Cheap Flights from Prague to Chicago, IL from $268

Return flight: Chicago – Prague

On Cheapflightsplus.com you will find 1000 connecting flights from Prague to Chicago. You can compare airfare deals from 36 airlines and multiple travel sites from $268, book and save on cheap plane tickets and last minute offers. Also check out PRG-CHI flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Prague to Chicago Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $268 (one-way), $460 (round-trip).
Direct flights
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Full flight schedule will help you in detecting at what time planes fly from Prague to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
07:20 — 15:55
06:55 — 08:05 BA853 British Airways
Prague — London
4h 40m stop
13:10 — 15:55 BA299 British Airways
London — Chicago
15h 35m
including layover
Find flight
from$369
07:20 — 18:15
07:20 — 08:30 BA853 British Airways
Prague — London
7h stop
15:30 — 18:15 BA297 British Airways
London — Chicago
17h 55m
including layover
Find flight
from$369
08:10 — 17:25
08:10 — 11:15 AY1228 Finnair
Prague — Helsinki
4h 45m stop
16:25 — 17:50 AY9 Finnair
Helsinki — Chicago
16h 15m
including layover
Find flight
from$409
08:10 — 17:25
08:10 — 11:15 BA6068 British Airways
Prague — Helsinki
4h 45m stop
16:25 — 17:50 BA6089 British Airways
Helsinki — Chicago
16h 15m
including layover
Find flight
from$411
09:40 — 18:15
09:40 — 10:45 W92601 Wizz Air UK
Prague — London
4h 45m stop
15:30 — 18:15 AY5537 Finnair
London — Chicago
15h 35m
including layover
Find flight
from$458
09:55 — 19:40
09:35 — 10:50 LO524 LOT
Prague — Warsaw
5h 35m stop
16:40 — 20:00 LO3 LOT
Warsaw — Chicago
16h 45m
including layover
Find flight
from$482
10:05 — 14:15
+1 day
10:05 — 13:05 QS1056 SmartWings
Prague — Madrid
22h 30m stop
11:35 — 14:15 AY5659 Finnair
Madrid — Chicago
35h 10m
including layover
Find flight
from$437
10:25 — 15:55
10:20 — 11:35 BA855 British Airways
Prague — London
1h 30m stop
13:10 — 15:55 BA299 British Airways
London — Chicago
12h 30m
including layover
Find flight
from$369
11:00 — 18:15
11:00 — 12:20 BA855 British Airways
Prague — London
3h 15m stop
15:45 — 18:45 BA297 British Airways
London — Chicago
14h 15m
including layover
Find flight
from$369
11:50 — 19:00
11:50 — 13:25 EI643 Aer Lingus
Prague — Dublin
3h 15m stop
16:40 — 19:00 EI125 Aer Lingus
Dublin — Chicago
14h 10m
including layover
Find flight
from$393
12:45 — 19:40
12:55 — 14:10 LO528 LOT
Prague — Warsaw
2h 40m stop
16:40 — 20:00 LO3 LOT
Warsaw — Chicago
13h 55m
including layover
Find flight
from$482
12:45 — 12:05
+1 day
12:45 — 14:00 LO528 LOT
Prague — Warsaw
19h 5m stop
09:05 — 12:05 LO31 LOT
Warsaw — Chicago
30h 20m
including layover
Find flight
from$495
13:40 — 12:50
+1 day
13:45 — 16:25 TP1241 TAP Portugal
Prague — Lisbon
17h 15m stop
13:15 — 16:30 TP243 TAP Portugal
Lisbon — Chicago
30h 10m
including layover
Find flight
from$452
14:00 — 21:15
14:00 — 15:55 FI537 Icelandair
Prague — Reykjavik
3h 40m stop
19:35 — 21:15 FI855 Icelandair
Reykjavik — Chicago
14h 15m
including layover
Find flight
from$412
14:15 — 09:40
+1 day
14:15 — 17:55 TK1774 Turkish Airlines
Prague — Istanbul
12h 35m stop
06:30 — 09:40 TK185 Turkish Airlines
Istanbul — Chicago
26h 25m
including layover
Find flight
from$548
15:35 — 18:15
+1 day
15:35 — 18:45 IB810 Iberia
Prague — Madrid
21h 55m stop
16:40 — 18:15 IB4230 Iberia
Madrid — Chicago
33h 40m
including layover
Find flight
from$485
15:35 — 14:15
+1 day
15:35 — 18:45 IB810 Iberia
Prague — Madrid
16h 50m stop
11:35 — 14:15 IB341 Iberia
Madrid — Chicago
29h 40m
including layover
Find flight
from$526
17:00 — 13:50
+1 day
17:00 — 18:05 W92603 Wizz Air UK
Prague — London
17h stop
11:05 — 13:50 BA295 British Airways
London — Chicago
27h 50m
including layover
Find flight
from$543
17:45 — 11:50
+1 day
21:25 — 22:35 BA861 British Airways
Prague — London
14h 20m stop
14:10 — 17:00 BA1542 British Airways
London — Chicago
25h 5m
including layover
Find flight
from$440
18:05 — 12:05
+1 day
18:05 — 19:20 LO522 LOT
Prague — Warsaw
13h 45m stop
09:05 — 12:05 LO31 LOT
Warsaw — Chicago
25h
including layover
Find flight
from$487
18:05 — 15:10
+1 day
18:05 — 19:20 LO522 LOT
Prague — Warsaw
16h 50m stop
12:10 — 15:10 LO1 LOT
Warsaw — Chicago
28h 5m
including layover
Find flight
from$487
19:30 — 17:25
+1 day
19:30 — 22:35 AY1224 Finnair
Prague — Helsinki
17h 25m stop
16:25 — 17:50 AY9 Finnair
Helsinki — Chicago
28h 55m
including layover
Find flight
from$409
19:40 — 14:15
+1 day
19:40 — 22:50 IB812 Iberia
Prague — Madrid
12h 45m stop
11:35 — 14:15 AY5659 Finnair
Madrid — Chicago
25h 35m
including layover
Find flight
from$446
20:45 — 13:55
+1 day
20:45 — 21:50 U22634 EasyJet
Prague — London
13h 20m stop
11:10 — 13:55 AY5535 Finnair
London — Chicago
24h 10m
including layover
Find flight
from$513
21:35 — 13:50
+1 day
18:55 — 20:05 BA857 British Airways
Prague — London
12h 30m stop
11:00 — 13:55 BA295 British Airways
London — Chicago
23h 15m
including layover
Find flight
from$369
21:35 — 15:55
+1 day
21:20 — 22:20 BA857 British Airways
Prague — London
14h 35m stop
13:10 — 15:55 BA299 British Airways
London — Chicago
25h 20m
including layover
Find flight
from$369
*Departure and arrival times - local. Updated on July 1, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Prague to Chicago depends on and how to choose the most interesting flight option for you.

Distance between Prague and Chicago is 7290 miles. Time difference between the cities is 7h. Airplanes depart 06:00 to 23:45 from 2 Prague airports and arrive 06:00 to 23:45 to 7 Chicago airports. Average flight time is 25h 25m.

  • The fastest flight 11h 25m
  • Average flight time 25h 25m
  • The earliest flight 06:00
  • The latest flight 23:45
  • Distance 4530 ml

The cheapest months to travel to Chicago are august (from 358 $), october (from 365 $), september (from 427 $).

The most expensive months are january (from 752 $), november (from 741 $), december (from 726 $).

What is the lowest airfare Prague to Chicago?

The cheapest plane ticket found by our users is $268. This airfare is for economy class on one-way D82621 flight by Djibouti Airlines for August 27, 2025 which leaves Ruzyne in Prague at 11:55 am and arrives at Chicago O'Hare International at 17:50.

Economy class
$268
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Business class
?
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First class
?
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Popular Airlines on the Route

The flight Prague — Chicago is served by 36 regular airlines and 8 low-cost airlines. Most of the flights on this route are operated by Condor Airlines - 3 departures per week at the price of from $ 567 . And the most expensive tickets are offered by Brussels Airlines airline - from $ 855.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 1000 flights with layovers on the route. The fastest connecting flight is LH1689 by Lufthansa takes 11h 25m and the cheapest is D82621 by Djibouti Airlines for $268.

  • DE - Condor Airlines
    from $567
    Find
  • W9 - Wizz Air UK
    from $320
    Find
  • VY - Vueling
    from $370
    Find
  • FI - Icelandair
    from $412
    Find
  • LO - LOT
    from $452
    Find
  • JU - Air Serbia
    from $350
    Find
  • FR - Ryanair
    from $356
    Find
  • LX - SWISS International Air Lines
    from $422
    Find
  • UA - United Airlines
    from $825
    Find
  • BT - airBaltic
    from $546
    Find
  • DY - Norwegian
    from $273
    Find
  • SK - SAS
    from $328
    Find
See more connecting flights

Airports

You can fly from Prague to Chicago from 2 airports (Ruzyne, Vodochody).

Prague airports

  • Ruzyne-PRG
    from $268
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  • Vodochody-VOD
    Find

Chicago airports

  • O'Hare International-ORD
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  • Midway-MDW
    Find
  • Dupage County-DPA
    Find
  • Chicago FSS-CHI
    Find
  • Merrill C Meigs (closed)-CGX
    Find
  • Pal-Waukee-PWK
    Find
  • Chicago NAS-NOH
    Find

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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