Cheap Flights from Fort Myers, FL to Louisville, KY from $50

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On Cheapflightsplus.com you will find 1 direct and 285 connecting flights from Fort Myers to Louisville. You can compare airfare deals from 5 airlines and multiple travel sites from $50, book and save on cheap plane tickets and last minute offers. Also check out RSW-SDF flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Fort Myers to Louisville Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $50 (one-way), $86 (round-trip).

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Best Flights from Fort Myers to Louisville Today

Take a look at the list of non stop flights and flights with layovers from Fort Myers to Louisville with the lowest price of $50. The fastest direct flight takes 2h 29m and the fastest connecting – 5h 38m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $50 Find flight	17:35 Fort Myers Southwest Florida Reg	20:04 Louisville Standiford Field	2h 29m	Mexicana	MX752

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 15, 2025

Flight Schedule Fort Myers (Florida) to Louisville (Kentucky)

Full flight schedule will help you in detecting at what time planes fly from Fort Myers to Louisville. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
06:00 — 08:55 +1 day	06:00 — 08:35 SY390 Sun Country Airlines Fort Myers — Minneapolis 21h 31m stop 06:06 — 08:55 SY1791 Sun Country Airlines Minneapolis — Louisville	26h 55m including layover	Find flight from$162
06:00 — 15:16 +1 day	06:00 — 08:35 SY390 Sun Country Airlines Fort Myers — Minneapolis 23h 37m stop 08:12 — 11:42 SY355 Sun Country Airlines Minneapolis — Atlanta 2h 12m stop 13:54 — 15:16 NK1858 Spirit Airlines Atlanta — Louisville	33h 16m including layover	Find flight from$194
07:00 — 13:33	07:00 — 08:40 UA1809 United Airlines Fort Myers — Houston 1h 28m stop 10:08 — 13:33 UA6150 United Airlines Houston — Louisville	6h 33m including layover	Find flight from$188
07:05 — 15:19	07:05 — 09:06 MX744 Mexicana Fort Myers — Raleigh 4h 40m stop 13:46 — 15:19 MX330 Mexicana Raleigh — Louisville	8h 14m including layover	Find flight from$111
09:15 — 17:16	09:15 — 11:30 UA1811 United Airlines Fort Myers — Chicago 3h 15m stop 14:45 — 17:16 UA4529 United Airlines Chicago — Louisville	8h 1m including layover	Find flight from$190
11:25 — 08:55 +1 day	12:48 — 15:24 SY384 Sun Country Airlines Fort Myers — Minneapolis 16h 6m stop 10:24 — 13:12 SY1791 Sun Country Airlines Minneapolis — Louisville	21h 30m including layover	Find flight from$162
12:28 — 20:28	12:28 — 14:43 UA2494 United Airlines Fort Myers — Chicago 3h 12m stop 17:55 — 20:28 UA3598 United Airlines Chicago — Louisville	8h including layover	Find flight from$190
14:30 — 20:33	14:30 — 16:45 UA1967 United Airlines Fort Myers — Chicago 1h 15m stop 18:00 — 20:33 UA3598 United Airlines Chicago — Louisville	6h 3m including layover	Find flight from$188
14:30 — 22:24	14:30 — 16:45 UA1967 United Airlines Fort Myers — Chicago 2h 59m stop 19:44 — 22:24 UA3551 United Airlines Chicago — Louisville	7h 54m including layover	Find flight from$188
15:30 — 22:58	15:30 — 18:25 UA2477 United Airlines Fort Myers — Newark 2h 5m stop 20:30 — 22:58 UA3609 United Airlines Newark — Louisville	7h 28m including layover	Find flight from$188
17:35 — 20:04	17:35 — 20:04 MX752 Mexicana Fort Myers — Louisville	2h 29m	Find flight from$50
19:20 — 14:46 +1 day	19:20 — 22:14 NK1199 Spirit Airlines Fort Myers — Detroit 7h 46m stop 06:00 — 07:39 NK1002 Spirit Airlines Detroit — Myrtle Beach 5h 32m stop 13:11 — 14:46 G41254 Allegiant Air Myrtle Beach — Louisville	19h 26m including layover	Find flight from$191
19:20 — 13:37 +1 day	19:20 — 22:14 NK1199 Spirit Airlines Fort Myers — Detroit 14h 11m stop 12:25 — 13:37 NK1255 Spirit Airlines Detroit — Louisville	18h 17m including layover	Find flight from$192
20:09 — 09:57 +1 day	20:09 — 23:02 NK2495 Spirit Airlines Fort Myers — Detroit 9h 42m stop 08:44 — 09:57 NK2794 Spirit Airlines Detroit — Louisville	13h 48m including layover	Find flight from$170
20:09 — 12:29 +1 day	20:09 — 23:02 NK2495 Spirit Airlines Fort Myers — Detroit 9h 10m stop 08:12 — 09:52 NK2476 Spirit Airlines Detroit — Myrtle Beach 1h 5m stop 10:57 — 12:29 NK2750 Spirit Airlines Myrtle Beach — Louisville	16h 20m including layover	Find flight from$173

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on September 15, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Fort Myers to Louisville depends on and how to choose the most interesting flight option for you.

Distance between Fort Myers and Louisville is 1347 miles. Time difference between the cities is 0h. Airplanes depart 06:00 to 21:57 from 2 Fort Myers airports and arrive 06:00 to 21:57 to 3 Louisville airports. Average flight time is 2h 29m.

The fastest flight 2h 29m
Average flight time 2h 29m
The earliest flight 06:00
The latest flight 21:57
Distance 837 ml

The cheapest months to travel to Louisville are august (from 50 $), july (from 60 $), october (from 188 $).

The most expensive months are september (from 207 $), october (from 188 $), july (from 60 $).

What is the lowest airfare Fort Myers to Louisville?

The cheapest plane ticket found by our users is $50. This airfare is for economy class on one-way MX752 flight by Mexicana for July 6, 2025 which leaves Southwest Florida Reg in Fort Myers at 17:35 am and arrives at Louisville Standiford Field at 20:04.

Economy class

$50

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Business class

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First class

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Popular Airlines on the Route

The flight Fort Myers — Louisville is served by 5 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Alaska Airlines - 10 departures per week at the price of from $ 6132 . And the most expensive tickets are offered by Alaska Airlines airline - from $ 6552.

Direct flights

There are 1 nonstop flights on the route. The fastest direct flight is MX752 by Mexicana takes 2h 29m and the cheapest is MX752 by Mexicana for $50.

MX - Mexicana

from $50

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Connecting Flights

There are 285 flights with layovers on the route. The fastest connecting flight is UA2211 by United Airlines takes 5h 38m and the cheapest is MX752 by Mexicana for $111.

AS - Alaska Airlines

from $6132

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SY - Sun Country Airlines

from $162

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MX - Mexicana

from $111

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UA - United Airlines

from $188

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NK - Spirit Airlines

from $170

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Airports

You can fly from Fort Myers to Louisville from 2 airports (Southwest Florida Reg, Page Field).

Fort Myers airports

Southwest Florida Reg-RSW

from $50
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Page Field-FMY

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Louisville airports

Standiford Field-SDF

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Intercontinental-LJC

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Bowman Field-LOU

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Airplanes

There are flights to Louisville from Fort Myers by 5 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Fort Myers

You may also consider searching for discounted plane tickets to some other popular places from Fort Myers within United States.

Fort Myers — Boston

from $77

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Fort Myers — New York

from $71

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Fort Myers — Key West

from $75

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Fort Myers — Orlando

from $75

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Fort Myers — Denver

from $61

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Fort Myers — Cleveland

from $65

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Fort Myers — Nashville

from $65

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Fort Myers — Chicago

from $53

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Fort Myers — Las Vegas

from $70

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Fort Myers — Dallas

from $70

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Top International Destinations from Fort Myers

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Fort Myers — Toronto

from $58

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Fort Myers — Cancun

from $68

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Fort Myers — Albany

from $62

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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