Cheap Flights from Denver, CO to Panama City from $258

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On Cheapflightsplus.com you will find 2 direct and 339 connecting flights from Denver to Panama City. You can compare airfare deals from 10 airlines and multiple travel sites from $258, book and save on cheap plane tickets and last minute offers. Also check out DEN-PTY flight schedule to find best flight time, convenient departure and arrival airports.

Find One-Way and Round-Trip Denver to Panama City Flight Deals

To find the cheapest one way airline ticket select the date with the lowest price on the calendar below and click «Find Flights». To search for round-trip flight deals click on the link «Check prices for return flights» and select the date of the return flight. Cheapest flights in November: $258 (one-way), $442 (round-trip).

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Best Flights from Denver to Panama City Today

Take a look at the list of non stop flights and flights with layovers from Denver to Panama City with the lowest price of $258. The fastest direct flight takes 5h 51m and the fastest connecting – 7h 26m.

Price	Departure	Arrival	Flight Duration	Airline	Flight
from $771 Find flight	22:42 Denver Denver International	05:33+1 день Panama City Tocumen	5h 51m	Compania Panamena de Aviacion	CM477
from $2519 Find flight	22:42 Denver Denver International	05:33+1 день Panama City Tocumen	5h 51m	United Airlines	UA7187
from $258 Find flight	15:58 Denver Denver International	12:35+1 день Panama City Tocumen	19h 37m layover 13h 0m - San Jose	United Airlines	UA536 AV643
from $281 Find flight	13:46 Denver Denver International	19:33+1 день Panama City Tocumen	28h 47m layover 21h 11m - Atlanta	Frontier Airlines	F93600 CM891
from $291 Find flight	00:59 Denver Denver International	19:33 Panama City Tocumen	17h 34m layover 10h 0m - Atlanta	Frontier Airlines	F93294 CM891
from $330 Find flight	00:34 Denver Denver International	14:30 Panama City Tocumen	12h 56m layover 5h 54m - Miami	Frontier Airlines	F93138 CM440
from $271 Find flight	00:34 Denver Denver International	12:35+1 день Panama City Tocumen	35h 1m layover 15h 10m - Miami 11h 35m - San Jose	Frontier Airlines	F93138 AV605 AV643
from $291 Find flight	00:59 Denver Denver International	20:37 Panama City Tocumen	18h 38m layover 3h 5m - Atlanta 7h 17m - Miami	Frontier Airlines	F93294 F94406 CM227
from $292 Find flight	00:23 Denver Denver International	00:10+1 день Panama City Tocumen	22h 47m layover 10h 25m - Orlando 3h 0m - Bogota	Frontier Airlines	F91734 AV219 AV40
from $298 Find flight	20:06 Denver Denver International	19:29+1 день Panama City Tocumen	22h 23m layover 10h 55m - Covington 2h 47m - Miami	Frontier Airlines	F91752 F91444 CM333
from $298 Find flight	20:06 Denver Denver International	20:37+1 день Panama City Tocumen	23h 31m layover 10h 55m - Covington 3h 55m - Miami	Frontier Airlines	F91752 F91444 CM227
from $298 Find flight	06:50 Denver Denver International	08:11+1 день Panama City Tocumen	24h 21m layover 9h 30m - Houston 6h 29m - Miami	Frontier Airlines	F93206 F91068 CM173
from $298 Find flight	06:50 Denver Denver International	08:30+1 день Panama City Tocumen	24h 40m layover 9h 30m - Houston 6h 48m - Miami	Frontier Airlines	F93206 F91068 CM246
from $298 Find flight	06:50 Denver Denver International	10:40+1 день Panama City Tocumen	26h 50m layover 9h 30m - Houston 8h 58m - Miami	Frontier Airlines	F93206 F91068 CM433
from $302 Find flight	08:25 Denver Denver International	10:25+1 день Panama City Tocumen	25h 0m layover 5h 58m - Los Angeles 9h 35m - San Salvador	Frontier Airlines	F92341 AV525 AV323
from $312 Find flight	16:28 Denver Denver International	00:10+2 дня Panama City Tocumen	30h 42m layover 17h 28m - Washington D.C. 2h 35m - Bogota	Frontier Airlines	F9690 AV247 AV40

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*Departure and arrival times - local. Prices indicated for one-way flights. Information updated on August 15, 2025

Flight Schedule Denver (Colorado) to Panama City

Full flight schedule will help you in detecting at what time planes fly from Denver to Panama City. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.

Departure	Flight Details	Flight Duration	Price
22:42 — 05:33 +1 day	22:42 — 05:33 CM477 Compania Panamena de Aviacion Denver — Panama City	5h 51m	Find flight from$771
22:42 — 05:33 +1 day	22:42 — 05:33 UA7187 United Airlines Denver — Panama City	5h 51m	Find flight from$2519
00:34 — 08:11 +1 day	00:34 — 06:30 F93138 Frontier Airlines Denver — Miami 23h 35m stop 06:05 — 08:11 CM173 Compania Panamena de Aviacion Miami — Panama City	30h 37m including layover	Find flight from$282
13:46 — 19:33 +1 day	13:39 — 19:02 F93600 Frontier Airlines Denver — Atlanta 21h 11m stop 16:10 — 19:33 CM891 Compania Panamena de Aviacion Atlanta — Panama City	28h 47m including layover	Find flight from$281
15:58 — 12:35 +1 day	15:58 — 21:15 UA536 United Airlines Denver — San Jose 13h stop 10:15 — 12:35 AV643 Avianca San Jose — Panama City	19h 37m including layover	Find flight from$258
00:34 — 12:35 +1 day	00:34 — 06:30 F93138 Frontier Airlines Denver — Miami 15h 10m stop 21:40 — 22:40 AV605 Avianca Miami — San Jose 11h 35m stop 10:15 — 12:35 AV643 Avianca San Jose — Panama City	35h 1m including layover	Find flight from$271
06:50 — 08:11 +1 day	06:50 — 10:24 F93206 Frontier Airlines Denver — Houston 9h 30m stop 19:54 — 23:36 F91068 Frontier Airlines Houston — Miami 6h 29m stop 06:05 — 08:11 CM173 Compania Panamena de Aviacion Miami — Panama City	24h 21m including layover	Find flight from$298
06:50 — 08:30 +1 day	06:50 — 10:24 F93206 Frontier Airlines Denver — Houston 9h 30m stop 19:54 — 23:36 F91068 Frontier Airlines Houston — Miami 6h 48m stop 06:24 — 08:30 CM246 Compania Panamena de Aviacion Miami — Panama City	24h 40m including layover	Find flight from$298
08:25 — 10:25 +1 day	08:25 — 09:57 F92341 Frontier Airlines Denver — Los Angeles 5h 58m stop 15:55 — 21:55 AV525 Avianca Los Angeles — San Salvador 9h 35m stop 07:30 — 10:25 AV323 Avianca San Salvador — Panama City	25h including layover	Find flight from$302
08:52 — 10:25 +1 day	08:44 — 14:35 F93312 Frontier Airlines Denver — Orlando 2h 7m stop 16:50 — 17:55 AV423 Avianca Orlando — San Salvador 13h 35m stop 07:30 — 10:25 AV323 Avianca San Salvador — Panama City	24h 33m including layover	Find flight from$314
10:57 — 16:30 +1 day	10:57 — 16:31 F92706 Frontier Airlines Denver — Washington D.C. 14h 29m stop 07:00 — 11:24 AV149 Avianca Washington D.C. — Bogota 3h 16m stop 14:40 — 16:30 AV60 Avianca Bogota — Panama City	28h 33m including layover	Find flight from$318
10:57 — 08:11 +1 day	10:57 — 16:31 F92706 Frontier Airlines Denver — Baltimore 3h 6m stop 19:37 — 22:29 F91665 Frontier Airlines Baltimore — Miami 7h 36m stop 06:05 — 08:11 CM173 Compania Panamena de Aviacion Miami — Panama City	20h 14m including layover	Find flight from$329
11:13 — 00:45 +1 day	07:02 — 13:08 F970 Frontier Airlines Denver — Cancun 2h stop 18:00 — 21:25 AV265 Avianca Cancun — Bogota 1h 20m stop 22:30 — 00:20 AV40 Avianca Bogota — Panama City	12h 32m including layover	Find flight from$303
11:40 — 12:35 +1 day	11:40 — 15:02 Y41761 Volaris Denver — Guadalajara 5h 25m stop 20:27 — 23:52 Q64059 Q6 Guadalajara — San Jose 10h 23m stop 10:15 — 12:35 AV643 Avianca San Jose — Panama City	23h 55m including layover	Find flight from$318
13:39 — 08:11 +1 day	13:39 — 18:55 F93600 Frontier Airlines Denver — Atlanta 3h 9m stop 22:04 — 00:05 F92272 Frontier Airlines Atlanta — Miami 6h stop 06:05 — 08:11 CM173 Compania Panamena de Aviacion Miami — Panama City	17h 32m including layover	Find flight from$323
16:28 — 00:10 +2 days	16:28 — 21:57 F9690 Frontier Airlines Denver — Washington D.C. 17h 28m stop 15:25 — 19:50 AV247 Avianca Washington D.C. — Bogota 2h 35m stop 22:25 — 00:10 AV40 Avianca Bogota — Panama City	30h 42m including layover	Find flight from$312
18:10 — 19:33 +1 day	18:10 — 19:15 F94967 Frontier Airlines Denver — Las Vegas 2h 33m stop 21:48 — 05:03 F92428 Frontier Airlines Las Vegas — Atlanta 11h 7m stop 16:10 — 19:33 CM891 Compania Panamena de Aviacion Atlanta — Panama City	24h 23m including layover	Find flight from$317
18:10 — 10:40 +1 day	17:51 — 18:56 F94967 Frontier Airlines Denver — Las Vegas 2h 33m stop 21:48 — 05:45 F94552 Frontier Airlines Las Vegas — Miami 2h 49m stop 08:34 — 10:40 CM433 Compania Panamena de Aviacion Miami — Panama City	15h 30m including layover	Find flight from$323
19:53 — 10:25 +2 days	19:53 — 23:36 F92996 Frontier Airlines Denver — Houston 18h 4m stop 17:40 — 19:35 AV425 Avianca Houston — San Salvador 11h 55m stop 07:30 — 10:25 AV323 Avianca San Salvador — Panama City	37h 32m including layover	Find flight from$320
19:53 — 10:25 +2 days	19:53 — 23:36 F92996 Frontier Airlines Denver — Houston 14h 29m stop 14:05 — 16:00 AV367 Avianca Houston — San Salvador 15h 30m stop 07:30 — 10:25 AV323 Avianca San Salvador — Panama City	37h 32m including layover	Find flight from$336
20:06 — 19:29 +1 day	20:06 — 00:54 F91752 Frontier Airlines Denver — Covington 10h 55m stop 11:49 — 14:36 F91444 Frontier Airlines Covington — Miami 2h 47m stop 17:23 — 19:29 CM333 Compania Panamena de Aviacion Miami — Panama City	22h 23m including layover	Find flight from$298
20:06 — 20:37 +1 day	20:06 — 00:54 F91752 Frontier Airlines Denver — Covington 10h 55m stop 11:49 — 14:36 F91444 Frontier Airlines Covington — Miami 3h 55m stop 18:31 — 20:37 CM227 Compania Panamena de Aviacion Miami — Panama City	23h 31m including layover	Find flight from$298
23:58 — 21:10 +1 day	23:58 — 05:28 F91114 Frontier Airlines Denver — Tampa 8h 47m stop 14:15 — 17:10 AV195 Avianca Tampa — Bogota 2h 15m stop 19:25 — 21:10 AV56 Avianca Bogota — Panama City	20h 12m including layover	Find flight from$305
23:58 — 19:33 +1 day	23:58 — 05:28 F91114 Frontier Airlines Denver — Tampa 57m stop 06:28 — 08:14 F92911 Frontier Airlines Tampa — Atlanta 7h 56m stop 16:10 — 19:33 CM891 Compania Panamena de Aviacion Atlanta — Panama City	18h 35m including layover	Find flight from$309

Departure	Arrival	Flight Details	Flight Time	Price
		stop stop	including layover	Find flight from$

*Departure and arrival times - local. Updated on August 15, 2025

Flight Information

Below we will explain in detail what the flights cost on the destination from Denver to Panama City depends on and how to choose the most interesting flight option for you.

Distance between Denver and Panama City is 4242 miles. Time difference between the cities is 2h. Airplanes depart 00:23 to 23:59 from 2 Denver airports and arrive 00:23 to 23:59 to 2 Panama City airports. Average flight time is 5h 51m.

The fastest flight 5h 51m
Average flight time 5h 51m
The earliest flight 00:23
The latest flight 23:59
Distance 2636 ml

The cheapest months to travel to Panama City are august (from 258 $), july (from 271 $), september (from 444 $).

The most expensive months are january (from 3 052 $), december (from 907 $), november (from 677 $).

What is the lowest airfare Denver to Panama City?

The cheapest plane ticket found by our users is $258. This airfare is for economy class on one-way UA536 flight by United Airlines for August 15, 2025 which leaves Denver International in Denver at 15:58 am and arrives at Panama City Tocumen at 12:35.

Economy class

$258

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Business class

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First class

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Popular Airlines on the Route

The flight Denver — Panama City is served by 10 regular airlines and 3 low-cost airlines. Most of the flights on this route are operated by Air Canada - 8 departures per week at the price of from $ 675 . And the most expensive tickets are offered by United Airlines airline - from $ 4297.

Direct flights

There are 2 nonstop flights on the route. The fastest direct flight is CM477 by Compania Panamena de Aviacion takes 5h 51m and the cheapest is UA536 by United Airlines for $771.

CM - Compania Panamena de Aviacion

from $771

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UA - United Airlines

from $2519

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Connecting Flights

There are 339 flights with layovers on the route. The fastest connecting flight is UA2676 by United Airlines takes 7h 26m and the cheapest is UA536 by United Airlines for $258.

AS - Alaska Airlines

from $428

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AC - Air Canada

from $675

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F9 - Frontier Airlines

from $271

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TK - Turkish Airlines

from $1271

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HA - Hawaiian Airlines

from $690

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Y4 - Volaris

from $318

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UA - United Airlines

from $258

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AM - Aeromexico

from $351

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VB - VivaAerobus

from $760

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Airports

You can fly from Denver to Panama City from 2 airports (Denver International, Arapahoe Co).

Denver airports

Denver International-DEN

from $258
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Arapahoe Co-APA

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Panama City airports

Tocumen-PTY

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Paitilla-PAC

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Airplanes

There are flights to Panama City from Denver by 10 airlines that use 0 aircraft brands. They range from huge modern airplanes to small-sized.

Top Domestic Destinations from Denver

You may also consider searching for discounted plane tickets to some other popular places from Denver within United States.

Denver — Las Vegas

from $70

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Denver — Phoenix

from $59

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Denver — Boston

from $68

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Denver — Seattle

from $75

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Denver — Orlando

from $74

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Denver — Chicago

from $66

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Denver — Miami

from $68

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Denver — Tampa

from $57

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Denver — Los Angeles

from $17

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Denver — Houston

from $67

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Top International Destinations from Denver

Our state-of-the art metasearch will definitely provide you with the best airfare on international flights. We’re proud to partner with many reliable travel suppliers located outside the US what gives us an opportunity to offer the most competitive prices on far destinations.

Denver — Cancun

from $66

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Denver — London

from $63

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Denver — Tokyo

from $75

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Denver — Vancouver

from $60

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Denver — Toronto

from $60

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Denver — Paris

from $75

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Denver — Mexico City

from $66

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Denver — Calgary

from $68

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Denver — Dublin

from $69

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Denver — San Jose

from $72

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How to book a plane ticket yourself?

Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.
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