Cheap Flights from Tampa, FL to Knoxville, TN from $110

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On Cheapflightsplus.com you will find 333 connecting flights from Tampa to Knoxville. You can compare airfare deals from 5 airlines and multiple travel sites from $110, book and save on cheap plane tickets and last minute offers. Also check out TPA-TYS flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Tampa to Knoxville Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $110 (one-way), $189 (round-trip).

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Best Flights from Tampa to Knoxville Today

Take a look at the list of non stop flights and flights with layovers from Tampa to Knoxville with the lowest price of $110. Take a look at the list of flights with layovers from Tampa to Knoxville from $110. There’re no direct flights. The fastest connecting flight – 4h 48m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $110 Find flight	06:30 Tampa Tampa Int.	22:10 Knoxville Mc Ghee Tyson	15h 40m layover 11h 3m - Houston	Spirit Airlines	NK2023 G41427
from $111 Find flight	21:30 Tampa Tampa Int.	16:35+1 день Knoxville Mc Ghee Tyson	19h 5m layover 11h 58m - Denver	Frontier Airlines	F93517 F92374
from $111 Find flight	21:22 Tampa Tampa Int.	08:19+1 день Knoxville Mc Ghee Tyson	10h 57m layover 7h 45m - Miami	Spirit Airlines	NK2234 G4499
from $114 Find flight	07:01 Tampa Tampa Int.	16:29 Knoxville Mc Ghee Tyson	9h 28m layover 2h 44m - Denver	Frontier Airlines	F91113 F92374
from $114 Find flight	23:09 Tampa Tampa Int.	22:10+1 день Knoxville Mc Ghee Tyson	23h 1m layover 18h 20m - Houston	Spirit Airlines	NK1861 G41427
from $115 Find flight	21:22 Tampa Tampa Int.	09:04+1 день Knoxville Mc Ghee Tyson	11h 42m layover 8h 30m - Miami	Spirit Airlines	NK2234 G4484
from $115 Find flight	21:22 Tampa Tampa Int.	14:38+1 день Knoxville Mc Ghee Tyson	17h 16m layover 14h 4m - Miami	Spirit Airlines	NK2234 G42126
from $116 Find flight	17:15 Tampa Tampa Int.	11:18+1 день Knoxville Mc Ghee Tyson	18h 3m layover 14h 53m - Miami	Spirit Airlines	NK323 G4531
from $131 Find flight	05:30 Tampa Tampa Int.	15:41 Knoxville Mc Ghee Tyson	10h 11m layover 7h 5m - Miami	Spirit Airlines	NK1955 G42118
from $131 Find flight	21:22 Tampa Tampa Int.	08:20+1 день Knoxville Mc Ghee Tyson	10h 58m layover 7h 45m - Miami	Spirit Airlines	NK2234 G4533
from $131 Find flight	17:15 Tampa Tampa Int.	15:36+1 день Knoxville Mc Ghee Tyson	22h 21m layover 19h 11m - Miami	Spirit Airlines	NK323 G42112
from $112 Find flight	05:20 Tampa Tampa Int.	22:03 Knoxville Mc Ghee Tyson	16h 43m layover 5h 36m - Miami 5h 11m - Houston	Spirit Airlines	NK2577 NK2678 G41427
from $112 Find flight	21:22 Tampa Tampa Int.	22:03+1 день Knoxville Mc Ghee Tyson	24h 41m layover 7h 35m - Miami 11h 8m - Houston	Spirit Airlines	NK2234 NK2082 G41427
from $112 Find flight	18:08 Tampa Tampa Int.	22:03+1 день Knoxville Mc Ghee Tyson	27h 55m layover 1h 6m - Chicago 19h 2m - Houston	Spirit Airlines	NK2162 NK2274 G41427
from $112 Find flight	13:30 Tampa Tampa Int.	22:03+1 день Knoxville Mc Ghee Tyson	32h 33m layover 5h 34m - Detroit 19h 5m - Houston	Spirit Airlines	NK2324 NK2590 G41427
from $137 Find flight	17:04 Tampa Tampa Int.	16:47+1 день Knoxville Mc Ghee Tyson	23h 43m layover 3h 51m - Atlanta 14h 55m - Washington D.C.	Spirit Airlines	NK2469 NK2343 G41398

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on August 08, 2025

Flight Schedule Tampa (Florida) to Knoxville (Tennessee)

Full flight schedule will help you in detecting at what time planes fly from Tampa to Knoxville. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
05:20 — 08:19 +1 day	05:20 — 06:20 NK2577 Spirit Airlines Tampa — Miami 23h 55m stop 06:15 — 08:19 G4499 Allegiant Air Miami — Knoxville	26h 59m including layover	Find flight from$111
05:20 — 13:57	05:20 — 06:20 NK2577 Spirit Airlines Tampa — Miami 5h 33m stop 11:53 — 13:57 G42157 Allegiant Air Miami — Knoxville	8h 37m including layover	Find flight from$120
06:15 — 23:03	06:15 — 07:47 NK2023 Spirit Airlines Tampa — Houston 12h 15m stop 20:02 — 23:03 G43027 Allegiant Air Houston — Knoxville	16h 48m including layover	Find flight from$152
06:30 — 22:10	06:15 — 07:47 NK2023 Spirit Airlines Tampa — Houston 11h 3m stop 19:01 — 22:03 G41427 Allegiant Air Houston — Knoxville	15h 40m including layover	Find flight from$110
07:01 — 16:29	06:50 — 09:01 F91113 Frontier Airlines Tampa — Denver 2h 44m stop 11:41 — 16:35 F92374 Frontier Airlines Denver — Knoxville	9h 28m including layover	Find flight from$114
07:30 — 13:23	07:30 — 09:34 UA2195 United Airlines Tampa — Chicago 1h 1m stop 10:35 — 13:23 UA4182 United Airlines Chicago — Knoxville	5h 53m including layover	Find flight from$266
08:30 — 14:58	08:30 — 10:50 UA659 United Airlines Tampa — Washington D.C. 2h 30m stop 13:20 — 14:58 UA4282 United Airlines Washington D.C. — Knoxville	6h 28m including layover	Find flight from$201
09:00 — 14:33	09:00 — 11:20 UA2331 United Airlines Tampa — Washington D.C. 1h 35m stop 12:55 — 14:33 UA4282 United Airlines Washington D.C. — Knoxville	5h 33m including layover	Find flight from$267
09:22 — 18:11	09:22 — 10:47 UA1945 United Airlines Tampa — Houston 3h 58m stop 14:45 — 18:11 UA4890 United Airlines Houston — Knoxville	8h 49m including layover	Find flight from$266
10:59 — 16:56	10:59 — 13:03 UA779 United Airlines Tampa — Chicago 57m stop 14:00 — 16:56 UA4498 United Airlines Chicago — Knoxville	5h 57m including layover	Find flight from$203
11:47 — 16:12 +1 day	11:47 — 14:12 SY214 Sun Country Airlines Tampa — Minneapolis 22h 57m stop 13:09 — 16:12 G43063 Allegiant Air Minneapolis — Knoxville	28h 25m including layover	Find flight from$139
11:47 — 16:11 +1 day	11:47 — 14:12 SY214 Sun Country Airlines Tampa — Minneapolis 22h 56m stop 13:08 — 16:11 G41416 Allegiant Air Minneapolis — Knoxville	28h 24m including layover	Find flight from$150
12:00 — 23:59	12:00 — 14:20 UA758 United Airlines Tampa — Washington D.C. 7h 53m stop 22:13 — 23:59 UA4304 United Airlines Washington D.C. — Knoxville	11h 59m including layover	Find flight from$269
12:38 — 18:38	12:38 — 14:42 UA1946 United Airlines Tampa — Chicago 1h 4m stop 15:46 — 18:38 UA454 United Airlines Chicago — Knoxville	6h including layover	Find flight from$201
14:03 — 20:42	14:03 — 16:27 UA326 United Airlines Tampa — Washington D.C. 2h 28m stop 18:55 — 20:42 UA4914 United Airlines Washington D.C. — Knoxville	6h 39m including layover	Find flight from$203
14:03 — 23:59	14:03 — 16:27 UA326 United Airlines Tampa — Washington D.C. 5h 46m stop 22:13 — 23:59 UA4304 United Airlines Washington D.C. — Knoxville	9h 56m including layover	Find flight from$269
16:06 — 22:35	16:06 — 18:23 UA533 United Airlines Tampa — Chicago 1h 27m stop 19:50 — 22:35 UA2005 United Airlines Chicago — Knoxville	6h 29m including layover	Find flight from$277
16:08 — 22:40	16:08 — 18:25 UA2362 United Airlines Tampa — Chicago 1h 30m stop 20:20 — 23:05 UA2005 United Airlines Chicago — Knoxville	6h 32m including layover	Find flight from$202
17:15 — 11:18 +1 day	17:15 — 18:22 NK323 Spirit Airlines Tampa — Miami 14h 53m stop 09:15 — 11:18 G4531 Allegiant Air Miami — Knoxville	18h 3m including layover	Find flight from$116
17:15 — 15:36 +1 day	17:15 — 18:22 NK323 Spirit Airlines Tampa — Miami 19h 11m stop 13:33 — 15:36 G42112 Allegiant Air Miami — Knoxville	22h 21m including layover	Find flight from$131
18:08 — 21:28 +1 day	18:08 — 20:08 NK2162 Spirit Airlines Tampa — Chicago 22h 52m stop 19:00 — 21:28 G41433 Allegiant Air Chicago — Knoxville	27h 20m including layover	Find flight from$209
18:11 — 16:00 +1 day	18:11 — 19:51 NK410 Spirit Airlines Tampa — Las Vegas 13h 14m stop 09:05 — 16:00 G462 Allegiant Air Las Vegas — Knoxville	21h 49m including layover	Find flight from$262
19:07 — 17:18 +1 day	18:08 — 20:08 NK2162 Spirit Airlines Tampa — Chicago 17h 34m stop 14:53 — 17:18 G43025 Allegiant Air Chicago — Knoxville	22h 11m including layover	Find flight from$155
19:07 — 17:20 +1 day	19:07 — 21:19 NK2162 Spirit Airlines Tampa — Chicago 17h 35m stop 14:54 — 17:20 G43046 Allegiant Air Chicago — Knoxville	22h 13m including layover	Find flight from$227
20:22 — 08:17 +1 day	20:22 — 21:32 NK2234 Spirit Airlines Tampa — Miami 8h 43m stop 06:15 — 08:17 G4508 Allegiant Air Miami — Knoxville	11h 55m including layover	Find flight from$133
20:57 — 16:47 +1 day	20:57 — 23:12 NK1596 Spirit Airlines Tampa — Washington D.C. 16h 1m stop 15:13 — 16:47 G41398 Allegiant Air Washington D.C. — Knoxville	19h 50m including layover	Find flight from$176
21:22 — 08:19 +1 day	21:22 — 22:30 NK2234 Spirit Airlines Tampa — Miami 7h 45m stop 06:15 — 08:19 G4499 Allegiant Air Miami — Knoxville	10h 57m including layover	Find flight from$111
21:30 — 16:35 +1 day	21:30 — 23:43 F93517 Frontier Airlines Tampa — Denver 11h 58m stop 11:41 — 16:35 F92374 Frontier Airlines Denver — Knoxville	19h 5m including layover	Find flight from$111
23:09 — 22:10 +1 day	23:09 — 00:43 NK1861 Spirit Airlines Tampa — Houston 18h 20m stop 19:03 — 22:10 G41427 Allegiant Air Houston — Knoxville	23h 1m including layover	Find flight from$114

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on August 8, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Tampa to Knoxville depends on and how to choose the most interesting flight option for you.

Distance between Tampa and Knoxville is 882 miles. Time difference between the cities is 0h. Airplanes depart 05:20 to 23:09 from 4 Tampa airports and arrive 05:20 to 23:09 to 1 Knoxville airport. Average flight time is 20h 19m.

The fastest flight 4h 48m
Average flight time 20h 19m
The earliest flight 05:20
The latest flight 23:09
Distance 549 ml

The cheapest months to travel to Knoxville are june (from 110 $), may (from 111 $), july (from 114 $).

The most expensive months are august (from 140 $), october (from 120 $), september (from 116 $).

What is the lowest airfare Tampa to Knoxville?

The cheapest plane ticket found by our users is $110. This airfare is for economy class on one-way NK2023 flight by Spirit Airlines for July 4, 2025 which leaves Tampa Int. in Tampa at 06:30 am and arrives at Knoxville Mc Ghee Tyson at 22:10.

Economy class

$110

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Business class

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First class

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Popular Airlines on the Route

The flight Tampa — Knoxville is served by 5 regular airlines and 3 low-cost airlines. Most of the flights on this route are operated by Frontier Airlines - 2 departures per week at the price of from $ 111 . And the most expensive tickets are offered by United Airlines airline - from $ 665.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 333 flights with layovers on the route. The fastest connecting flight is NK1955 by Spirit Airlines takes 4h 48m and the cheapest is NK2023 by Spirit Airlines for $110.

F9 - Frontier Airlines

from $111

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SY - Sun Country Airlines

from $139

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MX - Mexicana

from $239

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UA - United Airlines

from $201

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NK - Spirit Airlines

from $110

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Airports

You can fly from Tampa to Knoxville from 4 airports (Topp Of Tampa, Mac Dill AFB, Peter O'Knight, Tampa Int.).

Tampa airports

Topp Of Tampa-KYO

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Mac Dill AFB-MCF

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Peter O'Knight-TPF

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Tampa Int.-TPA

from $110
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Knoxville airports

Mc Ghee Tyson-TYS

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Airplanes

There are flights to Knoxville from Tampa by 5 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Tampa

You may also consider searching for discounted plane tickets to some other popular places from Tampa within United States.

Tampa — New York

from $61

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Tampa — Miami

from $68

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Tampa — Atlanta

from $59

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Tampa — Chicago

from $71

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Tampa — Boston

from $59

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Tampa — Las Vegas

from $70

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Tampa — Denver

from $56

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Tampa — Dallas

from $64

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Tampa — Houston

from $60

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Tampa — Key West

from $72

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Top International Destinations from Tampa

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Tampa — London

from $69

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Tampa — Toronto

from $69

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Tampa — Cancun

from $55

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Tampa — San Juan

from $57

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Tampa — Paris

from $55

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Tampa — Rome

from $64

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Tampa — Amsterdam

from $73

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Tampa — Vancouver

from $64

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Tampa — Montreal

from $71

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Tampa — Albany

from $66

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
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Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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