Cheap Flights from Des Moines, IA to San Diego, CA from $67

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On Cheapflightsplus.com you will find 135 connecting flights from Des Moines to San Diego. You can compare airfare deals from 4 airlines and multiple travel sites from $67, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAN flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to San Diego Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $67 (one-way), $115 (round-trip).

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Best Flights from Des Moines to San Diego Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to San Diego with the lowest price of $67. Take a look at the list of flights with layovers from Des Moines to San Diego from $67. There’re no direct flights. The fastest connecting flight – 5h 25m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $67 Find flight	21:21 Des Moines Des Moines International Airport	06:24+1 день San Diego San Diego	11h 3m layover 6h 41m - Denver	Frontier Airlines	F91677 F92817
from $125 Find flight	08:00 Des Moines Des Moines International Airport	14:15 San Diego San Diego	8h 15m layover 3h 44m - Las Vegas	Allegiant Air	G4442 NK3791
from $134 Find flight	15:35 Des Moines Des Moines International Airport	23:52 San Diego San Diego	10h 17m layover 5h 38m - Las Vegas	Allegiant Air	G4451 NK191
from $311 Find flight	06:00 Des Moines Des Moines International Airport	09:28 San Diego San Diego	5h 28m layover 0h 56m - Denver	United Airlines	UA497 UA2309
from $311 Find flight	13:49 Des Moines Des Moines International Airport	17:25 San Diego San Diego	5h 36m layover 0h 56m - Denver	United Airlines	UA5835 UA1281
from $311 Find flight	09:00 Des Moines Des Moines International Airport	12:53 San Diego San Diego	5h 53m layover 1h 10m - Denver	United Airlines	UA581 UA2381
from $311 Find flight	14:37 Des Moines Des Moines International Airport	20:05 San Diego San Diego	7h 28m layover 2h 56m - Phoenix	Alaska Airlines	AS4135 AS4295
from $311 Find flight	08:00 Des Moines Des Moines International Airport	13:50 San Diego San Diego	7h 50m layover 1h 47m - Houston	United Airlines	UA735 UA2486
from $311 Find flight	15:23 Des Moines Des Moines International Airport	22:22 San Diego San Diego	8h 59m layover 2h 59m - Chicago	United Airlines	UA1568 UA2735
from $188 Find flight	07:00 Des Moines Des Moines International Airport	22:17 San Diego San Diego	17h 17m layover 5h 3m - Santa Ana 6h 5m - Las Vegas	Allegiant Air	G4457 NK874 NK1496
from $193 Find flight	07:00 Des Moines Des Moines International Airport	18:15 San Diego San Diego	13h 15m layover 5h 3m - Santa Ana 1h 57m - Las Vegas	Allegiant Air	G4457 NK874 NK2907
from $201 Find flight	14:40 Des Moines Des Moines International Airport	06:40+1 день San Diego San Diego	18h 0m layover 6h 0m - Phoenix 6h 38m - Las Vegas	Allegiant Air	G4474 NK876 NK1496
from $224 Find flight	14:29 Des Moines Des Moines International Airport	08:13+1 день San Diego San Diego	19h 44m layover 5h 33m - Phoenix 8h 38m - Las Vegas	Allegiant Air	G42062 NK536 NK375
from $254 Find flight	08:00 Des Moines Des Moines International Airport	23:52 San Diego San Diego	17h 52m layover 3h 34m - Miami 4h 9m - Las Vegas	Allegiant Air	G4436 NK201 NK191
from $300 Find flight	08:30 Des Moines Des Moines International Airport	22:17 San Diego San Diego	15h 47m layover 4h 1m - Austin 5h 11m - Las Vegas	Allegiant Air	G42056 NK869 NK1496
from $305 Find flight	08:30 Des Moines Des Moines International Airport	18:15 San Diego San Diego	11h 45m layover 4h 1m - Austin 1h 3m - Las Vegas	Allegiant Air	G42056 NK869 NK2907

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on May 09, 2025

Flight Schedule Des Moines (Iowa) to San Diego (California)

Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Diego. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
05:00 — 11:34	05:00 — 07:35 AS6332 Alaska Airlines Des Moines — Phoenix 3h 38m stop 11:13 — 11:34 AS4295 Alaska Airlines Phoenix — San Diego	8h 34m including layover	Find flight from$312
05:45 — 09:29	05:45 — 07:02 UA4700 United Airlines Des Moines — Denver 56m stop 08:00 — 09:30 UA2309 United Airlines Denver — San Diego	5h 44m including layover	Find flight from$314
06:00 — 09:28	06:00 — 07:04 UA497 United Airlines Des Moines — Denver 56m stop 08:05 — 09:33 UA2309 United Airlines Denver — San Diego	5h 28m including layover	Find flight from$311
06:00 — 11:18	06:00 — 07:04 UA497 United Airlines Des Moines — Denver 2h 46m stop 10:20 — 11:48 UA1842 United Airlines Denver — San Diego	7h 18m including layover	Find flight from$311
08:00 — 14:15	08:00 — 09:11 G4442 Allegiant Air Des Moines — Las Vegas 3h 44m stop 12:55 — 14:15 NK3791 Spirit Airlines Las Vegas — San Diego	8h 15m including layover	Find flight from$125
08:00 — 12:20	08:00 — 09:11 G4442 Allegiant Air Des Moines — Las Vegas 1h 51m stop 11:02 — 12:20 NK1475 Spirit Airlines Las Vegas — San Diego	6h 20m including layover	Find flight from$165
09:00 — 12:53	09:02 — 10:17 UA581 United Airlines Des Moines — Denver 1h 10m stop 11:40 — 13:08 UA2381 United Airlines Denver — San Diego	5h 53m including layover	Find flight from$311
09:02 — 22:28	09:02 — 10:17 UA581 United Airlines Des Moines — Denver 10h 43m stop 21:00 — 22:28 UA765 United Airlines Denver — San Diego	15h 26m including layover	Find flight from$347
11:29 — 18:51	11:29 — 13:00 UA3417 United Airlines Des Moines — Chicago 3h 20m stop 16:20 — 18:51 UA2080 United Airlines Chicago — San Diego	9h 22m including layover	Find flight from$311
11:29 — 19:00	11:29 — 12:57 UA1373 United Airlines Des Moines — Chicago 3h 23m stop 16:20 — 19:00 UA2184 United Airlines Chicago — San Diego	9h 31m including layover	Find flight from$318
13:45 — 22:28	13:45 — 14:51 UA5669 United Airlines Des Moines — Denver 6h 9m stop 21:00 — 22:28 UA765 United Airlines Denver — San Diego	10h 43m including layover	Find flight from$366
13:49 — 17:25	13:45 — 14:51 UA5835 United Airlines Des Moines — Denver 56m stop 16:01 — 17:29 UA1281 United Airlines Denver — San Diego	5h 36m including layover	Find flight from$311
14:37 — 20:05	14:37 — 16:52 AS4135 Alaska Airlines Des Moines — Phoenix 2h 56m stop 19:48 — 20:05 AS4295 Alaska Airlines Phoenix — San Diego	7h 28m including layover	Find flight from$311
14:50 — 22:17	14:50 — 16:13 G42057 Allegiant Air Des Moines — Las Vegas 4h 52m stop 21:05 — 22:17 NK1496 Spirit Airlines Las Vegas — San Diego	9h 27m including layover	Find flight from$333
15:23 — 22:22	15:23 — 16:51 UA1568 United Airlines Des Moines — Chicago 2h 59m stop 19:50 — 22:22 UA2735 United Airlines Chicago — San Diego	8h 59m including layover	Find flight from$311
15:35 — 23:52	15:35 — 17:03 G4451 Allegiant Air Des Moines — Las Vegas 5h 38m stop 22:41 — 23:52 NK191 Spirit Airlines Las Vegas — San Diego	10h 17m including layover	Find flight from$134
17:07 — 23:49	18:51 — 19:57 F91677 Frontier Airlines Des Moines — Denver 3h 57m stop 19:56 — 21:25 F94989 Frontier Airlines Denver — San Diego	8h 42m including layover	Find flight from$172
17:13 — 22:40	17:13 — 18:20 UA1781 United Airlines Des Moines — Denver 2h 45m stop 21:05 — 22:40 UA486 United Airlines Denver — San Diego	7h 27m including layover	Find flight from$318
18:52 — 11:15 +1 day	18:52 — 19:58 F91677 Frontier Airlines Des Moines — Denver 13h 47m stop 09:45 — 11:15 F94927 Frontier Airlines Denver — San Diego	18h 23m including layover	Find flight from$67
18:52 — 23:56	18:52 — 19:58 F91677 Frontier Airlines Des Moines — Denver 2h 32m stop 22:30 — 23:56 F92711 Frontier Airlines Denver — San Diego	7h 4m including layover	Find flight from$157
21:21 — 06:24 +1 day	18:51 — 19:57 F91677 Frontier Airlines Des Moines — Denver 6h 41m stop 05:35 — 07:05 F92817 Frontier Airlines Denver — San Diego	11h 3m including layover	Find flight from$67

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on May 9, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to San Diego depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and San Diego is 2295 miles. Time difference between the cities is 2h. Airplanes depart 05:00 to 21:21 from 1 Des Moines airport and arrive 05:00 to 21:21 to 11 San Diego airports. Average flight time is 11h 53m.

The fastest flight 5h 25m
Average flight time 11h 53m
The earliest flight 05:00
The latest flight 21:21
Distance 1427 ml

The cheapest months to travel to San Diego are november (from 67 $), february (from 92 $), january (from 134 $).

The most expensive months are december (from 172 $), january (from 134 $), february (from 92 $).

What is the lowest airfare Des Moines to San Diego?

The cheapest plane ticket found by our users is $67. This airfare is for economy class on one-way F91677 flight by Frontier Airlines for February 21, 2025 which leaves Des Moines International Airport in Des Moines at 21:21 am and arrives at San Diego San Diego at 06:24.

Economy class

$67

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Popular Airlines on the Route

The flight Des Moines — San Diego is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Alaska Airlines - 24 departures per week at the price of from $ 311 . And the most expensive tickets are offered by Alaska Airlines airline - from $ 808.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 135 flights with layovers on the route. The fastest connecting flight is UA1781 by United Airlines takes 5h 25m and the cheapest is F91677 by Frontier Airlines for $67.

AS - Alaska Airlines

from $311

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F9 - Frontier Airlines

from $67

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UA - United Airlines

from $311

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G4 - Allegiant Air

from $125

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Airports

You can fly from Des Moines to San Diego from 1 airports (Des Moines International Airport).

Des Moines airports

Des Moines International Airport-DSM

from $67
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San Diego airports

San Diego-SAN

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San Diego Regional-USA

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Gillespie Field-SEE

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Golden Triangle Reg.-GTR

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El Cajon-CJN

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Lowndes County-UBS

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Miramar NAS-NKX

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Montgomery Field-MYF

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North Island NAS-NZY

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Brown Field Municipal-SDM

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AFB-CBM

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Airplanes

There are flights to San Diego from Des Moines by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Des Moines — Las Vegas

from $55

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Des Moines — Phoenix

from $71

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Des Moines — Dallas

from $73

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Des Moines — Austin

from $78

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Des Moines — Seattle

from $53

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Des Moines — Atlanta

from $58

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Des Moines — Miami

from $65

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Des Moines — Denver

from $54

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Des Moines — New Orleans

from $56

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Des Moines — San Diego

from $58

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Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Des Moines — Cancun

from $77

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Des Moines — London

from $70

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How to book a plane ticket yourself?

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Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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