diego	3h 31m	Find flight from$61
14:54 — 16:30	14:54 — 16:30 G4474 Allegiant Air Des Moines — San Diego	3h 36m	Find flight from$71
15:44 — 20:30	15:44 — 16:50 G42100 Allegiant Air Des Moines — Las Vegas 2h 24m stop 19:14 — 20:30 NK1150 Spirit Airlines Las Vegas — San Diego	6h 46m including layover	Find flight from$101
15:44 — 23:00	15:44 — 16:50 G42100 Allegiant Air Des Moines — Las Vegas 4h 56m stop 21:46 — 23:00 NK1152 Spirit Airlines Las Vegas — San Diego	9h 16m including layover	Find flight from$101
15:44 — 09:55 +1 day	15:44 — 16:50 G42100 Allegiant Air Des Moines — Las Vegas 15h 50m stop 08:40 — 09:55 NK1154 Spirit Airlines Las Vegas — San Diego	20h 11m including layover	Find flight from$103
22:31 — 07:13 +1 day	22:31 — 23:37 G415 Allegiant Air Des Moines — Las Vegas 6h 23m stop 06:00 — 07:13 NK2502 Spirit Airlines Las Vegas — San Diego	10h 42m including layover	Find flight from$97
22:31 — 18:26 +1 day	22:31 — 23:37 G415 Allegiant Air Des Moines — Las Vegas 17h 32m stop 17:09 — 18:26 NK2295 Spirit Airlines Las Vegas — San Diego	21h 55m including layover	Find flight from$97
22:31 — 23:29 +1 day	22:31 — 23:37 G415 Allegiant Air Des Moines — Las Vegas 22h 38m stop 22:15 — 23:29 NK2390 Spirit Airlines Las Vegas — San Diego	26h 58m including layover	Find flight from$97
22:31 — 09:55 +1 day	22:31 — 23:37 G415 Allegiant Air Des Moines — Las Vegas 9h 3m stop 08:40 — 09:55 NK1154 Spirit Airlines Las Vegas — San Diego	13h 24m including layover	Find flight from$98
22:31 — 17:55 +1 day	22:31 — 23:37 G415 Allegiant Air Des Moines — Las Vegas 17h 1m stop 16:38 — 17:55 NK1150 Spirit Airlines Las Vegas — San Diego	21h 24m including layover	Find flight from$98
22:31 — 23:00 +1 day	22:31 — 23:37 G415 Allegiant Air Des Moines — Las Vegas 22h 9m stop 21:46 — 23:00 NK1152 Spirit Airlines Las Vegas — San Diego	26h 29m including layover	Find flight from$98

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on September 17, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to San Diego depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and San Diego is 2295 miles. Time difference between the cities is 2h. Airplanes depart 05:00 to 22:31 from 1 Des Moines airport and arrive 05:00 to 22:31 to 11 San Diego airports. Average flight time is 3h 34m.

The fastest flight 3h 31m
Average flight time 3h 34m
The earliest flight 05:00
The latest flight 22:31
Distance 1427 ml

The cheapest months to travel to San Diego are july (from 61 $), august (from 62 $), september (from 209 $).

The most expensive months are february (from 372 $), november (from 365 $), september (from 209 $).

What is the lowest airfare Des Moines to San Diego?

The cheapest plane ticket found by our users is $61. This airfare is for economy class on one-way G42074 flight by Allegiant Air for July 4, 2025 which leaves Des Moines International Airport in Des Moines at 14:39 am and arrives at San Diego San Diego at 16:10.

Economy class

$61

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Business class

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First class

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Popular Airlines on the Route

The flight Des Moines — San Diego is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Alaska Airlines - 11 departures per week at the price of from $ 189 . And the most expensive tickets are offered by United Airlines airline - from $ 908.

Direct flights

There are 2 nonstop flights on the route. The fastest direct flight is G42074 by Allegiant Air takes 3h 31m and the cheapest is G42074 by Allegiant Air for $61.

G4 - Allegiant Air

from $61

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Connecting Flights

There are 192 flights with layovers on the route. The fastest connecting flight is UA4790 by United Airlines takes 5h 9m and the cheapest is G42074 by Allegiant Air for $97.

AS - Alaska Airlines

from $189

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F9 - Frontier Airlines

from $116

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UA - United Airlines

from $188

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G4 - Allegiant Air

from $97

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Airports

You can fly from Des Moines to San Diego from 1 airports (Des Moines International Airport).

Des Moines airports

Des Moines International Airport-DSM

from $61
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San Diego airports

San Diego-SAN

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San Diego Regional-USA

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Gillespie Field-SEE

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Golden Triangle Reg.-GTR

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El Cajon-CJN

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Lowndes County-UBS

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Miramar NAS-NKX

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Montgomery Field-MYF

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North Island NAS-NZY

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Brown Field Municipal-SDM

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AFB-CBM

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Airplanes

There are flights to San Diego from Des Moines by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Des Moines — Las Vegas

from $55

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Des Moines — Phoenix

from $71

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Des Moines — Dallas

from $73

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Des Moines — Austin

from $78

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Des Moines — Seattle

from $53

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Des Moines — Atlanta

from $58

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Des Moines — Miami

from $65

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Des Moines — Denver

from $54

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Des Moines — New Orleans

from $56

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Des Moines — San Diego

from $58

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Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Des Moines — Cancun

from $77

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Des Moines — London

from $70

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
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That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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