Cheap Flights from Des Moines, IA to Indianapolis, IN from $99

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On Cheapflightsplus.com you will find 123 connecting flights from Des Moines to Indianapolis. You can compare airfare deals from 2 airlines and multiple travel sites from $99, book and save on cheap plane tickets and last minute offers. Also check out DSM-IND flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to Indianapolis Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $99 (one-way), $170 (round-trip).

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Best Flights from Des Moines to Indianapolis Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to Indianapolis with the lowest price of $99. Take a look at the list of flights with layovers from Des Moines to Indianapolis from $99. There’re no direct flights. The fastest connecting flight – 3h 25m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $99 Find flight	08:30 Des Moines Des Moines International Airport	22:23 Indianapolis Indianapolis Int.	12h 53m layover 8h 19m - Jacksonville	Allegiant Air	G43450 G4607
from $112 Find flight	17:04 Des Moines Des Moines International Airport	19:15+1 день Indianapolis Indianapolis Int.	25h 11m layover 20h 10m - Sanford	Allegiant Air	G42850 G4600
from $113 Find flight	18:00 Des Moines Des Moines International Airport	20:34+1 день Indianapolis Indianapolis Int.	25h 34m layover 20h 31m - Sanford	Allegiant Air	G41314 G4593
from $114 Find flight	15:44 Des Moines Des Moines International Airport	15:26+1 день Indianapolis Indianapolis Int.	22h 42m layover 15h 55m - Las Vegas	Allegiant Air	G42100 G4613
from $121 Find flight	17:04 Des Moines Des Moines International Airport	09:20+1 день Indianapolis Indianapolis Int.	15h 16m layover 10h 8m - Orlando	Allegiant Air	G42850 NK1510
from $122 Find flight	10:40 Des Moines Des Moines International Airport	19:15 Indianapolis Indianapolis Int.	7h 35m layover 2h 9m - Punta Gorda	Allegiant Air	G4463 G42229
from $127 Find flight	09:30 Des Moines Des Moines International Airport	23:03 Indianapolis Indianapolis Int.	12h 33m layover 7h 36m - Clearwater	Allegiant Air	G41038 G4624
from $132 Find flight	10:40 Des Moines Des Moines International Airport	11:41+1 день Indianapolis Indianapolis Int.	24h 1m layover 18h 35m - Punta Gorda	Allegiant Air	G4453 G4633
from $135 Find flight	09:30 Des Moines Des Moines International Airport	14:00+1 день Indianapolis Indianapolis Int.	27h 30m layover 22h 33m - Clearwater	Allegiant Air	G41038 G4603
from $135 Find flight	15:45 Des Moines Des Moines International Airport	21:47+1 день Indianapolis Indianapolis Int.	29h 2m layover 23h 53m - Clearwater	Allegiant Air	G4467 G42231
from $137 Find flight	09:30 Des Moines Des Moines International Airport	21:57 Indianapolis Indianapolis Int.	11h 27m layover 6h 22m - Tampa	Allegiant Air	G41038 NK1520
from $140 Find flight	15:29 Des Moines Des Moines International Airport	23:39+1 день Indianapolis Indianapolis Int.	31h 10m layover 23h 25m - Portland	Allegiant Air	G4452 G43511
from $141 Find flight	11:35 Des Moines Des Moines International Airport	08:56+1 день Indianapolis Indianapolis Int.	20h 21m layover 14h 56m - Punta Gorda	Allegiant Air	G4463 G4851
from $143 Find flight	12:43 Des Moines Des Moines International Airport	13:23+1 день Indianapolis Indianapolis Int.	23h 40m layover 19h 15m - Austin	Allegiant Air	G4436 G4587
from $154 Find flight	14:00 Des Moines Des Moines International Airport	15:24+1 день Indianapolis Indianapolis Int.	24h 24m layover 5h 14m - Nashville 13h 13m - Newark	Allegiant Air	G4451 NK1419 NK1522
from $182 Find flight	08:35 Des Moines Des Moines International Airport	18:12 Indianapolis Indianapolis Int.	8h 37m layover 1h 18m - Newark 1h 5m - Atlanta	Allegiant Air	G4431 NK742 NK1115

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on July 12, 2025

Flight Schedule Des Moines (Iowa) to Indianapolis (Indiana)

Full flight schedule will help you in detecting at what time planes fly from Des Moines to Indianapolis. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
06:30 — 22:27	06:30 — 10:40 G4466 Allegiant Air Des Moines — Miami 9h 8m stop 19:48 — 22:27 G4609 Allegiant Air Miami — Indianapolis	14h 57m including layover	Find flight from$155
06:30 — 12:11 +1 day	06:30 — 10:40 G4469 Allegiant Air Des Moines — Miami 22h 52m stop 09:32 — 12:11 G4628 Allegiant Air Miami — Indianapolis	28h 41m including layover	Find flight from$160
07:30 — 12:48 +1 day	07:30 — 11:12 G4479 Allegiant Air Des Moines — Clearwater 23h 21m stop 10:33 — 12:48 G42254 Allegiant Air Clearwater — Indianapolis	28h 18m including layover	Find flight from$155
08:30 — 22:23	08:30 — 12:07 G43450 Allegiant Air Des Moines — Jacksonville 8h 19m stop 20:26 — 22:23 G4607 Allegiant Air Jacksonville — Indianapolis	12h 53m including layover	Find flight from$99
08:30 — 22:23	08:30 — 12:07 G43450 Allegiant Air Des Moines — Jacksonville 8h 19m stop 20:26 — 22:23 G4611 Allegiant Air Jacksonville — Indianapolis	12h 53m including layover	Find flight from$101
09:30 — 23:03	09:30 — 13:12 G41038 Allegiant Air Des Moines — Clearwater 7h 36m stop 20:48 — 23:03 G4624 Allegiant Air Clearwater — Indianapolis	12h 33m including layover	Find flight from$127
09:30 — 14:00 +1 day	09:30 — 13:12 G41038 Allegiant Air Des Moines — Clearwater 22h 33m stop 11:45 — 14:00 G4603 Allegiant Air Clearwater — Indianapolis	27h 30m including layover	Find flight from$135
10:40 — 19:15	10:40 — 14:42 G4463 Allegiant Air Des Moines — Punta Gorda 2h 9m stop 16:51 — 19:15 G42229 Allegiant Air Punta Gorda — Indianapolis	7h 35m including layover	Find flight from$122
10:40 — 11:41 +1 day	10:40 — 14:42 G4453 Allegiant Air Des Moines — Punta Gorda 18h 35m stop 09:17 — 11:41 G4633 Allegiant Air Punta Gorda — Indianapolis	24h 1m including layover	Find flight from$132
11:35 — 08:56 +1 day	11:35 — 15:34 G4463 Allegiant Air Des Moines — Punta Gorda 14h 56m stop 06:30 — 08:56 G4851 Allegiant Air Punta Gorda — Indianapolis	20h 21m including layover	Find flight from$141
11:35 — 16:32	11:35 — 13:09 UA2306 United Airlines Des Moines — Chicago 1h 11m stop 14:20 — 16:32 UA705 United Airlines Chicago — Indianapolis	3h 57m including layover	Find flight from$173
12:43 — 13:23 +1 day	12:43 — 14:45 G4436 Allegiant Air Des Moines — Austin 19h 15m stop 10:00 — 13:23 G4587 Allegiant Air Austin — Indianapolis	23h 40m including layover	Find flight from$143
12:43 — 13:23 +1 day	12:43 — 14:45 G4436 Allegiant Air Des Moines — Austin 19h 15m stop 10:00 — 13:23 G4589 Allegiant Air Austin — Indianapolis	23h 40m including layover	Find flight from$163
13:10 — 17:55	13:10 — 14:47 UA4779 United Airlines Des Moines — Chicago 54m stop 15:41 — 17:55 UA3690 United Airlines Chicago — Indianapolis	3h 45m including layover	Find flight from$173
13:10 — 20:09	13:10 — 14:47 UA4779 United Airlines Des Moines — Chicago 3h 8m stop 17:55 — 20:09 UA3628 United Airlines Chicago — Indianapolis	5h 59m including layover	Find flight from$173
14:39 — 22:23 +1 day	14:39 — 16:17 G42073 Allegiant Air Des Moines — Portland 23h 4m stop 15:21 — 22:23 G43511 Allegiant Air Portland — Indianapolis	30h 44m including layover	Find flight from$150
14:58 — 23:27	14:57 — 17:25 UA6033 United Airlines Des Moines — Houston 2h 38m stop 20:03 — 23:30 UA465 United Airlines Houston — Indianapolis	7h 29m including layover	Find flight from$173
15:44 — 15:26 +1 day	15:44 — 16:50 G42100 Allegiant Air Des Moines — Las Vegas 15h 55m stop 08:45 — 15:26 G4613 Allegiant Air Las Vegas — Indianapolis	22h 42m including layover	Find flight from$114
15:45 — 21:47 +1 day	15:45 — 19:33 G4467 Allegiant Air Des Moines — Clearwater 23h 53m stop 19:26 — 21:47 G42231 Allegiant Air Clearwater — Indianapolis	29h 2m including layover	Find flight from$135
17:04 — 19:15 +1 day	17:04 — 20:52 G42850 Allegiant Air Des Moines — Sanford 20h 10m stop 17:02 — 19:15 G4600 Allegiant Air Sanford — Indianapolis	25h 11m including layover	Find flight from$112
17:04 — 09:20 +1 day	17:04 — 20:52 G42850 Allegiant Air Des Moines — Orlando 10h 8m stop 07:00 — 09:20 NK1510 Spirit Airlines Orlando — Indianapolis	15h 16m including layover	Find flight from$121
18:00 — 20:34 +1 day	18:00 — 21:45 G41314 Allegiant Air Des Moines — Sanford 20h 31m stop 18:16 — 20:34 G4593 Allegiant Air Sanford — Indianapolis	25h 34m including layover	Find flight from$113
18:15 — 23:31	18:15 — 19:49 UA2347 United Airlines Des Moines — Chicago 1h 23m stop 21:12 — 23:31 UA3526 United Airlines Chicago — Indianapolis	4h 16m including layover	Find flight from$173
19:54 — 23:03 +1 day	19:54 — 23:39 G41057 Allegiant Air Des Moines — Clearwater 21h 9m stop 20:48 — 23:03 G42234 Allegiant Air Clearwater — Indianapolis	26h 9m including layover	Find flight from$150
22:31 — 15:26 +1 day	22:31 — 23:37 G415 Allegiant Air Des Moines — Las Vegas 9h 8m stop 08:45 — 15:26 G4616 Allegiant Air Las Vegas — Indianapolis	15h 55m including layover	Find flight from$218

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on July 12, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to Indianapolis depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and Indianapolis is 652 miles. Time difference between the cities is 1h. Airplanes depart 06:00 to 22:31 from 1 Des Moines airport and arrive 06:00 to 22:31 to 1 Indianapolis airport. Average flight time is 14h 57m.

The fastest flight 3h 25m
Average flight time 14h 57m
The earliest flight 06:00
The latest flight 22:31
Distance 406 ml

The cheapest months to travel to Indianapolis are july (from 99 $), august (from 113 $).

What is the lowest airfare Des Moines to Indianapolis?

The cheapest plane ticket found by our users is $99. This airfare is for economy class on one-way G43450 flight by Allegiant Air for July 24, 2025 which leaves Des Moines International Airport in Des Moines at 08:30 am and arrives at Indianapolis Indianapolis Int. at 22:23.

Economy class

$99

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First class

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Popular Airlines on the Route

The flight Des Moines — Indianapolis is served by 2 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by United Airlines - 53 departures per week at the price of from $ 173 . And the most expensive tickets are offered by United Airlines airline - from $ 590.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 123 flights with layovers on the route. The fastest connecting flight is UA1568 by United Airlines takes 3h 25m and the cheapest is G43450 by Allegiant Air for $99.

UA - United Airlines

from $173

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G4 - Allegiant Air

from $99

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Airports

You can fly from Des Moines to Indianapolis from 1 airports (Des Moines International Airport).

Des Moines airports

Des Moines International Airport-DSM

from $99
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Indianapolis airports

Indianapolis Int.-IND

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Airplanes

There are flights to Indianapolis from Des Moines by 2 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Des Moines — Las Vegas

from $55

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Des Moines — Phoenix

from $71

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Des Moines — Dallas

from $73

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Des Moines — Austin

from $78

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Des Moines — Seattle

from $53

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Des Moines — Atlanta

from $58

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Des Moines — Miami

from $65

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Des Moines — Denver

from $54

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Des Moines — New Orleans

from $56

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Des Moines — San Diego

from $58

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Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Des Moines — Cancun

from $77

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Des Moines — London

from $70

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How to book a plane ticket yourself?

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