Cheap Flights from Des Moines, IA to San Antonio, TX from $100

One way Round trip

Adults

Children under 12

Infants under 2 without place

Economy

Business

First

done

Return flight: San Antonio – Des Moines

Page navigation

Price Calendar Cheap Flights Flights Schedule

On Cheapflightsplus.com you will find 141 connecting flights from Des Moines to San Antonio. You can compare airfare deals from 3 airlines and multiple travel sites from $100, book and save on cheap plane tickets and last minute offers. Also check out DSM-SAT flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to San Antonio Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $100 (one-way), $171 (round-trip).

Direct flights

Check to choose departure date Check to choose departure date

Check prices for return flight

Find flights

Best Flights from Des Moines to San Antonio Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to San Antonio with the lowest price of $100. Take a look at the list of flights with layovers from Des Moines to San Antonio from $100. There’re no direct flights. The fastest connecting flight – 4h 15m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $100 Find flight	19:33 Des Moines Des Moines International Airport	18:02+1 день San Antonio San Antonio	22h 29m layover 18h 12m - Denver	Frontier Airlines	F91677 F92098
from $137 Find flight	13:15 Des Moines Des Moines International Airport	18:33+1 день San Antonio San Antonio	29h 18m layover 23h 30m - Las Vegas	Allegiant Air	G449 NK1586
from $143 Find flight	18:32 Des Moines Des Moines International Airport	05:00+2 дня San Antonio San Antonio	34h 28m layover 22h 46m - Nashville 3h 27m - Las Vegas	Allegiant Air	G4434 NK2249 NK2705
from $166 Find flight	18:32 Des Moines Des Moines International Airport	22:56+1 день San Antonio San Antonio	28h 24m layover 13h 18m - Nashville 7h 56m - Miami	Allegiant Air	G4439 NK1108 NK1477

Show all tickets

*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 15, 2025

Flight Schedule Des Moines (Iowa) to San Antonio (Texas)

Full flight schedule will help you in detecting at what time planes fly from Des Moines to San Antonio. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
06:00 — 12:47	06:00 — 07:03 UA4790 United Airlines Des Moines — Denver 2h 37m stop 09:40 — 12:47 UA1131 United Airlines Denver — San Antonio	6h 47m including layover	Find flight from$187
06:00 — 12:43	06:00 — 07:04 UA4790 United Airlines Des Moines — Denver 2h 31m stop 09:35 — 12:43 UA2063 United Airlines Denver — San Antonio	6h 43m including layover	Find flight from$188
06:02 — 10:59	06:02 — 08:27 UA1982 United Airlines Des Moines — Houston 1h 23m stop 09:50 — 10:59 UA6048 United Airlines Houston — San Antonio	4h 57m including layover	Find flight from$187
06:02 — 13:19	06:02 — 08:27 UA1982 United Airlines Des Moines — Houston 3h 43m stop 12:10 — 13:19 UA6138 United Airlines Houston — San Antonio	7h 17m including layover	Find flight from$187
06:15 — 10:37	06:15 — 08:42 UA1982 United Airlines Des Moines — Houston 48m stop 09:30 — 10:37 UA1371 United Airlines Houston — San Antonio	4h 22m including layover	Find flight from$188
06:15 — 13:20	06:02 — 08:27 UA1982 United Airlines Des Moines — Houston 3h 31m stop 12:10 — 13:16 UA468 United Airlines Houston — San Antonio	7h 5m including layover	Find flight from$188
06:24 — 11:45	06:24 — 08:05 UA4677 United Airlines Des Moines — Chicago 40m stop 08:45 — 11:45 UA490 United Airlines Chicago — San Antonio	5h 21m including layover	Find flight from$187
08:00 — 16:03	08:00 — 09:34 UA1363 United Airlines Des Moines — Chicago 3h 31m stop 13:05 — 16:03 UA2479 United Airlines Chicago — San Antonio	8h 3m including layover	Find flight from$188
11:25 — 18:41	11:25 — 12:57 UA2306 United Airlines Des Moines — Chicago 2h 50m stop 15:47 — 18:41 UA406 United Airlines Chicago — San Antonio	7h 16m including layover	Find flight from$187
13:15 — 18:33 +1 day	13:15 — 14:21 G449 Allegiant Air Des Moines — Las Vegas 23h 30m stop 13:51 — 18:33 NK1586 Spirit Airlines Las Vegas — San Antonio	29h 18m including layover	Find flight from$137
13:45 — 20:57	13:45 — 14:50 UA5751 United Airlines Des Moines — Denver 2h 52m stop 17:45 — 20:57 UA1110 United Airlines Denver — San Antonio	7h 12m including layover	Find flight from$187
15:35 — 22:55	15:25 — 16:58 UA1568 United Airlines Des Moines — Chicago 2h 42m stop 19:55 — 22:59 UA658 United Airlines Chicago — San Antonio	7h 20m including layover	Find flight from$188
17:17 — 23:59	17:12 — 18:15 UA2681 United Airlines Des Moines — Denver 2h 23m stop 20:43 — 23:59 UA1801 United Airlines Denver — San Antonio	6h 42m including layover	Find flight from$187
19:33 — 18:02 +1 day	19:33 — 20:33 F91677 Frontier Airlines Des Moines — Denver 18h 12m stop 14:45 — 18:02 F92098 Frontier Airlines Denver — San Antonio	22h 29m including layover	Find flight from$100
21:10 — 05:04 +1 day	21:10 — 22:26 G415 Allegiant Air Des Moines — Las Vegas 2h 4m stop 00:30 — 05:04 NK1058 Spirit Airlines Las Vegas — San Antonio	7h 54m including layover	Find flight from$167

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on September 15, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to San Antonio depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and San Antonio is 1404 miles. Time difference between the cities is 0h. Airplanes depart 06:00 to 22:31 from 1 Des Moines airport and arrive 06:00 to 22:31 to 5 San Antonio airports. Average flight time is 17h 33m.

The fastest flight 4h 15m
Average flight time 17h 33m
The earliest flight 06:00
The latest flight 22:31
Distance 873 ml

The cheapest months to travel to San Antonio are july (from 100 $), august (from 110 $), october (from 188 $).

The most expensive months are september (from 199 $), october (from 188 $), august (from 110 $).

What is the lowest airfare Des Moines to San Antonio?

The cheapest plane ticket found by our users is $100. This airfare is for economy class on one-way F91677 flight by Frontier Airlines for August 8, 2025 which leaves Des Moines International Airport in Des Moines at 19:33 am and arrives at San Antonio San Antonio at 18:02.

Economy class

$100

Find

Business class

Find

First class

Find

Popular Airlines on the Route

The flight Des Moines — San Antonio is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 1 departures per week at the price of from $ 100 . And the most expensive tickets are offered by United Airlines airline - from $ 686.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 141 flights with layovers on the route. The fastest connecting flight is UA6033 by United Airlines takes 4h 15m and the cheapest is F91677 by Frontier Airlines for $100.

F9 - Frontier Airlines

from $100

Find
UA - United Airlines

from $187

Find
G4 - Allegiant Air

from $137

Find

See more connecting flights

Airports

You can fly from Des Moines to San Antonio from 1 airports (Des Moines International Airport).

Des Moines airports

Des Moines International Airport-DSM

from $100
Find

San Antonio airports

Randolph AFB-RND

Find
Martindale AAF-MDA

Find
San Antonio-SAT

Find
Kelly AFB-SKF

Find
Stinson Municipal-SSF

Find

Airplanes

There are flights to San Antonio from Des Moines by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Des Moines — Las Vegas

from $55

Find
Des Moines — Phoenix

from $71

Find
Des Moines — Dallas

from $73

Find
Des Moines — Austin

from $78

Find
Des Moines — Seattle

from $53

Find
Des Moines — Atlanta

from $58

Find
Des Moines — Miami

from $65

Find
Des Moines — Denver

from $54

Find
Des Moines — New Orleans

from $56

Find
Des Moines — San Diego

from $58

Find

Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Des Moines — Cancun

from $77

Find
Des Moines — London

from $70

Find

How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
To find a plane ticket, please select dates.