Cheap Flights from Prague to Chicago, IL from $404

Return flight: Chicago – Prague
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On Cheapflightsplus.com you will find 12 connecting flights from Prague to Chicago. You can compare airfare deals from 6 airlines and multiple travel sites from $404, book and save on cheap plane tickets and last minute offers. Also check out PRG-CHI flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Prague to Chicago Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $404 (one-way), $693 (round-trip).
Direct flights
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Best Flights from Prague to Chicago Today

Take a look at the list of non stop flights and flights with layovers from Prague to Chicago with the lowest price of $404. Take a look at the list of flights with layovers from Prague to Chicago from $404. There’re no direct flights. The fastest connecting flight – 11h 35m.
Price Departure Arrival Flight Duration Airline Flight
from $404
Find flight
13:50
Prague
Ruzyne
 18:25
Chicago
O'Hare International
 11h 35m
layover
0h 50m - Munich
 United Airlines
UA9251
UA8855
from $417
Find flight
13:50
Prague
Ruzyne
 18:25
Chicago
O'Hare International
 11h 35m
layover
0h 50m - Munich
 Lufthansa
LH1691
LH434
from $1021
Find flight
09:50
Prague
Ruzyne
 16:15
Chicago
O'Hare International
 13h 25m
layover
1h 55m - Zurich
 SWISS International Air Lines
LX1485
LX8
from $1059
Find flight
18:45
Prague
Ruzyne
 12:15+1 день
Chicago
O'Hare International
 24h 30m
layover
13h 55m - Brussels
 Brussels Airlines
SN2812
SN8803
from $1063
Find flight
18:45
Prague
Ruzyne
 12:15+1 день
Chicago
O'Hare International
 24h 30m
layover
13h 55m - Brussels
 Brussels Airlines
SN2812
UA973
from $715
Find flight
08:00
Prague
Ruzyne
 17:20
Chicago
O'Hare International
 16h 20m
layover
2h 35m - Hagersten
1h 30m - Reykjavik
 Eurowings AG
EW4236
FI307
FI853
from $1033
Find flight
07:25
Prague
Ruzyne
 18:34
Chicago
O'Hare International
 18h 9m
layover
2h 15m - Vienna
2h 45m - Washington D.C.
 Austrian Airlines
OS712
OS93
OS7915
from $1036
Find flight
20:00
Prague
Ruzyne
 12:15+1 день
Chicago
O'Hare International
 23h 15m
layover
9h 45m - Zurich
1h 45m - Brussels
 SWISS International Air Lines
LX1499
LX786
LX3008
from $1050
Find flight
20:00
Prague
Ruzyne
 13:50+1 день
Chicago
O'Hare International
 24h 50m
layover
9h 45m - Zurich
2h 20m - London
 SWISS International Air Lines
LX1499
LX316
LX3044
from $1050
Find flight
20:00
Prague
Ruzyne
 17:00+1 день
Chicago
O'Hare International
 28h 0m
layover
9h 45m - Zurich
5h 30m - London
 SWISS International Air Lines
LX1499
LX316
LX3058
from $1055
Find flight
10:30
Prague
Ruzyne
 18:25
Chicago
O'Hare International
 14h 55m
layover
1h 35m - Frankfurt
1h 25m - Munich
 Lufthansa
LH1393
LH106
LH434
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on April 19, 2025
Full flight schedule will help you in detecting at what time planes fly from Prague to Chicago. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
09:50 — 16:15
09:35 — 11:00 LX1485 SWISS International Air Lines
Prague — Zurich
1h 55m stop
13:20 — 16:05 LX8 SWISS International Air Lines
Zurich — Chicago
13h 25m
including layover
Find flight
from$1021
13:50 — 18:25
13:15 — 14:05 UA9251 United Airlines
Prague — Munich
50m stop
15:30 — 18:10 UA8855 United Airlines
Munich — Chicago
11h 35m
including layover
Find flight
from$404
13:50 — 18:25
14:00 — 14:50 LH1691 Lufthansa
Prague — Munich
50m stop
15:40 — 18:55 LH434 Lufthansa
Munich — Chicago
11h 35m
including layover
Find flight
from$417
18:45 — 12:15
+1 day
18:45 — 20:15 SN2812 Brussels Airlines
Prague — Brussels
13h 55m stop
11:15 — 13:05 SN8803 Brussels Airlines
Brussels — Chicago
24h 30m
including layover
Find flight
from$1059
18:45 — 12:15
+1 day
18:45 — 20:15 SN2812 Brussels Airlines
Prague — Brussels
13h 55m stop
11:15 — 13:05 UA973 United Airlines
Brussels — Chicago
24h 30m
including layover
Find flight
from$1063
07:25 — 18:34
07:30 — 08:20 OS712 Austrian Airlines
Prague — Vienna
2h 15m stop
10:50 — 14:35 OS93 Austrian Airlines
Vienna — Washington D.C.
2h 45m stop
17:16 — 18:40 OS7915 Austrian Airlines
Washington D.C. — Chicago
18h 9m
including layover
Find flight
from$1033
08:00 — 17:20
19:45 — 21:45 EW4236 Eurowings AG
Prague — Hagersten
2h 35m stop
13:50 — 15:10 FI307 Icelandair
Hagersten — Reykjavik
1h 30m stop
16:45 — 18:20 FI853 Icelandair
Reykjavik — Chicago
16h 20m
including layover
Find flight
from$715
09:45 — 18:10
09:35 — 11:00 LX1485 SWISS International Air Lines
Prague — Zurich
2h 10m stop
13:05 — 14:00 LX1628 SWISS International Air Lines
Zurich — Milan
50m stop
15:10 — 18:00 LX3114 SWISS International Air Lines
Milan — Chicago
15h 25m
including layover
Find flight
from$1065
10:30 — 18:25
10:15 — 11:25 LH1393 Lufthansa
Prague — Frankfurt
1h 35m stop
13:15 — 14:10 LH106 Lufthansa
Frankfurt — Munich
1h 25m stop
15:25 — 18:15 LH434 Lufthansa
Munich — Chicago
14h 55m
including layover
Find flight
from$1055
20:00 — 12:15
+1 day
19:05 — 20:25 LX1499 SWISS International Air Lines
Prague — Zurich
9h 45m stop
07:25 — 08:45 LX786 SWISS International Air Lines
Zurich — Brussels
1h 45m stop
11:15 — 13:05 LX3008 SWISS International Air Lines
Brussels — Chicago
23h 15m
including layover
Find flight
from$1036
20:00 — 13:50
+1 day
19:05 — 20:25 LX1499 SWISS International Air Lines
Prague — Zurich
9h 45m stop
07:05 — 07:55 LX316 SWISS International Air Lines
Zurich — London
2h 20m stop
13:05 — 16:00 LX3044 SWISS International Air Lines
London — Chicago
24h 50m
including layover
Find flight
from$1050
20:00 — 17:00
+1 day
19:05 — 20:25 LX1499 SWISS International Air Lines
Prague — Zurich
9h 45m stop
07:05 — 07:55 LX316 SWISS International Air Lines
Zurich — London
5h 30m stop
15:20 — 18:15 LX3058 SWISS International Air Lines
London — Chicago
28h
including layover
Find flight
from$1050
*Departure and arrival times - local. Updated on April 19, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Prague to Chicago depends on and how to choose the most interesting flight option for you.

Distance between Prague and Chicago is 7290 miles. Time difference between the cities is 7h. Airplanes depart 07:25 to 20:00 from 2 Prague airports and arrive 07:25 to 20:00 to 7 Chicago airports. Average flight time is 17h 15m.

  • The fastest flight 11h 35m
  • Average flight time 17h 15m
  • The earliest flight 07:25
  • The latest flight 20:00
  • Distance 4530 ml

The cheapest months to travel to Chicago are april (from 404 $), november (from 732 $), december (from 920 $).

The most expensive months are january (from 1 059 $), february (from 1 000 $), december (from 920 $).

What is the lowest airfare Prague to Chicago?

The cheapest plane ticket found by our users is $404. This airfare is for economy class on one-way UA9251 flight by United Airlines for April 23, 2025 which leaves Ruzyne in Prague at 13:50 am and arrives at Chicago O'Hare International at 18:25.

Economy class
$404
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Business class
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First class
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Popular Airlines on the Route

The flight Prague — Chicago is served by 6 regular airlines . Most of the flights on this route are operated by Eurowings AG - 1 departures per week at the price of from $ 715 . And the most expensive tickets are offered by SWISS International Air Lines airline - from $ 1065.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 12 flights with layovers on the route. The fastest connecting flight is UA9251 by United Airlines takes 11h 35m and the cheapest is UA9251 by United Airlines for $404.

  • EW - Eurowings AG
    from $715
    Find
  • OS - Austrian Airlines
    from $1033
    Find
  • SN - Brussels Airlines
    from $1059
    Find
  • UA - United Airlines
    from $404
    Find
  • LH - Lufthansa
    from $417
    Find
  • LX - SWISS International Air Lines
    from $1021
    Find
See more connecting flights

Airports

You can fly from Prague to Chicago from 2 airports (Ruzyne, Vodochody).

Prague airports

  • Ruzyne-PRG
    from $404
    Find
  • Vodochody-VOD
    Find

Chicago airports

  • O'Hare International-ORD
    Find
  • Midway-MDW
    Find
  • Dupage County-DPA
    Find
  • Chicago FSS-CHI
    Find
  • Merrill C Meigs (closed)-CGX
    Find
  • Pal-Waukee-PWK
    Find
  • Chicago NAS-NOH
    Find

Airplanes

There are flights to Chicago from Prague by 6 airlines that use 5 aircraft brands. They range from huge modern airplanes to small-sized.

  • Embraer 195
    from $404
    Find
  • Bombardier CRJ 900
    from $417
    Find
  • Airbus A321NEO
    from $1 036
    Find
  • Airbus A320
    from $1 055
    Find
  • Airbus A319
    from $1 059
    Find

Top International Destinations from Prague

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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