Cheap Flights from Louisville, KY to Key West, FL from $86

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On Cheapflightsplus.com you will find 59 connecting flights from Louisville to Key West. You can compare airfare deals from 4 airlines and multiple travel sites from $86, book and save on cheap plane tickets and last minute offers. Also check out SDF-EYW flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Louisville to Key West Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $86 (one-way), $147 (round-trip).

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Best Flights from Louisville to Key West Today

Take a look at the list of non stop flights and flights with layovers from Louisville to Key West with the lowest price of $86. Take a look at the list of flights with layovers from Louisville to Key West from $86. There’re no direct flights. The fastest connecting flight – 6h 11m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $86 Find flight	15:47 Louisville Standiford Field	14:44+1 день Key West Key West Int.	22h 57m layover 19h 53m - Clearwater	Allegiant Air	G41099 G41048
from $102 Find flight	15:07 Louisville Standiford Field	15:08+1 день Key West Key West Int.	24h 1m layover 20h 56m - Clearwater	Spirit Airlines	NK2159 G41034
from $109 Find flight	15:36 Louisville Standiford Field	09:43+1 день Key West Key West Int.	18h 7m layover 14h 56m - Sanford	Allegiant Air	G42832 G42877
from $120 Find flight	18:57 Louisville Standiford Field	09:22+1 день Key West Key West Int.	14h 25m layover 11h 8m - Tampa	Mexicana	MX105 MX160
from $126 Find flight	17:34 Louisville Standiford Field	09:43+1 день Key West Key West Int.	16h 9m layover 12h 44m - Sanford	Spirit Airlines	NK2610 G42877
from $180 Find flight	18:57 Louisville Standiford Field	09:33+1 день Key West Key West Int.	14h 36m layover 11h 23m - Clearwater	Mexicana	MX105 G4971
from $193 Find flight	17:34 Louisville Standiford Field	13:07+1 день Key West Key West Int.	19h 33m layover 16h 4m - Orlando	Spirit Airlines	NK2610 MX162
from $140 Find flight	13:35 Louisville Standiford Field	09:43+1 день Key West Key West Int.	20h 8m layover 5h 15m - Myrtle Beach 10h 42m - Sanford	Spirit Airlines	NK2751 NK2089 G42877
from $143 Find flight	11:04 Louisville Standiford Field	15:08+1 день Key West Key West Int.	28h 4m layover 2h 4m - Detroit 20h 57m - Clearwater	Spirit Airlines	NK2795 NK2739 G41034
from $150 Find flight	11:34 Louisville Standiford Field	16:36+1 день Key West Key West Int.	29h 2m layover 7h 22m - Punta Gorda 14h 18m - Pittsburgh	Allegiant Air	G41451 G42750 G4991
from $155 Find flight	18:04 Louisville Standiford Field	18:42+1 день Key West Key West Int.	24h 38m layover 16h 15m - Punta Gorda 2h 24m - Fletcher	Allegiant Air	G42482 G41840 G4228
from $160 Find flight	10:54 Louisville Standiford Field	16:45+1 день Key West Key West Int.	29h 51m layover 9h 30m - Myrtle Beach 14h 28m - Indianapolis	Allegiant Air	G42969 G4631 G41285
from $164 Find flight	11:34 Louisville Standiford Field	16:36+1 день Key West Key West Int.	29h 2m layover 7h 26m - Punta Gorda 14h 15m - Pittsburgh	Allegiant Air	G43088 G42737 G41055
from $168 Find flight	12:32 Louisville Standiford Field	16:36+1 день Key West Key West Int.	28h 4m layover 7h 11m - Newark 14h 25m - Pittsburgh	Spirit Airlines	NK1785 NK1788 G41055
from $192 Find flight	17:43 Louisville Standiford Field	15:16+1 день Key West Key West Int.	21h 33m layover 12h 51m - Fort Walton Beach 2h 33m - Covington	Allegiant Air	G41490 G43069 G4426
from $195 Find flight	17:43 Louisville Standiford Field	16:36+1 день Key West Key West Int.	22h 53m layover 14h 8m - Fort Walton Beach 2h 14m - Pittsburgh	Allegiant Air	G41490 G42725 G41055

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on August 31, 2025

Flight Schedule Louisville (Kentucky) to Key West (Florida)

Full flight schedule will help you in detecting at what time planes fly from Louisville to Key West. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
06:15 — 14:11	06:15 — 08:30 UA3594 United Airlines Louisville — Newark 2h 10m stop 10:40 — 14:11 UA3687 United Airlines Newark — Key West	7h 56m including layover	Find flight from$284
06:30 — 12:41	06:30 — 08:42 UA3594 United Airlines Louisville — Newark 47m stop 09:29 — 12:41 UA1822 United Airlines Newark — Key West	6h 11m including layover	Find flight from$280
09:06 — 08:15 +1 day	09:06 — 11:15 NK143 Spirit Airlines Louisville — Orlando 19h 45m stop 07:00 — 08:15 MX159 Mexicana Orlando — Key West	23h 9m including layover	Find flight from$260
15:47 — 14:44 +1 day	15:47 — 17:47 G41099 Allegiant Air Louisville — Clearwater 19h 53m stop 13:40 — 14:44 G41048 Allegiant Air Clearwater — Key West	22h 57m including layover	Find flight from$86
15:52 — 15:08 +1 day	15:52 — 17:52 G41099 Allegiant Air Louisville — Clearwater 20h 13m stop 14:05 — 15:08 G41034 Allegiant Air Clearwater — Key West	23h 16m including layover	Find flight from$95
17:34 — 09:43 +1 day	17:34 — 19:48 NK2610 Spirit Airlines Louisville — Sanford 12h 44m stop 08:32 — 09:43 G42877 Allegiant Air Sanford — Key West	16h 9m including layover	Find flight from$126
18:57 — 09:22 +1 day	18:57 — 21:07 MX105 Mexicana Louisville — Tampa 11h 8m stop 08:15 — 09:22 MX160 Mexicana Tampa — Key West	14h 25m including layover	Find flight from$120
05:03 — 13:07 +1 day	05:03 — 07:25 NK2716 Spirit Airlines Louisville — Miami 22h 50m stop 06:15 — 07:18 NK2195 Spirit Airlines Miami — Orlando 4h 34m stop 11:52 — 13:07 MX162 Mexicana Orlando — Key West	32h 4m including layover	Find flight from$258
05:03 — 13:07 +1 day	05:03 — 07:25 NK2716 Spirit Airlines Louisville — Miami 11h 50m stop 19:15 — 20:24 NK2008 Spirit Airlines Miami — Orlando 15h 28m stop 11:52 — 13:07 MX162 Mexicana Orlando — Key West	32h 4m including layover	Find flight from$298
10:54 — 16:45 +1 day	10:54 — 12:21 G42969 Allegiant Air Louisville — Myrtle Beach 9h 30m stop 21:51 — 23:36 G4631 Allegiant Air Myrtle Beach — Indianapolis 14h 28m stop 14:04 — 16:45 G41285 Allegiant Air Indianapolis — Key West	29h 51m including layover	Find flight from$160
10:54 — 13:07 +1 day	10:54 — 12:21 G42969 Allegiant Air Louisville — Myrtle Beach 8h 3m stop 20:24 — 21:50 NK2089 Spirit Airlines Myrtle Beach — Orlando 14h 2m stop 11:52 — 13:07 MX162 Mexicana Orlando — Key West	26h 13m including layover	Find flight from$215
11:04 — 15:08 +1 day	11:04 — 12:22 NK2795 Spirit Airlines Louisville — Detroit 2h 4m stop 14:26 — 17:08 NK2739 Spirit Airlines Detroit — Clearwater 20h 57m stop 14:05 — 15:08 G41034 Allegiant Air Clearwater — Key West	28h 4m including layover	Find flight from$143
11:34 — 16:36 +1 day	11:34 — 13:49 G41451 Allegiant Air Louisville — Punta Gorda 7h 22m stop 21:11 — 23:36 G42750 Allegiant Air Punta Gorda — Pittsburgh 14h 18m stop 13:54 — 16:36 G4991 Allegiant Air Pittsburgh — Key West	29h 2m including layover	Find flight from$150
12:32 — 16:36 +1 day	12:32 — 14:54 NK1785 Spirit Airlines Louisville — Newark 7h 11m stop 22:05 — 23:29 NK1788 Spirit Airlines Newark — Pittsburgh 14h 25m stop 13:54 — 16:36 G41055 Allegiant Air Pittsburgh — Key West	28h 4m including layover	Find flight from$168
12:34 — 15:26 +1 day	12:34 — 13:15 G43102 Allegiant Air Louisville — Fort Walton Beach 6h 59m stop 20:14 — 22:44 G4256 Allegiant Air Fort Walton Beach — Fletcher 14h 43m stop 13:27 — 15:26 G4975 Allegiant Air Fletcher — Key West	26h 52m including layover	Find flight from$201
13:35 — 09:43 +1 day	13:35 — 15:09 NK2751 Spirit Airlines Louisville — Myrtle Beach 5h 15m stop 20:24 — 21:50 NK2089 Spirit Airlines Myrtle Beach — Sanford 10h 42m stop 08:32 — 09:43 G42877 Allegiant Air Sanford — Key West	20h 8m including layover	Find flight from$140
13:35 — 16:45 +1 day	13:35 — 15:09 NK2751 Spirit Airlines Louisville — Myrtle Beach 6h 42m stop 21:51 — 23:36 G4631 Allegiant Air Myrtle Beach — Indianapolis 14h 28m stop 14:04 — 16:45 G41285 Allegiant Air Indianapolis — Key West	27h 10m including layover	Find flight from$175
14:30 — 13:07 +1 day	14:30 — 15:54 NK2051 Spirit Airlines Louisville — Dallas 4h 35m stop 20:29 — 00:15 NK2263 Spirit Airlines Dallas — Orlando 11h 37m stop 11:52 — 13:07 MX162 Mexicana Orlando — Key West	22h 37m including layover	Find flight from$236
17:43 — 15:16 +1 day	17:43 — 18:24 G41490 Allegiant Air Louisville — Fort Walton Beach 12h 51m stop 07:15 — 10:10 G43069 Allegiant Air Fort Walton Beach — Covington 2h 33m stop 12:43 — 15:16 G4426 Allegiant Air Covington — Key West	21h 33m including layover	Find flight from$192
18:04 — 18:42 +1 day	18:04 — 20:19 G42482 Allegiant Air Louisville — Punta Gorda 16h 15m stop 12:34 — 14:19 G41840 Allegiant Air Punta Gorda — Fletcher 2h 24m stop 16:43 — 18:42 G4228 Allegiant Air Fletcher — Key West	24h 38m including layover	Find flight from$155
20:35 — 16:51 +1 day	20:35 — 21:16 G41495 Allegiant Air Louisville — Fort Walton Beach 9h 14m stop 06:30 — 09:38 G43116 Allegiant Air Fort Walton Beach — Pittsburgh 4h 31m stop 14:09 — 16:51 G4991 Allegiant Air Pittsburgh — Key West	20h 16m including layover	Find flight from$249
20:35 — 09:22 +2 days	20:35 — 22:11 MX229 Mexicana Louisville — Charleston 16h 37m stop 14:48 — 16:16 MX101 Mexicana Charleston — Tampa 15h 59m stop 08:15 — 09:22 MX160 Mexicana Tampa — Key West	36h 47m including layover	Find flight from$299

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on August 31, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Louisville to Key West depends on and how to choose the most interesting flight option for you.

Distance between Louisville and Key West is 1560 miles. Time difference between the cities is 0h. Airplanes depart 05:03 to 20:35 from 3 Louisville airports and arrive 05:03 to 20:35 to 2 Key West airports. Average flight time is 23h 53m.

The fastest flight 6h 11m
Average flight time 23h 53m
The earliest flight 05:03
The latest flight 20:35
Distance 970 ml

The cheapest months to travel to Key West are august (from 86 $), july (from 95 $), september (from 155 $).

The most expensive months are october (from 239 $), september (from 155 $), july (from 95 $).

What is the lowest airfare Louisville to Key West?

The cheapest plane ticket found by our users is $86. This airfare is for economy class on one-way G41099 flight by Allegiant Air for August 8, 2025 which leaves Standiford Field in Louisville at 15:47 am and arrives at Key West Key West Int. at 14:44.

Economy class

$86

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Business class

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First class

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Popular Airlines on the Route

The flight Louisville — Key West is served by 4 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Mexicana - 8 departures per week at the price of from $ 120 . And the most expensive tickets are offered by United Airlines airline - from $ 724.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 59 flights with layovers on the route. The fastest connecting flight is UA3594 by United Airlines takes 6h 11m and the cheapest is G41099 by Allegiant Air for $86.

MX - Mexicana

from $120

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UA - United Airlines

from $239

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G4 - Allegiant Air

from $86

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NK - Spirit Airlines

from $102

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Airports

You can fly from Louisville to Key West from 3 airports (Standiford Field, Intercontinental, Bowman Field).

Louisville airports

Standiford Field-SDF

from $86
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Intercontinental-LJC

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Bowman Field-LOU

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Key West airports

NAS-NQX

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Key West Int.-EYW

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Airplanes

There are flights to Key West from Louisville by 4 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Louisville

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Louisville — Orlando

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Louisville — Boston

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Louisville — Atlanta

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Louisville — Tampa

from $70

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Louisville — Houston

from $56

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Louisville — Dallas

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Louisville — Denver

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Top International Destinations from Louisville

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Louisville — Cancun

from $56

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How to book a plane ticket yourself?

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