Cheap Flights from Des Moines, IA to Indianapolis, IN from $94

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On Cheapflightsplus.com you will find 221 connecting flights from Des Moines to Indianapolis. You can compare airfare deals from 3 airlines and multiple travel sites from $94, book and save on cheap plane tickets and last minute offers. Also check out DSM-IND flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to Indianapolis Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $94 (one-way), $161 (round-trip).

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Best Flights from Des Moines to Indianapolis Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to Indianapolis with the lowest price of $94. Take a look at the list of flights with layovers from Des Moines to Indianapolis from $94. There’re no direct flights. The fastest connecting flight – 3h 25m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $94 Find flight	08:30 Des Moines Des Moines International Airport	22:23 Indianapolis Indianapolis Int.	12h 53m layover 8h 19m - Jacksonville	Allegiant Air	G43450 G4607
from $108 Find flight	20:38 Des Moines Des Moines International Airport	00:43+2 дня Indianapolis Indianapolis Int.	27h 5m layover 22h 21m - Denver	Frontier Airlines	F91677 F92346
from $141 Find flight	22:31 Des Moines Des Moines International Airport	18:38+1 день Indianapolis Indianapolis Int.	19h 7m layover 6h 8m - Las Vegas 4h 35m - Los Angeles	Allegiant Air	G415 NK2071 NK2545
from $172 Find flight	08:35 Des Moines Des Moines International Airport	18:12 Indianapolis Indianapolis Int.	8h 37m layover 1h 18m - Newark 1h 5m - Atlanta	Allegiant Air	G4431 NK742 NK1115

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 16, 2025

Flight Schedule Des Moines (Iowa) to Indianapolis (Indiana)

Full flight schedule will help you in detecting at what time planes fly from Des Moines to Indianapolis. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
06:00 — 17:49	06:00 — 09:43 G4441 Allegiant Air Des Moines — Tampa 5h 38m stop 15:21 — 17:49 NK2322 Spirit Airlines Tampa — Indianapolis	10h 49m including layover	Find flight from$123
08:30 — 22:23	08:30 — 12:07 G43450 Allegiant Air Des Moines — Jacksonville 8h 19m stop 20:26 — 22:23 G4607 Allegiant Air Jacksonville — Indianapolis	12h 53m including layover	Find flight from$94
08:30 — 22:23	08:30 — 12:07 G43450 Allegiant Air Des Moines — Jacksonville 8h 19m stop 20:26 — 22:23 G4611 Allegiant Air Jacksonville — Indianapolis	12h 53m including layover	Find flight from$96
08:35 — 18:52	08:35 — 12:05 G4431 Allegiant Air Des Moines — Newark 4h 30m stop 16:35 — 18:52 NK2112 Spirit Airlines Newark — Indianapolis	9h 17m including layover	Find flight from$109
09:30 — 23:03	09:30 — 13:12 G4973 Allegiant Air Des Moines — Clearwater 7h 36m stop 20:48 — 23:03 G42234 Allegiant Air Clearwater — Indianapolis	12h 33m including layover	Find flight from$102
09:30 — 23:03	09:30 — 13:12 G41038 Allegiant Air Des Moines — Clearwater 7h 36m stop 20:48 — 23:03 G4624 Allegiant Air Clearwater — Indianapolis	12h 33m including layover	Find flight from$120
09:30 — 14:00 +1 day	09:30 — 13:12 G41038 Allegiant Air Des Moines — Clearwater 22h 33m stop 11:45 — 14:00 G4603 Allegiant Air Clearwater — Indianapolis	27h 30m including layover	Find flight from$128
10:40 — 19:15	10:40 — 14:42 G4463 Allegiant Air Des Moines — Punta Gorda 2h 9m stop 16:51 — 19:15 G42229 Allegiant Air Punta Gorda — Indianapolis	7h 35m including layover	Find flight from$116
10:40 — 11:41 +1 day	10:40 — 14:42 G4453 Allegiant Air Des Moines — Punta Gorda 18h 35m stop 09:17 — 11:41 G4633 Allegiant Air Punta Gorda — Indianapolis	24h 1m including layover	Find flight from$125
15:44 — 15:26 +1 day	15:44 — 16:50 G42100 Allegiant Air Des Moines — Las Vegas 15h 55m stop 08:45 — 15:26 G4613 Allegiant Air Las Vegas — Indianapolis	22h 42m including layover	Find flight from$108
15:45 — 21:47 +1 day	15:45 — 19:33 G4467 Allegiant Air Des Moines — Clearwater 23h 53m stop 19:26 — 21:47 G42231 Allegiant Air Clearwater — Indianapolis	29h 2m including layover	Find flight from$128
17:04 — 19:15 +1 day	17:04 — 20:52 G42850 Allegiant Air Des Moines — Sanford 20h 10m stop 17:02 — 19:15 G4600 Allegiant Air Sanford — Indianapolis	25h 11m including layover	Find flight from$106
17:04 — 09:20 +1 day	17:04 — 20:52 G42850 Allegiant Air Des Moines — Orlando 10h 8m stop 07:00 — 09:20 NK1510 Spirit Airlines Orlando — Indianapolis	15h 16m including layover	Find flight from$114
18:00 — 20:34 +1 day	18:00 — 21:45 G41314 Allegiant Air Des Moines — Sanford 20h 31m stop 18:16 — 20:34 G4593 Allegiant Air Sanford — Indianapolis	25h 34m including layover	Find flight from$107
20:38 — 00:43 +2 days	20:38 — 21:48 F91677 Frontier Airlines Des Moines — Denver 22h 21m stop 20:09 — 00:43 F92346 Frontier Airlines Denver — Indianapolis	27h 5m including layover	Find flight from$108

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on September 16, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to Indianapolis depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and Indianapolis is 652 miles. Time difference between the cities is 1h. Airplanes depart 06:00 to 22:31 from 1 Des Moines airport and arrive 06:00 to 22:31 to 1 Indianapolis airport. Average flight time is 17h 59m.

The fastest flight 3h 25m
Average flight time 17h 59m
The earliest flight 06:00
The latest flight 22:31
Distance 406 ml

The cheapest months to travel to Indianapolis are july (from 94 $), august (from 107 $).

What is the lowest airfare Des Moines to Indianapolis?

The cheapest plane ticket found by our users is $94. This airfare is for economy class on one-way G43450 flight by Allegiant Air for August 7, 2025 which leaves Des Moines International Airport in Des Moines at 08:30 am and arrives at Indianapolis Indianapolis Int. at 22:23.

Economy class

$94

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First class

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Popular Airlines on the Route

The flight Des Moines — Indianapolis is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 1 departures per week at the price of from $ 108 . And the most expensive tickets are offered by United Airlines airline - from $ 488.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 221 flights with layovers on the route. The fastest connecting flight is UA1568 by United Airlines takes 3h 25m and the cheapest is G43450 by Allegiant Air for $94.

F9 - Frontier Airlines

from $108

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UA - United Airlines

from $159

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G4 - Allegiant Air

from $94

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Airports

You can fly from Des Moines to Indianapolis from 1 airports (Des Moines International Airport).

Des Moines airports

Des Moines International Airport-DSM

from $94
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Indianapolis airports

Indianapolis Int.-IND

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Airplanes

There are flights to Indianapolis from Des Moines by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Des Moines — Las Vegas

from $55

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Des Moines — Phoenix

from $71

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Des Moines — Dallas

from $73

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Des Moines — Austin

from $78

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Des Moines — Seattle

from $53

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Des Moines — Atlanta

from $58

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Des Moines — Miami

from $65

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Des Moines — Denver

from $54

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Des Moines — New Orleans

from $56

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Des Moines — San Diego

from $58

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Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Des Moines — Cancun

from $77

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Des Moines — London

from $70

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How to book a plane ticket yourself?

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That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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