Cheap Flights from Denver, CO to Panama City from $243

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On Cheapflightsplus.com you will find 2 direct and 339 connecting flights from Denver to Panama City. You can compare airfare deals from 10 airlines and multiple travel sites from $243, book and save on cheap plane tickets and last minute offers. Also check out DEN-PTY flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Denver to Panama City Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $243 (one-way), $417 (round-trip).
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Best Flights from Denver to Panama City Today

Take a look at the list of non stop flights and flights with layovers from Denver to Panama City with the lowest price of $243. The fastest direct flight takes 5h 51m and the fastest connecting – 7h 26m.
Price Departure Arrival Flight Duration Airline Flight
from $726
Find flight
22:42
Denver
Denver International
 05:33+1 день
Panama City
Tocumen
 5h 51m Compania Panamena de Aviacion
CM477
from $2345
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22:42
Denver
Denver International
 05:33+1 день
Panama City
Tocumen
 5h 51m United Airlines
UA7187
from $243
Find flight
15:58
Denver
Denver International
 12:35+1 день
Panama City
Tocumen
 19h 37m
layover
13h 0m - San Jose
 United Airlines
UA536
AV643
from $265
Find flight
13:46
Denver
Denver International
 19:33+1 день
Panama City
Tocumen
 28h 47m
layover
21h 11m - Atlanta
 Frontier Airlines
F93600
CM891
from $255
Find flight
00:34
Denver
Denver International
 12:35+1 день
Panama City
Tocumen
 35h 1m
layover
15h 10m - Miami
11h 35m - San Jose
 Frontier Airlines
F93138
AV605
AV643
from $294
Find flight
06:50
Denver
Denver International
 10:25+1 день
Panama City
Tocumen
 26h 35m
layover
3h 41m - Houston
15h 30m - San Salvador
 Frontier Airlines
F93206
AV367
AV323
Show all tickets
*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on September 18, 2025
Full flight schedule will help you in detecting at what time planes fly from Denver to Panama City. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
Departure Arrival Flight Details Flight Duration Price
00:34 — 12:35
+1 day
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
15h 10m stop
21:40 — 22:40 AV605 Avianca
Miami — San Jose
11h 35m stop
10:15 — 12:35 AV643 Avianca
San Jose — Panama City
35h 1m
including layover
Find flight
from$255
00:34 — 19:29
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
10h 53m stop
17:23 — 19:29 CM333 Compania Panamena de Aviacion
Miami — Panama City
17h 55m
including layover
Find flight
from$266
00:34 — 08:11
+1 day
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
23h 35m stop
06:05 — 08:11 CM173 Compania Panamena de Aviacion
Miami — Panama City
30h 37m
including layover
Find flight
from$266
00:34 — 08:30
+1 day
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
23h 54m stop
06:24 — 08:30 CM246 Compania Panamena de Aviacion
Miami — Panama City
30h 56m
including layover
Find flight
from$266
00:34 — 10:40
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
2h 4m stop
08:34 — 10:40 CM433 Compania Panamena de Aviacion
Miami — Panama City
9h 6m
including layover
Find flight
from$269
00:34 — 20:37
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
12h 1m stop
18:31 — 20:37 CM227 Compania Panamena de Aviacion
Miami — Panama City
19h 3m
including layover
Find flight
from$269
00:34 — 16:26
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
7h 50m stop
14:20 — 16:26 CM481 Compania Panamena de Aviacion
Miami — Panama City
14h 52m
including layover
Find flight
from$270
00:34 — 16:36
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
8h stop
14:26 — 16:36 CM410 Compania Panamena de Aviacion
Miami — Panama City
15h 2m
including layover
Find flight
from$270
00:34 — 21:10
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
4h 50m stop
11:20 — 14:05 AV9 Avianca
Miami — Bogota
5h 20m stop
19:25 — 21:10 AV56 Avianca
Bogota — Panama City
19h 36m
including layover
Find flight
from$272
00:34 — 00:45
+1 day
00:34 — 06:30 F93138 Frontier Airlines
Denver — Miami
12h 50m stop
19:20 — 21:59 AV127 Avianca
Miami — Bogota
1h 1m stop
23:00 — 00:45 AV40 Avianca
Bogota — Panama City
23h 11m
including layover
Find flight
from$273
00:59 — 19:33
00:59 — 06:10 F93294 Frontier Airlines
Denver — Atlanta
10h stop
16:10 — 19:33 CM891 Compania Panamena de Aviacion
Atlanta — Panama City
17h 34m
including layover
Find flight
from$271
13:46 — 19:33
+1 day
13:39 — 19:02 F93600 Frontier Airlines
Denver — Atlanta
21h 11m stop
16:10 — 19:33 CM891 Compania Panamena de Aviacion
Atlanta — Panama City
28h 47m
including layover
Find flight
from$265
15:58 — 12:35
+1 day
15:58 — 21:15 UA536 United Airlines
Denver — San Jose
13h stop
10:15 — 12:35 AV643 Avianca
San Jose — Panama City
19h 37m
including layover
Find flight
from$243
22:42 — 05:33
+1 day
22:42 — 05:33 CM477 Compania Panamena de Aviacion
Denver — Panama City
5h 51m
Find flight
from$726
22:42 — 05:33
+1 day
22:42 — 05:33 UA7187 United Airlines
Denver — Panama City
5h 51m
Find flight
from$2345
*Departure and arrival times - local. Updated on September 18, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Denver to Panama City depends on and how to choose the most interesting flight option for you.

Distance between Denver and Panama City is 4242 miles. Time difference between the cities is 2h. Airplanes depart 00:23 to 23:59 from 2 Denver airports and arrive 00:23 to 23:59 to 2 Panama City airports. Average flight time is 5h 51m.

  • The fastest flight 5h 51m
  • Average flight time 5h 51m
  • The earliest flight 00:23
  • The latest flight 23:59
  • Distance 2636 ml

The cheapest months to travel to Panama City are august (from 243 $), july (from 255 $), september (from 417 $).

The most expensive months are january (from 2 872 $), december (from 854 $), november (from 637 $).

What is the lowest airfare Denver to Panama City?

The cheapest plane ticket found by our users is $243. This airfare is for economy class on one-way UA536 flight by United Airlines for July 4, 2025 which leaves Denver International in Denver at 15:58 am and arrives at Panama City Tocumen at 12:35.

Economy class
$243
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Business class
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First class
?
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Popular Airlines on the Route

The flight Denver — Panama City is served by 10 regular airlines and 3 low-cost airlines. Most of the flights on this route are operated by Air Canada - 8 departures per week at the price of from $ 636 . And the most expensive tickets are offered by United Airlines airline - from $ 4044.

Direct flights

There are 2 nonstop flights on the route. The fastest direct flight is CM477 by Compania Panamena de Aviacion takes 5h 51m and the cheapest is UA536 by United Airlines for $726.

  • CM - Compania Panamena de Aviacion
    from $726
    Find
  • UA - United Airlines
    from $2345
    Find
See more direct flights

Connecting Flights

There are 339 flights with layovers on the route. The fastest connecting flight is UA2676 by United Airlines takes 7h 26m and the cheapest is UA536 by United Airlines for $243.

  • AS - Alaska Airlines
    from $403
    Find
  • AC - Air Canada
    from $636
    Find
  • F9 - Frontier Airlines
    from $255
    Find
  • TK - Turkish Airlines
    from $1196
    Find
  • HA - Hawaiian Airlines
    from $649
    Find
  • Y4 - Volaris
    from $299
    Find
  • UA - United Airlines
    from $243
    Find
  • AM - Aeromexico
    from $330
    Find
  • VB - VivaAerobus
    from $715
    Find
See more connecting flights

Airports

You can fly from Denver to Panama City from 2 airports (Denver International, Arapahoe Co).

Denver airports

  • Denver International-DEN
    from $243
    Find
  • Arapahoe Co-APA
    Find

Panama City airports

  • Tocumen-PTY
    Find
  • Paitilla-PAC
    Find

Airplanes

There are flights to Panama City from Denver by 10 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Denver

You may also consider searching for discounted plane tickets to some other popular places from Denver within United States.

Top International Destinations from Denver

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

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