Cheap Flights from Des Moines, IA to Fort Myers, FL from $270

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On Cheapflightsplus.com you will find 110 connecting flights from Des Moines to Fort Myers. You can compare airfare deals from 3 airlines and multiple travel sites from $270, book and save on cheap plane tickets and last minute offers. Also check out DSM-RSW flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Des Moines to Fort Myers Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $270 (one-way), $463 (round-trip).

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Best Flights from Des Moines to Fort Myers Today

Take a look at the list of non stop flights and flights with layovers from Des Moines to Fort Myers with the lowest price of $270. Take a look at the list of flights with layovers from Des Moines to Fort Myers from $270. There’re no direct flights. The fastest connecting flight – 5h 35m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $301 Find flight	08:00 Des Moines Des Moines International Airport	14:51 Fort Myers Southwest Florida Reg	5h 51m layover 1h 10m - Chicago	United Airlines	UA1363 UA2737
from $301 Find flight	15:05 Des Moines Des Moines International Airport	22:00 Fort Myers Southwest Florida Reg	5h 55m layover 0h 52m - Houston	United Airlines	UA6033 UA1955
from $301 Find flight	11:35 Des Moines Des Moines International Airport	20:15 Fort Myers Southwest Florida Reg	7h 40m layover 3h 0m - Chicago	United Airlines	UA2306 UA659
from $301 Find flight	13:49 Des Moines Des Moines International Airport	23:48 Fort Myers Southwest Florida Reg	8h 59m layover 3h 6m - Denver	United Airlines	UA5835 UA2671
from $335 Find flight	15:20 Des Moines Des Moines International Airport	21:55 Fort Myers Southwest Florida Reg	5h 35m layover 1h 7m - Chicago	United Airlines	UA1568 UA396
from $335 Find flight	15:00 Des Moines Des Moines International Airport	23:15 Fort Myers Southwest Florida Reg	7h 15m layover 2h 23m - Houston	United Airlines	UA6033 UA2357
from $335 Find flight	06:00 Des Moines Des Moines International Airport	15:23 Fort Myers Southwest Florida Reg	8h 23m layover 2h 39m - Denver	United Airlines	UA497 UA2601
from $335 Find flight	13:45 Des Moines Des Moines International Airport	23:33 Fort Myers Southwest Florida Reg	8h 48m layover 3h 2m - Denver	United Airlines	UA5669 UA493
from $361 Find flight	18:45 Des Moines Des Moines International Airport	11:21+1 день Fort Myers Southwest Florida Reg	15h 36m layover 10h 53m - Chicago	United Airlines	UA5286 UA1740
from $438 Find flight	05:45 Des Moines Des Moines International Airport	15:28 Fort Myers Southwest Florida Reg	8h 43m layover 2h 44m - Denver	United Airlines	UA4700 UA2601
from $270 Find flight	08:00 Des Moines Des Moines International Airport	20:03 Fort Myers Southwest Florida Reg	11h 3m layover 1h 9m - Miami 1h 5m - Pittsburgh	Allegiant Air	G4436 NK1612 NK321
from $321 Find flight	15:35 Des Moines Des Moines International Airport	12:32+1 день Fort Myers Southwest Florida Reg	19h 57m layover 1h 47m - Las Vegas 8h 1m - Minneapolis	Allegiant Air	G4451 SY108 SY383
from $327 Find flight	10:00 Des Moines Des Moines International Airport	10:16+1 день Fort Myers Southwest Florida Reg	23h 16m layover 5h 35m - Phoenix 7h 46m - Minneapolis	Allegiant Air	G4440 SY606 SY381
from $327 Find flight	10:00 Des Moines Des Moines International Airport	11:43+1 день Fort Myers Southwest Florida Reg	24h 43m layover 5h 35m - Phoenix 9h 13m - Minneapolis	Allegiant Air	G4440 SY606 SY383
from $327 Find flight	10:00 Des Moines Des Moines International Airport	13:50+1 день Fort Myers Southwest Florida Reg	26h 50m layover 5h 35m - Phoenix 11h 26m - Minneapolis	Allegiant Air	G4440 SY606 SY377
from $347 Find flight	07:00 Des Moines Des Moines International Airport	20:19 Fort Myers Southwest Florida Reg	12h 19m layover 2h 0m - Minneapolis 3h 14m - Toronto	WestJet	WS7182 WS6594 WS1172

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on May 09, 2025

Flight Schedule Des Moines (Iowa) to Fort Myers (Florida)

Full flight schedule will help you in detecting at what time planes fly from Des Moines to Fort Myers. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
05:45 — 13:43	05:40 — 06:57 UA4700 United Airlines Des Moines — Denver 59m stop 08:00 — 13:42 UA424 United Airlines Denver — Fort Myers	6h 58m including layover	Find flight from$301
05:45 — 15:28	05:40 — 06:57 UA4700 United Airlines Des Moines — Denver 2h 44m stop 09:42 — 15:23 UA2601 United Airlines Denver — Fort Myers	8h 43m including layover	Find flight from$438
06:00 — 15:23	06:00 — 07:04 UA497 United Airlines Des Moines — Denver 2h 39m stop 09:43 — 15:23 UA2601 United Airlines Denver — Fort Myers	8h 23m including layover	Find flight from$335
06:00 — 23:33	06:00 — 07:04 UA497 United Airlines Des Moines — Denver 10h 49m stop 17:53 — 23:33 UA493 United Airlines Denver — Fort Myers	16h 33m including layover	Find flight from$518
08:00 — 14:51	08:00 — 09:35 UA1363 United Airlines Des Moines — Chicago 1h 10m stop 10:45 — 14:51 UA2737 United Airlines Chicago — Fort Myers	5h 51m including layover	Find flight from$301
08:00 — 16:55	08:00 — 09:35 UA1363 United Airlines Des Moines — Chicago 3h 15m stop 12:50 — 16:55 UA1525 United Airlines Chicago — Fort Myers	7h 55m including layover	Find flight from$301
09:02 — 23:33	09:02 — 10:17 UA581 United Airlines Des Moines — Denver 7h 36m stop 17:53 — 23:33 UA493 United Airlines Denver — Fort Myers	13h 31m including layover	Find flight from$518
09:02 — 15:23 +1 day	09:02 — 10:17 UA581 United Airlines Des Moines — Denver 23h 26m stop 09:43 — 15:23 UA2601 United Airlines Denver — Fort Myers	29h 21m including layover	Find flight from$518
11:35 — 20:15	11:35 — 13:10 UA2306 United Airlines Des Moines — Chicago 3h stop 16:10 — 20:15 UA659 United Airlines Chicago — Fort Myers	7h 40m including layover	Find flight from$301
11:35 — 11:21 +1 day	11:25 — 12:53 UA2306 United Airlines Des Moines — Chicago 18h 5m stop 07:25 — 11:25 UA1740 United Airlines Chicago — Fort Myers	22h 46m including layover	Find flight from$361
13:45 — 23:33	13:45 — 14:51 UA5669 United Airlines Des Moines — Denver 3h 2m stop 17:53 — 23:33 UA493 United Airlines Denver — Fort Myers	8h 48m including layover	Find flight from$335
13:49 — 23:48	13:45 — 14:54 UA5835 United Airlines Des Moines — Denver 3h 6m stop 18:04 — 23:47 UA2671 United Airlines Denver — Fort Myers	8h 59m including layover	Find flight from$301
15:00 — 23:15	15:00 — 17:35 UA6033 United Airlines Des Moines — Houston 2h 23m stop 19:58 — 23:15 UA2357 United Airlines Houston — Fort Myers	7h 15m including layover	Find flight from$335
15:05 — 22:00	15:05 — 17:48 UA6033 United Airlines Des Moines — Houston 52m stop 18:40 — 22:00 UA1955 United Airlines Houston — Fort Myers	5h 55m including layover	Find flight from$301
17:10 — 15:23 +1 day	17:10 — 18:19 UA1781 United Airlines Des Moines — Denver 15h 27m stop 09:43 — 15:23 UA2601 United Airlines Denver — Fort Myers	21h 13m including layover	Find flight from$518
17:10 — 23:33 +1 day	17:10 — 18:19 UA1781 United Airlines Des Moines — Denver 23h 34m stop 17:53 — 23:33 UA493 United Airlines Denver — Fort Myers	29h 23m including layover	Find flight from$518
18:45 — 11:21 +1 day	18:45 — 20:22 UA5286 United Airlines Des Moines — Chicago 10h 53m stop 07:15 — 11:21 UA1740 United Airlines Chicago — Fort Myers	15h 36m including layover	Find flight from$361
18:45 — 12:52 +1 day	18:45 — 20:22 UA5286 United Airlines Des Moines — Chicago 12h 24m stop 08:46 — 12:52 UA335 United Airlines Chicago — Fort Myers	17h 7m including layover	Find flight from$361

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on May 9, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Des Moines to Fort Myers depends on and how to choose the most interesting flight option for you.

Distance between Des Moines and Fort Myers is 1991 miles. Time difference between the cities is 1h. Airplanes depart 05:45 to 18:54 from 1 Des Moines airport and arrive 05:45 to 18:54 to 2 Fort Myers airports. Average flight time is 17h 34m.

The fastest flight 5h 35m
Average flight time 17h 34m
The earliest flight 05:45
The latest flight 18:54
Distance 1238 ml

The cheapest months to travel to Fort Myers are january (from 270 $), february (from 327 $), november (from 335 $).

The most expensive months are december (from 347 $), november (from 335 $), february (from 327 $).

What is the lowest airfare Des Moines to Fort Myers?

The cheapest plane ticket found by our users is $270. This airfare is for economy class on one-way G4436 flight by Allegiant Air for January 12, 2025 which leaves Des Moines International Airport in Des Moines at 08:00 am and arrives at Fort Myers Southwest Florida Reg at 20:03.

Economy class

$270

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Business class

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First class

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Popular Airlines on the Route

The flight Des Moines — Fort Myers is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by United Airlines - 84 departures per week at the price of from $ 301 . And the most expensive tickets are offered by Allegiant Air airline - from $ 847.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 110 flights with layovers on the route. The fastest connecting flight is UA1568 by United Airlines takes 5h 35m and the cheapest is G4436 by Allegiant Air for $270.

UA - United Airlines

from $301

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WS - WestJet

from $347

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G4 - Allegiant Air

from $270

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Airports

You can fly from Des Moines to Fort Myers from 1 airports (Des Moines International Airport).

Des Moines airports

Des Moines International Airport-DSM

from $270
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Fort Myers airports

Southwest Florida Reg-RSW

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Page Field-FMY

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Airplanes

There are flights to Fort Myers from Des Moines by 3 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Des Moines

You may also consider searching for discounted plane tickets to some other popular places from Des Moines within United States.

Des Moines — Las Vegas

from $55

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Des Moines — Phoenix

from $71

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Des Moines — Dallas

from $73

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Des Moines — Austin

from $78

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Des Moines — Seattle

from $53

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Des Moines — Atlanta

from $58

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Des Moines — Miami

from $65

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Des Moines — Denver

from $54

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Des Moines — New Orleans

from $56

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Des Moines — San Diego

from $58

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Top International Destinations from Des Moines

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Des Moines — Cancun

from $77

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Des Moines — London

from $70

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How to book a plane ticket yourself?

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That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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