Cheap Flights from Myrtle Beach, SC to Key West, FL from $138
On Cheapflightsplus.com you will find 66 connecting flights from Myrtle Beach to Key West. You can compare airfare deals from 4 airlines and multiple travel sites from $138, book and save on cheap plane tickets and last minute offers. Also check out MYR-EYW flight schedule to find best flight time, convenient departure and arrival airports.
Find One-Way and Round-Trip Myrtle Beach to Key West Flight Deals
To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights».
To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight.
Cheapest flights in November: $138 (one-way), $237 (round-trip).
Direct flights
Check prices for return flight
Best Flights from Myrtle Beach to Key West Today
Take a look at the list of non stop flights and flights with layovers from Myrtle Beach to Key West with the lowest price of $138. Take a look at the list of flights with layovers from Myrtle Beach to Key West from $138. There’re no direct flights. The fastest connecting flight – 6h 53m.
| Price | Departure | Arrival | Flight Duration | Airline | Flight |
|---|---|---|---|---|---|
| from $138 | 17:31 Myrtle Beach AFB | 16:51+1 день Key West Key West Int. | 23h 20m layover 19h 7m - Pittsburgh | Allegiant Air | G43683 G4991 |
| from $180 | 13:40 Myrtle Beach AFB | 09:33+1 день Key West Key West Int. | 19h 53m layover 17h 13m - Clearwater | Mexicana | MX173 G4971 |
| from $193 | 17:03 Myrtle Beach AFB | 15:16+1 день Key West Key West Int. | 22h 13m layover 18h 2m - Covington | Allegiant Air | G42037 G4426 |
| from $205 | 06:10 Myrtle Beach AFB | 13:07 Key West Key West Int. | 6h 57m layover 4h 20m - Orlando | Spirit Airlines | NK1289 MX162 |
| from $158 | 21:51 Myrtle Beach AFB | 14:43+1 день Key West Key West Int. | 16h 52m layover 9h 13m - Covington 2h 48m - Clearwater | Allegiant Air | G4407 G41990 G41034 |
| from $171 | 11:52 Myrtle Beach AFB | 14:10+1 день Key West Key West Int. | 26h 18m layover 20h 7m - Huntington 2h 2m - Sanford | Allegiant Air | G4993 G42932 G41340 |
| from $174 | 14:20 Myrtle Beach AFB | 14:10+1 день Key West Key West Int. | 23h 50m layover 17h 7m - Fort Wayne 1h 24m - Sanford | Allegiant Air | G42735 G42835 G41340 |
| from $187 | 08:34 Myrtle Beach AFB | 16:36+1 день Key West Key West Int. | 32h 2m layover 11h 35m - Newark 14h 25m - Pittsburgh | Spirit Airlines | NK1003 NK1788 G4991 |
| from $189 | 17:06 Myrtle Beach AFB | 14:10+1 день Key West Key West Int. | 21h 4m layover 14h 37m - Akron 1h 24m - Sanford | Allegiant Air | G42783 G42958 G41340 |
| from $191 | 10:17 Myrtle Beach AFB | 09:33+1 день Key West Key West Int. | 23h 16m layover 7h 12m - Plattsburgh 9h 26m - Clearwater | Allegiant Air | G43681 G42674 G4971 |
| from $192 | 12:18 Myrtle Beach AFB | 08:03+1 день Key West Key West Int. | 19h 45m layover 4h 44m - Detroit 9h 29m - Clearwater | Spirit Airlines | NK3184 NK2083 G4971 |
| from $192 | 12:18 Myrtle Beach AFB | 14:43+1 день Key West Key West Int. | 26h 25m layover 4h 44m - Detroit 16h 9m - Clearwater | Spirit Airlines | NK3184 NK2083 G41034 |
| from $194 | 16:04 Myrtle Beach AFB | 14:44+1 день Key West Key West Int. | 22h 40m layover 2h 26m - Albany 14h 16m - Clearwater | Allegiant Air | G4408 G41010 G41048 |
| from $200 | 10:17 Myrtle Beach AFB | 09:33+1 день Key West Key West Int. | 23h 16m layover 7h 12m - Plattsburgh 9h 26m - Clearwater | Allegiant Air | G43681 G42720 G4971 |
| from $203 | 14:49 Myrtle Beach AFB | 15:08+1 день Key West Key West Int. | 24h 19m layover 16h 56m - Fort Wayne 2h 17m - Clearwater | Allegiant Air | G42732 G42676 G41034 |
| from $205 | 06:14 Myrtle Beach AFB | 09:33+1 день Key West Key West Int. | 27h 19m layover 0h 31m - Miami 23h 3m - Clearwater | Spirit Airlines | NK1491 NK1757 G4971 |
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on July 13, 2025
Flight Schedule Myrtle Beach (South Carolina) to Key West (Florida)
Full flight schedule will help you in detecting at what time planes fly from Myrtle Beach to Key West. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
| Departure | Arrival | Flight Details | Flight Duration | Price |
|---|---|---|---|---|
|
06:10 — 13:07
|
06:10 — 07:32
NK1289
Spirit Airlines
Myrtle Beach — Orlando
4h 20m stop
11:52 — 13:07
MX162
Mexicana
Orlando — Key West
|
6h 57m including layover |
Find flight
from$205 |
|
|
13:40 — 09:33
+1 day
|
13:40 — 15:17
MX173
Mexicana
Myrtle Beach — Clearwater
17h 13m stop
08:30 — 09:33
G4971
Allegiant Air
Clearwater — Key West
|
19h 53m including layover |
Find flight
from$180 |
|
|
13:40 — 09:22
+1 day
|
13:40 — 15:17
MX173
Mexicana
Myrtle Beach — Tampa
16h 58m stop
08:15 — 09:22
MX160
Mexicana
Tampa — Key West
|
19h 42m including layover |
Find flight
from$232 |
|
|
16:31 — 16:36
+1 day
|
16:31 — 18:02
G43683
Allegiant Air
Myrtle Beach — Pittsburgh
19h 52m stop
13:54 — 16:36
G41055
Allegiant Air
Pittsburgh — Key West
|
24h 5m including layover |
Find flight
from$169 |
|
|
17:03 — 15:16
+1 day
|
17:03 — 18:41
G4407
Allegiant Air
Myrtle Beach — Covington
18h 2m stop
12:43 — 15:16
G4426
Allegiant Air
Covington — Key West
|
22h 13m including layover |
Find flight
from$152 |
|
|
17:31 — 16:51
+1 day
|
16:31 — 18:02
G43683
Allegiant Air
Myrtle Beach — Pittsburgh
19h 7m stop
13:54 — 16:36
G4991
Allegiant Air
Pittsburgh — Key West
|
23h 20m including layover |
Find flight
from$138 |
|
|
19:04 — 15:22
+1 day
|
19:04 — 20:45
G4407
Allegiant Air
Myrtle Beach — Covington
16h 6m stop
12:51 — 15:22
G4417
Allegiant Air
Covington — Key West
|
20h 18m including layover |
Find flight
from$216 |
|
|
19:29 — 13:07
+1 day
|
19:29 — 20:56
NK1645
Spirit Airlines
Myrtle Beach — Orlando
14h 56m stop
11:52 — 13:07
MX162
Mexicana
Orlando — Key West
|
17h 38m including layover |
Find flight
from$261 |
|
|
06:14 — 09:33
+1 day
|
06:14 — 08:05
NK1491
Spirit Airlines
Myrtle Beach — Miami
31m stop
08:36 — 09:27
NK1757
Spirit Airlines
Miami — Clearwater
23h 3m stop
08:30 — 09:33
G4971
Allegiant Air
Clearwater — Key West
|
27h 19m including layover |
Find flight
from$205 |
|
|
08:34 — 16:36
+1 day
|
08:34 — 10:30
NK1003
Spirit Airlines
Myrtle Beach — Newark
11h 35m stop
22:05 — 23:29
NK1788
Spirit Airlines
Newark — Pittsburgh
14h 25m stop
13:54 — 16:36
G4991
Allegiant Air
Pittsburgh — Key West
|
32h 2m including layover |
Find flight
from$187 |
|
|
08:34 — 13:07
+1 day
|
08:34 — 10:30
NK1003
Spirit Airlines
Myrtle Beach — Newark
40m stop
11:10 — 14:03
NK1559
Spirit Airlines
Newark — Orlando
21h 49m stop
11:52 — 13:07
MX162
Mexicana
Orlando — Key West
|
28h 33m including layover |
Find flight
from$384 |
|
|
09:37 — 13:07
+1 day
|
09:37 — 11:00
MX172
Mexicana
Myrtle Beach —
3h 29m stop
14:29 — 16:34
MX217
Mexicana
— Orlando
19h 18m stop
11:52 — 13:07
MX162
Mexicana
Orlando — Key West
|
24h 2m including layover |
Find flight
from$340 |
|
|
10:17 — 09:33
+1 day
|
10:17 — 12:31
G43681
Allegiant Air
Myrtle Beach — Plattsburgh
7h 12m stop
19:43 — 23:04
G42674
Allegiant Air
Plattsburgh — Clearwater
9h 26m stop
08:30 — 09:33
G4971
Allegiant Air
Clearwater — Key West
|
23h 16m including layover |
Find flight
from$191 |
|
|
10:17 — 09:33
+1 day
|
10:17 — 12:31
G43681
Allegiant Air
Myrtle Beach — Plattsburgh
7h 12m stop
19:43 — 23:04
G42720
Allegiant Air
Plattsburgh — Clearwater
9h 26m stop
08:30 — 09:33
G4971
Allegiant Air
Clearwater — Key West
|
23h 16m including layover |
Find flight
from$200 |
|
|
11:46 — 13:07
+1 day
|
10:46 — 12:31
MX572
Mexicana
Myrtle Beach — Scranton
6h 47m stop
20:18 — 22:59
MX761
Mexicana
Scranton — Orlando
12h 53m stop
11:52 — 13:07
MX162
Mexicana
Orlando — Key West
|
25h 21m including layover |
Find flight
from$360 |
|
|
11:52 — 14:10
+1 day
|
11:52 — 13:06
G4993
Allegiant Air
Myrtle Beach — Huntington
20h 7m stop
09:13 — 10:58
G42932
Allegiant Air
Huntington — Sanford
2h 2m stop
13:00 — 14:10
G41340
Allegiant Air
Sanford — Key West
|
26h 18m including layover |
Find flight
from$171 |
|
|
12:18 — 08:03
+1 day
|
12:18 — 14:12
NK3184
Spirit Airlines
Myrtle Beach — Detroit
4h 44m stop
18:56 — 21:31
NK2083
Spirit Airlines
Detroit — Clearwater
9h 29m stop
07:00 — 08:03
G4971
Allegiant Air
Clearwater — Key West
|
19h 45m including layover |
Find flight
from$192 |
|
|
12:18 — 14:43
+1 day
|
12:18 — 14:12
NK3184
Spirit Airlines
Myrtle Beach — Detroit
4h 44m stop
18:56 — 21:31
NK2083
Spirit Airlines
Detroit — Clearwater
16h 9m stop
13:40 — 14:43
G41034
Allegiant Air
Clearwater — Key West
|
26h 25m including layover |
Find flight
from$192 |
|
|
14:20 — 14:10
+1 day
|
14:20 — 16:10
G42735
Allegiant Air
Myrtle Beach — Fort Wayne
17h 7m stop
09:17 — 11:36
G42835
Allegiant Air
Fort Wayne — Sanford
1h 24m stop
13:00 — 14:10
G41340
Allegiant Air
Sanford — Key West
|
23h 50m including layover |
Find flight
from$174 |
|
|
14:49 — 15:08
+1 day
|
14:49 — 16:33
G42732
Allegiant Air
Myrtle Beach — Fort Wayne
16h 56m stop
09:29 — 11:48
G42676
Allegiant Air
Fort Wayne — Clearwater
2h 17m stop
14:05 — 15:08
G41034
Allegiant Air
Clearwater — Key West
|
24h 19m including layover |
Find flight
from$203 |
|
|
15:16 — 09:33
+1 day
|
15:16 — 16:41
NK1815
Spirit Airlines
Myrtle Beach — Chicago
3h 48m stop
20:29 — 00:19
NK1763
Spirit Airlines
Chicago — Clearwater
8h 11m stop
08:30 — 09:33
G4971
Allegiant Air
Clearwater — Key West
|
18h 17m including layover |
Find flight
from$222 |
|
|
15:32 — 13:07
+1 day
|
15:32 — 17:10
G41188
Allegiant Air
Myrtle Beach — Akron
12h 50m stop
06:00 — 08:27
MX246
Mexicana
Akron — Orlando
3h 25m stop
11:52 — 13:07
MX162
Mexicana
Orlando — Key West
|
21h 35m including layover |
Find flight
from$271 |
|
|
16:04 — 14:44
+1 day
|
16:04 — 17:56
G4408
Allegiant Air
Myrtle Beach — Albany
2h 26m stop
20:22 — 23:24
G41010
Allegiant Air
Albany — Clearwater
14h 16m stop
13:40 — 14:44
G41048
Allegiant Air
Clearwater — Key West
|
22h 40m including layover |
Find flight
from$194 |
|
|
20:57 — 15:08
+1 day
|
20:57 — 23:01
NK1007
Spirit Airlines
Myrtle Beach — Detroit
6h 44m stop
05:45 — 08:25
NK1235
Spirit Airlines
Detroit — Clearwater
5h 40m stop
14:05 — 15:08
G41034
Allegiant Air
Clearwater — Key West
|
18h 11m including layover |
Find flight
from$225 |
|
|
20:57 — 14:44
+1 day
|
20:57 — 23:01
NK1007
Spirit Airlines
Myrtle Beach — Detroit
6h 44m stop
05:45 — 08:25
NK1235
Spirit Airlines
Detroit — Clearwater
5h 15m stop
13:40 — 14:44
G41048
Allegiant Air
Clearwater — Key West
|
17h 47m including layover |
Find flight
from$247 |
|
|
21:10 — 14:43
+1 day
|
21:10 — 22:53
G4162
Allegiant Air
Myrtle Beach — Allentown
8h 37m stop
07:30 — 10:05
G4177
Allegiant Air
Allentown — Clearwater
3h 35m stop
13:40 — 14:43
G41034
Allegiant Air
Clearwater — Key West
|
17h 33m including layover |
Find flight
from$211 |
|
|
21:51 — 14:43
+1 day
|
21:51 — 23:32
G4407
Allegiant Air
Myrtle Beach — Covington
9h 13m stop
08:45 — 10:52
G41990
Allegiant Air
Covington — Clearwater
2h 48m stop
13:40 — 14:43
G41034
Allegiant Air
Clearwater — Key West
|
16h 52m including layover |
Find flight
from$158 |
|
*Departure and arrival times - local. Updated on July 13, 2025
Flight Information
Below we will explain in detail what the flights cost on the destination from Myrtle Beach to Key West depends on and how to choose the most interesting flight option for you.
Distance between Myrtle Beach and Key West is 1051 miles. Time difference between the cities is 0h. Airplanes depart 06:10 to 21:51 from 2 Myrtle Beach airports and arrive 06:10 to 21:51 to 2 Key West airports. Average flight time is 22h 37m.
- The fastest flight 6h 53m
- Average flight time 22h 37m
- The earliest flight 06:10
- The latest flight 21:51
- Distance 654 ml
The cheapest months to travel to Key West are july (from 138 $), august (from 158 $), september (from 247 $).
The most expensive months are october (from 369 $), september (from 247 $), august (from 158 $).
What is the lowest airfare Myrtle Beach to Key West?
The cheapest plane ticket found by our users is $138. This airfare is for economy class on one-way G43683 flight by Allegiant Air for July 24, 2025 which leaves AFB in Myrtle Beach at 17:31 am and arrives at Key West Key West Int. at 16:51.
Economy class
$138
Business class
?
First class
?
Popular Airlines on the Route
The flight Myrtle Beach — Key West is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Mexicana - 19 departures per week at the price of from $ 180 . And the most expensive tickets are offered by United Airlines airline - from $ 490.
Direct flights
There’re no direct flights on this route. Try flights with stops.
Connecting Flights
There are 66 flights with layovers on the route. The fastest connecting flight is NK1491 by Spirit Airlines takes 6h 53m and the cheapest is G43683 by Allegiant Air for $138.
- MX - Mexicanafrom $180Find
- UA - United Airlinesfrom $468Find
- G4 - Allegiant Airfrom $138Find
- NK - Spirit Airlinesfrom $187Find
See more connecting flights
Airports
You can fly from Myrtle Beach to Key West from 2 airports (AFB, Grand Strand Airport).
Myrtle Beach airports
- AFB-MYRfrom $138Find
- Grand Strand Airport-CREFind
Key West airports
- NAS-NQXFind
- Key West Int.-EYWFind
Airplanes
There are flights to Key West from Myrtle Beach by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.
Top Domestic Destinations from Myrtle Beach
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Top International Destinations from Myrtle Beach
Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.
- from $57Find
How to book a plane ticket yourself?
- Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
- Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
- Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
- Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
- That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
To find a plane ticket, please select dates.