Cheap Flights from Rome to San Francisco, CA from $666

Return flight: San Francisco – Rome
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On Cheapflightsplus.com you will find 1 connecting flights from Rome to San Francisco. You can compare airfare deals from 1 airlines and multiple travel sites from $666, book and save on cheap plane tickets and last minute offers. Also check out ROM-SFO flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Rome to San Francisco Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $666 (one-way), $1142 (round-trip).
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Best Flights from Rome to San Francisco Today

Take a look at the list of non stop flights and flights with layovers from Rome to San Francisco with the lowest price of $666. Take a look at the list of flights with layovers from Rome to San Francisco from $666. There’re no direct flights. The fastest connecting flight – 14h 30m.
Price Departure Arrival Flight Duration Airline Flight
from $666
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07:05
Rome
Fiumicino
 12:35
San Francisco
San Francisco
 14h 30m
layover
1h 0m - Frankfurt
 Lufthansa
LH243
LH454
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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on February 22, 2025
Full flight schedule will help you in detecting at what time planes fly from Rome to San Francisco. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
07:05 — 12:35
07:05 — 09:00 LH243 Lufthansa
Rome — Frankfurt
1h stop
10:20 — 12:35 LH454 Lufthansa
Frankfurt — San Francisco
14h 30m
including layover
Find flight
from$666
*Departure and arrival times - local. Updated on February 22, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Rome to San Francisco depends on and how to choose the most interesting flight option for you.

Distance between Rome and San Francisco is 10061 miles. Time difference between the cities is 9h. Airplanes depart 07:05 to 07:05 from 4 Rome airports and arrive 07:05 to 07:05 to 3 San Francisco airports. Average flight time is 14h 30m.

  • The fastest flight 14h 30m
  • Average flight time 14h 30m
  • The earliest flight 07:05
  • The latest flight 07:05
  • Distance 6252 ml

The cheapest months to travel to San Francisco are february (from 666 $), november (from 1 514 $), december (from 1 518 $).

The most expensive months are october (from 2 379 $), january (from 1 562 $), december (from 1 518 $).

What is the lowest airfare Rome to San Francisco?

The cheapest plane ticket found by our users is $666. This airfare is for economy class on one-way LH243 flight by Lufthansa for February 27, 2025 which leaves Fiumicino in Rome at 07:05 am and arrives at San Francisco San Francisco at 12:35.

Economy class
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Popular Airlines on the Route

The flight Rome — San Francisco is served by 1 regular airline . Most of the flights on this route are operated by Lufthansa - 1 departures per week at the price of from $ 666 . And the most expensive tickets are offered by Lufthansa airline - from $ 666.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 1 flights with layovers on the route. The fastest connecting flight is LH243 by Lufthansa takes 14h 30m and the cheapest is LH243 by Lufthansa for $666.

  • LH - Lufthansa
    from $666
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Airports

You can fly from Rome to San Francisco from 4 airports (Termini Rail Stn., Mestre Rail Stn., Ciampino, Fiumicino).

Rome airports

  • Termini Rail Stn.-XRJ
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  • Mestre Rail Stn.-XVY
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  • Ciampino-CIA
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  • Fiumicino-FCO
    from $666
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San Francisco airports

  • San Francisco-SFO
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  • Embarkadero-EMB
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  • China Basin Heliport-JCC
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Airplanes

There are flights to San Francisco from Rome by 1 airlines that use 1 aircraft brands. They range from huge modern airplanes to small-sized.

  • Airbus A321neo
    from $666
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Top International Destinations from Rome

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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