Cheap Flights from Des Moines, IA to San Antonio, TX from $67

On Cheapflightsplus.com you will find 75 connecting flights from Des Moines to San Antonio. You can compare airfare deals from 3 airlines and multiple travel sites from $67, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAT flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to San Antonio Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $67 (one-way), $115 (round-trip).
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Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Antonio. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
05:45 — 13:10
05:45 — 07:02 UA4700 United Airlines
Des Moines — Denver
2h 56m stop
10:05 — 13:21 UA1131 United Airlines
Denver — San Antonio
7h 25m
including layover
Find flight
from$282
05:45 — 16:40
05:45 — 07:02 UA4700 United Airlines
Des Moines — Denver
6h 24m stop
13:26 — 16:40 UA1022 United Airlines
Denver — San Antonio
10h 55m
including layover
Find flight
from$552
06:00 — 13:07
06:00 — 07:04 UA497 United Airlines
Des Moines — Denver
2h 51m stop
09:55 — 13:07 UA1131 United Airlines
Denver — San Antonio
7h 7m
including layover
Find flight
from$317
06:00 — 23:38
06:00 — 07:04 UA497 United Airlines
Des Moines — Denver
13h 21m stop
20:25 — 23:38 UA2028 United Airlines
Denver — San Antonio
17h 38m
including layover
Find flight
from$347
08:00 — 13:07
08:00 — 10:33 UA735 United Airlines
Des Moines — Houston
1h 26m stop
11:59 — 13:07 UA274 United Airlines
Houston — San Antonio
5h 7m
including layover
Find flight
from$279
08:00 — 15:26
08:00 — 10:33 UA735 United Airlines
Des Moines — Houston
3h 47m stop
14:20 — 15:26 UA1264 United Airlines
Houston — San Antonio
7h 26m
including layover
Find flight
from$279
09:00 — 16:40
09:02 — 10:17 UA581 United Airlines
Des Moines — Denver
3h 16m stop
13:41 — 16:54 UA1022 United Airlines
Denver — San Antonio
7h 40m
including layover
Find flight
from$279
09:02 — 23:38
09:02 — 10:17 UA581 United Airlines
Des Moines — Denver
10h 8m stop
20:25 — 23:38 UA2028 United Airlines
Denver — San Antonio
14h 36m
including layover
Find flight
from$347
13:45 — 20:55
13:45 — 14:51 UA5835 United Airlines
Des Moines — Denver
2h 52m stop
17:43 — 20:55 UA1762 United Airlines
Denver — San Antonio
7h 10m
including layover
Find flight
from$280
13:45 — 20:37
13:45 — 14:51 UA5669 United Airlines
Des Moines — Denver
2h 34m stop
17:25 — 20:37 UA1762 United Airlines
Denver — San Antonio
6h 52m
including layover
Find flight
from$317
14:10 — 06:57
+1 day
14:10 — 18:11 F91868 Frontier Airlines
Des Moines — Orlando
10h 50m stop
05:01 — 06:57 F91653 Frontier Airlines
Orlando — San Antonio
16h 47m
including layover
Find flight
from$545
15:00 — 21:18
15:00 — 17:35 UA6033 United Airlines
Des Moines — Houston
2h 35m stop
20:10 — 21:18 UA1338 United Airlines
Houston — San Antonio
6h 18m
including layover
Find flight
from$280
15:05 — 21:18
15:05 — 17:48 UA6033 United Airlines
Des Moines — Houston
2h 18m stop
20:06 — 21:18 UA1589 United Airlines
Houston — San Antonio
6h 13m
including layover
Find flight
from$282
17:10 — 23:38
17:10 — 18:19 UA1781 United Airlines
Des Moines — Denver
2h 6m stop
20:25 — 23:38 UA2028 United Airlines
Denver — San Antonio
6h 28m
including layover
Find flight
from$317
17:15 — 16:40
+1 day
17:10 — 18:19 UA1781 United Airlines
Des Moines — Denver
19h 6m stop
13:41 — 16:54 UA1022 United Airlines
Denver — San Antonio
23h 25m
including layover
Find flight
from$335
18:45 — 12:29
+1 day
18:45 — 20:22 UA5286 United Airlines
Des Moines — Chicago
12h 53m stop
09:15 — 12:29 UA1834 United Airlines
Chicago — San Antonio
17h 44m
including layover
Find flight
from$521
18:45 — 23:15
+1 day
18:45 — 20:22 UA5286 United Airlines
Des Moines — Chicago
23h 41m stop
20:03 — 23:15 UA1504 United Airlines
Chicago — San Antonio
28h 30m
including layover
Find flight
from$521
21:21 — 08:19
+1 day
18:51 — 19:57 F91677 Frontier Airlines
Des Moines — Denver
6h 46m stop
16:25 — 19:38 F92356 Frontier Airlines
Denver — San Antonio
10h 58m
including layover
Find flight
from$67
07:30 — 23:30
07:30 — 11:05 G4431 Allegiant Air
Des Moines — Newark
5h 4m stop
16:09 — 19:09 NK1861 Spirit Airlines
Newark — Orlando
2h 17m stop
21:26 — 23:30 NK446 Spirit Airlines
Orlando — San Antonio
16h
including layover
Find flight
from$196
07:30 — 04:59
+1 day
07:30 — 11:05 G4431 Allegiant Air
Des Moines — Newark
5h 38m stop
16:43 — 19:23 NK3733 Spirit Airlines
Newark — Las Vegas
5h 3m stop
00:26 — 04:59 NK1058 Spirit Airlines
Las Vegas — San Antonio
21h 29m
including layover
Find flight
from$196
*Departure and arrival times - local. Updated on May 9, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to San Antonio depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and San Antonio is 1404 miles. Time difference between the cities is 0h. Airplanes depart 05:45 to 21:21 from 1 Des Moines airport and arrive 05:45 to 21:21 to 5 San Antonio airports. Average flight time is 10h 8m.

  • The fastest flight 4h 28m
  • Average flight time 10h 8m
  • The earliest flight 05:45
  • The latest flight 21:21
  • Distance 873 ml

The cheapest months to travel to San Antonio are november (from 67 $), february (from 80 $), december (from 279 $).

The most expensive months are january (from 282 $), december (from 279 $), february (from 80 $).

What is the lowest airfare Des Moines to San Antonio?

The cheapest plane ticket found by our users is $67. This airfare is for economy class on one-way F91677 flight by Frontier Airlines for February 21, 2025 which leaves Des Moines International Airport in Des Moines at 21:21 am and arrives at San Antonio San Antonio at 08:19.

Economy class
$67
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Business class
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First class
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Popular Airlines on the Route

The flight Des Moines — San Antonio is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 2 departures per week at the price of from $ 67 . And the most expensive tickets are offered by United Airlines airline - from $ 685.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 75 flights with layovers on the route. The fastest connecting flight is UA6033 by United Airlines takes 4h 28m and the cheapest is F91677 by Frontier Airlines for $67.

  • F9 - Frontier Airlines
    from $67
    Find
  • UA - United Airlines
    from $279
    Find
  • G4 - Allegiant Air
    from $196
    Find
See more connecting flights

Airports

You can fly from Des Moines to San Antonio from 1 airports (Des Moines International Airport).

Des Moines airports

  • Des Moines International Airport-DSM
    from $67
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San Antonio airports

  • Randolph AFB-RND
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  • Martindale AAF-MDA
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  • San Antonio-SAT
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  • Kelly AFB-SKF
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  • Stinson Municipal-SSF
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How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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