Cheap Flights from Detroit, MI to Key West, FL from $129

On Cheapflightsplus.com you will find 112 connecting flights from Detroit to Key West. You can compare airfare deals from 3 airlines and multiple travel sites from $129, book and save on cheap plane tickets and last minute offers. Also check out DTT-EYW flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Detroit to Key West Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $129 (one-way), $221 (round-trip).
Direct flights
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Full flight schedule will help you in detecting at what time planes fly from Detroit to Key West. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
07:30 — 09:43
+1 day
07:30 — 10:13 NK2456 Spirit Airlines
Detroit — Sanford
22h 19m stop
08:32 — 09:43 G42877 Allegiant Air
Sanford — Key West
26h 13m
including layover
Find flight
from$129
09:04 — 09:12
+1 day
09:04 — 11:41 NK2384 Spirit Airlines
Detroit — Clearwater
20h 29m stop
08:10 — 09:12 G4973 Allegiant Air
Clearwater — Key West
24h 8m
including layover
Find flight
from$138
13:55 — 12:41
+1 day
13:55 — 15:47 UA3701 United Airlines
Detroit — Newark
17h 42m stop
09:29 — 12:41 UA1822 United Airlines
Newark — Key West
22h 46m
including layover
Find flight
from$409
15:32 — 13:07
+1 day
15:32 — 18:19 NK2109 Spirit Airlines
Detroit — Orlando
17h 33m stop
12:02 — 13:17 MX162 Mexicana
Orlando — Key West
21h 35m
including layover
Find flight
from$261
18:56 — 09:12
+1 day
18:56 — 21:31 NK2083 Spirit Airlines
Detroit — Clearwater
10h 39m stop
08:10 — 09:12 G4973 Allegiant Air
Clearwater — Key West
14h 16m
including layover
Find flight
from$138
20:25 — 13:07
+1 day
20:25 — 23:09 NK1261 Spirit Airlines
Detroit — Orlando
12h 43m stop
11:52 — 13:07 MX162 Mexicana
Orlando — Key West
16h 42m
including layover
Find flight
from$223
21:16 — 13:07
+1 day
21:16 — 23:59 NK2456 Spirit Airlines
Detroit — Orlando
11h 53m stop
12:02 — 13:17 MX162 Mexicana
Orlando — Key West
15h 51m
including layover
Find flight
from$261
21:56 — 09:22
+1 day
21:56 — 00:39 NK2676 Spirit Airlines
Detroit — Tampa
7h 36m stop
08:15 — 09:22 MX160 Mexicana
Tampa — Key West
11h 26m
including layover
Find flight
from$192
05:15 — 16:45
+1 day
05:15 — 07:22 NK2350 Spirit Airlines
Detroit — Atlanta
8h stop
15:22 — 16:50 NK2559 Spirit Airlines
Atlanta — Indianapolis
21h 14m stop
14:04 — 16:45 G41285 Allegiant Air
Indianapolis — Key West
35h 30m
including layover
Find flight
from$179
05:40 — 09:12
+1 day
05:40 — 08:41 NK1451 Spirit Airlines
Detroit — Miami
6h 24m stop
15:05 — 16:10 NK322 Spirit Airlines
Miami — Clearwater
16h stop
08:10 — 09:12 G4973 Allegiant Air
Clearwater — Key West
27h 32m
including layover
Find flight
from$180
06:10 — 09:43
+1 day
06:10 — 07:50 NK2496 Spirit Airlines
Detroit — New York
4h 5m stop
11:55 — 14:47 NK2392 Spirit Airlines
New York — Sanford
17h 45m stop
08:32 — 09:43 G42877 Allegiant Air
Sanford — Key West
27h 33m
including layover
Find flight
from$227
06:10 — 13:07
+1 day
06:10 — 07:39 NK1553 Spirit Airlines
Detroit — Baltimore
10h 58m stop
18:37 — 21:07 NK1961 Spirit Airlines
Baltimore — Orlando
14h 45m stop
11:52 — 13:07 MX162 Mexicana
Orlando — Key West
30h 57m
including layover
Find flight
from$260
07:58 — 09:33
+1 day
07:58 — 08:39 NK1547 Spirit Airlines
Detroit — Nashville
3h 48m stop
12:27 — 15:15 G4348 Allegiant Air
Nashville — Clearwater
17h 15m stop
08:30 — 09:33 G4971 Allegiant Air
Clearwater — Key West
25h 35m
including layover
Find flight
from$185
08:00 — 13:07
+1 day
08:00 — 08:55 NK1257 Spirit Airlines
Detroit — North Kansas City
4h 19m stop
13:14 — 16:58 NK1525 Spirit Airlines
North Kansas City — Orlando
18h 54m stop
11:52 — 13:07 MX162 Mexicana
Orlando — Key West
29h 7m
including layover
Find flight
from$237
08:12 — 16:45
+1 day
08:12 — 09:52 NK2476 Spirit Airlines
Detroit — Myrtle Beach
11h 59m stop
21:51 — 23:36 G4631 Allegiant Air
Myrtle Beach — Indianapolis
14h 28m stop
14:04 — 16:45 G41285 Allegiant Air
Indianapolis — Key West
32h 33m
including layover
Find flight
from$204
09:07 — 16:36
+1 day
09:07 — 10:48 NK1415 Spirit Airlines
Detroit — Newark
11h 17m stop
22:05 — 23:29 NK1788 Spirit Airlines
Newark — Pittsburgh
14h 25m stop
13:54 — 16:36 G4991 Allegiant Air
Pittsburgh — Key West
31h 29m
including layover
Find flight
from$154
10:51 — 09:12
+1 day
10:51 — 13:52 NK3721 Spirit Airlines
Detroit — Miami
1h 13m stop
15:05 — 16:10 NK322 Spirit Airlines
Miami — Clearwater
16h stop
08:10 — 09:12 G4973 Allegiant Air
Clearwater — Key West
22h 21m
including layover
Find flight
from$180
10:54 — 09:33
+1 day
10:54 — 13:01 NK2641 Spirit Airlines
Detroit — Houston
6h 14m stop
19:15 — 22:17 NK2024 Spirit Airlines
Houston — Clearwater
10h 13m stop
08:30 — 09:33 G4971 Allegiant Air
Clearwater — Key West
22h 39m
including layover
Find flight
from$267
11:17 — 09:33
+1 day
11:17 — 12:13 NK2312 Spirit Airlines
Detroit — West Memphis
8h 29m stop
20:43 — 23:37 G41019 Allegiant Air
West Memphis — Clearwater
8h 59m stop
08:30 — 09:33 G4971 Allegiant Air
Clearwater — Key West
22h 16m
including layover
Find flight
from$207
12:25 — 14:44
+1 day
12:25 — 13:37 NK1255 Spirit Airlines
Detroit — Louisville
2h 10m stop
15:47 — 17:47 G41099 Allegiant Air
Louisville — Clearwater
19h 53m stop
13:40 — 14:44 G41048 Allegiant Air
Clearwater — Key West
26h 19m
including layover
Find flight
from$159
12:25 — 15:08
+1 day
12:25 — 13:37 NK1255 Spirit Airlines
Detroit — Louisville
2h 15m stop
15:52 — 17:52 G41099 Allegiant Air
Louisville — Clearwater
20h 13m stop
14:05 — 15:08 G41034 Allegiant Air
Clearwater — Key West
26h 43m
including layover
Find flight
from$169
13:15 — 16:36
+1 day
13:15 — 14:54 NK2013 Spirit Airlines
Detroit — Hartford
16h 16m stop
07:10 — 08:45 MX546 Mexicana
Hartford — Pittsburgh
5h 9m stop
13:54 — 16:36 G41055 Allegiant Air
Pittsburgh — Key West
27h 21m
including layover
Find flight
from$248
14:20 — 09:43
+1 day
14:20 — 16:00 NK2695 Spirit Airlines
Detroit — Newark
5h 55m stop
21:55 — 00:53 NK2116 Spirit Airlines
Newark — Sanford
7h 39m stop
08:32 — 09:43 G42877 Allegiant Air
Sanford — Key West
19h 23m
including layover
Find flight
from$193
14:20 — 15:30
+1 day
14:20 — 16:00 NK2695 Spirit Airlines
Detroit — Newark
17h 55m stop
09:55 — 11:50 G4238 Allegiant Air
Newark — Fletcher
1h 40m stop
13:30 — 15:30 G4977 Allegiant Air
Fletcher — Key West
25h 10m
including layover
Find flight
from$223
17:05 — 18:42
+1 day
17:05 — 18:45 NK2318 Spirit Airlines
Detroit — Newark
17h 10m stop
11:55 — 13:50 G4217 Allegiant Air
Newark — Fletcher
2h 53m stop
16:43 — 18:42 G4228 Allegiant Air
Fletcher — Key West
25h 37m
including layover
Find flight
from$215
17:25 — 13:07
+1 day
17:25 — 19:09 NK2476 Spirit Airlines
Detroit — Myrtle Beach
1h 15m stop
20:24 — 21:50 NK2089 Spirit Airlines
Myrtle Beach — Orlando
14h 2m stop
12:02 — 13:17 MX162 Mexicana
Orlando — Key West
19h 42m
including layover
Find flight
from$247
18:09 — 16:36
+1 day
18:09 — 19:50 NK1078 Spirit Airlines
Detroit — Newark
2h 15m stop
22:05 — 23:29 NK1788 Spirit Airlines
Newark — Pittsburgh
14h 25m stop
13:54 — 16:36 G4991 Allegiant Air
Pittsburgh — Key West
22h 27m
including layover
Find flight
from$154
20:20 — 13:07
+1 day
20:20 — 23:29 NK2793 Spirit Airlines
Detroit — Miami
6h 46m stop
06:15 — 07:18 NK2195 Spirit Airlines
Miami — Orlando
4h 34m stop
12:02 — 13:17 MX162 Mexicana
Orlando — Key West
16h 47m
including layover
Find flight
from$236
22:04 — 13:07
+1 day
22:04 — 00:17 NK2493 Spirit Airlines
Detroit — Atlanta
5h 8m stop
05:25 — 06:45 NK2287 Spirit Airlines
Atlanta — Orlando
5h 7m stop
12:02 — 13:17 MX162 Mexicana
Orlando — Key West
15h 3m
including layover
Find flight
from$218
*Departure and arrival times - local. Updated on July 5, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Detroit to Key West depends on and how to choose the most interesting flight option for you.

Distance between Detroit and Key West is 1980 miles. Time difference between the cities is 0h. Airplanes depart 05:00 to 22:04 from 2 Detroit airports and arrive 05:00 to 22:04 to 2 Key West airports. Average flight time is 25h 36m.

  • The fastest flight 7h 56m
  • Average flight time 25h 36m
  • The earliest flight 05:00
  • The latest flight 22:04
  • Distance 1231 ml

The cheapest months to travel to Key West are june (from 119 $), july (from 129 $), october (from 138 $).

The most expensive months are september (from 215 $), august (from 159 $), october (from 138 $).

What is the lowest airfare Detroit to Key West?

The cheapest plane ticket found by our users is $129. This airfare is for economy class on one-way NK2456 flight by Spirit Airlines for July 5, 2025 which leaves All airports in Detroit at 07:30 am and arrives at Key West Key West Int. at 09:43.

Economy class
$129
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Business class
?
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First class
?
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Popular Airlines on the Route

The flight Detroit — Key West is served by 3 regular airlines and 2 low-cost airlines. Most of the flights on this route are operated by Sun Country Airlines - 1 departures per week at the price of from $ 352 . And the most expensive tickets are offered by United Airlines airline - from $ 691.

Direct flights

There’re no direct flights on this route. Try flights with stops.

Connecting Flights

There are 112 flights with layovers on the route. The fastest connecting flight is NK1066 by Spirit Airlines takes 7h 56m and the cheapest is NK2456 by Spirit Airlines for $129.

  • SY - Sun Country Airlines
    from $352
    Find
  • UA - United Airlines
    from $312
    Find
  • NK - Spirit Airlines
    from $129
    Find
See more connecting flights

Airports

You can fly from Detroit to Key West from 2 airports (Willow Run, Detroit City).

Detroit airports

  • Willow Run-YIP
    Find
  • Detroit City-DET
    Find

Key West airports

  • NAS-NQX
    Find
  • Key West Int.-EYW
    Find

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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