Cheap Flights from Tampa, FL to Key West, FL from $45

Return flight: Key West – Tampa

On Cheapflightsplus.com you will find 5 direct and 142 connecting flights from Tampa to Key West. You can compare airfare deals from 5 airlines and multiple travel sites from $45, book and save on cheap plane tickets and last minute offers. Also check out TPA-EYW flight schedule to find best flight time, convenient departure and arrival airports.

Flight Information

Below we will explain in detail what the flights cost on the destination from Tampa to Key West depends on and how to choose the most interesting flight option for you.

Distance between Tampa and Key West is 388 miles. Time difference between the cities is 0h. Airplanes depart 05:20 to 21:59 from 4 Tampa airports and arrive 05:20 to 21:59 to 2 Key West airports. Average flight time is 1h 15m.

  • The fastest flight 1h 7m
  • Average flight time 1h 15m
  • The earliest flight 05:20
  • The latest flight 21:59
  • Distance 242 ml

The cheapest months to travel to Key West are july (from 45 $), june (from 46 $), august (from 46 $).

The most expensive months are february (from 115 $), january (from 115 $), december (from 114 $).

What is the lowest airfare Tampa to Key West?

The cheapest plane ticket found by our users is $45. This airfare is for economy class on one-way UA3135 flight by United Airlines for July 4, 2025 which leaves Tampa Int. in Tampa at 11:00 am and arrives at Key West Key West Int. at 12:15.

Economy class
$45
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Business class
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First class
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Flight Schedule Tampa (Florida) to Key West (Florida)

06:45 — 08:00
1h 15m flight time
Find flight
from$76
Tampa — Key West
UA3134 United Airlines
08:00 — 09:07
1h 7m flight time
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from$93
Tampa — Key West
MX144 Mexicana
08:15 — 09:22
1h 7m flight time
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from$51
Tampa — Key West
MX160 Mexicana
10:32 — 16:36
6h 4m flight time
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from$128
10:32 — 12:46 Tampa — Pittsburgh
NK1760 Spirit Airlines
1h 8m stop
13:54 — 16:36 Pittsburgh — Key West
G41055 Allegiant Air
10:32 — 16:36
6h 4m flight time
Find flight
from$180
10:32 — 12:46 Tampa — Pittsburgh
NK1760 Spirit Airlines
1h 8m stop
13:54 — 16:36 Pittsburgh — Key West
G4991 Allegiant Air
11:00 — 12:15
1h 15m flight time
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from$45
Tampa — Key West
UA3135 United Airlines
11:37 — 15:30+1day
27h 53m flight time
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from$171
11:37 — 12:44 Tampa — Miami
NK2577 Spirit Airlines
5h 57m stop
18:41 — 20:42 Miami — Fletcher
G4502 Allegiant Air
16h 48m stop
13:30 — 15:30 Fletcher — Key West
G4977 Allegiant Air
12:45 — 14:00
1h 15m flight time
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from$76
Tampa — Key West
UA3136 United Airlines
14:20 — 16:45+1day
26h 25m flight time
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from$141
14:20 — 16:36 Tampa — Indianapolis
NK2322 Spirit Airlines
21h 30m stop
14:06 — 16:45 Indianapolis — Key West
G41335 Allegiant Air
15:21 — 16:45+1day
25h 24m flight time
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from$116
15:21 — 17:49 Tampa — Indianapolis
NK2322 Spirit Airlines
20h 15m stop
14:04 — 16:45 Indianapolis — Key West
G41285 Allegiant Air
15:21 — 16:42+1day
25h 21m flight time
Find flight
from$145
15:21 — 17:49 Tampa — Indianapolis
NK2322 Spirit Airlines
20h 16m stop
14:05 — 16:42 Indianapolis — Key West
G41230 Allegiant Air
17:41 — 16:36+1day
22h 55m flight time
Find flight
from$185
17:41 — 20:10 Tampa — Pittsburgh
MX140 Mexicana
17h 44m stop
13:59 — 16:41 Pittsburgh — Key West
G4991 Allegiant Air
17:41 — 16:36+1day
22h 55m flight time
Find flight
from$185
17:41 — 20:10 Tampa — Pittsburgh
MX140 Mexicana
17h 44m stop
13:54 — 16:36 Pittsburgh — Key West
G41055 Allegiant Air
20:22 — 16:45+1day
20h 23m flight time
Find flight
from$173
20:22 — 21:32 Tampa — Miami
NK2234 Spirit Airlines
43m stop
22:15 — 00:59 Miami — Indianapolis
NK2128 Spirit Airlines
13h 5m stop
14:04 — 16:45 Indianapolis — Key West
G41285 Allegiant Air
21:22 — 15:16+1day
17h 54m flight time
Find flight
from$169
21:22 — 22:30 Tampa — Miami
NK2234 Spirit Airlines
7h 45m stop
06:15 — 08:16 Miami — Fletcher
G4534 Allegiant Air
5h 1m stop
13:17 — 15:16 Fletcher — Key West
G41022 Allegiant Air
Full flight schedule will help you in detecting at what time planes fly from Tampa to Key West. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
*Departure and arrival times - local. Updated on October 6, 2025.

Popular Airlines on the Route

The flight Tampa — Key West is served by 5 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Sun Country Airlines - 1 departures per week at the price of from $ 242 . And the most expensive tickets are offered by United Airlines airline - from $ 1835.

Direct flights

There are 5 nonstop flights on the route. The fastest direct flight is MX160 by Mexicana takes 1h 7m and the cheapest is UA3135 by United Airlines for $45.

  • MX - Mexicana
    from $51
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  • UA - United Airlines
    from $45
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Connecting Flights

There are 142 flights with layovers on the route. The fastest connecting flight is 3M57 by Gulfstream International Airlines takes 3h 5m and the cheapest is UA3135 by United Airlines for $116.

  • SY - Sun Country Airlines
    from $242
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  • 3M - Gulfstream International Airlines
    from $192
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  • MX - Mexicana
    from $185
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  • UA - United Airlines
    from $194
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  • NK - Spirit Airlines
    from $116
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See more connecting flights

Airports

You can fly from Tampa to Key West from 4 airports (Topp Of Tampa, Mac Dill AFB, Peter O'Knight, Tampa Int.).

Tampa airports

  • Topp Of Tampa-KYO
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  • Mac Dill AFB-MCF
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  • Peter O'Knight-TPF
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  • Tampa Int.-TPA
    from $45
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Key West airports

  • NAS-NQX
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  • Key West Int.-EYW
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How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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