Cheap Flights from Rome to San Francisco, CA from $307

Return flight: San Francisco – Rome

On Cheapflightsplus.com you will find 3 direct and 998 connecting flights from Rome to San Francisco. You can compare airfare deals from 38 airlines and multiple travel sites from $307, book and save on cheap plane tickets and last minute offers. Also check out ROM-SFO flight schedule to find best flight time, convenient departure and arrival airports.

Flight Information

Below we will explain in detail what the flights cost on the destination from Rome to San Francisco depends on and how to choose the most interesting flight option for you.

Distance between Rome and San Francisco is 10061 miles. Time difference between the cities is 9h. Airplanes depart 05:45 to 23:55 from 4 Rome airports and arrive 05:45 to 23:55 to 3 San Francisco airports. Average flight time is 12h 35m.

  • The fastest flight 12h 35m
  • Average flight time 12h 35m
  • The earliest flight 05:45
  • The latest flight 23:55
  • Distance 6252 ml

The cheapest months to travel to San Francisco are august (from 307 $), october (from 379 $), september (from 418 $).

The most expensive months are january (from 609 $), february (from 607 $), november (from 607 $).

What is the lowest airfare Rome to San Francisco?

The cheapest plane ticket found by our users is $307. This airfare is for economy class on one-way VY6109 flight by Vueling for August 7, 2025 which leaves Fiumicino in Rome at 06:25 am and arrives at San Francisco San Francisco at 17:25.

Economy class
$307
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Business class
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First class
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Flight Schedule Rome to San Francisco (California)

06:25 — 17:25
20h flight time
Find flight
from$307
06:25 — 08:15 Rome — Barcelona
VY6109 Vueling
5h 5m stop
14:05 — 18:10 Barcelona — San Francisco
VY9791 Vueling
06:40 — 23:59
26h 19m flight time
Find flight
from$370
06:40 — 08:55 Rome — Paris
W46061 Aero Services Executive
7h 45m stop
16:40 — 19:05 Paris — Los Angeles
N0311 N0
3h 29m stop
22:34 — 23:59 Los Angeles — San Francisco
HA6206 Hawaiian Airlines
07:15 — 16:08
17h 53m flight time
Find flight
from$347
07:15 — 10:55 Rome — Los Angeles
N0411 N0
3h 49m stop
15:05 — 16:34 Los Angeles — San Francisco
HA6207 Hawaiian Airlines
07:15 — 16:08
17h 53m flight time
Find flight
from$350
07:15 — 10:55 Rome — Los Angeles
N0411 N0
3h 49m stop
15:05 — 16:34 Los Angeles — San Francisco
AS2149 Alaska Airlines
07:15 — 17:05
18h 50m flight time
Find flight
from$350
07:15 — 10:55 Rome — Los Angeles
N0411 N0
4h 43m stop
16:41 — 18:13 Los Angeles — San Francisco
AS3407 Alaska Airlines
07:25 — 17:25
19h flight time
Find flight
from$349
07:25 — 09:15 Rome — Barcelona
W46017 Aero Services Executive
4h 5m stop
14:05 — 18:10 Barcelona — San Francisco
VY9791 Vueling
09:00 — 17:25
17h 25m flight time
Find flight
from$307
09:05 — 11:05 Rome — Barcelona
VY6101 Vueling
2h 20m stop
14:05 — 18:10 Barcelona — San Francisco
VY9791 Vueling
09:10 — 13:15
13h 5m flight time
Find flight
from$730
Rome — San Francisco
AZ640 Alitalia
15:40 — 19:15
12h 35m flight time
Find flight
from$888
Rome — San Francisco
UA506 United Airlines
15:40 — 19:15
12h 35m flight time
Find flight
from$1650
Rome — San Francisco
LH9360 Lufthansa
18:50 — 17:25+1day
31h 35m flight time
Find flight
from$336
18:50 — 20:45 Rome — Barcelona
VY6113 Vueling
16h 35m stop
13:20 — 17:25 Barcelona — San Francisco
VY9791 Vueling
19:05 — 17:25+1day
31h 20m flight time
Find flight
from$349
19:05 — 20:55 Rome — Barcelona
W46019 Aero Services Executive
16h 25m stop
14:05 — 18:10 Barcelona — San Francisco
VY9791 Vueling
19:20 — 17:25+1day
31h 5m flight time
Find flight
from$323
19:45 — 21:40 Rome — Barcelona
VY6103 Vueling
16h 5m stop
14:05 — 18:10 Barcelona — San Francisco
VY9791 Vueling
22:15 — 17:25+1day
28h 10m flight time
Find flight
from$323
21:40 — 23:35 Rome — Barcelona
VY6107 Vueling
13h 10m stop
14:05 — 18:10 Barcelona — San Francisco
VY9791 Vueling
22:55 — 17:25+1day
27h 30m flight time
Find flight
from$319
21:40 — 23:35 Rome — Barcelona
VY6111 Vueling
12h 30m stop
14:05 — 18:10 Barcelona — San Francisco
VY9791 Vueling
Full flight schedule will help you in detecting at what time planes fly from Rome to San Francisco. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
*Departure and arrival times - local. Updated on October 7, 2025.

Popular Airlines on the Route

The flight Rome — San Francisco is served by 38 regular airlines and 10 low-cost airlines. Most of the flights on this route are operated by Condor Airlines - 2 departures per week at the price of from $ 618 . And the most expensive tickets are offered by Lufthansa airline - from $ 1650.

Direct flights

There are 3 nonstop flights on the route. The fastest direct flight is UA506 by United Airlines takes 12h 35m and the cheapest is VY6109 by Vueling for $730.

  • AZ - Alitalia
    from $730
    Find
  • UA - United Airlines
    from $888
    Find
  • LH - Lufthansa
    from $1650
    Find
See more direct flights

Connecting Flights

There are 998 flights with layovers on the route. The fastest connecting flight is KL1600 by KLM takes 14h 15m and the cheapest is VY6109 by Vueling for $307.

  • DE - Condor Airlines
    from $618
    Find
  • XZ - Ivoire Aero-Services
    from $523
    Find
  • VY - Vueling
    from $307
    Find
  • FI - Icelandair
    from $528
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  • JU - Air Serbia
    from $591
    Find
  • FR - Ryanair
    from $419
    Find
  • LX - SWISS International Air Lines
    from $1042
    Find
  • LY - EL AL
    from $1019
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  • A3 - Aegean Airlines
    from $541
    Find
  • DY - Norwegian
    from $742
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  • IB - Iberia
    from $501
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  • SN - Brussels Airlines
    from $657
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See more connecting flights

Airports

You can fly from Rome to San Francisco from 4 airports (Termini Rail Stn., Mestre Rail Stn., Ciampino, Fiumicino).

Rome airports

  • Termini Rail Stn.-XRJ
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  • Mestre Rail Stn.-XVY
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  • Ciampino-CIA
    from $646
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  • Fiumicino-FCO
    from $307
    Find

San Francisco airports

  • San Francisco-SFO
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  • Embarkadero-EMB
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  • China Basin Heliport-JCC
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How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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