Cheap Flights from Chicago, IL to Prague from $246

Return flight: Prague – Chicago
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On Cheapflightsplus.com you will find 1000 connecting flights from Chicago to Prague. You can compare airfare deals from 23 airlines and multiple travel sites from $246, book and save on cheap plane tickets and last minute offers. Also check out CHI-PRG flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Chicago to Prague Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $246 (one-way), $422 (round-trip).
Direct flights
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Best Flights from Chicago to Prague Today

Take a look at the list of non stop flights and flights with layovers from Chicago to Prague with the lowest price of $246. Take a look at the list of flights with layovers from Chicago to Prague from $246. There’re no direct flights. The fastest connecting flight – 10h 20m.
Price Departure Arrival Flight Duration Airline Flight
from $288
Find flight
22:15
Chicago
O'Hare International
 13:05+2 дня
Prague
Ruzyne
 31h 50m
layover
22h 0m - Reykjavik
 Icelandair
FI856
FI536
from $348
Find flight
11:25
Chicago
O'Hare International
 18:25+1 день
Prague
Ruzyne
 24h 0m
layover
11h 0m - Istanbul
 Turkish Airlines
TK186
TK1769
from $246
Find flight
19:25
Chicago
O'Hare International
 18:50+1 день
Prague
Ruzyne
 16h 25m
layover
1h 0m - Reykjavik
4h 35m - Copenhagen
 Icelandair
FI852
FI204
D82066
from $249
Find flight
19:39
Chicago
O'Hare International
 09:00+3 дня
Prague
Ruzyne
 54h 21m
layover
21h 8m - Orlando
19h 50m - London
 Spirit Airlines
NK507
Z0784
W92602
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 13, 2025
Full flight schedule will help you in detecting at what time planes fly from Chicago to Prague. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
11:25 — 18:25
+1 day
11:25 — 05:45 TK186 Turkish Airlines
Chicago — Istanbul
11h stop
16:45 — 18:25 TK1769 Turkish Airlines
Istanbul — Prague
24h
including layover
Find flight
from$348
11:25 — 08:25
+1 day
11:55 — 07:10 TK186 Turkish Airlines
Chicago — Istanbul
1h 5m stop
08:10 — 09:00 TK1767 Turkish Airlines
Istanbul — Prague
14h
including layover
Find flight
from$349
11:25 — 14:30
+1 day
11:25 — 05:45 TK186 Turkish Airlines
Chicago — Istanbul
7h 5m stop
12:50 — 14:30 TK1771 Turkish Airlines
Istanbul — Prague
20h 5m
including layover
Find flight
from$349
11:25 — 13:10
+1 day
11:25 — 05:45 TK186 Turkish Airlines
Chicago — Istanbul
5h 45m stop
11:30 — 13:10 TK1773 Turkish Airlines
Istanbul — Prague
18h 45m
including layover
Find flight
from$352
19:15 — 20:15
+1 day
19:15 — 10:45 SK944 SAS
Chicago — Copenhagen
8h 15m stop
19:30 — 20:45 SK1761 SAS
Copenhagen — Prague
18h
including layover
Find flight
from$351
19:25 — 13:05
+1 day
19:25 — 06:40 FI852 Icelandair
Chicago — Reykjavik
40m stop
07:20 — 13:05 FI536 Icelandair
Reykjavik — Prague
10h 40m
including layover
Find flight
from$309
19:50 — 08:25
+2 days
19:50 — 14:40 TK6 Turkish Airlines
Chicago — Istanbul
16h 10m stop
06:50 — 08:25 TK1767 Turkish Airlines
Istanbul — Prague
29h 35m
including layover
Find flight
from$348
19:50 — 14:30
+2 days
19:50 — 14:40 TK6 Turkish Airlines
Chicago — Istanbul
22h 10m stop
12:50 — 14:30 TK1771 Turkish Airlines
Istanbul — Prague
35h 40m
including layover
Find flight
from$348
19:50 — 18:25
+1 day
19:50 — 14:40 TK6 Turkish Airlines
Chicago — Istanbul
2h 5m stop
16:45 — 18:25 TK1769 Turkish Airlines
Istanbul — Prague
15h 35m
including layover
Find flight
from$349
22:15 — 13:05
+2 days
22:15 — 09:20 FI856 Icelandair
Chicago — Reykjavik
22h stop
07:20 — 13:05 FI536 Icelandair
Reykjavik — Prague
31h 50m
including layover
Find flight
from$288
23:20 — 20:05
+1 day
23:20 — 16:00 JU507 Air Serbia
Chicago — Belgrade
1h 55m stop
17:55 — 20:05 JU174 Air Serbia
Belgrade — Prague
13h 45m
including layover
Find flight
from$382
23:45 — 08:25
+2 days
23:45 — 18:05 TK156 Turkish Airlines
Chicago — Istanbul
12h 45m stop
06:50 — 08:25 TK1767 Turkish Airlines
Istanbul — Prague
25h 40m
including layover
Find flight
from$348
23:45 — 14:30
+2 days
23:45 — 18:05 TK156 Turkish Airlines
Chicago — Istanbul
18h 45m stop
12:50 — 14:30 TK1771 Turkish Airlines
Istanbul — Prague
31h 45m
including layover
Find flight
from$348
23:45 — 18:25
+2 days
23:45 — 18:05 TK156 Turkish Airlines
Chicago — Istanbul
22h 40m stop
16:45 — 18:25 TK1769 Turkish Airlines
Istanbul — Prague
35h 40m
including layover
Find flight
from$348
23:45 — 13:10
+2 days
23:45 — 18:05 TK156 Turkish Airlines
Chicago — Istanbul
17h 25m stop
11:30 — 13:10 TK1773 Turkish Airlines
Istanbul — Prague
30h 25m
including layover
Find flight
from$354
*Departure and arrival times - local. Updated on September 13, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Chicago to Prague depends on and how to choose the most interesting flight option for you.

Distance between Chicago and Prague is 7290 miles. Time difference between the cities is 7h. Airplanes depart 05:40 to 23:45 from 7 Chicago airports and arrive 05:40 to 23:45 to 2 Prague airports. Average flight time is 19h 46m.

  • The fastest flight 10h 20m
  • Average flight time 19h 46m
  • The earliest flight 05:40
  • The latest flight 23:45
  • Distance 4530 ml

Popular Airlines on the Route

The flight Chicago — Prague is served by 23 regular airlines and 4 low-cost airlines. Most of the flights on this route are operated by KLM - 16 departures per week at the price of from $ 456 . And the most expensive tickets are offered by TAP Portugal airline - from $ 3306.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 1000 flights with layovers on the route. The fastest connecting flight is LH437 by Lufthansa takes 10h 20m.

  • KL - KLM
    from $456
    Find
  • AC - Air Canada
    from $363
    Find
  • FI - Icelandair
    from $246
    Find
  • LO - LOT
    from $573
    Find
  • OS - Austrian Airlines
    from $433
    Find
  • EI - Aer Lingus
    from $523
    Find
  • AF - Air France
    from $456
    Find
  • SY - Sun Country Airlines
    from $335
    Find
  • JU - Air Serbia
    from $382
    Find
  • LX - SWISS International Air Lines
    from $429
    Find
  • UA - United Airlines
    from $471
    Find
  • F9 - Frontier Airlines
    from $284
    Find
See more connecting flights

Airports

You can fly from Chicago to Prague from 7 airports (O'Hare International, Midway, Dupage County, Chicago FSS, Merrill C Meigs (closed), Pal-Waukee, Chicago NAS).

Chicago airports

  • O'Hare International-ORD
    from $246
    Find
  • Midway-MDW
    from $284
    Find
  • Dupage County-DPA
    Find
  • Chicago FSS-CHI
    Find
  • Merrill C Meigs (closed)-CGX
    Find
  • Pal-Waukee-PWK
    Find
  • Chicago NAS-NOH
    Find

Prague airports

  • Ruzyne-PRG
    Find
  • Vodochody-VOD
    Find

Airplanes

There are flights to Prague from Chicago by 23 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Chicago

You may also consider searching for discounted plane tickets to some other popular places from Chicago within United States.

Top International Destinations from Chicago

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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