Cheap Flights from Knoxville, TN to San Francisco, CA from $73

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On Cheapflightsplus.com you will find 123 connecting flights from Knoxville to San Francisco. You can compare airfare deals from 4 airlines and multiple travel sites from $73, book and save on cheap plane tickets and last minute offers. Also check out TYS-SFO flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Knoxville to San Francisco Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $73 (one-way), $125 (round-trip).

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Best Flights from Knoxville to San Francisco Today

Take a look at the list of non stop flights and flights with layovers from Knoxville to San Francisco with the lowest price of $73. Take a look at the list of flights with layovers from Knoxville to San Francisco from $73. There’re no direct flights. The fastest connecting flight – 7h 25m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $73 Find flight	19:30 Knoxville Mc Ghee Tyson	00:15+1 день San Francisco San Francisco	7h 45m layover 1h 40m - Denver	Frontier Airlines	F94369 F93439
from $381 Find flight	07:00 Knoxville Mc Ghee Tyson	11:33 San Francisco San Francisco	7h 33m layover 0h 43m - Chicago	United Airlines	UA1677 UA1387
from $381 Find flight	16:25 Knoxville Mc Ghee Tyson	22:56 San Francisco San Francisco	9h 31m layover 3h 4m - Denver	United Airlines	UA1303 UA2190
from $409 Find flight	17:46 Knoxville Mc Ghee Tyson	23:08 San Francisco San Francisco	8h 22m layover 1h 25m - Chicago	United Airlines	UA5305 UA210
from $409 Find flight	17:10 Knoxville Mc Ghee Tyson	22:57 San Francisco San Francisco	8h 47m layover 1h 45m - Houston	United Airlines	UA4854 UA1351
from $409 Find flight	16:30 Knoxville Mc Ghee Tyson	22:55 San Francisco San Francisco	9h 25m layover 3h 4m - Denver	United Airlines	UA1819 UA2190
from $409 Find flight	07:00 Knoxville Mc Ghee Tyson	13:28 San Francisco San Francisco	9h 28m layover 2h 34m - Chicago	United Airlines	UA776 UA343
from $409 Find flight	17:10 Knoxville Mc Ghee Tyson	23:59 San Francisco San Francisco	9h 49m layover 2h 51m - Houston	United Airlines	UA4854 UA725
from $409 Find flight	11:50 Knoxville Mc Ghee Tyson	18:48 San Francisco San Francisco	9h 58m layover 3h 9m - Houston	United Airlines	UA4302 UA2034
from $411 Find flight	07:00 Knoxville Mc Ghee Tyson	12:02 San Francisco San Francisco	8h 2m layover 1h 0m - Houston	United Airlines	UA4913 UA1293
from $411 Find flight	05:45 Knoxville Mc Ghee Tyson	11:16 San Francisco San Francisco	8h 31m layover 0h 52m - Washington D.C.	United Airlines	UA4311 UA1116
from $462 Find flight	08:55 Knoxville Mc Ghee Tyson	22:55 San Francisco San Francisco	17h 0m layover 10h 32m - Denver	United Airlines	UA5673 UA2190
from $273 Find flight	12:25 Knoxville Mc Ghee Tyson	10:32+1 день San Francisco San Francisco	25h 7m layover 4h 52m - Orlando 10h 41m - Minneapolis	Allegiant Air	G41420 SY348 SY391
from $309 Find flight	06:30 Knoxville Mc Ghee Tyson	17:05 San Francisco San Francisco	13h 35m layover 3h 12m - Orlando 0h 56m - Minneapolis	Allegiant Air	G43032 SY342 SY395
from $309 Find flight	12:50 Knoxville Mc Ghee Tyson	10:08+1 день San Francisco San Francisco	24h 18m layover 5h 7m - Orlando 9h 24m - Minneapolis	Allegiant Air	G41437 SY348 SY391
from $387 Find flight	05:45 Knoxville Mc Ghee Tyson	13:48 San Francisco San Francisco	11h 3m layover 0h 54m - Washington D.C. 1h 6m - Chicago	United Airlines	UA4311 UA2440 UA343

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on May 11, 2025

Flight Schedule Knoxville (Tennessee) to San Francisco (California)

Full flight schedule will help you in detecting at what time planes fly from Knoxville to San Francisco. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
05:45 — 11:16	05:45 — 07:33 UA4311 United Airlines Knoxville — Washington D.C. 52m stop 08:30 — 11:21 UA1116 United Airlines Washington D.C. — San Francisco	8h 31m including layover	Find flight from$411
05:45 — 15:42	05:45 — 07:33 UA4311 United Airlines Knoxville — Washington D.C. 5h 2m stop 12:35 — 15:42 UA1392 United Airlines Washington D.C. — San Francisco	12h 57m including layover	Find flight from$513
06:45 — 12:05	06:45 — 08:36 UA4913 United Airlines Knoxville — Houston 1h 4m stop 09:40 — 12:05 UA1605 United Airlines Houston — San Francisco	8h 20m including layover	Find flight from$474
07:00 — 11:33	07:00 — 08:02 UA1677 United Airlines Knoxville — Chicago 43m stop 08:45 — 11:33 UA1387 United Airlines Chicago — San Francisco	7h 33m including layover	Find flight from$381
07:00 — 13:28	07:00 — 08:01 UA776 United Airlines Knoxville — Chicago 2h 34m stop 10:35 — 13:28 UA343 United Airlines Chicago — San Francisco	9h 28m including layover	Find flight from$409
08:55 — 15:14	08:55 — 10:33 UA5673 United Airlines Knoxville — Denver 2h 52m stop 13:45 — 15:34 UA1812 United Airlines Denver — San Francisco	9h 19m including layover	Find flight from$409
08:55 — 13:20	08:55 — 10:33 UA5673 United Airlines Knoxville — Denver 58m stop 11:31 — 13:20 UA1561 United Airlines Denver — San Francisco	7h 25m including layover	Find flight from$412
09:25 — 17:14	09:25 — 11:06 UA4841 United Airlines Knoxville — Houston 3h 46m stop 14:52 — 17:14 UA1297 United Airlines Houston — San Francisco	10h 49m including layover	Find flight from$411
09:25 — 14:23	09:25 — 11:06 UA4841 United Airlines Knoxville — Houston 54m stop 12:00 — 14:23 UA1057 United Airlines Houston — San Francisco	7h 58m including layover	Find flight from$412
10:50 — 17:18	10:50 — 11:54 UA5300 United Airlines Knoxville — Chicago 2h 31m stop 14:25 — 17:18 UA1165 United Airlines Chicago — San Francisco	9h 28m including layover	Find flight from$486
10:55 — 17:13	10:55 — 11:59 UA5300 United Airlines Knoxville — Chicago 2h 21m stop 14:20 — 17:13 UA1496 United Airlines Chicago — San Francisco	9h 18m including layover	Find flight from$512
11:50 — 18:48	11:50 — 13:26 UA4302 United Airlines Knoxville — Houston 3h 9m stop 16:35 — 18:48 UA2034 United Airlines Houston — San Francisco	9h 58m including layover	Find flight from$409
11:50 — 17:25	11:50 — 13:26 UA4302 United Airlines Knoxville — Houston 1h 37m stop 15:03 — 17:25 UA1253 United Airlines Houston — San Francisco	8h 35m including layover	Find flight from$412
13:13 — 20:41	13:13 — 14:13 AS4378 Alaska Airlines Knoxville — Chicago 3h 44m stop 17:57 — 20:41 AS597 Alaska Airlines Chicago — San Francisco	10h 28m including layover	Find flight from$512
13:55 — 18:45	13:58 — 15:02 UA5844 United Airlines Knoxville — Chicago 59m stop 16:10 — 18:50 UA2409 United Airlines Chicago — San Francisco	7h 50m including layover	Find flight from$486
14:35 — 22:55	14:35 — 16:15 UA4848 United Airlines Knoxville — Washington D.C. 3h 38m stop 19:53 — 22:55 UA1992 United Airlines Washington D.C. — San Francisco	11h 20m including layover	Find flight from$412
14:35 — 20:50	14:35 — 16:15 UA4848 United Airlines Knoxville — Washington D.C. 1h 45m stop 18:00 — 20:50 UA769 United Airlines Washington D.C. — San Francisco	9h 15m including layover	Find flight from$488
16:19 — 12:50 +1 day	16:19 — 17:51 F94369 Frontier Airlines Knoxville — Denver 17h stop 10:51 — 12:50 F91229 Frontier Airlines Denver — San Francisco	23h 31m including layover	Find flight from$106
16:25 — 22:56	16:25 — 18:01 UA1303 United Airlines Knoxville — Denver 3h 4m stop 21:05 — 22:56 UA2190 United Airlines Denver — San Francisco	9h 31m including layover	Find flight from$381
17:10 — 22:57	17:10 — 18:50 UA4854 United Airlines Knoxville — Houston 1h 45m stop 20:35 — 22:57 UA1351 United Airlines Houston — San Francisco	8h 47m including layover	Find flight from$409
17:42 — 08:13 +1 day	19:30 — 20:46 F94369 Frontier Airlines Knoxville — Denver 11h 46m stop 13:35 — 15:23 F91093 Frontier Airlines Denver — San Francisco	17h 31m including layover	Find flight from$79
19:25 — 01:07 +1 day	19:25 — 21:15 UA4324 United Airlines Knoxville — Washington D.C. 50m stop 22:05 — 01:07 UA2136 United Airlines Washington D.C. — San Francisco	8h 42m including layover	Find flight from$512
19:30 — 00:15 +1 day	19:30 — 20:46 F94369 Frontier Airlines Knoxville — Denver 1h 40m stop 22:26 — 00:15 F93439 Frontier Airlines Denver — San Francisco	7h 45m including layover	Find flight from$73
22:35 — 12:49 +1 day	22:35 — 23:54 F94369 Frontier Airlines Knoxville — Denver 11h 6m stop 11:00 — 12:49 F91997 Frontier Airlines Denver — San Francisco	17h 14m including layover	Find flight from$175

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on May 11, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Knoxville to San Francisco depends on and how to choose the most interesting flight option for you.

Distance between Knoxville and San Francisco is 3403 miles. Time difference between the cities is 3h. Airplanes depart 05:45 to 22:35 from 1 Knoxville airport and arrive 05:45 to 22:35 to 3 San Francisco airports. Average flight time is 11h.

The fastest flight 7h 25m
Average flight time 11h
The earliest flight 05:45
The latest flight 22:35
Distance 2115 ml

The cheapest months to travel to San Francisco are november (from 73 $), february (from 104 $), december (from 106 $).

The most expensive months are january (from 381 $), december (from 106 $), february (from 104 $).

What is the lowest airfare Knoxville to San Francisco?

The cheapest plane ticket found by our users is $73. This airfare is for economy class on one-way F94369 flight by Frontier Airlines for November 13, 2024 which leaves Mc Ghee Tyson in Knoxville at 19:30 am and arrives at San Francisco San Francisco at 00:15.

Economy class

$73

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First class

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Popular Airlines on the Route

The flight Knoxville — San Francisco is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Alaska Airlines - 2 departures per week at the price of from $ 512 . And the most expensive tickets are offered by United Airlines airline - from $ 933.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 123 flights with layovers on the route. The fastest connecting flight is UA5673 by United Airlines takes 7h 25m and the cheapest is F94369 by Frontier Airlines for $73.

AS - Alaska Airlines

from $512

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F9 - Frontier Airlines

from $73

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UA - United Airlines

from $381

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G4 - Allegiant Air

from $273

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Airports

You can fly from Knoxville to San Francisco from 1 airports (Mc Ghee Tyson).

Knoxville airports

Mc Ghee Tyson-TYS

from $73
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San Francisco airports

San Francisco-SFO

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Embarkadero-EMB

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China Basin Heliport-JCC

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Airplanes

There are flights to San Francisco from Knoxville by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Knoxville

You may also consider searching for discounted plane tickets to some other popular places from Knoxville within United States.

Knoxville — Orlando

from $73

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Knoxville — Las Vegas

from $74

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Knoxville — Chicago

from $76

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Knoxville — Denver

from $74

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Knoxville — Miami

from $66

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Knoxville — Boston

from $69

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Knoxville — Houston

from $54

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Knoxville — New Orleans

from $56

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Knoxville — Tampa

from $80

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Knoxville — Austin

from $54

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Top International Destinations from Knoxville

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Knoxville — Cancun

from $69

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Knoxville — Panama City

from $61

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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