Cheap Flights from Des Moines, IA to Indianapolis, IN from $99

On Cheapflightsplus.com you will find 123 connecting flights from Des Moines to Indianapolis. You can compare airfare deals from 2 airlines and multiple travel sites from $99, book and save on cheap plane tickets and last minute offers. Also check out DSM-IND flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to Indianapolis Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $99 (one-way), $170 (round-trip).
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Full flight schedule will help you in detecting at what time planes fly from Des Moines to Indianapolis. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
06:30 — 22:27
06:30 — 10:40 G4466 Allegiant Air
Des Moines — Miami
9h 8m stop
19:48 — 22:27 G4609 Allegiant Air
Miami — Indianapolis
14h 57m
including layover
Find flight
from$155
06:30 — 12:11
+1 day
06:30 — 10:40 G4469 Allegiant Air
Des Moines — Miami
22h 52m stop
09:32 — 12:11 G4628 Allegiant Air
Miami — Indianapolis
28h 41m
including layover
Find flight
from$160
07:30 — 12:48
+1 day
07:30 — 11:12 G4479 Allegiant Air
Des Moines — Clearwater
23h 21m stop
10:33 — 12:48 G42254 Allegiant Air
Clearwater — Indianapolis
28h 18m
including layover
Find flight
from$155
08:30 — 22:23
08:30 — 12:07 G43450 Allegiant Air
Des Moines — Jacksonville
8h 19m stop
20:26 — 22:23 G4607 Allegiant Air
Jacksonville — Indianapolis
12h 53m
including layover
Find flight
from$99
08:30 — 22:23
08:30 — 12:07 G43450 Allegiant Air
Des Moines — Jacksonville
8h 19m stop
20:26 — 22:23 G4611 Allegiant Air
Jacksonville — Indianapolis
12h 53m
including layover
Find flight
from$101
09:30 — 23:03
09:30 — 13:12 G41038 Allegiant Air
Des Moines — Clearwater
7h 36m stop
20:48 — 23:03 G4624 Allegiant Air
Clearwater — Indianapolis
12h 33m
including layover
Find flight
from$127
09:30 — 14:00
+1 day
09:30 — 13:12 G41038 Allegiant Air
Des Moines — Clearwater
22h 33m stop
11:45 — 14:00 G4603 Allegiant Air
Clearwater — Indianapolis
27h 30m
including layover
Find flight
from$135
10:40 — 19:15
10:40 — 14:42 G4463 Allegiant Air
Des Moines — Punta Gorda
2h 9m stop
16:51 — 19:15 G42229 Allegiant Air
Punta Gorda — Indianapolis
7h 35m
including layover
Find flight
from$122
10:40 — 11:41
+1 day
10:40 — 14:42 G4453 Allegiant Air
Des Moines — Punta Gorda
18h 35m stop
09:17 — 11:41 G4633 Allegiant Air
Punta Gorda — Indianapolis
24h 1m
including layover
Find flight
from$132
11:35 — 08:56
+1 day
11:35 — 15:34 G4463 Allegiant Air
Des Moines — Punta Gorda
14h 56m stop
06:30 — 08:56 G4851 Allegiant Air
Punta Gorda — Indianapolis
20h 21m
including layover
Find flight
from$141
11:35 — 16:32
11:35 — 13:09 UA2306 United Airlines
Des Moines — Chicago
1h 11m stop
14:20 — 16:32 UA705 United Airlines
Chicago — Indianapolis
3h 57m
including layover
Find flight
from$173
12:43 — 13:23
+1 day
12:43 — 14:45 G4436 Allegiant Air
Des Moines — Austin
19h 15m stop
10:00 — 13:23 G4587 Allegiant Air
Austin — Indianapolis
23h 40m
including layover
Find flight
from$143
12:43 — 13:23
+1 day
12:43 — 14:45 G4436 Allegiant Air
Des Moines — Austin
19h 15m stop
10:00 — 13:23 G4589 Allegiant Air
Austin — Indianapolis
23h 40m
including layover
Find flight
from$163
13:10 — 17:55
13:10 — 14:47 UA4779 United Airlines
Des Moines — Chicago
54m stop
15:41 — 17:55 UA3690 United Airlines
Chicago — Indianapolis
3h 45m
including layover
Find flight
from$173
13:10 — 20:09
13:10 — 14:47 UA4779 United Airlines
Des Moines — Chicago
3h 8m stop
17:55 — 20:09 UA3628 United Airlines
Chicago — Indianapolis
5h 59m
including layover
Find flight
from$173
14:39 — 22:23
+1 day
14:39 — 16:17 G42073 Allegiant Air
Des Moines — Portland
23h 4m stop
15:21 — 22:23 G43511 Allegiant Air
Portland — Indianapolis
30h 44m
including layover
Find flight
from$150
14:58 — 23:27
14:57 — 17:25 UA6033 United Airlines
Des Moines — Houston
2h 38m stop
20:03 — 23:30 UA465 United Airlines
Houston — Indianapolis
7h 29m
including layover
Find flight
from$173
15:44 — 15:26
+1 day
15:44 — 16:50 G42100 Allegiant Air
Des Moines — Las Vegas
15h 55m stop
08:45 — 15:26 G4613 Allegiant Air
Las Vegas — Indianapolis
22h 42m
including layover
Find flight
from$114
15:45 — 21:47
+1 day
15:45 — 19:33 G4467 Allegiant Air
Des Moines — Clearwater
23h 53m stop
19:26 — 21:47 G42231 Allegiant Air
Clearwater — Indianapolis
29h 2m
including layover
Find flight
from$135
17:04 — 19:15
+1 day
17:04 — 20:52 G42850 Allegiant Air
Des Moines — Sanford
20h 10m stop
17:02 — 19:15 G4600 Allegiant Air
Sanford — Indianapolis
25h 11m
including layover
Find flight
from$112
17:04 — 09:20
+1 day
17:04 — 20:52 G42850 Allegiant Air
Des Moines — Orlando
10h 8m stop
07:00 — 09:20 NK1510 Spirit Airlines
Orlando — Indianapolis
15h 16m
including layover
Find flight
from$121
18:00 — 20:34
+1 day
18:00 — 21:45 G41314 Allegiant Air
Des Moines — Sanford
20h 31m stop
18:16 — 20:34 G4593 Allegiant Air
Sanford — Indianapolis
25h 34m
including layover
Find flight
from$113
18:15 — 23:31
18:15 — 19:49 UA2347 United Airlines
Des Moines — Chicago
1h 23m stop
21:12 — 23:31 UA3526 United Airlines
Chicago — Indianapolis
4h 16m
including layover
Find flight
from$173
19:54 — 23:03
+1 day
19:54 — 23:39 G41057 Allegiant Air
Des Moines — Clearwater
21h 9m stop
20:48 — 23:03 G42234 Allegiant Air
Clearwater — Indianapolis
26h 9m
including layover
Find flight
from$150
22:31 — 15:26
+1 day
22:31 — 23:37 G415 Allegiant Air
Des Moines — Las Vegas
9h 8m stop
08:45 — 15:26 G4616 Allegiant Air
Las Vegas — Indianapolis
15h 55m
including layover
Find flight
from$218
*Departure and arrival times - local. Updated on July 12, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to Indianapolis depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and Indianapolis is 652 miles. Time difference between the cities is 1h. Airplanes depart 06:00 to 22:31 from 1 Des Moines airport and arrive 06:00 to 22:31 to 1 Indianapolis airport. Average flight time is 14h 57m.

  • The fastest flight 3h 25m
  • Average flight time 14h 57m
  • The earliest flight 06:00
  • The latest flight 22:31
  • Distance 406 ml

The cheapest months to travel to Indianapolis are july (from 99 $), august (from 113 $).

What is the lowest airfare Des Moines to Indianapolis?

The cheapest plane ticket found by our users is $99. This airfare is for economy class on one-way G43450 flight by Allegiant Air for July 24, 2025 which leaves Des Moines International Airport in Des Moines at 08:30 am and arrives at Indianapolis Indianapolis Int. at 22:23.

Economy class
$99
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Business class
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First class
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Popular Airlines on the Route

The flight Des Moines — Indianapolis is served by 2 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by United Airlines - 53 departures per week at the price of from $ 173 . And the most expensive tickets are offered by United Airlines airline - from $ 590.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 123 flights with layovers on the route. The fastest connecting flight is UA1568 by United Airlines takes 3h 25m and the cheapest is G43450 by Allegiant Air for $99.

  • UA - United Airlines
    from $173
    Find
  • G4 - Allegiant Air
    from $99
    Find
See more connecting flights

Airports

You can fly from Des Moines to Indianapolis from 1 airports (Des Moines International Airport).

Des Moines airports

  • Des Moines International Airport-DSM
    from $99
    Find

Indianapolis airports

  • Indianapolis Int.-IND
    Find

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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