Cheap Flights from San Antonio, TX to Des Moines, IA from $95

Return flight: Des Moines – San Antonio
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On Cheapflightsplus.com you will find 140 connecting flights from San Antonio to Des Moines. You can compare airfare deals from 4 airlines and multiple travel sites from $95, book and save on cheap plane tickets and last minute offers. Also check out SAT-DSM flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip San Antonio to Des Moines Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $95 (one-way), $163 (round-trip).
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Best Flights from San Antonio to Des Moines Today

Take a look at the list of non stop flights and flights with layovers from San Antonio to Des Moines with the lowest price of $95. Take a look at the list of flights with layovers from San Antonio to Des Moines from $95. There’re no direct flights. The fastest connecting flight – 4h 20m.
Price Departure Arrival Flight Duration Airline Flight
from $95
Find flight
17:38
San Antonio
San Antonio
 18:05+1 день
Des Moines
Des Moines International Airport
 24h 27m
layover
20h 34m - Nashville
 Spirit Airlines
NK1876
G4448
from $111
Find flight
20:14
San Antonio
San Antonio
 18:48+1 день
Des Moines
Des Moines International Airport
 22h 34m
layover
18h 15m - Denver
 Frontier Airlines
F92097
F91678
from $129
Find flight
08:33
San Antonio
San Antonio
 18:05+1 день
Des Moines
Des Moines International Airport
 33h 32m
layover
3h 28m - Orlando
23h 36m - Nashville
 Spirit Airlines
NK1359
NK1456
G4448
from $154
Find flight
07:10
San Antonio
San Antonio
 22:38
Des Moines
Des Moines International Airport
 15h 28m
layover
3h 15m - Miami
5h 29m - Nashville
 Spirit Airlines
NK1463
NK2047
G4466
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 15, 2025
Full flight schedule will help you in detecting at what time planes fly from San Antonio to Des Moines. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
05:15 — 10:36
05:15 — 06:34 UA1399 United Airlines
San Antonio — Denver
1h 11m stop
07:45 — 10:36 UA5718 United Airlines
Denver — Des Moines
5h 21m
including layover
Find flight
from$188
06:30 — 12:23
06:30 — 09:29 UA2008 United Airlines
San Antonio — Chicago
1h 18m stop
10:47 — 12:23 UA5446 United Airlines
Chicago — Des Moines
5h 53m
including layover
Find flight
from$190
06:45 — 14:44
06:45 — 09:44 UA2629 United Airlines
San Antonio — Chicago
3h 28m stop
13:12 — 14:44 UA3535 United Airlines
Chicago — Des Moines
7h 59m
including layover
Find flight
from$188
07:30 — 14:16
07:18 — 08:22 UA1486 United Airlines
San Antonio — Houston
3h 19m stop
11:55 — 14:17 UA6166 United Airlines
Houston — Des Moines
6h 46m
including layover
Find flight
from$188
08:33 — 13:31
+1 day
08:33 — 12:17 NK1359 Spirit Airlines
San Antonio — Sanford
23h 21m stop
11:38 — 13:31 G4434 Allegiant Air
Sanford — Des Moines
28h 58m
including layover
Find flight
from$174
08:55 — 16:10
08:55 — 10:12 UA1424 United Airlines
San Antonio — Denver
3h 13m stop
13:25 — 16:10 UA2265 United Airlines
Denver — Des Moines
7h 15m
including layover
Find flight
from$188
09:56 — 14:16
09:39 — 10:45 UA1798 United Airlines
San Antonio — Houston
53m stop
11:55 — 14:16 UA6166 United Airlines
Houston — Des Moines
4h 20m
including layover
Find flight
from$188
16:21 — 22:17
16:21 — 17:25 UA1066 United Airlines
San Antonio — Houston
2h 30m stop
19:55 — 22:17 UA1780 United Airlines
Houston — Des Moines
5h 56m
including layover
Find flight
from$188
16:36 — 23:59
16:30 — 18:02 UA624 United Airlines
San Antonio — Denver
2h 55m stop
21:03 — 23:59 UA5954 United Airlines
Denver — Des Moines
7h 23m
including layover
Find flight
from$188
17:38 — 18:05
+1 day
17:38 — 19:51 NK1876 Spirit Airlines
San Antonio — Nashville
20h 34m stop
16:26 — 18:06 G4448 Allegiant Air
Nashville — Des Moines
24h 27m
including layover
Find flight
from$95
17:38 — 22:38
17:38 — 19:51 NK1876 Spirit Airlines
San Antonio — Nashville
1h 7m stop
20:58 — 22:38 G4466 Allegiant Air
Nashville — Des Moines
5h
including layover
Find flight
from$102
17:38 — 22:38
17:38 — 19:51 NK1876 Spirit Airlines
San Antonio — Nashville
1h 7m stop
20:58 — 22:38 G4442 Allegiant Air
Nashville — Des Moines
5h
including layover
Find flight
from$116
17:56 — 22:17
17:56 — 19:02 UA2170 United Airlines
San Antonio — Houston
53m stop
19:55 — 22:17 UA1780 United Airlines
Houston — Des Moines
4h 21m
including layover
Find flight
from$188
18:13 — 18:06
+1 day
18:16 — 20:26 NK2039 Spirit Airlines
San Antonio — Nashville
20h stop
18:27 — 20:09 G4442 Allegiant Air
Nashville — Des Moines
23h 53m
including layover
Find flight
from$104
20:14 — 18:48
+1 day
20:14 — 21:45 F92097 Frontier Airlines
San Antonio — Denver
18h 15m stop
16:00 — 18:48 F91678 Frontier Airlines
Denver — Des Moines
22h 34m
including layover
Find flight
from$111
*Departure and arrival times - local. Updated on September 15, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from San Antonio to Des Moines depends on and how to choose the most interesting flight option for you.

Distance between San Antonio and Des Moines is 1404 miles. Time difference between the cities is 0h. Airplanes depart 05:00 to 22:57 from 5 San Antonio airports and arrive 05:00 to 22:57 to 1 Des Moines airport. Average flight time is 19h 24m.

  • The fastest flight 4h 20m
  • Average flight time 19h 24m
  • The earliest flight 05:00
  • The latest flight 22:57
  • Distance 873 ml

The cheapest months to travel to Des Moines are july (from 95 $), august (from 95 $), october (from 184 $).

The most expensive months are february (from 607 $), december (from 424 $), november (from 305 $).

What is the lowest airfare San Antonio to Des Moines?

The cheapest plane ticket found by our users is $95. This airfare is for economy class on one-way NK1876 flight by Spirit Airlines for August 7, 2025 which leaves San Antonio in San Antonio at 17:38 am and arrives at Des Moines Des Moines International Airport at 18:05.

Economy class
$95
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Business class
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First class
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Popular Airlines on the Route

The flight San Antonio — Des Moines is served by 4 regular airlines and 3 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 1 departures per week at the price of from $ 111 . And the most expensive tickets are offered by United Airlines airline - from $ 483.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 140 flights with layovers on the route. The fastest connecting flight is UA1798 by United Airlines takes 4h 20m and the cheapest is NK1876 by Spirit Airlines for $95.

  • F9 - Frontier Airlines
    from $111
    Find
  • SY - Sun Country Airlines
    from $238
    Find
  • UA - United Airlines
    from $188
    Find
  • NK - Spirit Airlines
    from $95
    Find
See more connecting flights

Airports

You can fly from San Antonio to Des Moines from 5 airports (Randolph AFB, Martindale AAF, San Antonio, Kelly AFB, Stinson Municipal).

San Antonio airports

  • Randolph AFB-RND
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  • Martindale AAF-MDA
    Find
  • San Antonio-SAT
    from $95
    Find
  • Kelly AFB-SKF
    Find
  • Stinson Municipal-SSF
    Find

Des Moines airports

  • Des Moines International Airport-DSM
    Find

Airplanes

There are flights to Des Moines from San Antonio by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from San Antonio

You may also consider searching for discounted plane tickets to some other popular places from San Antonio within United States.

Top International Destinations from San Antonio

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
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  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

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