Cheap Flights from Knoxville, TN to Key West, FL from $94

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On Cheapflightsplus.com you will find 93 connecting flights from Knoxville to Key West. You can compare airfare deals from 1 airlines and multiple travel sites from $94, book and save on cheap plane tickets and last minute offers. Also check out TYS-EYW flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Knoxville to Key West Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $94 (one-way), $161 (round-trip).

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Best Flights from Knoxville to Key West Today

Take a look at the list of non stop flights and flights with layovers from Knoxville to Key West with the lowest price of $94. Take a look at the list of flights with layovers from Knoxville to Key West from $94. There’re no direct flights. The fastest connecting flight – 6h 1m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $94 Find flight	14:23 Knoxville Mc Ghee Tyson	14:10+1 день Key West Key West Int.	23h 47m layover 21h 2m - Sanford	Allegiant Air	G43062 G41340
from $109 Find flight	08:47 Knoxville Mc Ghee Tyson	09:12+1 день Key West Key West Int.	24h 25m layover 21h 44m - Clearwater	Allegiant Air	G42708 G4973
from $148 Find flight	10:54 Knoxville Mc Ghee Tyson	15:26+1 день Key West Key West Int.	28h 32m layover 8h 12m - Miami 14h 16m - Fletcher	Allegiant Air	G4494 G4248 G4975
from $174 Find flight	07:00 Knoxville Mc Ghee Tyson	16:36+1 день Key West Key West Int.	33h 36m layover 9h 3m - Clearwater 17h 52m - Pittsburgh	Allegiant Air	G43038 G42672 G41055

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 15, 2025

Flight Schedule Knoxville (Tennessee) to Key West (Florida)

Full flight schedule will help you in detecting at what time planes fly from Knoxville to Key West. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
07:00 — 09:33 +1 day	07:00 — 08:41 G43048 Allegiant Air Knoxville — Clearwater 23h 49m stop 08:30 — 09:33 G4971 Allegiant Air Clearwater — Key West	26h 33m including layover	Find flight from$97
07:00 — 09:33 +1 day	07:00 — 08:41 G43038 Allegiant Air Knoxville — Clearwater 23h 49m stop 08:30 — 09:33 G4971 Allegiant Air Clearwater — Key West	26h 33m including layover	Find flight from$106
08:30 — 15:08	08:30 — 10:11 G43035 Allegiant Air Knoxville — Clearwater 3h 54m stop 14:05 — 15:08 G41034 Allegiant Air Clearwater — Key West	6h 38m including layover	Find flight from$107
08:30 — 08:04 +1 day	08:30 — 10:11 G43035 Allegiant Air Knoxville — Clearwater 20h 49m stop 07:00 — 08:04 G4971 Allegiant Air Clearwater — Key West	23h 34m including layover	Find flight from$107
08:47 — 09:12 +1 day	08:47 — 10:26 G42708 Allegiant Air Knoxville — Clearwater 21h 44m stop 08:10 — 09:12 G4973 Allegiant Air Clearwater — Key West	24h 25m including layover	Find flight from$109
10:54 — 15:26 +1 day	10:54 — 12:58 G4494 Allegiant Air Knoxville — Miami 8h 12m stop 21:10 — 23:11 G4248 Allegiant Air Miami — Fletcher 14h 16m stop 13:27 — 15:26 G4975 Allegiant Air Fletcher — Key West	28h 32m including layover	Find flight from$148
12:39 — 09:33 +1 day	12:39 — 14:20 G41404 Allegiant Air Knoxville — Clearwater 18h 10m stop 08:30 — 09:33 G4971 Allegiant Air Clearwater — Key West	20h 54m including layover	Find flight from$123
12:39 — 09:33 +1 day	12:39 — 14:20 G43058 Allegiant Air Knoxville — Clearwater 18h 10m stop 08:30 — 09:33 G4971 Allegiant Air Clearwater — Key West	20h 54m including layover	Find flight from$139
13:31 — 09:43 +1 day	13:31 — 15:04 G41436 Allegiant Air Knoxville — Sanford 17h 28m stop 08:32 — 09:43 G42877 Allegiant Air Sanford — Key West	20h 12m including layover	Find flight from$126
14:13 — 08:03 +1 day	14:13 — 15:53 G41429 Allegiant Air Knoxville — Clearwater 15h 7m stop 07:00 — 08:03 G4971 Allegiant Air Clearwater — Key West	17h 50m including layover	Find flight from$121
14:23 — 14:10 +1 day	14:23 — 15:58 G43062 Allegiant Air Knoxville — Sanford 21h 2m stop 13:00 — 14:10 G41340 Allegiant Air Sanford — Key West	23h 47m including layover	Find flight from$94
17:29 — 08:04 +1 day	17:29 — 19:10 G43062 Allegiant Air Knoxville — Clearwater 11h 50m stop 07:00 — 08:04 G4971 Allegiant Air Clearwater — Key West	14h 35m including layover	Find flight from$107
18:10 — 15:08 +1 day	18:10 — 19:51 G43030 Allegiant Air Knoxville — Clearwater 18h 14m stop 14:05 — 15:08 G41034 Allegiant Air Clearwater — Key West	20h 58m including layover	Find flight from$97
18:12 — 14:43 +1 day	18:12 — 19:52 G43020 Allegiant Air Knoxville — Clearwater 17h 48m stop 13:40 — 14:43 G41034 Allegiant Air Clearwater — Key West	20h 31m including layover	Find flight from$106
18:19 — 09:43 +1 day	18:19 — 19:52 G43027 Allegiant Air Knoxville — Sanford 12h 40m stop 08:32 — 09:43 G42877 Allegiant Air Sanford — Key West	15h 24m including layover	Find flight from$110

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on September 15, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Knoxville to Key West depends on and how to choose the most interesting flight option for you.

Distance between Knoxville and Key West is 1270 miles. Time difference between the cities is 0h. Airplanes depart 06:00 to 21:31 from 1 Knoxville airport and arrive 06:00 to 21:31 to 2 Key West airports. Average flight time is 26h 13m.

The fastest flight 6h 1m
Average flight time 26h 13m
The earliest flight 06:00
The latest flight 21:31
Distance 790 ml

The cheapest months to travel to Key West are august (from 94 $), july (from 97 $), october (from 109 $).

The most expensive months are september (from 182 $), october (from 109 $), july (from 97 $).

What is the lowest airfare Knoxville to Key West?

The cheapest plane ticket found by our users is $94. This airfare is for economy class on one-way G43062 flight by Allegiant Air for August 16, 2025 which leaves Mc Ghee Tyson in Knoxville at 14:23 am and arrives at Key West Key West Int. at 14:10.

Economy class

$94

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Business class

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First class

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Popular Airlines on the Route

The flight Knoxville — Key West is served by 1 regular airline and 1 low-cost airline. Most of the flights on this route are operated by Allegiant Air - 93 departures per week at the price of from $ 94 . And the most expensive tickets are offered by Allegiant Air airline - from $ 378.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 93 flights with layovers on the route. The fastest connecting flight is G41404 by Allegiant Air takes 6h 1m and the cheapest is G43062 by Allegiant Air for $94.

G4 - Allegiant Air

from $94

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Airports

You can fly from Knoxville to Key West from 1 airports (Mc Ghee Tyson).

Knoxville airports

Mc Ghee Tyson-TYS

from $94
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Key West airports

NAS-NQX

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Key West Int.-EYW

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Airplanes

There are flights to Key West from Knoxville by 1 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Knoxville

You may also consider searching for discounted plane tickets to some other popular places from Knoxville within United States.

Knoxville — Orlando

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Knoxville — Las Vegas

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Knoxville — Chicago

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Knoxville — Denver

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Knoxville — Miami

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Knoxville — Boston

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Knoxville — Houston

from $54

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Knoxville — New Orleans

from $56

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Knoxville — Tampa

from $80

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Knoxville — Austin

from $54

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Top International Destinations from Knoxville

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Knoxville — Cancun

from $69

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Knoxville — Panama City

from $61

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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