Cheap Flights from Des Moines, IA to San Antonio, TX from $108
Return flight: San Antonio – Des Moines
On Cheapflightsplus.com you will find 78 connecting flights from Des Moines to San Antonio. You can compare airfare deals from 3 airlines and multiple travel sites from $108, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAT flight schedule to find best flight time, convenient departure and arrival airports.
Find One-Way and Round-Trip Des Moines to San Antonio Flight Deals
To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights».
To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight.
Cheapest flights in November: $108 (one-way), $185 (round-trip).
Direct flights
Check prices for return flight
Best Flights from Des Moines to San Antonio Today
Take a look at the list of non stop flights and flights with layovers from Des Moines to San Antonio with the lowest price of $108. Take a look at the list of flights with layovers from Des Moines to San Antonio from $108. There’re no direct flights. The fastest connecting flight – 4h 15m.
| Price | Departure | Arrival | Flight Duration | Airline | Flight |
|---|---|---|---|---|---|
| from $108 | 19:33 Des Moines Des Moines International Airport | 18:02+1 день San Antonio San Antonio | 22h 29m layover 18h 12m - Denver | Frontier Airlines | F91677 F92098 |
| from $147 | 13:15 Des Moines Des Moines International Airport | 18:33+1 день San Antonio San Antonio | 29h 18m layover 23h 30m - Las Vegas | Allegiant Air | G449 NK1586 |
| from $180 | 21:10 Des Moines Des Moines International Airport | 05:04+1 день San Antonio San Antonio | 7h 54m layover 2h 4m - Las Vegas | Allegiant Air | G415 NK1058 |
| from $202 | 06:15 Des Moines Des Moines International Airport | 10:37 San Antonio San Antonio | 4h 22m layover 0h 48m - Houston | United Airlines | UA1982 UA1371 |
| from $202 | 06:00 Des Moines Des Moines International Airport | 12:43 San Antonio San Antonio | 6h 43m layover 2h 31m - Denver | United Airlines | UA4790 UA2063 |
| from $202 | 06:15 Des Moines Des Moines International Airport | 13:20 San Antonio San Antonio | 7h 5m layover 3h 31m - Houston | United Airlines | UA1982 UA468 |
| from $202 | 15:35 Des Moines Des Moines International Airport | 22:55 San Antonio San Antonio | 7h 20m layover 2h 42m - Chicago | United Airlines | UA1568 UA658 |
| from $202 | 08:00 Des Moines Des Moines International Airport | 16:03 San Antonio San Antonio | 8h 3m layover 3h 31m - Chicago | United Airlines | UA1363 UA2479 |
| from $205 | 11:35 Des Moines Des Moines International Airport | 16:51 San Antonio San Antonio | 5h 16m layover 1h 5m - Denver | United Airlines | UA5711 UA1022 |
| from $205 | 14:58 Des Moines Des Moines International Airport | 21:17 San Antonio San Antonio | 6h 19m layover 2h 45m - Houston | United Airlines | UA6033 UA1542 |
| from $205 | 06:00 Des Moines Des Moines International Airport | 12:48 San Antonio San Antonio | 6h 48m layover 2h 36m - Denver | United Airlines | UA4790 UA1544 |
| from $178 | 18:32 Des Moines Des Moines International Airport | 22:56+1 день San Antonio San Antonio | 28h 24m layover 13h 18m - Nashville 7h 56m - Miami | Allegiant Air | G4439 NK1108 NK1477 |
| from $191 | 06:30 Des Moines Des Moines International Airport | 13:06+1 день San Antonio San Antonio | 30h 36m layover 12h 34m - Houston 9h 3m - Los Angeles | Allegiant Air | G4437 NK1143 NK1273 |
| from $194 | 13:59 Des Moines Des Moines International Airport | 22:56+1 день San Antonio San Antonio | 32h 57m layover 17h 51m - Nashville 7h 56m - Miami | Allegiant Air | G4451 NK1108 NK1477 |
| from $202 | 06:30 Des Moines Des Moines International Airport | 19:43+1 день San Antonio San Antonio | 37h 13m layover 22h 15m - Miami 7h 47m - Orlando | Allegiant Air | G4466 NK1639 NK1356 |
| from $206 | 08:35 Des Moines Des Moines International Airport | 19:43+1 день San Antonio San Antonio | 35h 8m layover 18h 54m - New York 7h 54m - Orlando | Allegiant Air | G4431 NK1571 NK1356 |
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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on July 14, 2025
Flight Schedule Des Moines (Iowa) to San Antonio (Texas)
Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Antonio. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
| Departure | Arrival | Flight Details | Flight Duration | Price |
|---|---|---|---|---|
|
06:00 — 12:43
|
06:00 — 07:04
UA4790
United Airlines
Des Moines — Denver
2h 31m stop
09:35 — 12:43
UA2063
United Airlines
Denver — San Antonio
|
6h 43m including layover |
Find flight
from$202 |
|
|
08:00 — 16:03
|
08:00 — 09:34
UA1363
United Airlines
Des Moines — Chicago
3h 31m stop
13:05 — 16:03
UA2479
United Airlines
Chicago — San Antonio
|
8h 3m including layover |
Find flight
from$202 |
|
|
09:08 — 16:51
|
09:15 — 10:17
UA581
United Airlines
Des Moines — Denver
3h 36m stop
13:46 — 17:00
UA1022
United Airlines
Denver — San Antonio
|
7h 43m including layover |
Find flight
from$205 |
|
|
09:08 — 20:46
|
09:08 — 10:05
UA581
United Airlines
Des Moines — Denver
7h 30m stop
17:35 — 20:46
UA1110
United Airlines
Denver — San Antonio
|
11h 38m including layover |
Find flight
from$331 |
|
|
11:35 — 16:51
|
11:23 — 12:31
UA5711
United Airlines
Des Moines — Denver
1h 5m stop
13:46 — 17:00
UA1022
United Airlines
Denver — San Antonio
|
5h 16m including layover |
Find flight
from$205 |
|
|
11:35 — 12:48
+1 day
|
11:35 — 12:36
UA5711
United Airlines
Des Moines — Denver
21h 4m stop
09:40 — 12:48
UA1544
United Airlines
Denver — San Antonio
|
25h 13m including layover |
Find flight
from$295 |
|
|
13:15 — 18:33
+1 day
|
13:15 — 14:21
G449
Allegiant Air
Des Moines — Las Vegas
23h 30m stop
13:51 — 18:33
NK1586
Spirit Airlines
Las Vegas — San Antonio
|
29h 18m including layover |
Find flight
from$147 |
|
|
14:57 — 19:12
|
14:57 — 17:25
UA6033
United Airlines
Des Moines — Houston
40m stop
18:05 — 19:12
UA1477
United Airlines
Houston — San Antonio
|
4h 15m including layover |
Find flight
from$215 |
|
|
14:58 — 21:17
|
14:57 — 17:25
UA6033
United Airlines
Des Moines — Houston
2h 45m stop
20:20 — 21:27
UA1542
United Airlines
Houston — San Antonio
|
6h 19m including layover |
Find flight
from$205 |
|
|
15:35 — 22:55
|
15:25 — 16:58
UA1568
United Airlines
Des Moines — Chicago
2h 42m stop
19:55 — 22:59
UA658
United Airlines
Chicago — San Antonio
|
7h 20m including layover |
Find flight
from$202 |
|
|
17:12 — 23:59
|
17:12 — 18:15
UA1781
United Airlines
Des Moines — Denver
2h 28m stop
20:43 — 23:59
UA1801
United Airlines
Denver — San Antonio
|
6h 47m including layover |
Find flight
from$227 |
|
|
17:17 — 23:59
|
17:12 — 18:15
UA2681
United Airlines
Des Moines — Denver
2h 23m stop
20:43 — 23:59
UA1801
United Airlines
Denver — San Antonio
|
6h 42m including layover |
Find flight
from$238 |
|
|
19:33 — 18:02
+1 day
|
19:33 — 20:33
F91677
Frontier Airlines
Des Moines — Denver
18h 12m stop
14:45 — 18:02
F92098
Frontier Airlines
Denver — San Antonio
|
22h 29m including layover |
Find flight
from$108 |
|
|
21:10 — 05:04
+1 day
|
21:10 — 22:26
G415
Allegiant Air
Des Moines — Las Vegas
2h 4m stop
00:30 — 05:04
NK1058
Spirit Airlines
Las Vegas — San Antonio
|
7h 54m including layover |
Find flight
from$180 |
|
|
06:30 — 13:06
+1 day
|
06:30 — 08:52
G4437
Allegiant Air
Des Moines — Houston
12h 34m stop
21:26 — 23:07
NK1143
Spirit Airlines
Houston — Los Angeles
9h 3m stop
08:10 — 13:06
NK1273
Spirit Airlines
Los Angeles — San Antonio
|
30h 36m including layover |
Find flight
from$191 |
|
|
08:35 — 23:25
|
08:35 — 12:05
G4431
Allegiant Air
Des Moines — Newark
4h 5m stop
16:10 — 19:00
NK502
Spirit Airlines
Newark — Orlando
2h 43m stop
21:43 — 23:25
NK446
Spirit Airlines
Orlando — San Antonio
|
14h 50m including layover |
Find flight
from$201 |
|
|
13:59 — 22:56
+1 day
|
13:59 — 15:35
G4451
Allegiant Air
Des Moines — Nashville
17h 51m stop
09:26 — 12:44
NK1108
Spirit Airlines
Nashville — Miami
7h 56m stop
20:40 — 22:56
NK1477
Spirit Airlines
Miami — San Antonio
|
32h 57m including layover |
Find flight
from$194 |
|
|
15:44 — 09:47
+1 day
|
15:44 — 16:50
G42100
Allegiant Air
Des Moines — Las Vegas
7h 9m stop
23:59 — 05:06
SY778
Sun Country Airlines
Las Vegas — Minneapolis
1h 54m stop
07:00 — 09:47
SY1835
Sun Country Airlines
Minneapolis — San Antonio
|
18h 3m including layover |
Find flight
from$219 |
|
|
18:32 — 22:56
+1 day
|
18:32 — 20:08
G4439
Allegiant Air
Des Moines — Nashville
13h 18m stop
09:26 — 12:44
NK1108
Spirit Airlines
Nashville — Miami
7h 56m stop
20:40 — 22:56
NK1477
Spirit Airlines
Miami — San Antonio
|
28h 24m including layover |
Find flight
from$178 |
|
|
18:32 — 22:56
+1 day
|
18:32 — 20:08
G4439
Allegiant Air
Des Moines — Nashville
20h 26m stop
16:34 — 19:53
NK2048
Spirit Airlines
Nashville — Miami
47m stop
20:40 — 22:56
NK1477
Spirit Airlines
Miami — San Antonio
|
28h 24m including layover |
Find flight
from$178 |
|
*Departure and arrival times - local. Updated on July 14, 2025
Flight Information
Below we will explain in detail what the flights cost on the destination from Des Moines to San Antonio depends on and how to choose the most interesting flight option for you.
Distance between Des Moines and San Antonio is 1404 miles. Time difference between the cities is 0h. Airplanes depart 06:00 to 21:10 from 1 Des Moines airport and arrive 06:00 to 21:10 to 5 San Antonio airports. Average flight time is 12h 41m.
- The fastest flight 4h 15m
- Average flight time 12h 41m
- The earliest flight 06:00
- The latest flight 21:10
- Distance 873 ml
The cheapest months to travel to San Antonio are july (from 108 $), august (from 118 $), october (from 202 $).
The most expensive months are september (from 214 $), october (from 202 $), august (from 118 $).
What is the lowest airfare Des Moines to San Antonio?
The cheapest plane ticket found by our users is $108. This airfare is for economy class on one-way F91677 flight by Frontier Airlines for July 14, 2025 which leaves Des Moines International Airport in Des Moines at 19:33 am and arrives at San Antonio San Antonio at 18:02.
Economy class
$108
Business class
?
First class
?
Popular Airlines on the Route
The flight Des Moines — San Antonio is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 1 departures per week at the price of from $ 108 . And the most expensive tickets are offered by United Airlines airline - from $ 643.
Direct flights
There’re no direct flights on this route. Try flights with stops.
Connecting Flights
There are 78 flights with layovers on the route. The fastest connecting flight is UA6033 by United Airlines takes 4h 15m and the cheapest is F91677 by Frontier Airlines for $108.
- F9 - Frontier Airlinesfrom $108Find
- UA - United Airlinesfrom $202Find
- G4 - Allegiant Airfrom $147Find
See more connecting flights
Airports
You can fly from Des Moines to San Antonio from 1 airports (Des Moines International Airport).
Des Moines airports
- Des Moines International Airport-DSMfrom $108Find
San Antonio airports
- Randolph AFB-RNDFind
- Martindale AAF-MDAFind
- San Antonio-SATFind
- Kelly AFB-SKFFind
- Stinson Municipal-SSFFind
Airplanes
There are flights to San Antonio from Des Moines by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.
Top Domestic Destinations from Des Moines
You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.
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Top International Destinations from Des Moines
Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.
- from $77Find
- from $70Find
How to book a plane ticket yourself?
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