Cheap Flights from Myrtle Beach, SC to Key West, FL from $110
On Cheapflightsplus.com you will find 92 connecting flights from Myrtle Beach to Key West. You can compare airfare deals from 4 airlines and multiple travel sites from $110, book and save on cheap plane tickets and last minute offers. Also check out MYR-EYW flight schedule to find best flight time, convenient departure and arrival airports.
Flight Information
Below we will explain in detail what the flights cost on the destination from Myrtle Beach to Key West depends on and how to choose the most interesting flight option for you.
Distance between Myrtle Beach and Key West is 1051 miles. Time difference between the cities is 0h. Airplanes depart 05:15 to 21:51 from 2 Myrtle Beach airports and arrive 05:15 to 21:51 to 2 Key West airports. Average flight time is 22h 21m.
- The fastest flight 6h 53m
- Average flight time 22h 21m
- The earliest flight 05:15
- The latest flight 21:51
- Distance 654 ml
Best Flights from Myrtle Beach to Key West Today
| Price | Departure | Arrival | Flight Duration | Airline | Flight |
|---|---|---|---|---|---|
| from $110 | 20:24 Myrtle Beach AFB | 09:43+1 день Key West Key West Int. | 13h 19m layover 10h 42m - Sanford | Spirit Airlines | NK2089 G42877 |
| from $117 | 21:51 Myrtle Beach AFB | 16:45+1 день Key West Key West Int. | 18h 54m layover 14h 28m - Indianapolis | Allegiant Air | G4631 G41285 |
| from $153 | 21:51 Myrtle Beach AFB | 14:43+1 день Key West Key West Int. | 16h 52m layover 9h 13m - Covington 2h 48m - Clearwater | Allegiant Air | G4407 G41990 G41034 |
| from $172 | 10:57 Myrtle Beach AFB | 09:43+1 день Key West Key West Int. | 22h 46m layover 3h 7m - Louisville 14h 56m - Sanford | Spirit Airlines | NK2750 G42832 G42877 |
The cheapest months to travel to Key West are july (from 110 $), august (from 153 $), september (from 240 $).
The most expensive months are october (from 358 $), september (from 240 $), august (from 153 $).
What is the lowest airfare Myrtle Beach to Key West?
The cheapest plane ticket found by our users is $110. This airfare is for economy class on one-way NK2089 flight by Spirit Airlines for July 5, 2025 which leaves AFB in Myrtle Beach at 20:24 am and arrives at Key West Key West Int. at 09:43.
Flight Schedule Myrtle Beach (South Carolina) to Key West (Florida)
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Popular Airlines on the Route
The flight Myrtle Beach — Key West is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Mexicana - 19 departures per week at the price of from $ 175 . And the most expensive tickets are offered by United Airlines airline - from $ 476.
Direct flights
There’re no direct flights on this route. Try flights with stops.
Connecting Flights
There are 92 flights with layovers on the route. The fastest connecting flight is NK1491 by Spirit Airlines takes 6h 53m and the cheapest is NK2089 by Spirit Airlines for $110.
- MX - Mexicanafrom $175Find
- UA - United Airlinesfrom $449Find
- NK - Spirit Airlinesfrom $110Find
- G4 - Allegiant Airfrom $117Find
Airports
You can fly from Myrtle Beach to Key West from 2 airports (AFB, Grand Strand Airport).
Myrtle Beach airports
- AFB-MYRfrom $110Find
- Grand Strand Airport-CREFind
Key West airports
- NAS-NQXFind
- Key West Int.-EYWFind
Airplanes
There are flights to Key West from Myrtle Beach by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.
Top Domestic Destinations from Myrtle Beach
You may also consider searching for discounted plane tickets to some other popular places from Myrtle Beach within United States.
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Top International Destinations from Myrtle Beach
Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.
- from $57Find
How to book a plane ticket yourself?
- Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
- Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
- Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
- Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
- That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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