Cheap Flights from Denver, CO to Panama City from $249

On Cheapflightsplus.com you will find 2 direct and 339 connecting flights from Denver to Panama City. You can compare airfare deals from 10 airlines and multiple travel sites from $249, book and save on cheap plane tickets and last minute offers. Also check out DEN-PTY flight schedule to find best flight time, convenient departure and arrival airports.

Flight Information

Below we will explain in detail what the flights cost on the destination from Denver to Panama City depends on and how to choose the most interesting flight option for you.

Distance between Denver and Panama City is 4242 miles. Time difference between the cities is 2h. Airplanes depart 00:23 to 23:59 from 2 Denver airports and arrive 00:23 to 23:59 to 2 Panama City airports. Average flight time is 5h 51m.

  • The fastest flight 5h 51m
  • Average flight time 5h 51m
  • The earliest flight 00:23
  • The latest flight 23:59
  • Distance 2636 ml

The cheapest months to travel to Panama City are august (from 249 $), july (from 262 $), september (from 429 $).

The most expensive months are january (from 2 950 $), december (from 877 $), november (from 715 $).

What is the lowest airfare Denver to Panama City?

The cheapest plane ticket found by our users is $249. This airfare is for economy class on one-way UA536 flight by United Airlines for July 4, 2025 which leaves Denver International in Denver at 15:58 am and arrives at Panama City Tocumen at 12:35.

Economy class
$249
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Business class
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First class
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Flight Schedule Denver (Colorado) to Panama City

00:34 — 12:35+1day
35h 1m flight time
Find flight
from$262
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
15h 10m stop
21:40 — 22:40 Miami — San Jose
AV605 Avianca
11h 35m stop
10:15 — 12:35 San Jose — Panama City
AV643 Avianca
00:34 — 19:29
17h 55m flight time
Find flight
from$273
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
10h 53m stop
17:23 — 19:29 Miami — Panama City
CM333 Compania Panamena de Aviacion
00:34 — 08:11+1day
30h 37m flight time
Find flight
from$273
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
23h 35m stop
06:05 — 08:11 Miami — Panama City
CM173 Compania Panamena de Aviacion
00:34 — 08:30+1day
30h 56m flight time
Find flight
from$273
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
23h 54m stop
06:24 — 08:30 Miami — Panama City
CM246 Compania Panamena de Aviacion
00:34 — 10:40
9h 6m flight time
Find flight
from$276
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
2h 4m stop
08:34 — 10:40 Miami — Panama City
CM433 Compania Panamena de Aviacion
00:34 — 20:37
19h 3m flight time
Find flight
from$276
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
12h 1m stop
18:31 — 20:37 Miami — Panama City
CM227 Compania Panamena de Aviacion
00:34 — 16:26
14h 52m flight time
Find flight
from$278
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
7h 50m stop
14:20 — 16:26 Miami — Panama City
CM481 Compania Panamena de Aviacion
00:34 — 16:36
15h 2m flight time
Find flight
from$278
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
8h stop
14:26 — 16:36 Miami — Panama City
CM410 Compania Panamena de Aviacion
00:34 — 21:10
19h 36m flight time
Find flight
from$279
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
4h 50m stop
11:20 — 14:05 Miami — Bogota
AV9 Avianca
5h 20m stop
19:25 — 21:10 Bogota — Panama City
AV56 Avianca
00:34 — 00:45+1day
23h 11m flight time
Find flight
from$280
00:34 — 06:30 Denver — Miami
F93138 Frontier Airlines
12h 50m stop
19:20 — 21:59 Miami — Bogota
AV127 Avianca
1h 1m stop
23:00 — 00:45 Bogota — Panama City
AV40 Avianca
00:59 — 19:33
17h 34m flight time
Find flight
from$278
00:59 — 06:10 Denver — Atlanta
F93294 Frontier Airlines
10h stop
16:10 — 19:33 Atlanta — Panama City
CM891 Compania Panamena de Aviacion
13:46 — 19:33+1day
28h 47m flight time
Find flight
from$272
13:39 — 19:02 Denver — Atlanta
F93600 Frontier Airlines
21h 11m stop
16:10 — 19:33 Atlanta — Panama City
CM891 Compania Panamena de Aviacion
15:58 — 12:35+1day
19h 37m flight time
Find flight
from$249
15:58 — 21:15 Denver — San Jose
UA536 United Airlines
13h stop
10:15 — 12:35 San Jose — Panama City
AV643 Avianca
22:42 — 05:33+1day
5h 51m flight time
Find flight
from$746
Denver — Panama City
CM477 Compania Panamena de Aviacion
22:42 — 05:33+1day
5h 51m flight time
Find flight
from$2408
Denver — Panama City
UA7187 United Airlines
Full flight schedule will help you in detecting at what time planes fly from Denver to Panama City. You can also specify the concrete flights and airlines on the route and how long the flight actually is. Use the calendar for today, tomorrow or other specific date as some flights are available only on certain days of the week.
*Departure and arrival times - local. Updated on November 4, 2025.

Popular Airlines on the Route

The flight Denver — Panama City is served by 10 regular airlines and 3 low-cost airlines. Most of the flights on this route are operated by Air Canada - 8 departures per week at the price of from $ 653 . And the most expensive tickets are offered by United Airlines airline - from $ 4153.

Direct flights

There are 2 nonstop flights on the route. The fastest direct flight is CM477 by Compania Panamena de Aviacion takes 5h 51m and the cheapest is UA536 by United Airlines for $746.

  • CM - Compania Panamena de Aviacion
    from $746
    Find
  • UA - United Airlines
    from $2408
    Find
See more direct flights

Connecting Flights

There are 339 flights with layovers on the route. The fastest connecting flight is UA2676 by United Airlines takes 7h 26m and the cheapest is UA536 by United Airlines for $249.

  • AS - Alaska Airlines
    from $414
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  • AC - Air Canada
    from $653
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  • F9 - Frontier Airlines
    from $262
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  • TK - Turkish Airlines
    from $1228
    Find
  • HA - Hawaiian Airlines
    from $667
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  • Y4 - Volaris
    from $307
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  • UA - United Airlines
    from $249
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  • AM - Aeromexico
    from $339
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  • VB - VivaAerobus
    from $735
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See more connecting flights

Airports

You can fly from Denver to Panama City from 2 airports (Denver International, Arapahoe Co).

Denver airports

  • Denver International-DEN
    from $249
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  • Arapahoe Co-APA
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Panama City airports

  • Tocumen-PTY
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  • Paitilla-PAC
    Find

How to book a plane ticket yourself?

How to book an air ticket yourself?
  • Fill in the search parameters — cities of departure and destination, departure and return dates and click «Find flights»
  • Select the best flight that you like. Please, check the airports of departure and arrival. Select the best fare, but pay attention to the following flight details - airports of departure and arrival, flight duration and layovers. Please use filters and sort to find the best flight.
  • Click «Buy» when you are ready — our system will redirect you to the site that sells the selected flight ticket.
  • Fill in all passenger and payment information — passport and contact information, please double check all passengers’ names and make a payment for your itinerary.
  • That's it — you will receive an email with your e-ticket usually within 10 minutes after your flight is confirmed. Please, print the e-ticket and have it with you at the airport. You would need to have only a passport and/or a required form of ID to travel. Please, check your Visa requirements if you travel outside of the United States or Canada.

    To find a plane ticket, please select dates.

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