Cheap Flights from Indianapolis, IN to Des Moines, IA from $102

Return flight: Des Moines – Indianapolis
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On Cheapflightsplus.com you will find 231 connecting flights from Indianapolis to Des Moines. You can compare airfare deals from 5 airlines and multiple travel sites from $102, book and save on cheap plane tickets and last minute offers. Also check out IND-DSM flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Indianapolis to Des Moines Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $102 (one-way), $175 (round-trip).
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Best Flights from Indianapolis to Des Moines Today

Take a look at the list of non stop flights and flights with layovers from Indianapolis to Des Moines with the lowest price of $102. Take a look at the list of flights with layovers from Indianapolis to Des Moines from $102. There’re no direct flights. The fastest connecting flight – 3h 50m.
Price Departure Arrival Flight Duration Airline Flight
from $102
Find flight
17:45
Indianapolis
Indianapolis Int.
 12:23+1 день
Des Moines
Des Moines International Airport
 19h 38m
layover
14h 35m - Clearwater
 Allegiant Air
G4624
G4462
from $103
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13:00
Indianapolis
Indianapolis Int.
 18:48
Des Moines
Des Moines International Airport
 6h 48m
layover
2h 7m - Denver
 Frontier Airlines
F92345
F91678
from $128
Find flight
21:28
Indianapolis
Indianapolis Int.
 18:06+1 день
Des Moines
Des Moines International Airport
 21h 38m
layover
11h 1m - Sanford
4h 56m - Nashville
 Allegiant Air
G41252
G41968
G4448
from $145
Find flight
17:45
Indianapolis
Indianapolis Int.
 21:45+1 день
Des Moines
Des Moines International Airport
 29h 0m
layover
1h 25m - Miami
20h 46m - Sanford
 Spirit Airlines
NK272
NK676
G4463
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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 16, 2025
Full flight schedule will help you in detecting at what time planes fly from Indianapolis to Des Moines. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
06:00 — 18:48
06:00 — 06:52 F92347 Frontier Airlines
Indianapolis — Denver
9h 8m stop
16:00 — 18:48 F91678 Frontier Airlines
Denver — Des Moines
13h 48m
including layover
Find flight
from$109
09:00 — 08:40
+1 day
09:00 — 11:13 G4624 Allegiant Air
Indianapolis — Clearwater
19h 37m stop
06:50 — 08:40 G4986 Allegiant Air
Clearwater — Des Moines
24h 40m
including layover
Find flight
from$104
09:00 — 22:10
09:00 — 11:13 G42213 Allegiant Air
Indianapolis — Clearwater
9h 7m stop
20:20 — 22:10 G4473 Allegiant Air
Clearwater — Des Moines
14h 10m
including layover
Find flight
from$123
09:00 — 08:40
+1 day
09:00 — 11:13 G42213 Allegiant Air
Indianapolis — Clearwater
19h 37m stop
06:50 — 08:40 G4986 Allegiant Air
Clearwater — Des Moines
24h 40m
including layover
Find flight
from$123
09:00 — 19:04
09:00 — 11:13 G4624 Allegiant Air
Indianapolis — Clearwater
6h 1m stop
17:14 — 19:04 G41085 Allegiant Air
Clearwater — Des Moines
11h 4m
including layover
Find flight
from$147
09:40 — 16:14
09:40 — 11:53 G41279 Allegiant Air
Indianapolis — Sanford
2h 28m stop
14:21 — 16:14 G41321 Allegiant Air
Sanford — Des Moines
7h 34m
including layover
Find flight
from$130
09:40 — 13:31
+1 day
09:40 — 11:53 G41279 Allegiant Air
Indianapolis — Sanford
23h 45m stop
11:38 — 13:31 G4434 Allegiant Air
Sanford — Des Moines
28h 51m
including layover
Find flight
from$130
09:40 — 16:14
09:40 — 11:53 G41342 Allegiant Air
Indianapolis — Sanford
2h 28m stop
14:21 — 16:14 G42841 Allegiant Air
Sanford — Des Moines
7h 34m
including layover
Find flight
from$142
13:00 — 18:48
13:00 — 13:53 F92345 Frontier Airlines
Indianapolis — Denver
2h 7m stop
16:00 — 18:48 F91678 Frontier Airlines
Denver — Des Moines
6h 48m
including layover
Find flight
from$103
15:08 — 08:49
+1 day
15:08 — 17:50 G4609 Allegiant Air
Indianapolis — Miami
12h 40m stop
06:30 — 08:49 G42137 Allegiant Air
Miami — Des Moines
18h 41m
including layover
Find flight
from$110
17:40 — 09:50
+1 day
17:40 — 20:03 G4634 Allegiant Air
Indianapolis — Punta Gorda
11h 47m stop
07:50 — 09:50 G4460 Allegiant Air
Punta Gorda — Des Moines
17h 10m
including layover
Find flight
from$134
17:45 — 12:23
+1 day
17:45 — 19:58 G4624 Allegiant Air
Indianapolis — Clearwater
14h 35m stop
10:33 — 12:23 G4462 Allegiant Air
Clearwater — Des Moines
19h 38m
including layover
Find flight
from$102
21:15 — 15:32
+1 day
21:15 — 23:37 G42993 Allegiant Air
Indianapolis — Sarasota
14h 1m stop
13:38 — 15:32 G42099 Allegiant Air
Sarasota — Des Moines
19h 17m
including layover
Find flight
from$113
21:15 — 20:53
+1 day
21:15 — 23:37 G42993 Allegiant Air
Indianapolis — Sarasota
19h 22m stop
18:59 — 20:53 G4471 Allegiant Air
Sarasota — Des Moines
24h 38m
including layover
Find flight
from$113
21:28 — 16:14
+1 day
21:28 — 23:38 G41252 Allegiant Air
Indianapolis — Sanford
14h 43m stop
14:21 — 16:14 G42841 Allegiant Air
Sanford — Des Moines
19h 46m
including layover
Find flight
from$106
*Departure and arrival times - local. Updated on September 16, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Indianapolis to Des Moines depends on and how to choose the most interesting flight option for you.

Distance between Indianapolis and Des Moines is 652 miles. Time difference between the cities is 1h. Airplanes depart 06:00 to 21:57 from 1 Indianapolis airport and arrive 06:00 to 21:57 to 1 Des Moines airport. Average flight time is 18h 41m.

  • The fastest flight 3h 50m
  • Average flight time 18h 41m
  • The earliest flight 06:00
  • The latest flight 21:57
  • Distance 406 ml

The cheapest months to travel to Des Moines are july (from 102 $), august (from 103 $), october (from 145 $).

The most expensive months are september (from 170 $), october (from 145 $), august (from 103 $).

What is the lowest airfare Indianapolis to Des Moines?

The cheapest plane ticket found by our users is $102. This airfare is for economy class on one-way G4624 flight by Allegiant Air for July 4, 2025 which leaves Indianapolis Int. in Indianapolis at 17:45 am and arrives at Des Moines Des Moines International Airport at 12:23.

Economy class
$102
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Business class
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First class
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Popular Airlines on the Route

The flight Indianapolis — Des Moines is served by 5 regular airlines and 4 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 2 departures per week at the price of from $ 103 . And the most expensive tickets are offered by United Airlines airline - from $ 462.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 231 flights with layovers on the route. The fastest connecting flight is UA3677 by United Airlines takes 3h 50m and the cheapest is G4624 by Allegiant Air for $102.

  • F9 - Frontier Airlines
    from $103
    Find
  • SY - Sun Country Airlines
    from $179
    Find
  • UA - United Airlines
    from $161
    Find
  • G4 - Allegiant Air
    from $102
    Find
  • NK - Spirit Airlines
    from $145
    Find
See more connecting flights

Airports

You can fly from Indianapolis to Des Moines from 1 airports (Indianapolis Int.).

Indianapolis airports

  • Indianapolis Int.-IND
    from $102
    Find

Des Moines airports

  • Des Moines International Airport-DSM
    Find

Airplanes

There are flights to Des Moines from Indianapolis by 5 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Indianapolis

You may also consider searching for discounted plane tickets to some other popular places from Indianapolis within United States.

Top International Destinations from Indianapolis

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
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  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

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