Cheap Flights from Houston, TX to Knoxville, TN from $362

Return flight: Knoxville – Houston
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On Cheapflightsplus.com you will find 44 connecting flights from Houston to Knoxville. You can compare airfare deals from 4 airlines and multiple travel sites from $362, book and save on cheap plane tickets and last minute offers. Also check out HOU-TYS flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Houston to Knoxville Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $362 (one-way), $621 (round-trip).
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Best Flights from Houston to Knoxville Today

Take a look at the list of non stop flights and flights with layovers from Houston to Knoxville with the lowest price of $362. Take a look at the list of flights with layovers from Houston to Knoxville from $362. There’re no direct flights. The fastest connecting flight – 6h 55m.
Price Departure Arrival Flight Duration Airline Flight
from $368
Find flight
21:34
Houston
George Bush
 10:13+1 день
Knoxville
Mc Ghee Tyson
 11h 39m
layover
7h 3m - Chicago
 United Airlines
UA2234
UA5726
from $449
Find flight
06:30
Houston
George Bush
 16:47
Knoxville
Mc Ghee Tyson
 9h 17m
layover
4h 41m - Washington D.C.
 Spirit Airlines
NK2317
G41398
from $362
Find flight
16:30
Houston
George Bush
 13:11+2 дня
Knoxville
Mc Ghee Tyson
 43h 41m
layover
15h 2m - Raleigh
21h 58m - Clearwater
 Frontier Airlines
F94610
F93373
G43063
from $481
Find flight
18:15
Houston
Hobby
 15:51+1 день
Knoxville
Mc Ghee Tyson
 20h 36m
layover
7h 31m - New Haven
4h 17m - Miami
 Casino Express
XP300
XP323
G41876
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 15, 2025
Full flight schedule will help you in detecting at what time planes fly from Houston to Knoxville. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
06:30 — 16:47
06:30 — 10:32 NK2317 Spirit Airlines
Houston — Washington D.C.
4h 41m stop
15:13 — 16:47 G41398 Allegiant Air
Washington D.C. — Knoxville
9h 17m
including layover
Find flight
from$449
07:20 — 15:15
07:20 — 08:54 UA2433 United Airlines
Houston — Denver
1h 31m stop
10:25 — 15:15 UA1631 United Airlines
Denver — Knoxville
6h 55m
including layover
Find flight
from$497
14:20 — 10:13
+1 day
14:20 — 17:10 UA2135 United Airlines
Houston — Chicago
14h 8m stop
07:18 — 10:13 UA5726 United Airlines
Chicago — Knoxville
18h 53m
including layover
Find flight
from$676
16:30 — 13:11
+2 days
16:30 — 20:30 F94610 Frontier Airlines
Houston — Raleigh
15h 2m stop
11:32 — 13:32 F93373 Frontier Airlines
Raleigh — Clearwater
21h 58m stop
11:30 — 13:11 G43063 Allegiant Air
Clearwater — Knoxville
43h 41m
including layover
Find flight
from$362
16:30 — 19:54
+2 days
16:30 — 20:30 F94610 Frontier Airlines
Houston — Raleigh
22h 30m stop
19:00 — 21:02 F91039 Frontier Airlines
Raleigh — Sanford
21h 15m stop
18:17 — 19:54 G43060 Allegiant Air
Sanford — Knoxville
50h 24m
including layover
Find flight
from$363
16:30 — 15:02
+2 days
16:30 — 20:30 F94610 Frontier Airlines
Houston — Raleigh
22h 30m stop
19:00 — 21:02 F91039 Frontier Airlines
Raleigh — Sanford
16h 23m stop
13:25 — 15:02 G43050 Allegiant Air
Sanford — Knoxville
45h 32m
including layover
Find flight
from$371
16:30 — 15:02
+2 days
16:30 — 20:30 F94610 Frontier Airlines
Houston — Raleigh
14h 27m stop
10:57 — 12:51 F91785 Frontier Airlines
Raleigh — Sanford
24h 34m stop
13:25 — 15:02 G43050 Allegiant Air
Sanford — Knoxville
45h 32m
including layover
Find flight
from$382
16:30 — 14:34
+2 days
16:30 — 20:30 F94610 Frontier Airlines
Houston — Raleigh
23h 7m stop
19:37 — 21:55 NK1984 Spirit Airlines
Raleigh — Miami
14h 35m stop
12:30 — 14:34 G42105 Allegiant Air
Miami — Knoxville
45h 4m
including layover
Find flight
from$481
17:05 — 10:13
+1 day
16:59 — 19:55 UA2296 United Airlines
Houston — Chicago
11h 20m stop
07:15 — 10:09 UA5726 United Airlines
Chicago — Knoxville
16h 8m
including layover
Find flight
from$453
17:05 — 13:25
+1 day
17:05 — 19:58 UA2296 United Airlines
Houston — Chicago
14h 37m stop
10:35 — 13:25 UA4194 United Airlines
Chicago — Knoxville
19h 20m
including layover
Find flight
from$676
17:05 — 22:37
+1 day
17:05 — 19:58 UA2296 United Airlines
Houston — Chicago
23h 49m stop
19:47 — 22:37 UA2005 United Airlines
Chicago — Knoxville
28h 32m
including layover
Find flight
from$676
18:15 — 15:51
+1 day
18:15 — 22:59 XP300 Casino Express
Houston — New Haven
7h 31m stop
06:30 — 09:30 XP323 Casino Express
New Haven — Miami
4h 17m stop
13:47 — 15:51 G41876 Allegiant Air
Miami — Knoxville
20h 36m
including layover
Find flight
from$481
18:32 — 14:11
+1 day
18:32 — 21:51 F92562 Frontier Airlines
Houston — Clearwater
14h 39m stop
12:30 — 14:11 G43047 Allegiant Air
Clearwater — Knoxville
18h 39m
including layover
Find flight
from$497
19:00 — 15:51
+1 day
19:00 — 22:59 NK2608 Spirit Airlines
Houston — Baltimore
7h 38m stop
06:37 — 09:15 NK1224 Spirit Airlines
Baltimore — Miami
4h 32m stop
13:47 — 15:51 G41876 Allegiant Air
Miami — Knoxville
19h 51m
including layover
Find flight
from$594
21:34 — 10:13
+1 day
21:34 — 00:15 UA2234 United Airlines
Houston — Chicago
7h 3m stop
07:18 — 10:13 UA5726 United Airlines
Chicago — Knoxville
11h 39m
including layover
Find flight
from$368
*Departure and arrival times - local. Updated on September 15, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Houston to Knoxville depends on and how to choose the most interesting flight option for you.

Distance between Houston and Knoxville is 1257 miles. Time difference between the cities is 1h. Airplanes depart 06:30 to 21:57 from 15 Houston airports and arrive 06:30 to 21:57 to 1 Knoxville airport. Average flight time is 16h 29m.

  • The fastest flight 6h 55m
  • Average flight time 16h 29m
  • The earliest flight 06:30
  • The latest flight 21:57
  • Distance 782 ml

The cheapest months to travel to Knoxville are august (from 362 $), september (from 368 $), june (from 453 $).

What is the lowest airfare Houston to Knoxville?

The cheapest plane ticket found by our users is $362. This airfare is for economy class on one-way F94610 flight by Frontier Airlines for August 29, 2025 which leaves George Bush in Houston at 16:30 am and arrives at Knoxville Mc Ghee Tyson at 13:11.

Economy class
$362
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Business class
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First class
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Popular Airlines on the Route

The flight Houston — Knoxville is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 6 departures per week at the price of from $ 362 . And the most expensive tickets are offered by United Airlines airline - from $ 890.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 44 flights with layovers on the route. The fastest connecting flight is UA2433 by United Airlines takes 6h 55m and the cheapest is F94610 by Frontier Airlines for $362.

  • F9 - Frontier Airlines
    from $362
    Find
  • XP - Casino Express
    from $481
    Find
  • UA - United Airlines
    from $368
    Find
  • NK - Spirit Airlines
    from $449
    Find
See more connecting flights

Airports

You can fly from Houston to Knoxville from 15 airports (Ellington Field, West Houston, Hobby, Park Ten Heliport, Andrau Airpark, George Bush, Greenway Plaza H/P, David Wayne Hooks, Transco Twr Galleria, Westchase Hilton H/P, Spaceland, Woodlawns, Marriot Astrodome Heliport, Central Bus. District, Houston Municipal).

Houston airports

  • Ellington Field-EFD
    Find
  • West Houston-IWS
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  • Hobby-HOU
    from $481
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  • Park Ten Heliport-JPT
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  • Andrau Airpark-AAP
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  • George Bush-IAH
    from $362
    Find
  • Greenway Plaza H/P-JGP
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  • David Wayne Hooks-DWH
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  • Transco Twr Galleria-JGQ
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  • Westchase Hilton H/P-JWH
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  • Spaceland-SPX
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  • Woodlawns-JWL
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  • Marriot Astrodome Heliport-JMA
    Find
  • Central Bus. District-JDX
    Find
  • Houston Municipal-SGR
    Find

Knoxville airports

  • Mc Ghee Tyson-TYS
    Find

Airplanes

There are flights to Knoxville from Houston by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Houston

You may also consider searching for discounted plane tickets to some other popular places from Houston within United States.

Top International Destinations from Houston

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
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