Cheap Flights from Des Moines, IA to San Antonio, TX from $67

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On Cheapflightsplus.com you will find 75 connecting flights from Des Moines to San Antonio. You can compare airfare deals from 3 airlines and multiple travel sites from $67, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAT flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to San Antonio Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $67 (one-way), $115 (round-trip).

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Best Flights from Des Moines to San Antonio Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to San Antonio with the lowest price of $67. Take a look at the list of flights with layovers from Des Moines to San Antonio from $67. There’re no direct flights. The fastest connecting flight – 4h 28m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $67 Find flight	21:21 Des Moines Des Moines International Airport	08:19+1 день San Antonio San Antonio	10h 58m layover 6h 46m - Denver	Frontier Airlines	F91677 F92356
from $279 Find flight	08:00 Des Moines Des Moines International Airport	13:07 San Antonio San Antonio	5h 7m layover 1h 26m - Houston	United Airlines	UA735 UA274
from $279 Find flight	09:00 Des Moines Des Moines International Airport	16:40 San Antonio San Antonio	7h 40m layover 3h 16m - Denver	United Airlines	UA581 UA1022
from $280 Find flight	15:00 Des Moines Des Moines International Airport	21:18 San Antonio San Antonio	6h 18m layover 2h 35m - Houston	United Airlines	UA6033 UA1338
from $280 Find flight	13:45 Des Moines Des Moines International Airport	20:55 San Antonio San Antonio	7h 10m layover 2h 52m - Denver	United Airlines	UA5835 UA1762
from $282 Find flight	15:05 Des Moines Des Moines International Airport	21:18 San Antonio San Antonio	6h 13m layover 2h 18m - Houston	United Airlines	UA6033 UA1589
from $282 Find flight	05:45 Des Moines Des Moines International Airport	13:10 San Antonio San Antonio	7h 25m layover 2h 56m - Denver	United Airlines	UA4700 UA1131
from $282 Find flight	15:27 Des Moines Des Moines International Airport	23:15 San Antonio San Antonio	7h 48m layover 2h 58m - Chicago	United Airlines	UA3457 UA1504
from $324 Find flight	08:00 Des Moines Des Moines International Airport	13:27 San Antonio San Antonio	5h 27m layover 1h 39m - Houston	United Airlines	UA1982 UA2378
from $196 Find flight	07:30 Des Moines Des Moines International Airport	23:30 San Antonio San Antonio	16h 0m layover 5h 4m - Newark 2h 17m - Orlando	Allegiant Air	G4431 NK1861 NK446
from $196 Find flight	07:30 Des Moines Des Moines International Airport	04:59+1 день San Antonio San Antonio	21h 29m layover 5h 38m - Newark 5h 3m - Las Vegas	Allegiant Air	G4431 NK3733 NK1058
from $228 Find flight	07:30 Des Moines Des Moines International Airport	23:30 San Antonio San Antonio	16h 0m layover 3h 15m - Newark 4h 10m - Orlando	Allegiant Air	G4431 NK922 NK446
from $281 Find flight	14:40 Des Moines Des Moines International Airport	04:59+1 день San Antonio San Antonio	14h 19m layover 6h 0m - Phoenix 1h 34m - Las Vegas	Allegiant Air	G4474 NK876 NK1058
from $288 Find flight	11:35 Des Moines Des Moines International Airport	19:22 San Antonio San Antonio	7h 47m layover 0h 52m - Chicago 1h 6m - Houston	United Airlines	UA2306 UA1373 UA1477
from $288 Find flight	15:27 Des Moines Des Moines International Airport	23:14 San Antonio San Antonio	7h 47m layover 0h 45m - Chicago 1h 15m - Houston	United Airlines	UA3457 UA1568 UA6158
from $288 Find flight	11:35 Des Moines Des Moines International Airport	21:18 San Antonio San Antonio	9h 43m layover 0h 52m - Chicago 3h 2m - Houston	United Airlines	UA2306 UA1373 UA1589

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on May 09, 2025

Flight Schedule Des Moines (Iowa) to San Antonio (Texas)

Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Antonio. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
05:45 — 13:10	05:45 — 07:02 UA4700 United Airlines Des Moines — Denver 2h 56m stop 10:05 — 13:21 UA1131 United Airlines Denver — San Antonio	7h 25m including layover	Find flight from$282
05:45 — 16:40	05:45 — 07:02 UA4700 United Airlines Des Moines — Denver 6h 24m stop 13:26 — 16:40 UA1022 United Airlines Denver — San Antonio	10h 55m including layover	Find flight from$552
06:00 — 13:07	06:00 — 07:04 UA497 United Airlines Des Moines — Denver 2h 51m stop 09:55 — 13:07 UA1131 United Airlines Denver — San Antonio	7h 7m including layover	Find flight from$317
06:00 — 23:38	06:00 — 07:04 UA497 United Airlines Des Moines — Denver 13h 21m stop 20:25 — 23:38 UA2028 United Airlines Denver — San Antonio	17h 38m including layover	Find flight from$347
08:00 — 13:07	08:00 — 10:33 UA735 United Airlines Des Moines — Houston 1h 26m stop 11:59 — 13:07 UA274 United Airlines Houston — San Antonio	5h 7m including layover	Find flight from$279
08:00 — 15:26	08:00 — 10:33 UA735 United Airlines Des Moines — Houston 3h 47m stop 14:20 — 15:26 UA1264 United Airlines Houston — San Antonio	7h 26m including layover	Find flight from$279
09:00 — 16:40	09:02 — 10:17 UA581 United Airlines Des Moines — Denver 3h 16m stop 13:41 — 16:54 UA1022 United Airlines Denver — San Antonio	7h 40m including layover	Find flight from$279
09:02 — 23:38	09:02 — 10:17 UA581 United Airlines Des Moines — Denver 10h 8m stop 20:25 — 23:38 UA2028 United Airlines Denver — San Antonio	14h 36m including layover	Find flight from$347
13:45 — 20:55	13:45 — 14:51 UA5835 United Airlines Des Moines — Denver 2h 52m stop 17:43 — 20:55 UA1762 United Airlines Denver — San Antonio	7h 10m including layover	Find flight from$280
13:45 — 20:37	13:45 — 14:51 UA5669 United Airlines Des Moines — Denver 2h 34m stop 17:25 — 20:37 UA1762 United Airlines Denver — San Antonio	6h 52m including layover	Find flight from$317
14:10 — 06:57 +1 day	14:10 — 18:11 F91868 Frontier Airlines Des Moines — Orlando 10h 50m stop 05:01 — 06:57 F91653 Frontier Airlines Orlando — San Antonio	16h 47m including layover	Find flight from$545
15:00 — 21:18	15:00 — 17:35 UA6033 United Airlines Des Moines — Houston 2h 35m stop 20:10 — 21:18 UA1338 United Airlines Houston — San Antonio	6h 18m including layover	Find flight from$280
15:05 — 21:18	15:05 — 17:48 UA6033 United Airlines Des Moines — Houston 2h 18m stop 20:06 — 21:18 UA1589 United Airlines Houston — San Antonio	6h 13m including layover	Find flight from$282
17:10 — 23:38	17:10 — 18:19 UA1781 United Airlines Des Moines — Denver 2h 6m stop 20:25 — 23:38 UA2028 United Airlines Denver — San Antonio	6h 28m including layover	Find flight from$317
17:15 — 16:40 +1 day	17:10 — 18:19 UA1781 United Airlines Des Moines — Denver 19h 6m stop 13:41 — 16:54 UA1022 United Airlines Denver — San Antonio	23h 25m including layover	Find flight from$335
18:45 — 12:29 +1 day	18:45 — 20:22 UA5286 United Airlines Des Moines — Chicago 12h 53m stop 09:15 — 12:29 UA1834 United Airlines Chicago — San Antonio	17h 44m including layover	Find flight from$521
18:45 — 23:15 +1 day	18:45 — 20:22 UA5286 United Airlines Des Moines — Chicago 23h 41m stop 20:03 — 23:15 UA1504 United Airlines Chicago — San Antonio	28h 30m including layover	Find flight from$521
21:21 — 08:19 +1 day	18:51 — 19:57 F91677 Frontier Airlines Des Moines — Denver 6h 46m stop 16:25 — 19:38 F92356 Frontier Airlines Denver — San Antonio	10h 58m including layover	Find flight from$67
07:30 — 23:30	07:30 — 11:05 G4431 Allegiant Air Des Moines — Newark 5h 4m stop 16:09 — 19:09 NK1861 Spirit Airlines Newark — Orlando 2h 17m stop 21:26 — 23:30 NK446 Spirit Airlines Orlando — San Antonio	16h including layover	Find flight from$196
07:30 — 04:59 +1 day	07:30 — 11:05 G4431 Allegiant Air Des Moines — Newark 5h 38m stop 16:43 — 19:23 NK3733 Spirit Airlines Newark — Las Vegas 5h 3m stop 00:26 — 04:59 NK1058 Spirit Airlines Las Vegas — San Antonio	21h 29m including layover	Find flight from$196

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on May 9, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to San Antonio depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and San Antonio is 1404 miles. Time difference between the cities is 0h. Airplanes depart 05:45 to 21:21 from 1 Des Moines airport and arrive 05:45 to 21:21 to 5 San Antonio airports. Average flight time is 10h 8m.

The fastest flight 4h 28m
Average flight time 10h 8m
The earliest flight 05:45
The latest flight 21:21
Distance 873 ml

The cheapest months to travel to San Antonio are november (from 67 $), february (from 80 $), december (from 279 $).

The most expensive months are january (from 282 $), december (from 279 $), february (from 80 $).

What is the lowest airfare Des Moines to San Antonio?

The cheapest plane ticket found by our users is $67. This airfare is for economy class on one-way F91677 flight by Frontier Airlines for February 21, 2025 which leaves Des Moines International Airport in Des Moines at 21:21 am and arrives at San Antonio San Antonio at 08:19.

Economy class

$67

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Popular Airlines on the Route

The flight Des Moines — San Antonio is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 2 departures per week at the price of from $ 67 . And the most expensive tickets are offered by United Airlines airline - from $ 685.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 75 flights with layovers on the route. The fastest connecting flight is UA6033 by United Airlines takes 4h 28m and the cheapest is F91677 by Frontier Airlines for $67.

F9 - Frontier Airlines

from $67

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UA - United Airlines

from $279

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G4 - Allegiant Air

from $196

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Airports

You can fly from Des Moines to San Antonio from 1 airports (Des Moines International Airport).

Des Moines airports

Des Moines International Airport-DSM

from $67
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San Antonio airports

Randolph AFB-RND

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Martindale AAF-MDA

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San Antonio-SAT

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Kelly AFB-SKF

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Stinson Municipal-SSF

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Airplanes

There are flights to San Antonio from Des Moines by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Des Moines — Las Vegas

from $55

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Des Moines — Phoenix

from $71

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Des Moines — Dallas

from $73

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Des Moines — Austin

from $78

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Des Moines — Seattle

from $53

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Des Moines — Atlanta

from $58

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Des Moines — Miami

from $65

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Des Moines — Denver

from $54

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Des Moines — New Orleans

from $56

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Des Moines — San Diego

from $58

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Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Des Moines — Cancun

from $77

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Des Moines — London

from $70

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
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That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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