Cheap Flights from Prague to Chicago, IL from $348

Return flight: Chicago – Prague
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On Cheapflightsplus.com you will find 1000 connecting flights from Prague to Chicago. You can compare airfare deals from 36 airlines and multiple travel sites from $348, book and save on cheap plane tickets and last minute offers. Also check out PRG-CHI flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Prague to Chicago Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $348 (one-way), $597 (round-trip).
Direct flights
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Best Flights from Prague to Chicago Today

Take a look at the list of non stop flights and flights with layovers from Prague to Chicago with the lowest price of $348. Take a look at the list of flights with layovers from Prague to Chicago from $348. There’re no direct flights. The fastest connecting flight – 11h 25m.
Price Departure Arrival Flight Duration Airline Flight
from $444
Find flight
13:50
Prague
Ruzyne
 18:15
Chicago
O'Hare International
 11h 25m
layover
1h 0m - Munich
 Lufthansa
LH1691
LH434
from $470
Find flight
10:25
Prague
Ruzyne
 15:55
Chicago
O'Hare International
 12h 30m
layover
1h 30m - London
 British Airways
BA855
BA299
from $341
Find flight
11:55
Prague
Ruzyne
 17:50+1 день
Chicago
O'Hare International
 36h 55m
layover
23h 25m - Hagersten
1h 10m - Helsinki
 Djibouti Airlines
D82621
AY808
AY9
from $348
Find flight
06:05
Prague
Ruzyne
 19:00
Chicago
O'Hare International
 19h 55m
layover
2h 25m - Geneva
5h 15m - Dublin
 Eurowings AG
EW4230
EI681
EI125
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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 13, 2025
Full flight schedule will help you in detecting at what time planes fly from Prague to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
08:10 — 17:25
08:10 — 11:15 AY1228 Finnair
Prague — Helsinki
4h 45m stop
16:25 — 17:50 AY9 Finnair
Helsinki — Chicago
16h 15m
including layover
Find flight
from$520
08:10 — 17:25
08:10 — 11:15 BA6068 British Airways
Prague — Helsinki
4h 45m stop
16:25 — 17:50 BA6089 British Airways
Helsinki — Chicago
16h 15m
including layover
Find flight
from$524
08:10 — 17:25
08:10 — 11:15 AY1228 Finnair
Prague — Helsinki
4h 45m stop
16:25 — 17:50 IB6422 Iberia
Helsinki — Chicago
16h 15m
including layover
Find flight
from$564
10:05 — 14:15
+1 day
10:05 — 13:05 QS1056 SmartWings
Prague — Madrid
22h 30m stop
11:35 — 14:15 AY5659 Finnair
Madrid — Chicago
35h 10m
including layover
Find flight
from$556
10:25 — 15:55
10:20 — 11:35 BA855 British Airways
Prague — London
1h 30m stop
13:10 — 15:55 BA299 British Airways
London — Chicago
12h 30m
including layover
Find flight
from$470
11:35 — 17:25
11:35 — 14:50 AY1222 Finnair
Prague — Helsinki
1h 10m stop
16:25 — 17:50 AY9 Finnair
Helsinki — Chicago
12h 50m
including layover
Find flight
from$520
11:35 — 17:25
11:35 — 14:50 BA6096 British Airways
Prague — Helsinki
1h 10m stop
16:25 — 17:50 BA6089 British Airways
Helsinki — Chicago
12h 50m
including layover
Find flight
from$524
11:50 — 19:00
11:50 — 13:25 EI643 Aer Lingus
Prague — Dublin
3h 15m stop
16:40 — 19:00 EI125 Aer Lingus
Dublin — Chicago
14h 10m
including layover
Find flight
from$510
13:50 — 18:15
14:00 — 14:50 LH1691 Lufthansa
Prague — Munich
1h stop
15:40 — 18:55 LH434 Lufthansa
Munich — Chicago
11h 25m
including layover
Find flight
from$444
14:00 — 21:15
14:00 — 15:55 FI537 Icelandair
Prague — Reykjavik
3h 40m stop
19:35 — 21:15 FI855 Icelandair
Reykjavik — Chicago
14h 15m
including layover
Find flight
from$525
19:30 — 17:25
+1 day
19:30 — 22:35 AY1224 Finnair
Prague — Helsinki
17h 25m stop
16:25 — 17:50 AY9 Finnair
Helsinki — Chicago
28h 55m
including layover
Find flight
from$520
21:35 — 13:50
+1 day
18:55 — 20:05 BA857 British Airways
Prague — London
12h 30m stop
11:00 — 13:55 BA295 British Airways
London — Chicago
23h 15m
including layover
Find flight
from$470
21:35 — 15:55
+1 day
21:20 — 22:20 BA857 British Airways
Prague — London
14h 35m stop
13:10 — 15:55 BA299 British Airways
London — Chicago
25h 20m
including layover
Find flight
from$470
21:35 — 11:50
+1 day
21:20 — 22:20 BA857 British Airways
Prague — London
10h 40m stop
09:15 — 11:55 BA1542 British Airways
London — Chicago
21h 15m
including layover
Find flight
from$559
21:35 — 17:00
+1 day
21:35 — 22:35 BA857 British Airways
Prague — London
15h 50m stop
14:25 — 17:00 BA1546 British Airways
London — Chicago
26h 25m
including layover
Find flight
from$559
*Departure and arrival times - local. Updated on September 13, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Prague to Chicago depends on and how to choose the most interesting flight option for you.

Distance between Prague and Chicago is 7290 miles. Time difference between the cities is 7h. Airplanes depart 06:00 to 23:45 from 2 Prague airports and arrive 06:00 to 23:45 to 7 Chicago airports. Average flight time is 25h 25m.

  • The fastest flight 11h 25m
  • Average flight time 25h 25m
  • The earliest flight 06:00
  • The latest flight 23:45
  • Distance 4530 ml

Popular Airlines on the Route

The flight Prague — Chicago is served by 36 regular airlines and 8 low-cost airlines. Most of the flights on this route are operated by Condor Airlines - 3 departures per week at the price of from $ 721 . And the most expensive tickets are offered by Iberia airline - from $ 2266.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 1000 flights with layovers on the route. The fastest connecting flight is LH1691 by Lufthansa takes 11h 25m.

  • DE - Condor Airlines
    from $721
    Find
  • W9 - Wizz Air UK
    from $407
    Find
  • VY - Vueling
    from $471
    Find
  • FI - Icelandair
    from $525
    Find
  • LO - LOT
    from $575
    Find
  • JU - Air Serbia
    from $445
    Find
  • FR - Ryanair
    from $453
    Find
  • LX - SWISS International Air Lines
    from $537
    Find
  • UA - United Airlines
    from $1049
    Find
  • BT - airBaltic
    from $639
    Find
  • DY - Norwegian
    from $348
    Find
  • SK - SAS
    from $418
    Find
See more connecting flights

Airports

You can fly from Prague to Chicago from 2 airports (Ruzyne, Vodochody).

Prague airports

  • Ruzyne-PRG
    from $341
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  • Vodochody-VOD
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Chicago airports

  • O'Hare International-ORD
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  • Midway-MDW
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  • Dupage County-DPA
    Find
  • Chicago FSS-CHI
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  • Merrill C Meigs (closed)-CGX
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  • Pal-Waukee-PWK
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  • Chicago NAS-NOH
    Find

Airplanes

There are flights to Chicago from Prague by 36 airlines that use 5 aircraft brands. They range from huge modern airplanes to small-sized.

  • Bombardier CRJ 900
    from $444
    Find
  • Airbus A321
    from $706
    Find
  • Embraer 195
    from $969
    Find
  • Airbus A320
    from $1 028
    Find
  • Airbus A321NEO
    from $1 078
    Find

Top International Destinations from Prague

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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