Cheap Flights from Rome to San Francisco, CA from $238

Return flight: San Francisco – Rome

On Cheapflightsplus.com you will find 3 direct and 998 connecting flights from Rome to San Francisco. You can compare airfare deals from 38 airlines and multiple travel sites from $238, book and save on cheap plane tickets and last minute offers. Also check out ROM-SFO flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Rome to San Francisco Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $238 (one-way), $408 (round-trip).
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Full flight schedule will help you in detecting at what time planes fly from Rome to San Francisco. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
09:10 — 13:15
09:10 — 13:15 AZ640 Alitalia
Rome — San Francisco
13h 5m
Find flight
from$567
15:40 — 19:15
15:40 — 19:15 UA506 United Airlines
Rome — San Francisco
12h 35m
Find flight
from$661
15:40 — 19:15
15:40 — 19:15 LH9360 Lufthansa
Rome — San Francisco
12h 35m
Find flight
from$1279
06:25 — 17:25
06:25 — 08:15 VY6109 Vueling
Rome — Barcelona
5h 5m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
20h
including layover
Find flight
from$238
07:15 — 16:08
07:15 — 10:55 N0411 N0
Rome — Los Angeles
3h 49m stop
15:05 — 16:34 HA6207 Hawaiian Airlines
Los Angeles — San Francisco
17h 53m
including layover
Find flight
from$269
07:25 — 17:25
07:25 — 09:15 W46017 Aero Services Executive
Rome — Barcelona
4h 5m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
19h
including layover
Find flight
from$270
09:00 — 17:25
09:05 — 11:05 VY6101 Vueling
Rome — Barcelona
2h 20m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
17h 25m
including layover
Find flight
from$238
09:00 — 17:25
09:00 — 10:50 AZ74 Alitalia
Rome — Barcelona
2h 30m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
17h 25m
including layover
Find flight
from$330
10:00 — 18:10
10:00 — 15:00 BA1628 British Airways
Rome — Dallas
1h 35m stop
16:35 — 18:12 BA2495 British Airways
Dallas — San Francisco
17h 10m
including layover
Find flight
from$323
10:00 — 22:57
10:00 — 15:00 BA1628 British Airways
Rome — Dallas
6h 7m stop
21:07 — 22:57 BA6767 British Airways
Dallas — San Francisco
21h 57m
including layover
Find flight
from$323
11:05 — 19:43
11:05 — 14:30 BA1569 British Airways
Rome — Chicago
2h 30m stop
17:46 — 20:23 BA5318 British Airways
Chicago — San Francisco
17h 38m
including layover
Find flight
from$323
11:05 — 09:17
+1 day
11:05 — 14:30 BA1569 British Airways
Rome — Chicago
16h 15m stop
06:45 — 09:18 BA5508 British Airways
Chicago — San Francisco
31h 12m
including layover
Find flight
from$326
13:10 — 19:07
+1 day
13:10 — 16:40 BA1576 British Airways
Rome — Philadelphia
23h 10m stop
16:30 — 19:28 BA5440 British Airways
Philadelphia — San Francisco
38h 57m
including layover
Find flight
from$324
13:50 — 18:47
+1 day
13:50 — 18:35 BA1635 British Airways
Rome — Miami
21h 25m stop
15:57 — 19:00 BA5019 British Airways
Miami — San Francisco
37h 57m
including layover
Find flight
from$324
17:15 — 13:50
+1 day
17:35 — 19:20 BA559 British Airways
Rome — London
15h 55m stop
11:45 — 15:00 BA285 British Airways
London — San Francisco
29h 35m
including layover
Find flight
from$324
17:15 — 17:25
+1 day
16:55 — 18:35 BA559 British Airways
Rome — London
19h 25m stop
14:15 — 17:25 BA287 British Airways
London — San Francisco
33h 10m
including layover
Find flight
from$330
18:50 — 17:25
+1 day
18:50 — 20:45 VY6113 Vueling
Rome — Barcelona
16h 35m stop
13:20 — 17:25 VY9791 Vueling
Barcelona — San Francisco
31h 35m
including layover
Find flight
from$261
19:05 — 17:25
+1 day
19:05 — 20:55 W46019 Aero Services Executive
Rome — Barcelona
16h 25m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
31h 20m
including layover
Find flight
from$271
19:20 — 17:25
+1 day
19:45 — 21:40 VY6103 Vueling
Rome — Barcelona
16h 5m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
31h 5m
including layover
Find flight
from$251
21:00 — 13:50
+1 day
13:15 — 15:10 BA555 British Airways
Rome — London
12h 10m stop
11:45 — 15:00 BA285 British Airways
London — San Francisco
25h 50m
including layover
Find flight
from$324
21:25 — 17:25
+1 day
21:25 — 23:15 AZ78 Alitalia
Rome — Barcelona
14h 5m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
29h
including layover
Find flight
from$307
22:15 — 17:25
+1 day
21:40 — 23:35 VY6107 Vueling
Rome — Barcelona
13h 10m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
28h 10m
including layover
Find flight
from$251
22:55 — 17:25
+1 day
21:40 — 23:35 VY6111 Vueling
Rome — Barcelona
12h 30m stop
14:05 — 18:10 VY9791 Vueling
Barcelona — San Francisco
27h 30m
including layover
Find flight
from$247
06:40 — 23:59
06:40 — 08:55 W46061 Aero Services Executive
Rome — Paris
7h 45m stop
16:40 — 19:05 N0311 N0
Paris — Los Angeles
3h 29m stop
22:34 — 23:59 HA6206 Hawaiian Airlines
Los Angeles — San Francisco
26h 19m
including layover
Find flight
from$287
14:15 — 10:40
+1 day
14:15 — 16:05 VY6111 Vueling
Rome — Barcelona
2h 25m stop
18:30 — 21:40 VY9797 Vueling
Barcelona — Newark
9h 50m stop
07:30 — 10:40 HA4903 Hawaiian Airlines
Newark — San Francisco
29h 25m
including layover
Find flight
from$327
14:15 — 10:40
+1 day
14:15 — 16:05 VY6111 Vueling
Rome — Barcelona
2h 25m stop
18:30 — 21:40 VY9797 Vueling
Barcelona — Newark
9h 50m stop
07:30 — 10:40 AS373 Alaska Airlines
Newark — San Francisco
29h 25m
including layover
Find flight
from$330
20:20 — 17:54
+2 days
20:20 — 22:25 U24818 EasyJet
Rome — Paris
16h 25m stop
14:50 — 17:30 BF730 Bluebird Cargo
Paris — Los Angeles
22h 51m stop
16:21 — 17:54 AS3407 Alaska Airlines
Los Angeles — San Francisco
54h 34m
including layover
Find flight
from$327
23:00 — 20:53
+1 day
23:00 — 01:15 FR9612 Ryanair
Rome — Dublin
10h 15m stop
11:30 — 14:10 WS35 WestJet
Dublin — Toronto
4h 10m stop
18:20 — 20:53 AC745 Air Canada
Toronto — San Francisco
30h 53m
including layover
Find flight
from$325
*Departure and arrival times - local. Updated on June 4, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Rome to San Francisco depends on and how to choose the most interesting flight option for you.

Distance between Rome and San Francisco is 10061 miles. Time difference between the cities is 9h. Airplanes depart 05:45 to 23:55 from 4 Rome airports and arrive 05:45 to 23:55 to 3 San Francisco airports. Average flight time is 12h 35m.

  • The fastest flight 12h 35m
  • Average flight time 12h 35m
  • The earliest flight 05:45
  • The latest flight 23:55
  • Distance 6252 ml

The cheapest months to travel to San Francisco are august (from 318 $), october (from 393 $), september (from 433 $).

The most expensive months are october (from 1 211 $), june (from 828 $), january (from 631 $).

What is the lowest airfare Rome to San Francisco?

The cheapest plane ticket found by our users is $238. This airfare is for economy class on one-way VY6109 flight by Vueling for August 28, 2025 which leaves Fiumicino in Rome at 06:25 am and arrives at San Francisco San Francisco at 17:25.

Economy class
$238
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Business class
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First class
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Popular Airlines on the Route

The flight Rome — San Francisco is served by 38 regular airlines and 10 low-cost airlines. Most of the flights on this route are operated by Condor Airlines - 2 departures per week at the price of from $ 480 . And the most expensive tickets are offered by Lufthansa airline - from $ 1279.

Direct flights

There are 3 nonstop flights on the route. The fastest direct flight is UA506 by United Airlines takes 12h 35m and the cheapest is VY6109 by Vueling for $567.

  • AZ - Alitalia
    from $567
    Find
  • UA - United Airlines
    from $661
    Find
  • LH - Lufthansa
    from $1279
    Find
See more direct flights

Connecting Flights

There are 998 flights with layovers on the route. The fastest connecting flight is KL1600 by KLM takes 14h 15m and the cheapest is VY6109 by Vueling for $238.

  • DE - Condor Airlines
    from $480
    Find
  • XZ - Ivoire Aero-Services
    from $405
    Find
  • VY - Vueling
    from $238
    Find
  • FI - Icelandair
    from $410
    Find
  • JU - Air Serbia
    from $459
    Find
  • FR - Ryanair
    from $325
    Find
  • LX - SWISS International Air Lines
    from $809
    Find
  • LY - EL AL
    from $792
    Find
  • A3 - Aegean Airlines
    from $420
    Find
  • DY - Norwegian
    from $576
    Find
  • IB - Iberia
    from $389
    Find
  • SN - Brussels Airlines
    from $510
    Find
See more connecting flights

Airports

You can fly from Rome to San Francisco from 4 airports (Termini Rail Stn., Mestre Rail Stn., Ciampino, Fiumicino).

Rome airports

  • Termini Rail Stn.-XRJ
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  • Mestre Rail Stn.-XVY
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  • Ciampino-CIA
    from $501
    Find
  • Fiumicino-FCO
    from $238
    Find

San Francisco airports

  • San Francisco-SFO
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  • Embarkadero-EMB
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  • China Basin Heliport-JCC
    Find

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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