Cheap Flights from Des Moines, IA to Chicago, IL from $151

Return flight: Chicago – Des Moines
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On Cheapflightsplus.com you will find 5 direct and 24 connecting flights from Des Moines to Chicago. You can compare airfare deals from 3 airlines and multiple travel sites from $151, book and save on cheap plane tickets and last minute offers. Also check out DSM-CHI flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to Chicago Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $151 (one-way), $259 (round-trip).
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Best Flights from Des Moines to Chicago Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to Chicago with the lowest price of $151. The fastest direct flight takes 1h 28m and the fastest connecting – 5h 25m.
Price Departure Arrival Flight Duration Airline Flight
from $151
Find flight
18:45
Des Moines
Des Moines International Airport
 20:22
Chicago
O'Hare International
 1h 37m United Airlines
UA5286
from $151
Find flight
15:27
Des Moines
Des Moines International Airport
 17:05
Chicago
O'Hare International
 1h 38m United Airlines
UA3457
from $153
Find flight
11:29
Des Moines
Des Moines International Airport
 12:57
Chicago
O'Hare International
 1h 28m United Airlines
UA1373
from $311
Find flight
11:35
Des Moines
Des Moines International Airport
 13:13
Chicago
O'Hare International
 1h 38m United Airlines
UA4469
from $384
Find flight
15:15
Des Moines
Des Moines International Airport
 16:45
Chicago
O'Hare International
 1h 30m United Airlines
UA4393
from $260
Find flight
13:49
Des Moines
Des Moines International Airport
 23:59
Chicago
O'Hare International
 10h 10m
layover
5h 30m - Denver
 United Airlines
UA5835
UA377
from $270
Find flight
17:15
Des Moines
Des Moines International Airport
 09:38+1 день
Chicago
O'Hare International
 16h 23m
layover
11h 40m - Denver
 United Airlines
UA1781
UA532
from $270
Find flight
17:15
Des Moines
Des Moines International Airport
 11:20+1 день
Chicago
O'Hare International
 18h 5m
layover
13h 25m - Denver
 United Airlines
UA1781
UA1811
from $275
Find flight
15:05
Des Moines
Des Moines International Airport
 09:14+1 день
Chicago
O'Hare International
 18h 9m
layover
12h 34m - Houston
 United Airlines
UA6033
UA411
from $275
Find flight
15:05
Des Moines
Des Moines International Airport
 10:14+1 день
Chicago
O'Hare International
 19h 9m
layover
13h 34m - Houston
 United Airlines
UA6033
UA1431
from $365
Find flight
09:10
Des Moines
Des Moines International Airport
 22:38
Chicago
O'Hare International
 13h 28m
layover
8h 53m - Denver
 United Airlines
UA581
UA2258
from $426
Find flight
14:10
Des Moines
Des Moines International Airport
 00:59+1 день
Chicago
O'Hare International
 10h 49m
layover
4h 48m - Orlando
 Frontier Airlines
F91868
F93043
from $432
Find flight
17:15
Des Moines
Des Moines International Airport
 23:59
Chicago
O'Hare International
 6h 44m
layover
2h 9m - Denver
 United Airlines
UA1781
UA377
from $437
Find flight
17:13
Des Moines
Des Moines International Airport
 22:38
Chicago
O'Hare International
 5h 25m
layover
0h 50m - Denver
 United Airlines
UA1781
UA2258
from $462
Find flight
05:45
Des Moines
Des Moines International Airport
 13:15
Chicago
O'Hare International
 7h 30m
layover
2h 43m - Denver
 United Airlines
UA4700
UA2329
from $290
Find flight
15:44
Des Moines
Des Moines International Airport
 09:55+1 день
Chicago
O'Hare International
 18h 11m
layover
5h 4m - Las Vegas
1h 44m - Miami
 Allegiant Air
G42062
NK954
NK2
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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on January 21, 2025
Full flight schedule will help you in detecting at what time planes fly from Des Moines to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
11:29 — 12:57
11:29 — 12:57 UA1373 United Airlines
Des Moines — Chicago
1h 28m
Find flight
from$153
11:35 — 13:13
11:35 — 13:13 UA4469 United Airlines
Des Moines — Chicago
1h 38m
Find flight
from$311
15:15 — 16:45
15:15 — 16:45 UA4393 United Airlines
Des Moines — Chicago
1h 30m
Find flight
from$384
15:27 — 17:05
15:27 — 17:05 UA3457 United Airlines
Des Moines — Chicago
1h 38m
Find flight
from$151
18:45 — 20:22
18:45 — 20:22 UA5286 United Airlines
Des Moines — Chicago
1h 37m
Find flight
from$151
05:45 — 13:15
05:45 — 07:02 UA4700 United Airlines
Des Moines — Denver
2h 43m stop
09:40 — 13:18 UA2329 United Airlines
Denver — Chicago
7h 30m
including layover
Find flight
from$462
05:45 — 11:20
05:45 — 07:02 UA4700 United Airlines
Des Moines — Denver
49m stop
07:45 — 11:20 UA1811 United Airlines
Denver — Chicago
5h 35m
including layover
Find flight
from$509
08:00 — 17:10
08:00 — 10:37 UA735 United Airlines
Des Moines — Houston
3h 43m stop
14:20 — 17:10 UA1293 United Airlines
Houston — Chicago
9h 10m
including layover
Find flight
from$551
08:00 — 14:55
08:00 — 10:36 UA1982 United Airlines
Des Moines — Houston
1h 34m stop
12:10 — 14:55 UA1168 United Airlines
Houston — Chicago
6h 55m
including layover
Find flight
from$563
09:00 — 19:31
09:00 — 10:10 UA581 United Airlines
Des Moines — Denver
5h 45m stop
15:55 — 19:31 UA1495 United Airlines
Denver — Chicago
10h 31m
including layover
Find flight
from$260
09:10 — 22:38
09:02 — 10:17 UA581 United Airlines
Des Moines — Denver
8h 53m stop
19:20 — 22:51 UA2258 United Airlines
Denver — Chicago
13h 28m
including layover
Find flight
from$365
13:49 — 23:59
13:45 — 14:51 UA5835 United Airlines
Des Moines — Denver
5h 30m stop
20:50 — 00:22 UA377 United Airlines
Denver — Chicago
10h 10m
including layover
Find flight
from$260
13:49 — 11:20
+1 day
13:49 — 14:59 UA5835 United Airlines
Des Moines — Denver
16h 46m stop
07:45 — 11:20 UA1811 United Airlines
Denver — Chicago
21h 31m
including layover
Find flight
from$270
14:10 — 00:59
+1 day
10:57 — 14:53 F91868 Frontier Airlines
Des Moines — Orlando
4h 48m stop
07:30 — 09:52 F93043 Frontier Airlines
Orlando — Chicago
10h 49m
including layover
Find flight
from$426
14:10 — 09:13
+1 day
10:57 — 14:53 F91868 Frontier Airlines
Des Moines — Orlando
13h 14m stop
08:26 — 10:28 F91457 Frontier Airlines
Orlando — Chicago
19h 3m
including layover
Find flight
from$426
15:05 — 09:14
+1 day
15:00 — 17:35 UA6033 United Airlines
Des Moines — Houston
12h 34m stop
06:30 — 09:12 UA411 United Airlines
Houston — Chicago
18h 9m
including layover
Find flight
from$275
17:15 — 09:38
+1 day
17:10 — 18:19 UA1781 United Airlines
Des Moines — Denver
11h 40m stop
06:05 — 09:36 UA532 United Airlines
Denver — Chicago
16h 23m
including layover
Find flight
from$270
17:15 — 11:20
+1 day
17:06 — 18:15 UA1781 United Airlines
Des Moines — Denver
13h 25m stop
07:50 — 11:29 UA1811 United Airlines
Denver — Chicago
18h 5m
including layover
Find flight
from$270
*Departure and arrival times - local. Updated on January 21, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to Chicago depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and Chicago is 501 miles. Time difference between the cities is 0h. Airplanes depart 05:45 to 18:45 from 1 Des Moines airport and arrive 05:45 to 18:45 to 7 Chicago airports. Average flight time is 1h 37m.

  • The fastest flight 1h 28m
  • Average flight time 1h 37m
  • The earliest flight 05:45
  • The latest flight 18:45
  • Distance 312 ml

The cheapest months to travel to Chicago are january (from 82 $), february (from 151 $), december (from 190 $).

The most expensive months are october (from 737 $), november (from 258 $), december (from 190 $).

What is the lowest airfare Des Moines to Chicago?

The cheapest plane ticket found by our users is $151. This airfare is for economy class on one-way UA5286 flight by United Airlines for February 1, 2025 which leaves Des Moines International Airport in Des Moines at 18:45 am and arrives at Chicago O'Hare International at 20:22.

Economy class
$151
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Business class
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First class
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Popular Airlines on the Route

The flight Des Moines — Chicago is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 2 departures per week at the price of from $ 426 . And the most expensive tickets are offered by United Airlines airline - from $ 563.

Direct flights

There are 5 nonstop flights on the route. The fastest direct flight is UA1373 by United Airlines takes 1h 28m and the cheapest is UA5286 by United Airlines for $151.

See more direct flights

Connecting Flights

There are 24 flights with layovers on the route. The fastest connecting flight is UA1781 by United Airlines takes 5h 25m and the cheapest is UA5286 by United Airlines for $260.

See more connecting flights

Airports

You can fly from Des Moines to Chicago from 1 airports (Des Moines International Airport).

Des Moines airports

  • Des Moines International Airport-DSM
    from $151
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Chicago airports

  • O'Hare International-ORD
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  • Midway-MDW
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  • Dupage County-DPA
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  • Chicago FSS-CHI
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  • Merrill C Meigs (closed)-CGX
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  • Pal-Waukee-PWK
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  • Chicago NAS-NOH
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Airplanes

There are flights to Chicago from Des Moines by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

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