Cheap Flights from Rome to San Francisco, CA from $305

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On Cheapflightsplus.com you will find 3 direct and 998 connecting flights from Rome to San Francisco. You can compare airfare deals from 38 airlines and multiple travel sites from $305, book and save on cheap plane tickets and last minute offers. Also check out ROM-SFO flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Rome to San Francisco Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $305 (one-way), $523 (round-trip).

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Best Flights from Rome to San Francisco Today

Take a look at the list of non stop flights and flights with layovers from Rome to San Francisco with the lowest price of $305. The fastest direct flight takes 12h 35m and the fastest connecting – 14h 15m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $755 Find flight	09:10 Rome Fiumicino	13:15 San Francisco San Francisco	13h 5m	Alitalia	AZ640
from $883 Find flight	15:40 Rome Fiumicino	19:15 San Francisco San Francisco	12h 35m	United Airlines	UA506
from $1638 Find flight	15:40 Rome Fiumicino	19:15 San Francisco San Francisco	12h 35m	Lufthansa	LH9360
from $305 Find flight	09:00 Rome Fiumicino	17:25 San Francisco San Francisco	17h 25m layover 2h 20m - Barcelona	Vueling	VY6101 VY9791
from $345 Find flight	07:15 Rome Fiumicino	16:08 San Francisco San Francisco	17h 53m layover 3h 49m - Los Angeles	N0	N0411 HA6207
from $368 Find flight	06:40 Rome Fiumicino	23:59 San Francisco San Francisco	26h 19m layover 7h 45m - Paris 3h 29m - Los Angeles	Aero Services Executive	W46061 N0311 HA6206
from $395 Find flight	19:05 Rome Fiumicino	14:55+1 день San Francisco San Francisco	28h 50m layover 8h 50m - New York 2h 11m - Seattle	N0	N0401 HA4991 HA6901

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 16, 2025

Flight Schedule Rome to San Francisco (California)

Full flight schedule will help you in detecting at what time planes fly from Rome to San Francisco. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
06:25 — 17:25	06:25 — 08:15 VY6109 Vueling Rome — Barcelona 5h 5m stop 14:05 — 18:10 VY9791 Vueling Barcelona — San Francisco	20h including layover	Find flight from$305
06:40 — 23:59	06:40 — 08:55 W46061 Aero Services Executive Rome — Paris 7h 45m stop 16:40 — 19:05 N0311 N0 Paris — Los Angeles 3h 29m stop 22:34 — 23:59 HA6206 Hawaiian Airlines Los Angeles — San Francisco	26h 19m including layover	Find flight from$368
07:15 — 16:08	07:15 — 10:55 N0411 N0 Rome — Los Angeles 3h 49m stop 15:05 — 16:34 HA6207 Hawaiian Airlines Los Angeles — San Francisco	17h 53m including layover	Find flight from$345
07:15 — 16:08	07:15 — 10:55 N0411 N0 Rome — Los Angeles 3h 49m stop 15:05 — 16:34 AS2149 Alaska Airlines Los Angeles — San Francisco	17h 53m including layover	Find flight from$348
07:15 — 17:05	07:15 — 10:55 N0411 N0 Rome — Los Angeles 4h 43m stop 16:41 — 18:13 AS3407 Alaska Airlines Los Angeles — San Francisco	18h 50m including layover	Find flight from$348
07:25 — 17:25	07:25 — 09:15 W46017 Aero Services Executive Rome — Barcelona 4h 5m stop 14:05 — 18:10 VY9791 Vueling Barcelona — San Francisco	19h including layover	Find flight from$347
09:00 — 17:25	09:05 — 11:05 VY6101 Vueling Rome — Barcelona 2h 20m stop 14:05 — 18:10 VY9791 Vueling Barcelona — San Francisco	17h 25m including layover	Find flight from$305
09:10 — 13:15	09:10 — 13:15 AZ640 Alitalia Rome — San Francisco	13h 5m	Find flight from$755
15:40 — 19:15	15:40 — 19:15 UA506 United Airlines Rome — San Francisco	12h 35m	Find flight from$883
15:40 — 19:15	15:40 — 19:15 LH9360 Lufthansa Rome — San Francisco	12h 35m	Find flight from$1638
18:50 — 17:25 +1 day	18:50 — 20:45 VY6113 Vueling Rome — Barcelona 16h 35m stop 13:20 — 17:25 VY9791 Vueling Barcelona — San Francisco	31h 35m including layover	Find flight from$334
19:05 — 17:25 +1 day	19:05 — 20:55 W46019 Aero Services Executive Rome — Barcelona 16h 25m stop 14:05 — 18:10 VY9791 Vueling Barcelona — San Francisco	31h 20m including layover	Find flight from$347
19:20 — 17:25 +1 day	19:45 — 21:40 VY6103 Vueling Rome — Barcelona 16h 5m stop 14:05 — 18:10 VY9791 Vueling Barcelona — San Francisco	31h 5m including layover	Find flight from$321
22:15 — 17:25 +1 day	21:40 — 23:35 VY6107 Vueling Rome — Barcelona 13h 10m stop 14:05 — 18:10 VY9791 Vueling Barcelona — San Francisco	28h 10m including layover	Find flight from$321
22:55 — 17:25 +1 day	21:40 — 23:35 VY6111 Vueling Rome — Barcelona 12h 30m stop 14:05 — 18:10 VY9791 Vueling Barcelona — San Francisco	27h 30m including layover	Find flight from$317

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on September 16, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Rome to San Francisco depends on and how to choose the most interesting flight option for you.

Distance between Rome and San Francisco is 10061 miles. Time difference between the cities is 9h. Airplanes depart 05:45 to 23:55 from 4 Rome airports and arrive 05:45 to 23:55 to 3 San Francisco airports. Average flight time is 12h 35m.

The fastest flight 12h 35m
Average flight time 12h 35m
The earliest flight 05:45
The latest flight 23:55
Distance 6252 ml

The cheapest months to travel to San Francisco are august (from 305 $), october (from 377 $), september (from 416 $).

The most expensive months are october (from 1 163 $), january (from 605 $), february (from 604 $).

What is the lowest airfare Rome to San Francisco?

The cheapest plane ticket found by our users is $305. This airfare is for economy class on one-way VY6109 flight by Vueling for August 7, 2025 which leaves Fiumicino in Rome at 06:25 am and arrives at San Francisco San Francisco at 17:25.

Economy class

$305

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Business class

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First class

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Popular Airlines on the Route

The flight Rome — San Francisco is served by 38 regular airlines and 10 low-cost airlines. Most of the flights on this route are operated by Condor Airlines - 2 departures per week at the price of from $ 614 . And the most expensive tickets are offered by Lufthansa airline - from $ 1638.

Direct flights

There are 3 nonstop flights on the route. The fastest direct flight is UA506 by United Airlines takes 12h 35m and the cheapest is VY6109 by Vueling for $755.

AZ - Alitalia

from $755

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UA - United Airlines

from $883

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LH - Lufthansa

from $1638

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Connecting Flights

There are 998 flights with layovers on the route. The fastest connecting flight is KL1600 by KLM takes 14h 15m and the cheapest is VY6109 by Vueling for $305.

DE - Condor Airlines

from $614

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XZ - Ivoire Aero-Services

from $520

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VY - Vueling

from $305

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FI - Icelandair

from $525

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JU - Air Serbia

from $588

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FR - Ryanair

from $417

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LX - SWISS International Air Lines

from $1036

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LY - EL AL

from $1014

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A3 - Aegean Airlines

from $538

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DY - Norwegian

from $846

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IB - Iberia

from $498

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SN - Brussels Airlines

from $653

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Airports

You can fly from Rome to San Francisco from 4 airports (Termini Rail Stn., Mestre Rail Stn., Ciampino, Fiumicino).

Rome airports

Termini Rail Stn.-XRJ

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Mestre Rail Stn.-XVY

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Ciampino-CIA

from $642
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Fiumicino-FCO

from $305
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San Francisco airports

San Francisco-SFO

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Embarkadero-EMB

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China Basin Heliport-JCC

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Airplanes

There are flights to San Francisco from Rome by 38 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top International Destinations from Rome

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Rome — Boston

from $218

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Rome — Miami

from $64

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Rome — Chicago

from $64

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Rome — New York

from $408

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Rome — Seattle

from $77

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Rome — Atlanta

from $62

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Rome — Los Angeles

from $67

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Rome — Dallas

from $56

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Rome — Orlando

from $65

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Rome — San Francisco

from $55

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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