Cheap Flights from Knoxville, TN to Key West, FL from $135

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On Cheapflightsplus.com you will find 96 connecting flights from Knoxville to Key West. You can compare airfare deals from 2 airlines and multiple travel sites from $135, book and save on cheap plane tickets and last minute offers. Also check out TYS-EYW flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Knoxville to Key West Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $135 (one-way), $232 (round-trip).

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Best Flights from Knoxville to Key West Today

Take a look at the list of non stop flights and flights with layovers from Knoxville to Key West with the lowest price of $135. Take a look at the list of flights with layovers from Knoxville to Key West from $135. There’re no direct flights. The fastest connecting flight – 5h 54m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $135 Find flight	09:00 Knoxville Mc Ghee Tyson	15:51 Key West Key West Int.	6h 51m layover 4h 7m - Clearwater	Allegiant Air	G43061 G4971
from $302 Find flight	09:15 Knoxville Mc Ghee Tyson	16:03 Key West Key West Int.	6h 48m layover 1h 10m - Houston	United Airlines	UA4841 UA6200
from $302 Find flight	07:05 Knoxville Mc Ghee Tyson	16:03 Key West Key West Int.	8h 58m layover 3h 20m - Houston	United Airlines	UA4913 UA6200
from $348 Find flight	07:00 Knoxville Mc Ghee Tyson	15:01 Key West Key West Int.	8h 1m layover 2h 54m - Chicago	United Airlines	UA1469 UA1385
from $350 Find flight	05:45 Knoxville Mc Ghee Tyson	11:39 Key West Key West Int.	5h 54m layover 0h 54m - Washington D.C.	United Airlines	UA4311 UA6217
from $402 Find flight	07:00 Knoxville Mc Ghee Tyson	15:01 Key West Key West Int.	8h 1m layover 2h 54m - Chicago	United Airlines	UA776 UA325
from $376 Find flight	05:45 Knoxville Mc Ghee Tyson	18:55 Key West Key West Int.	13h 10m layover 0h 52m - Washington D.C. 6h 38m - Miami	United Airlines	UA4311 UA1825 UA3094
from $387 Find flight	10:35 Knoxville Mc Ghee Tyson	09:15+1 день Key West Key West Int.	22h 40m layover 2h 15m - Houston 14h 9m - Tampa	United Airlines	UA4302 UA1478 UA3135
from $403 Find flight	05:45 Knoxville Mc Ghee Tyson	17:15 Key West Key West Int.	11h 30m layover 1h 12m - Washington D.C. 4h 42m - Tampa	United Airlines	UA4311 UA683 UA3137
from $403 Find flight	05:45 Knoxville Mc Ghee Tyson	09:15+1 день Key West Key West Int.	27h 30m layover 1h 12m - Washington D.C. 20h 42m - Tampa	United Airlines	UA4311 UA683 UA3135
from $414 Find flight	09:55 Knoxville Mc Ghee Tyson	18:55 Key West Key West Int.	9h 0m layover 1h 33m - Washington D.C. 1h 50m - Miami	United Airlines	UA4325 UA528 UA3094
from $423 Find flight	07:05 Knoxville Mc Ghee Tyson	18:55 Key West Key West Int.	11h 50m layover 1h 25m - Houston 4h 2m - Miami	United Airlines	UA4913 UA1068 UA3094
from $423 Find flight	14:35 Knoxville Mc Ghee Tyson	18:55+1 день Key West Key West Int.	28h 20m layover 1h 40m - Washington D.C. 21h 8m - Miami	United Airlines	UA4848 UA1379 UA3094
from $445 Find flight	19:25 Knoxville Mc Ghee Tyson	10:10+1 день Key West Key West Int.	14h 45m layover 1h 15m - Washington D.C. 7h 51m - Orlando	United Airlines	UA4324 UA689 UA3075
from $445 Find flight	19:25 Knoxville Mc Ghee Tyson	14:20+1 день Key West Key West Int.	18h 55m layover 1h 15m - Washington D.C. 12h 1m - Orlando	United Airlines	UA4324 UA689 UA3071
from $445 Find flight	10:55 Knoxville Mc Ghee Tyson	10:10+1 день Key West Key West Int.	23h 15m layover 2h 21m - Chicago 14h 37m - Orlando	United Airlines	UA5300 UA2042 UA3075

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on March 20, 2025

Flight Schedule Knoxville (Tennessee) to Key West (Florida)

Full flight schedule will help you in detecting at what time planes fly from Knoxville to Key West. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
05:45 — 11:39	05:45 — 07:31 UA4311 United Airlines Knoxville — Washington D.C. 54m stop 08:25 — 11:39 UA6217 United Airlines Washington D.C. — Key West	5h 54m including layover	Find flight from$350
07:00 — 15:01	07:00 — 08:01 UA1469 United Airlines Knoxville — Chicago 2h 54m stop 10:55 — 15:01 UA1385 United Airlines Chicago — Key West	8h 1m including layover	Find flight from$348
07:05 — 16:03	06:45 — 08:36 UA4913 United Airlines Knoxville — Houston 3h 20m stop 12:09 — 16:01 UA6200 United Airlines Houston — Key West	8h 58m including layover	Find flight from$302
09:00 — 15:51	09:00 — 10:43 G43061 Allegiant Air Knoxville — Clearwater 4h 7m stop 14:50 — 15:51 G4971 Allegiant Air Clearwater — Key West	6h 51m including layover	Find flight from$135
09:15 — 16:03	09:10 — 11:01 UA4841 United Airlines Knoxville — Houston 1h 10m stop 12:09 — 16:01 UA6200 United Airlines Houston — Key West	6h 48m including layover	Find flight from$302
13:55 — 14:50 +1 day	13:55 — 14:51 UA5844 United Airlines Knoxville — Chicago 19h 45m stop 10:36 — 14:50 UA2070 United Airlines Chicago — Key West	24h 55m including layover	Find flight from$486
17:43 — 15:01 +1 day	17:43 — 18:52 UA5330 United Airlines Knoxville — Chicago 16h 3m stop 10:55 — 15:01 UA1385 United Airlines Chicago — Key West	21h 18m including layover	Find flight from$723
17:47 — 14:50 +1 day	17:47 — 18:50 UA5305 United Airlines Knoxville — Chicago 15h 46m stop 10:36 — 14:50 UA2070 United Airlines Chicago — Key West	21h 3m including layover	Find flight from$486
05:45 — 18:55	05:45 — 07:33 UA4311 United Airlines Knoxville — Washington D.C. 52m stop 08:25 — 11:12 UA1825 United Airlines Washington D.C. — Miami 6h 38m stop 17:50 — 18:55 UA3094 United Airlines Miami — Key West	13h 10m including layover	Find flight from$376
10:35 — 09:15 +1 day	10:35 — 12:20 UA4302 United Airlines Knoxville — Houston 2h 15m stop 14:35 — 17:51 UA1478 United Airlines Houston — Tampa 14h 9m stop 08:00 — 09:15 UA3135 United Airlines Tampa — Key West	22h 40m including layover	Find flight from$387
10:55 — 10:10 +1 day	10:55 — 11:59 UA5300 United Airlines Knoxville — Chicago 2h 21m stop 14:20 — 18:08 UA2042 United Airlines Chicago — Orlando 14h 37m stop 08:45 — 10:10 UA3075 United Airlines Orlando — Key West	23h 15m including layover	Find flight from$445
11:50 — 10:10 +1 day	11:50 — 13:26 UA4302 United Airlines Knoxville — Houston 1h 9m stop 14:35 — 18:00 UA496 United Airlines Houston — Orlando 14h 45m stop 08:45 — 10:10 UA3075 United Airlines Orlando — Key West	22h 20m including layover	Find flight from$446
11:50 — 10:10 +1 day	11:50 — 13:26 UA4302 United Airlines Knoxville — Houston 3h 39m stop 17:05 — 20:30 UA332 United Airlines Houston — Orlando 12h 15m stop 08:45 — 10:10 UA3075 United Airlines Orlando — Key West	22h 20m including layover	Find flight from$446
14:06 — 10:10 +1 day	14:06 — 15:12 UA3716 United Airlines Knoxville — Chicago 2h 43m stop 17:55 — 21:44 UA2113 United Airlines Chicago — Orlando 11h 1m stop 08:45 — 10:10 UA3075 United Airlines Orlando — Key West	20h 4m including layover	Find flight from$446
14:35 — 18:55 +1 day	14:35 — 16:15 UA4848 United Airlines Knoxville — Washington D.C. 1h 40m stop 17:55 — 20:42 UA1379 United Airlines Washington D.C. — Miami 21h 8m stop 17:50 — 18:55 UA3094 United Airlines Miami — Key West	28h 20m including layover	Find flight from$423
19:25 — 10:10 +1 day	19:25 — 21:15 UA4324 United Airlines Knoxville — Washington D.C. 1h 15m stop 22:30 — 00:54 UA689 United Airlines Washington D.C. — Orlando 7h 51m stop 08:45 — 10:10 UA3075 United Airlines Orlando — Key West	14h 45m including layover	Find flight from$445
19:25 — 14:20 +1 day	19:25 — 21:15 UA4324 United Airlines Knoxville — Washington D.C. 1h 15m stop 22:30 — 00:54 UA689 United Airlines Washington D.C. — Orlando 12h 1m stop 12:55 — 14:20 UA3071 United Airlines Orlando — Key West	18h 55m including layover	Find flight from$445

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on March 20, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Knoxville to Key West depends on and how to choose the most interesting flight option for you.

Distance between Knoxville and Key West is 1270 miles. Time difference between the cities is 0h. Airplanes depart 05:45 to 19:25 from 1 Knoxville airport and arrive 05:45 to 19:25 to 2 Key West airports. Average flight time is 23h 41m.

The fastest flight 5h 54m
Average flight time 23h 41m
The earliest flight 05:45
The latest flight 19:25
Distance 790 ml

The cheapest months to travel to Key West are november (from 135 $), february (from 302 $), december (from 376 $).

What is the lowest airfare Knoxville to Key West?

The cheapest plane ticket found by our users is $135. This airfare is for economy class on one-way G43061 flight by Allegiant Air for November 13, 2024 which leaves Mc Ghee Tyson in Knoxville at 09:00 am and arrives at Key West Key West Int. at 15:51.

Economy class

$135

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Business class

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First class

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Popular Airlines on the Route

The flight Knoxville — Key West is served by 2 regular airlines and 1 low-cost airline. Most of the flights on this route are operated by United Airlines - 95 departures per week at the price of from $ 302 . And the most expensive tickets are offered by United Airlines airline - from $ 727.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 96 flights with layovers on the route. The fastest connecting flight is UA4311 by United Airlines takes 5h 54m and the cheapest is G43061 by Allegiant Air for $135.

UA - United Airlines

from $302

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G4 - Allegiant Air

from $135

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Airports

You can fly from Knoxville to Key West from 1 airports (Mc Ghee Tyson).

Knoxville airports

Mc Ghee Tyson-TYS

from $135
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Key West airports

NAS-NQX

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Key West Int.-EYW

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Airplanes

There are flights to Key West from Knoxville by 2 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Knoxville

You may also consider searching for discounted plane tickets to some other popular places from Knoxville within United States.

Knoxville — Orlando

from $73

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Knoxville — Las Vegas

from $74

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Knoxville — Chicago

from $76

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Knoxville — Denver

from $74

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Knoxville — Miami

from $66

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Knoxville — Boston

from $69

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Knoxville — Houston

from $54

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Knoxville — New Orleans

from $56

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Knoxville — Tampa

from $80

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Knoxville — Austin

from $54

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Top International Destinations from Knoxville

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Knoxville — Cancun

from $69

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Knoxville — Panama City

from $61

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How to book a plane ticket yourself?

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That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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