Cheap Flights from Santa Ana, CA to Chicago, IL from $66

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On Cheapflightsplus.com you will find 17 direct and 279 connecting flights from Santa Ana to Chicago. You can compare airfare deals from 7 airlines and multiple travel sites from $66, book and save on cheap plane tickets and last minute offers. Also check out SNA-CHI flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Santa Ana to Chicago Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $66 (one-way), $113 (round-trip).

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Best Flights from Santa Ana to Chicago Today

Take a look at the list of non stop flights and flights with layovers from Santa Ana to Chicago with the lowest price of $66. The fastest direct flight takes 4h 10m and the fastest connecting – 5h 31m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $222 Find flight	15:07 Santa Ana John Wayne	21:24 Chicago O'Hare International	4h 17m	Alaska Airlines	AS4237
from $223 Find flight	10:30 Santa Ana John Wayne	16:41 Chicago O'Hare International	4h 11m	United Airlines	UA2849
from $270 Find flight	10:19 Santa Ana John Wayne	16:30 Chicago O'Hare International	4h 11m	Alaska Airlines	AS6068
from $66 Find flight	12:01 Santa Ana John Wayne	20:54 Chicago Midway	6h 53m layover 1h 51m - Denver	Frontier Airlines	F94372 F92210
from $90 Find flight	19:58 Santa Ana John Wayne	06:03+1 день Chicago O'Hare International	8h 5m layover 3h 20m - Las Vegas	Spirit Airlines	NK1447 NK1053

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 18, 2025

Flight Schedule Santa Ana (California) to Chicago (Illinois)

Full flight schedule will help you in detecting at what time planes fly from Santa Ana to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
06:45 — 13:06	06:45 — 13:06 UA2649 United Airlines Santa Ana — Chicago	4h 21m	Find flight from$238
07:55 — 14:05	07:55 — 14:05 AS4336 Alaska Airlines Santa Ana — Chicago	4h 10m	Find flight from$225
10:19 — 16:37	10:19 — 16:37 AS4756 Alaska Airlines Santa Ana — Chicago	4h 18m	Find flight from$222
10:30 — 16:41	10:30 — 16:41 UA2849 United Airlines Santa Ana — Chicago	4h 11m	Find flight from$223
10:30 — 16:41	10:30 — 16:41 UA2075 United Airlines Santa Ana — Chicago	4h 11m	Find flight from$250
10:38 — 16:52	10:38 — 16:52 AS4625 Alaska Airlines Santa Ana — Chicago	4h 14m	Find flight from$252
11:34 — 17:48	11:34 — 17:48 AS4714 Alaska Airlines Santa Ana — Chicago	4h 14m	Find flight from$240
12:01 — 20:54	12:22 — 15:49 F94372 Frontier Airlines Santa Ana — Denver 1h 51m stop 08:50 — 12:13 F92210 Frontier Airlines Denver — Chicago	6h 53m including layover	Find flight from$66
13:48 — 19:59	13:48 — 19:59 UA1383 United Airlines Santa Ana — Chicago	4h 11m	Find flight from$223
13:48 — 19:59	13:48 — 19:59 UA276 United Airlines Santa Ana — Chicago	4h 11m	Find flight from$225
14:02 — 20:13	14:02 — 20:13 UA1641 United Airlines Santa Ana — Chicago	4h 11m	Find flight from$238
15:07 — 21:24	15:07 — 21:24 AS4237 Alaska Airlines Santa Ana — Chicago	4h 17m	Find flight from$222
15:09 — 21:24	15:09 — 21:24 AS4546 Alaska Airlines Santa Ana — Chicago	4h 15m	Find flight from$239
15:37 — 06:03 +1 day	15:37 — 16:58 NK1163 Spirit Airlines Santa Ana — Las Vegas 7h 36m stop 00:34 — 06:03 NK1053 Spirit Airlines Las Vegas — Chicago	12h 26m including layover	Find flight from$90
19:58 — 06:03 +1 day	19:58 — 21:14 NK1447 Spirit Airlines Santa Ana — Las Vegas 3h 20m stop 00:34 — 06:03 NK1053 Spirit Airlines Las Vegas — Chicago	8h 5m including layover	Find flight from$90

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on September 18, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Santa Ana to Chicago depends on and how to choose the most interesting flight option for you.

Distance between Santa Ana and Chicago is 2792 miles. Time difference between the cities is 2h. Airplanes depart 06:45 to 21:15 from 3 Santa Ana airports and arrive 06:45 to 21:15 to 7 Chicago airports. Average flight time is 4h 11m.

The fastest flight 4h 10m
Average flight time 4h 11m
The earliest flight 06:45
The latest flight 21:15
Distance 1735 ml

The cheapest months to travel to Chicago are november (from 66 $), september (from 66 $), january (from 87 $).

The most expensive months are october (from 102 $), december (from 91 $), august (from 90 $).

What is the lowest airfare Santa Ana to Chicago?

The cheapest plane ticket found by our users is $66. This airfare is for economy class on one-way F94372 flight by Frontier Airlines for September 24, 2025 which leaves John Wayne in Santa Ana at 12:01 am and arrives at Chicago Midway at 20:54.

Economy class

$66

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Business class

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First class

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Popular Airlines on the Route

The flight Santa Ana — Chicago is served by 7 regular airlines and 3 low-cost airlines. Most of the flights on this route are operated by Alaska Airlines - 55 departures per week at the price of from $ 127 . And the most expensive tickets are offered by United Airlines airline - from $ 619.

Direct flights

There are 17 nonstop flights on the route. The fastest direct flight is AS4336 by Alaska Airlines takes 4h 10m and the cheapest is F94372 by Frontier Airlines for $222.

AS - Alaska Airlines

from $222

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UA - United Airlines

from $223

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Connecting Flights

There are 279 flights with layovers on the route. The fastest connecting flight is NK870 by Spirit Airlines takes 5h 31m and the cheapest is F94372 by Frontier Airlines for $66.

AS - Alaska Airlines

from $127

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F9 - Frontier Airlines

from $66

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HA - Hawaiian Airlines

from $118

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MX - Mexicana

from $340

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UA - United Airlines

from $232

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NK - Spirit Airlines

from $90

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G4 - Allegiant Air

from $182

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Airports

You can fly from Santa Ana to Chicago from 3 airports (John Wayne, Santa Ana Heliport, Centerport Heliport).

Santa Ana airports

John Wayne-SNA

from $66
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Santa Ana Heliport-DNT

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Centerport Heliport-JOC

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Chicago airports

O'Hare International-ORD

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Midway-MDW

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Dupage County-DPA

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Chicago FSS-CHI

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Merrill C Meigs (closed)-CGX

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Pal-Waukee-PWK

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Chicago NAS-NOH

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Airplanes

There are flights to Chicago from Santa Ana by 7 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Santa Ana

You may also consider searching for discounted plane tickets to some other popular places from Santa Ana within United States.

Santa Ana — Las Vegas

from $58

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Santa Ana — Seattle

from $71

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Santa Ana — Denver

from $67

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Santa Ana — Chicago

from $59

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Santa Ana — New York

from $78

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Santa Ana — Houston

from $55

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Top International Destinations from Santa Ana

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
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That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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