Cheap Flights from Des Moines, IA to San Diego, CA from $48

On Cheapflightsplus.com you will find 2 direct and 192 connecting flights from Des Moines to San Diego. You can compare airfare deals from 4 airlines and multiple travel sites from $48, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAN flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to San Diego Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $48 (one-way), $82 (round-trip).
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Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Diego. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
14:39 — 16:10
14:39 — 16:10 G42074 Allegiant Air
Des Moines — San Diego
3h 31m
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from$48
14:54 — 16:30
14:54 — 16:30 G4474 Allegiant Air
Des Moines — San Diego
3h 36m
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from$55
06:24 — 11:33
06:24 — 08:05 UA4677 United Airlines
Des Moines — Chicago
1h stop
09:05 — 11:33 UA660 United Airlines
Chicago — San Diego
7h 9m
including layover
Find flight
from$147
09:15 — 12:52
09:15 — 10:17 UA581 United Airlines
Des Moines — Denver
1h 11m stop
11:28 — 12:52 UA2412 United Airlines
Denver — San Diego
5h 37m
including layover
Find flight
from$147
09:15 — 15:08
09:15 — 10:17 UA581 United Airlines
Des Moines — Denver
3h 27m stop
13:44 — 15:08 UA1302 United Airlines
Denver — San Diego
7h 53m
including layover
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from$147
13:15 — 23:29
13:15 — 14:21 G448 Allegiant Air
Des Moines — Las Vegas
7h 54m stop
22:15 — 23:29 NK2390 Spirit Airlines
Las Vegas — San Diego
12h 14m
including layover
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from$79
13:15 — 09:55
+1 day
13:15 — 14:21 G449 Allegiant Air
Des Moines — Las Vegas
18h 19m stop
08:40 — 09:55 NK1154 Spirit Airlines
Las Vegas — San Diego
22h 40m
including layover
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from$79
15:44 — 20:30
15:44 — 16:50 G42100 Allegiant Air
Des Moines — Las Vegas
2h 24m stop
19:14 — 20:30 NK1150 Spirit Airlines
Las Vegas — San Diego
6h 46m
including layover
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from$79
15:44 — 23:00
15:44 — 16:50 G42100 Allegiant Air
Des Moines — Las Vegas
4h 56m stop
21:46 — 23:00 NK1152 Spirit Airlines
Las Vegas — San Diego
9h 16m
including layover
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from$79
20:38 — 23:55
19:33 — 20:33 F91677 Frontier Airlines
Des Moines — Denver
41m stop
22:29 — 23:52 F92711 Frontier Airlines
Denver — San Diego
5h 17m
including layover
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from$90
20:38 — 11:10
+1 day
19:33 — 20:33 F91677 Frontier Airlines
Des Moines — Denver
11h 56m stop
09:44 — 11:10 F92817 Frontier Airlines
Denver — San Diego
16h 32m
including layover
Find flight
from$95
21:10 — 09:14
+1 day
21:10 — 22:26 G415 Allegiant Air
Des Moines — Las Vegas
9h 34m stop
08:00 — 09:14 NK1496 Spirit Airlines
Las Vegas — San Diego
14h 4m
including layover
Find flight
from$87
21:10 — 10:45
+1 day
21:10 — 22:26 G415 Allegiant Air
Des Moines — Las Vegas
11h 4m stop
09:30 — 10:45 NK1475 Spirit Airlines
Las Vegas — San Diego
15h 35m
including layover
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from$87
22:31 — 07:13
+1 day
22:31 — 23:37 G415 Allegiant Air
Des Moines — Las Vegas
6h 23m stop
06:00 — 07:13 NK2502 Spirit Airlines
Las Vegas — San Diego
10h 42m
including layover
Find flight
from$75
22:31 — 18:26
+1 day
22:31 — 23:37 G415 Allegiant Air
Des Moines — Las Vegas
17h 32m stop
17:09 — 18:26 NK2295 Spirit Airlines
Las Vegas — San Diego
21h 55m
including layover
Find flight
from$75
06:00 — 13:57
06:00 — 07:03 UA4790 United Airlines
Des Moines — Denver
58m stop
08:01 — 09:34 UA1638 United Airlines
Denver — Los Angeles
3h 18m stop
12:52 — 13:57 UA4712 United Airlines
Los Angeles — San Diego
9h 57m
including layover
Find flight
from$151
07:00 — 07:13
+1 day
07:00 — 08:31 G4464 Allegiant Air
Des Moines — Santa Ana
8h 51m stop
17:22 — 18:44 NK3171 Spirit Airlines
Santa Ana — Las Vegas
11h 16m stop
06:00 — 07:13 NK2502 Spirit Airlines
Las Vegas — San Diego
26h 13m
including layover
Find flight
from$130
07:00 — 07:13
+1 day
07:00 — 08:31 G4464 Allegiant Air
Des Moines — Santa Ana
11h 9m stop
19:40 — 20:56 NK2337 Spirit Airlines
Santa Ana — Las Vegas
9h 4m stop
06:00 — 07:13 NK2502 Spirit Airlines
Las Vegas — San Diego
26h 13m
including layover
Find flight
from$130
08:35 — 09:55
+1 day
08:35 — 12:05 G4431 Allegiant Air
Des Moines — Newark
9h 55m stop
22:00 — 00:37 NK1386 Spirit Airlines
Newark — Las Vegas
8h 3m stop
08:40 — 09:55 NK1154 Spirit Airlines
Las Vegas — San Diego
27h 20m
including layover
Find flight
from$141
08:35 — 17:55
+1 day
08:35 — 12:05 G4431 Allegiant Air
Des Moines — Newark
19h 15m stop
07:20 — 09:50 NK1585 Spirit Airlines
Newark — Las Vegas
6h 48m stop
16:38 — 17:55 NK1150 Spirit Airlines
Las Vegas — San Diego
35h 20m
including layover
Find flight
from$141
11:25 — 20:38
11:25 — 12:57 UA2306 United Airlines
Des Moines — Chicago
1h 38m stop
14:35 — 16:27 UA503 United Airlines
Chicago — Denver
2h 47m stop
19:14 — 20:38 UA540 United Airlines
Denver — San Diego
11h 13m
including layover
Find flight
from$151
17:12 — 23:44
17:12 — 18:15 UA2681 United Airlines
Des Moines — Denver
1h 10m stop
19:25 — 20:58 UA1368 United Airlines
Denver — Los Angeles
1h 45m stop
22:43 — 23:44 UA5612 United Airlines
Los Angeles — San Diego
8h 32m
including layover
Find flight
from$151
*Departure and arrival times - local. Updated on June 1, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to San Diego depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and San Diego is 2295 miles. Time difference between the cities is 2h. Airplanes depart 05:00 to 22:31 from 1 Des Moines airport and arrive 05:00 to 22:31 to 11 San Diego airports. Average flight time is 3h 34m.

  • The fastest flight 3h 31m
  • Average flight time 3h 34m
  • The earliest flight 05:00
  • The latest flight 22:31
  • Distance 1427 ml

The cheapest months to travel to San Diego are july (from 64 $), august (from 64 $), september (from 217 $).

The most expensive months are february (from 388 $), november (from 380 $), september (from 217 $).

What is the lowest airfare Des Moines to San Diego?

The cheapest plane ticket found by our users is $48. This airfare is for economy class on one-way G42074 flight by Allegiant Air for July 4, 2025 which leaves Des Moines International Airport in Des Moines at 14:39 am and arrives at San Diego San Diego at 16:10.

Economy class
$48
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Business class
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First class
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Popular Airlines on the Route

The flight Des Moines — San Diego is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Alaska Airlines - 11 departures per week at the price of from $ 147 . And the most expensive tickets are offered by United Airlines airline - from $ 709.

Direct flights

There are 2 nonstop flights on the route. The fastest direct flight is G42074 by Allegiant Air takes 3h 31m and the cheapest is G42074 by Allegiant Air for $48.

  • G4 - Allegiant Air
    from $48
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See more direct flights

Connecting Flights

There are 192 flights with layovers on the route. The fastest connecting flight is UA4790 by United Airlines takes 5h 9m and the cheapest is G42074 by Allegiant Air for $75.

  • AS - Alaska Airlines
    from $147
    Find
  • F9 - Frontier Airlines
    from $90
    Find
  • UA - United Airlines
    from $147
    Find
  • G4 - Allegiant Air
    from $75
    Find
See more connecting flights

Airports

You can fly from Des Moines to San Diego from 1 airports (Des Moines International Airport).

Des Moines airports

  • Des Moines International Airport-DSM
    from $48
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San Diego airports

  • San Diego-SAN
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  • San Diego Regional-USA
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  • Gillespie Field-SEE
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  • Golden Triangle Reg.-GTR
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  • El Cajon-CJN
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  • Lowndes County-UBS
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  • Miramar NAS-NKX
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  • Montgomery Field-MYF
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  • North Island NAS-NZY
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  • Brown Field Municipal-SDM
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  • AFB-CBM
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How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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