Cheap Flights from Des Moines, IA to San Diego, CA from $62

On Cheapflightsplus.com you will find 2 direct and 192 connecting flights from Des Moines to San Diego. You can compare airfare deals from 4 airlines and multiple travel sites from $62, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAN flight schedule to find best flight time, convenient departure and arrival airports.

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to San Diego depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and San Diego is 2295 miles. Time difference between the cities is 2h. Airplanes depart 05:00 to 22:31 from 1 Des Moines airport and arrive 05:00 to 22:31 to 11 San Diego airports. Average flight time is 3h 34m.

  • The fastest flight 3h 31m
  • Average flight time 3h 34m
  • The earliest flight 05:00
  • The latest flight 22:31
  • Distance 1427 ml

The cheapest months to travel to San Diego are july (from 62 $), august (from 62 $), september (from 210 $).

The most expensive months are february (from 375 $), november (from 367 $), september (from 210 $).

What is the lowest airfare Des Moines to San Diego?

The cheapest plane ticket found by our users is $62. This airfare is for economy class on one-way G42074 flight by Allegiant Air for July 4, 2025 which leaves Des Moines International Airport in Des Moines at 14:39 am and arrives at San Diego San Diego at 16:10.

Economy class
$62
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Business class
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First class
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Flight Schedule Des Moines (Iowa) to San Diego (California)

13:15 — 09:55+1day
22h 40m flight time
Find flight
from$102
13:15 — 14:21 Des Moines — Las Vegas
G449 Allegiant Air
18h 19m stop
08:40 — 09:55 Las Vegas — San Diego
NK1154 Spirit Airlines
13:15 — 23:29
12h 14m flight time
Find flight
from$103
13:15 — 14:21 Des Moines — Las Vegas
G448 Allegiant Air
7h 54m stop
22:15 — 23:29 Las Vegas — San Diego
NK2390 Spirit Airlines
13:15 — 13:17+1day
26h 2m flight time
Find flight
from$103
13:15 — 14:21 Des Moines — Las Vegas
G448 Allegiant Air
21h 39m stop
12:00 — 13:17 Las Vegas — San Diego
NK2295 Spirit Airlines
13:25 — 09:55+1day
22h 30m flight time
Find flight
from$111
13:15 — 14:21 Des Moines — Las Vegas
G448 Allegiant Air
18h 9m stop
08:40 — 09:55 Las Vegas — San Diego
NK1154 Spirit Airlines
14:39 — 16:10
3h 31m flight time
Find flight
from$62
Des Moines — San Diego
G42074 Allegiant Air
14:54 — 16:30
3h 36m flight time
Find flight
from$72
Des Moines — San Diego
G4474 Allegiant Air
15:44 — 20:30
6h 46m flight time
Find flight
from$102
15:44 — 16:50 Des Moines — Las Vegas
G42100 Allegiant Air
2h 24m stop
19:14 — 20:30 Las Vegas — San Diego
NK1150 Spirit Airlines
15:44 — 23:00
9h 16m flight time
Find flight
from$102
15:44 — 16:50 Des Moines — Las Vegas
G42100 Allegiant Air
4h 56m stop
21:46 — 23:00 Las Vegas — San Diego
NK1152 Spirit Airlines
15:44 — 09:55+1day
20h 11m flight time
Find flight
from$104
15:44 — 16:50 Des Moines — Las Vegas
G42100 Allegiant Air
15h 50m stop
08:40 — 09:55 Las Vegas — San Diego
NK1154 Spirit Airlines
22:31 — 07:13+1day
10h 42m flight time
Find flight
from$97
22:31 — 23:37 Des Moines — Las Vegas
G415 Allegiant Air
6h 23m stop
06:00 — 07:13 Las Vegas — San Diego
NK2502 Spirit Airlines
22:31 — 18:26+1day
21h 55m flight time
Find flight
from$97
22:31 — 23:37 Des Moines — Las Vegas
G415 Allegiant Air
17h 32m stop
17:09 — 18:26 Las Vegas — San Diego
NK2295 Spirit Airlines
22:31 — 23:29+1day
26h 58m flight time
Find flight
from$97
22:31 — 23:37 Des Moines — Las Vegas
G415 Allegiant Air
22h 38m stop
22:15 — 23:29 Las Vegas — San Diego
NK2390 Spirit Airlines
22:31 — 09:55+1day
13h 24m flight time
Find flight
from$99
22:31 — 23:37 Des Moines — Las Vegas
G415 Allegiant Air
9h 3m stop
08:40 — 09:55 Las Vegas — San Diego
NK1154 Spirit Airlines
22:31 — 17:55+1day
21h 24m flight time
Find flight
from$99
22:31 — 23:37 Des Moines — Las Vegas
G415 Allegiant Air
17h 1m stop
16:38 — 17:55 Las Vegas — San Diego
NK1150 Spirit Airlines
22:31 — 23:00+1day
26h 29m flight time
Find flight
from$99
22:31 — 23:37 Des Moines — Las Vegas
G415 Allegiant Air
22h 9m stop
21:46 — 23:00 Las Vegas — San Diego
NK1152 Spirit Airlines
Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Diego. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
*Departure and arrival times - local. Updated on October 19, 2025.

Popular Airlines on the Route

The flight Des Moines — San Diego is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Alaska Airlines - 11 departures per week at the price of from $ 190 . And the most expensive tickets are offered by United Airlines airline - from $ 913.

Direct flights

There are 2 nonstop flights on the route. The fastest direct flight is G42074 by Allegiant Air takes 3h 31m and the cheapest is G42074 by Allegiant Air for $62.

  • G4 - Allegiant Air
    from $62
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See more direct flights

Connecting Flights

There are 192 flights with layovers on the route. The fastest connecting flight is UA4790 by United Airlines takes 5h 9m and the cheapest is G42074 by Allegiant Air for $97.

  • AS - Alaska Airlines
    from $190
    Find
  • F9 - Frontier Airlines
    from $117
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  • UA - United Airlines
    from $189
    Find
  • G4 - Allegiant Air
    from $97
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See more connecting flights

Airports

You can fly from Des Moines to San Diego from 1 airports (Des Moines International Airport).

Des Moines airports

  • Des Moines International Airport-DSM
    from $62
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San Diego airports

  • San Diego-SAN
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  • San Diego Regional-USA
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  • Gillespie Field-SEE
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  • Golden Triangle Reg.-GTR
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  • El Cajon-CJN
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  • Lowndes County-UBS
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  • Miramar NAS-NKX
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  • Montgomery Field-MYF
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  • North Island NAS-NZY
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  • Brown Field Municipal-SDM
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  • AFB-CBM
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How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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