American Airlines Des Moines to Chicago Flights

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Cheapflightsplus.com will find cheap American Airlines flights from Des Moines to Chicago. Compare airline ticket prices and book air tickets starting from $112 from trusted online travel agencies, web sites and directly from airlines. Check flights schedule of American Airlines, arrivals and departure details below.

Find Cheap Airfare Des Moines (IA) — Chicago (IL) by American Airlines

To find cheap tickets choose a day of your departure with attractive price on the graph below and click «Find flights». For round trip flights please click «Check prices for return flight». The cheapest airfare is in january: one-way - $112, two-way – $192.

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Cheap Flights from Des Moines to Chicago by American Airlines

Look at the list of plane tickets for the most popular direct and connecting flights by American Airlines, their prices start from $112. The fastest nonstop flight takes 1h 21m. The fastest connecting flight — 5h 17m.

Price	Departure	Arrival	Flight Time	Airline	Flight
from $112 Find flight	6:04 am Des Moines Des Moines International Airport	7:29 am Chicago O'Hare International	1h 25m	American Airlines	AA4206
from $112 Find flight	8:39 am Des Moines Des Moines International Airport	10:00 am Chicago O'Hare International	1h 21m	American Airlines	AA4200
from $112 Find flight	5:04 pm Des Moines Des Moines International Airport	6:29 pm Chicago O'Hare International	1h 25m	American Airlines	AA2995
from $112 Find flight	7:24 pm Des Moines Des Moines International Airport	8:50 pm Chicago O'Hare International	1h 26m	American Airlines	AA3455
from $133 Find flight	11:38 am Des Moines Des Moines International Airport	1:04 pm Chicago O'Hare International	1h 26m	American Airlines	AA3064
from $133 Find flight	12:20 pm Des Moines Des Moines International Airport	1:42 pm Chicago O'Hare International	1h 22m	American Airlines	AA3407
from $179 Find flight	2:15 pm Des Moines Des Moines International Airport	3:39 pm Chicago O'Hare International	1h 24m	American Airlines	AA4144
from $212 Find flight	6:06 am Des Moines Des Moines International Airport	2:09 pm Chicago O'Hare International	8h 3m layover 3h 1m - Philadelphia	American Airlines	AA4490 AA2011
from $215 Find flight	5:37 am Des Moines Des Moines International Airport	1:58 pm Chicago O'Hare International	8h 21m layover 3h 33m - Washington D.C.	American Airlines	AA4534 AA985
from $215 Find flight	5:37 am Des Moines Des Moines International Airport	12:16 pm Chicago O'Hare International	6h 39m layover 1h 56m - Washington D.C.	American Airlines	AA4534 AA1033
from $219 Find flight	5:37 am Des Moines Des Moines International Airport	8:22 pm Chicago O'Hare International	14h 45m layover 9h 53m - Washington D.C.	American Airlines	AA4534 AA1015
from $219 Find flight	5:37 am Des Moines Des Moines International Airport	6:57 pm Chicago O'Hare International	13h 20m layover 8h 23m - Washington D.C.	American Airlines	AA4534 AA1486
from $219 Find flight	5:37 am Des Moines Des Moines International Airport	3:46 pm Chicago O'Hare International	10h 9m layover 5h 23m - Washington D.C.	American Airlines	AA4534 AA1609
from $255 Find flight	1:14 pm Des Moines Des Moines International Airport	10:54 pm Chicago O'Hare International	9h 40m layover 4h 31m - Philadelphia	American Airlines	AA4413 AA1680
from $300 Find flight	1:14 pm Des Moines Des Moines International Airport	7:27 pm Chicago O'Hare International	6h 13m layover 0h 56m - Philadelphia	American Airlines	AA4383 AA490
from $221 Find flight	5:37 am Des Moines Des Moines International Airport	2:07 pm Chicago O'Hare International	8h 30m layover 0h 53m - Washington D.C. 1h 3m - New York	American Airlines	AA4534 AA4756 AA367

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*Departure and arrival times are local. Prices are for one-way flights. Information refreshed on 01/15/2025

American Airlines Flight Schedule Des Moines to Chicago

Below is a detailed 2025 flight schedule for today, tomorrow and all other days. It may vary depending on season and a day of the week of your desired trip. We recommend booking your itinerary at least 2 weeks prior your travel to get the best price and availability by the airline.

Departure	Flight Details	Flight Time	Price
11:38 am — 1:04 pm	11:38 am — 1:04 pm AA3064 American Airlines Des Moines — Chicago	1h 26m	Find flight from$133
12:20 pm — 1:42 pm	12:20 pm — 1:42 pm AA3407 American Airlines Des Moines — Chicago	1h 22m	Find flight from$133
2:15 pm — 3:39 pm	2:15 pm — 3:39 pm AA4144 American Airlines Des Moines — Chicago	1h 24m	Find flight from$179
5:04 pm — 6:29 pm	5:04 pm — 6:29 pm AA2995 American Airlines Des Moines — Chicago	1h 25m	Find flight from$112
6:04 am — 7:29 am	6:04 am — 7:29 am AA4206 American Airlines Des Moines — Chicago	1h 25m	Find flight from$112
7:24 pm — 8:50 pm	7:24 pm — 8:50 pm AA3455 American Airlines Des Moines — Chicago	1h 26m	Find flight from$112
8:39 am — 10:00 am	8:39 am — 10:00 am AA4200 American Airlines Des Moines — Chicago	1h 21m	Find flight from$112
1:14 pm — 10:49 pm	1:14 pm — 4:54 pm AA4383 American Airlines Des Moines — Philadelphia 4h 31m stop 9:25 pm — 10:49 pm AA1680 American Airlines Philadelphia — Chicago	9h 35m including layover	Find flight from$216
1:14 pm — 6:10 am +1 day	1:14 pm — 4:54 pm AA4383 American Airlines Des Moines — Philadelphia 12h 6m stop 5:00 am — 6:10 am AA2324 American Airlines Philadelphia — Chicago	16h 56m including layover	Find flight from$216
2:41 pm — 0:25 am +1 day	2:41 pm — 3:40 pm AA1959 American Airlines Des Moines — Phoenix 3h 15m stop 6:55 pm — 0:25 am AA630 American Airlines Phoenix — Chicago	9h 44m including layover	Find flight from$318
3:14 pm — 12:37 pm +1 day	3:14 pm — 6:47 pm AA5192 American Airlines Des Moines — Charlotte 16h 38m stop 11:25 am — 12:37 pm AA1110 American Airlines Charlotte — Chicago	21h 23m including layover	Find flight from$371
3:17 pm — 8:50 am +1 day	3:17 pm — 6:47 pm AA5192 American Airlines Des Moines — Charlotte 12h 49m stop 7:36 am — 8:50 am AA462 American Airlines Charlotte — Chicago	17h 33m including layover	Find flight from$371
5:37 am — 1:58 pm	5:37 am — 9:07 am AA4534 American Airlines Des Moines — Washington D.C. 3h 33m stop 12:40 pm — 1:58 pm AA985 American Airlines Washington D.C. — Chicago	8h 21m including layover	Find flight from$215
6:06 am — 2:09 pm	6:06 am — 9:45 am AA4490 American Airlines Des Moines — Philadelphia 3h 1m stop 12:46 pm — 2:09 pm AA2011 American Airlines Philadelphia — Chicago	8h 3m including layover	Find flight from$212
12:02 pm — 9:04 pm	12:02 pm — 3:30 pm AA5421 American Airlines Des Moines — Charlotte 2h 22m stop 5:52 pm — 7:16 pm AA5704 American Airlines Charlotte — Covington 1h 24m stop 8:40 pm — 9:04 pm AA3283 American Airlines Covington — Chicago	9h 2m including layover	Find flight from$250
7:00 am — 9:04 pm	7:00 am — 10:31 am AA5677 American Airlines Des Moines — Charlotte 43m stop 11:14 am — 12:37 pm AA5069 American Airlines Charlotte — Covington 8h 3m stop 8:40 pm — 9:04 pm AA3283 American Airlines Covington — Chicago	14h 4m including layover	Find flight from$226

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times are local. Last updated on 01/15/2025

Flight Information

There are 7 flights by American Airlines from Des Moines to Chicago every week with departures from Des Moines International Airport. All flights arrive at Chicago FSS, Midway, O'Hare International, Chicago NAS, Merrill C Meigs (closed), Dupage County, Pal-Waukee.

Departures start from 11:38 am to 8:39 am. Nonstop flight is 1h 21m. The time difference between Des Moines and Chicago is 0h.

The fastest flight 1h 21m
Average flight time 1h 25m
The earliest flight 11:38 am
The latest flight 8:39 am
Distance 312 ml

The cheapest flight by American Airlines that our users were able to find is $112. This airfare is economy class on one-way AA4206 flight for October 19, 2018 leaving Des Moines International Airport in Des Moines at 6:04 am, it includes all taxes and additional fees.

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American Airlines Airplanes on the Route

List of the most popular American Airlines airplanes flying from Des Moines to Chicago:

Embraer RJ145

from $112

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Canadair Regional Jet 700

from $112

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Embraer 175 (short wing)

from $112

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Embraer 175

from $216

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Boeing MD-80

from $263

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Other Popular Airlines on the Route

Besides American Airlines there are other 3 airline carriers between Des Moines and Chicago. Please review schedules and prices from the most popular airlines to find the best airfare deals from Des Moines to Chicago.

Nonstop flights

There are 12 direct flights every day from Des Moines. Airlines and fares are below:

UA - United Airlines

from $153

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Connecting Flights

List of flights with layovers (1 and more stops):

F9 - Frontier Airlines

from $431

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UA - United Airlines

from $263

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G4 - Allegiant Air

from $293

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See more connecting flights

How to book an air ticket yourself?

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