Cheap Flights from Louisville, KY to Key West, FL from $86

On Cheapflightsplus.com you will find 59 connecting flights from Louisville to Key West. You can compare airfare deals from 4 airlines and multiple travel sites from $86, book and save on cheap plane tickets and last minute offers. Also check out SDF-EYW flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Louisville to Key West Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $86 (one-way), $147 (round-trip).
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Full flight schedule will help you in detecting at what time planes fly from Louisville to Key West. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
06:15 — 14:11
06:15 — 08:30 UA3594 United Airlines
Louisville — Newark
2h 10m stop
10:40 — 14:11 UA3687 United Airlines
Newark — Key West
7h 56m
including layover
Find flight
from$284
06:30 — 12:41
06:30 — 08:42 UA3594 United Airlines
Louisville — Newark
47m stop
09:29 — 12:41 UA1822 United Airlines
Newark — Key West
6h 11m
including layover
Find flight
from$280
09:06 — 08:15
+1 day
09:06 — 11:15 NK143 Spirit Airlines
Louisville — Orlando
19h 45m stop
07:00 — 08:15 MX159 Mexicana
Orlando — Key West
23h 9m
including layover
Find flight
from$260
15:47 — 14:44
+1 day
15:47 — 17:47 G41099 Allegiant Air
Louisville — Clearwater
19h 53m stop
13:40 — 14:44 G41048 Allegiant Air
Clearwater — Key West
22h 57m
including layover
Find flight
from$86
15:52 — 15:08
+1 day
15:52 — 17:52 G41099 Allegiant Air
Louisville — Clearwater
20h 13m stop
14:05 — 15:08 G41034 Allegiant Air
Clearwater — Key West
23h 16m
including layover
Find flight
from$95
17:34 — 09:43
+1 day
17:34 — 19:48 NK2610 Spirit Airlines
Louisville — Sanford
12h 44m stop
08:32 — 09:43 G42877 Allegiant Air
Sanford — Key West
16h 9m
including layover
Find flight
from$126
18:57 — 09:22
+1 day
18:57 — 21:07 MX105 Mexicana
Louisville — Tampa
11h 8m stop
08:15 — 09:22 MX160 Mexicana
Tampa — Key West
14h 25m
including layover
Find flight
from$120
05:03 — 13:07
+1 day
05:03 — 07:25 NK2716 Spirit Airlines
Louisville — Miami
22h 50m stop
06:15 — 07:18 NK2195 Spirit Airlines
Miami — Orlando
4h 34m stop
11:52 — 13:07 MX162 Mexicana
Orlando — Key West
32h 4m
including layover
Find flight
from$258
05:03 — 13:07
+1 day
05:03 — 07:25 NK2716 Spirit Airlines
Louisville — Miami
11h 50m stop
19:15 — 20:24 NK2008 Spirit Airlines
Miami — Orlando
15h 28m stop
11:52 — 13:07 MX162 Mexicana
Orlando — Key West
32h 4m
including layover
Find flight
from$298
10:54 — 16:45
+1 day
10:54 — 12:21 G42969 Allegiant Air
Louisville — Myrtle Beach
9h 30m stop
21:51 — 23:36 G4631 Allegiant Air
Myrtle Beach — Indianapolis
14h 28m stop
14:04 — 16:45 G41285 Allegiant Air
Indianapolis — Key West
29h 51m
including layover
Find flight
from$160
10:54 — 13:07
+1 day
10:54 — 12:21 G42969 Allegiant Air
Louisville — Myrtle Beach
8h 3m stop
20:24 — 21:50 NK2089 Spirit Airlines
Myrtle Beach — Orlando
14h 2m stop
11:52 — 13:07 MX162 Mexicana
Orlando — Key West
26h 13m
including layover
Find flight
from$215
11:04 — 15:08
+1 day
11:04 — 12:22 NK2795 Spirit Airlines
Louisville — Detroit
2h 4m stop
14:26 — 17:08 NK2739 Spirit Airlines
Detroit — Clearwater
20h 57m stop
14:05 — 15:08 G41034 Allegiant Air
Clearwater — Key West
28h 4m
including layover
Find flight
from$143
11:34 — 16:36
+1 day
11:34 — 13:49 G41451 Allegiant Air
Louisville — Punta Gorda
7h 22m stop
21:11 — 23:36 G42750 Allegiant Air
Punta Gorda — Pittsburgh
14h 18m stop
13:54 — 16:36 G4991 Allegiant Air
Pittsburgh — Key West
29h 2m
including layover
Find flight
from$150
12:32 — 16:36
+1 day
12:32 — 14:54 NK1785 Spirit Airlines
Louisville — Newark
7h 11m stop
22:05 — 23:29 NK1788 Spirit Airlines
Newark — Pittsburgh
14h 25m stop
13:54 — 16:36 G41055 Allegiant Air
Pittsburgh — Key West
28h 4m
including layover
Find flight
from$168
12:34 — 15:26
+1 day
12:34 — 13:15 G43102 Allegiant Air
Louisville — Fort Walton Beach
6h 59m stop
20:14 — 22:44 G4256 Allegiant Air
Fort Walton Beach — Fletcher
14h 43m stop
13:27 — 15:26 G4975 Allegiant Air
Fletcher — Key West
26h 52m
including layover
Find flight
from$201
13:35 — 09:43
+1 day
13:35 — 15:09 NK2751 Spirit Airlines
Louisville — Myrtle Beach
5h 15m stop
20:24 — 21:50 NK2089 Spirit Airlines
Myrtle Beach — Sanford
10h 42m stop
08:32 — 09:43 G42877 Allegiant Air
Sanford — Key West
20h 8m
including layover
Find flight
from$140
13:35 — 16:45
+1 day
13:35 — 15:09 NK2751 Spirit Airlines
Louisville — Myrtle Beach
6h 42m stop
21:51 — 23:36 G4631 Allegiant Air
Myrtle Beach — Indianapolis
14h 28m stop
14:04 — 16:45 G41285 Allegiant Air
Indianapolis — Key West
27h 10m
including layover
Find flight
from$175
14:30 — 13:07
+1 day
14:30 — 15:54 NK2051 Spirit Airlines
Louisville — Dallas
4h 35m stop
20:29 — 00:15 NK2263 Spirit Airlines
Dallas — Orlando
11h 37m stop
11:52 — 13:07 MX162 Mexicana
Orlando — Key West
22h 37m
including layover
Find flight
from$236
17:43 — 15:16
+1 day
17:43 — 18:24 G41490 Allegiant Air
Louisville — Fort Walton Beach
12h 51m stop
07:15 — 10:10 G43069 Allegiant Air
Fort Walton Beach — Covington
2h 33m stop
12:43 — 15:16 G4426 Allegiant Air
Covington — Key West
21h 33m
including layover
Find flight
from$192
18:04 — 18:42
+1 day
18:04 — 20:19 G42482 Allegiant Air
Louisville — Punta Gorda
16h 15m stop
12:34 — 14:19 G41840 Allegiant Air
Punta Gorda — Fletcher
2h 24m stop
16:43 — 18:42 G4228 Allegiant Air
Fletcher — Key West
24h 38m
including layover
Find flight
from$155
20:35 — 16:51
+1 day
20:35 — 21:16 G41495 Allegiant Air
Louisville — Fort Walton Beach
9h 14m stop
06:30 — 09:38 G43116 Allegiant Air
Fort Walton Beach — Pittsburgh
4h 31m stop
14:09 — 16:51 G4991 Allegiant Air
Pittsburgh — Key West
20h 16m
including layover
Find flight
from$249
20:35 — 09:22
+2 days
20:35 — 22:11 MX229 Mexicana
Louisville — Charleston
16h 37m stop
14:48 — 16:16 MX101 Mexicana
Charleston — Tampa
15h 59m stop
08:15 — 09:22 MX160 Mexicana
Tampa — Key West
36h 47m
including layover
Find flight
from$299
*Departure and arrival times - local. Updated on August 31, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Louisville to Key West depends on and how to choose the most interesting flight option for you.

Distance between Louisville and Key West is 1560 miles. Time difference between the cities is 0h. Airplanes depart 05:03 to 20:35 from 3 Louisville airports and arrive 05:03 to 20:35 to 2 Key West airports. Average flight time is 23h 53m.

  • The fastest flight 6h 11m
  • Average flight time 23h 53m
  • The earliest flight 05:03
  • The latest flight 20:35
  • Distance 970 ml

The cheapest months to travel to Key West are august (from 86 $), july (from 95 $), september (from 155 $).

The most expensive months are october (from 239 $), september (from 155 $), july (from 95 $).

What is the lowest airfare Louisville to Key West?

The cheapest plane ticket found by our users is $86. This airfare is for economy class on one-way G41099 flight by Allegiant Air for August 8, 2025 which leaves Standiford Field in Louisville at 15:47 am and arrives at Key West Key West Int. at 14:44.

Economy class
$86
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Business class
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First class
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Popular Airlines on the Route

The flight Louisville — Key West is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Mexicana - 8 departures per week at the price of from $ 120 . And the most expensive tickets are offered by United Airlines airline - from $ 724.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 59 flights with layovers on the route. The fastest connecting flight is UA3594 by United Airlines takes 6h 11m and the cheapest is G41099 by Allegiant Air for $86.

  • MX - Mexicana
    from $120
    Find
  • UA - United Airlines
    from $239
    Find
  • G4 - Allegiant Air
    from $86
    Find
  • NK - Spirit Airlines
    from $102
    Find
See more connecting flights

Airports

You can fly from Louisville to Key West from 3 airports (Standiford Field, Intercontinental, Bowman Field).

Louisville airports

  • Standiford Field-SDF
    from $86
    Find
  • Intercontinental-LJC
    Find
  • Bowman Field-LOU
    Find

Key West airports

  • NAS-NQX
    Find
  • Key West Int.-EYW
    Find

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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