Cheap Flights from Myrtle Beach, SC to Key West, FL from $217

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On Cheapflightsplus.com you will find 92 connecting flights from Myrtle Beach to Key West. You can compare airfare deals from 2 airlines and multiple travel sites from $217, book and save on cheap plane tickets and last minute offers. Also check out MYR-EYW flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Myrtle Beach to Key West Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $217 (one-way), $372 (round-trip).
Direct flights
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Best Flights from Myrtle Beach to Key West Today

Take a look at the list of non stop flights and flights with layovers from Myrtle Beach to Key West with the lowest price of $217. Take a look at the list of flights with layovers from Myrtle Beach to Key West from $217. There’re no direct flights. The fastest connecting flight – 10h 41m.
Price Departure Arrival Flight Duration Airline Flight
from $217
Find flight
06:00
Myrtle Beach
AFB
 16:41
Key West
Key West Int.
 10h 41m
layover
1h 8m - Miami
2h 12m - Indianapolis
 Spirit Airlines
NK3646
NK1950
G42877
from $288
Find flight
12:53
Myrtle Beach
AFB
 09:15+1 день
Key West
Key West Int.
 20h 22m
layover
3h 7m - Newark
10h 57m - Tampa
 United Airlines
UA2206
UA2471
UA3135
from $558
Find flight
13:53
Myrtle Beach
AFB
 15:01+1 день
Key West
Key West Int.
 25h 8m
layover
2h 25m - Newark
14h 48m - Chicago
 United Airlines
UA3638
UA254
UA325
from $558
Find flight
13:53
Myrtle Beach
AFB
 15:01+1 день
Key West
Key West Int.
 25h 8m
layover
3h 43m - Newark
13h 33m - Chicago
 United Airlines
UA3638
UA546
UA325
from $559
Find flight
13:53
Myrtle Beach
AFB
 09:15+1 день
Key West
Key West Int.
 19h 22m
layover
4h 15m - Newark
8h 42m - Tampa
 United Airlines
UA3638
UA212
UA3135
from $559
Find flight
13:53
Myrtle Beach
AFB
 13:15+1 день
Key West
Key West Int.
 23h 22m
layover
4h 15m - Newark
12h 42m - Tampa
 United Airlines
UA3638
UA212
UA3136
from $559
Find flight
13:53
Myrtle Beach
AFB
 17:15+1 день
Key West
Key West Int.
 27h 22m
layover
4h 15m - Newark
16h 42m - Tampa
 United Airlines
UA3638
UA212
UA3137
from $560
Find flight
13:53
Myrtle Beach
AFB
 10:10+2 дня
Key West
Key West Int.
 44h 17m
layover
23h 10m - Newark
14h 38m - Orlando
 United Airlines
UA3638
UA287
UA3075
from $560
Find flight
13:53
Myrtle Beach
AFB
 10:10+2 дня
Key West
Key West Int.
 44h 17m
layover
20h 20m - Newark
17h 29m - Orlando
 United Airlines
UA3638
UA2114
UA3075
from $565
Find flight
13:53
Myrtle Beach
AFB
 09:15+1 день
Key West
Key West Int.
 19h 22m
layover
2h 5m - Newark
10h 52m - Tampa
 United Airlines
UA3638
UA2471
UA3135
from $565
Find flight
13:53
Myrtle Beach
AFB
 09:15+1 день
Key West
Key West Int.
 19h 22m
layover
1h 5m - Newark
11h 52m - Tampa
 United Airlines
UA3638
UA2280
UA3135
from $565
Find flight
13:53
Myrtle Beach
AFB
 13:15+1 день
Key West
Key West Int.
 23h 22m
layover
2h 5m - Newark
14h 52m - Tampa
 United Airlines
UA3638
UA2471
UA3136
from $565
Find flight
13:53
Myrtle Beach
AFB
 13:15+1 день
Key West
Key West Int.
 23h 22m
layover
1h 5m - Newark
15h 52m - Tampa
 United Airlines
UA3638
UA2280
UA3136
from $565
Find flight
13:53
Myrtle Beach
AFB
 17:15+1 день
Key West
Key West Int.
 27h 22m
layover
2h 5m - Newark
18h 52m - Tampa
 United Airlines
UA3638
UA2471
UA3137
from $565
Find flight
13:53
Myrtle Beach
AFB
 17:15+1 день
Key West
Key West Int.
 27h 22m
layover
1h 5m - Newark
19h 52m - Tampa
 United Airlines
UA3638
UA2280
UA3137
from $572
Find flight
13:53
Myrtle Beach
AFB
 17:15+1 день
Key West
Key West Int.
 27h 22m
layover
15h 20m - Newark
5h 38m - Tampa
 United Airlines
UA3638
UA394
UA3137
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on May 10, 2025
Full flight schedule will help you in detecting at what time planes fly from Myrtle Beach to Key West. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
06:00 — 16:41
06:00 — 07:49 NK3646 Spirit Airlines
Myrtle Beach — Miami
1h 8m stop
08:57 — 11:46 NK1950 Spirit Airlines
Miami — Indianapolis
2h 12m stop
13:58 — 16:41 G42877 Allegiant Air
Indianapolis — Key West
10h 41m
including layover
Find flight
from$217
12:53 — 09:15
+1 day
12:53 — 14:53 UA2206 United Airlines
Myrtle Beach — Newark
3h 7m stop
18:00 — 21:03 UA2471 United Airlines
Newark — Tampa
10h 57m stop
08:00 — 09:15 UA3135 United Airlines
Tampa — Key West
20h 22m
including layover
Find flight
from$288
12:53 — 09:15
+1 day
12:53 — 14:53 UA2206 United Airlines
Myrtle Beach — Newark
1h 36m stop
16:29 — 19:32 UA2280 United Airlines
Newark — Tampa
12h 28m stop
08:00 — 09:15 UA3135 United Airlines
Tampa — Key West
20h 22m
including layover
Find flight
from$288
13:53 — 15:01
+1 day
13:53 — 16:00 UA3638 United Airlines
Myrtle Beach — Newark
2h 25m stop
18:25 — 20:07 UA254 United Airlines
Newark — Chicago
14h 48m stop
10:55 — 15:01 UA325 United Airlines
Chicago — Key West
25h 8m
including layover
Find flight
from$558
13:53 — 15:01
+1 day
13:53 — 16:00 UA3638 United Airlines
Myrtle Beach — Newark
3h 43m stop
19:43 — 21:22 UA546 United Airlines
Newark — Chicago
13h 33m stop
10:55 — 15:01 UA325 United Airlines
Chicago — Key West
25h 8m
including layover
Find flight
from$558
*Departure and arrival times - local. Updated on May 10, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Myrtle Beach to Key West depends on and how to choose the most interesting flight option for you.

Distance between Myrtle Beach and Key West is 1051 miles. Time difference between the cities is 0h. Airplanes depart 06:00 to 13:53 from 2 Myrtle Beach airports and arrive 06:00 to 13:53 to 2 Key West airports. Average flight time is 27h 22m.

  • The fastest flight 10h 41m
  • Average flight time 27h 22m
  • The earliest flight 06:00
  • The latest flight 13:53
  • Distance 654 ml

The cheapest months to travel to Key West are december (from 217 $), november (from 288 $).

What is the lowest airfare Myrtle Beach to Key West?

The cheapest plane ticket found by our users is $217. This airfare is for economy class on one-way NK3646 flight by Spirit Airlines for December 8, 2024 which leaves AFB in Myrtle Beach at 06:00 am and arrives at Key West Key West Int. at 16:41.

Economy class
$217
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Business class
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First class
?
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Popular Airlines on the Route

The flight Myrtle Beach — Key West is served by 2 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by United Airlines - 91 departures per week at the price of from $ 288 . And the most expensive tickets are offered by United Airlines airline - from $ 920.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 92 flights with layovers on the route. The fastest connecting flight is NK3646 by Spirit Airlines takes 10h 41m and the cheapest is NK3646 by Spirit Airlines for $217.

  • UA - United Airlines
    from $288
    Find
  • NK - Spirit Airlines
    from $217
    Find
See more connecting flights

Airports

You can fly from Myrtle Beach to Key West from 2 airports (AFB, Grand Strand Airport).

Myrtle Beach airports

  • AFB-MYR
    from $217
    Find
  • Grand Strand Airport-CRE
    Find

Key West airports

  • NAS-NQX
    Find
  • Key West Int.-EYW
    Find

Airplanes

There are flights to Key West from Myrtle Beach by 2 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Myrtle Beach

You may also consider searching for discounted plane tickets to some other popular places from Myrtle Beach within United States.

Top International Destinations from Myrtle Beach

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
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  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

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